Fight Aging! Newsletter, June 26th 2023
This study explored the association between different cooking fuel types and the risk of cancer and all-cause mortality among seniors constructing Cox regression models. Data were obtained by linking waves of 6, 7, and 8 of the Chinese Longitudinal Healthy Longevity Survey, which included a total of 7,269 participants who were 65 years old and over. Cooking fuels were categorized as either biomass, fossil, or clean fuels. And the effects of switching cooking fuels on death risk were also investigated using Cox regression models. The results indicate that, compared with the users of clean fuels, individuals using bio...
Source: Fight Aging! - June 25, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Buried Alive
Getting my first post-operation MRI was no fun. (Source: Depth-First)
Source: Depth-First - June 25, 2023 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs

Dealing with Brain MRIs
Shedding light on a little-discussed aspect of having brain cancer. (Source: Depth-First)
Source: Depth-First - June 22, 2023 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs

Pump Up the Potassium
The element potassium plays a pivotal role in our bodies. It’s found in all our cells, where it regulates their volume and pressure. To do this, our bodies carefully control potassium levels so that the concentration is about 30 times higher inside cells than outside. Potassium works closely with sodium, which regulates the extracellular fluid volume and has a higher concentration outside cells than inside. These concentration differences create an electrochemical gradient, or a membrane potential. Potassium is the primary regulator of the pressure and volume inside cells, and it’s important for nerve transmiss...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 21, 2023 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Molecular Structures Cellular Processes Element Proteins Source Type: blogs

Psychedelic Science 2023 – Film Festival Day
I love how friendly and open the vibe is here at Psychedelic Science 2023 in Denver. As we were heading down the elevator in our hotel yesterday, we got to chatting with an enthusiastic attendee on the way out. She told us they had to cap registrations at 11,500 and turn away 70 interested vendors. That doesn’t surprise me. We’re clearly in a wave of surging interest in psychedelics. I’m here because I’m keenly interested to learn more about the potential for using psychedelics for self-development. I’ve only done a few psychedelic journeys so far, and I’d say there’s a 99% chan...
Source: Steve Pavlina's Personal Development Blog - June 21, 2023 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Creating Reality Lifestyle Source Type: blogs

Senolytic Drug Discovery as a Proving Ground for New Machine Learning Approaches
In principle, machine learning can be used to make small molecule drug discovery run more rapidly, more cost-effectively, and with a greater chance of success. The development of senolytic drugs to clear senescent cells is a good proving ground for this type of approach, and will likely accelerate investment into machine learning driven drug discovery platforms with broad application. Firstly, the state of the science shows that senescent cells are vulnerable to mechanisms that can be targeted effectively by small molecules. Secondly, it is also clear that far from all of these mechanisms are known and much remains to be d...
Source: Fight Aging! - June 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Can You Drink Coconut Water With Hypertension?
Conclusion So, circling back to our initial question: Can you drink coconut water if you have hypertension? The evidence seems to suggest that the answer is yes, provided it’s consumed in moderation, given its potassium and magnesium content. However, one must not overlook potential risks associated with overconsumption. A cornerstone of any dietary change, especially concerning a health condition like hypertension, is professional healthcare advice. Always consult your healthcare provider before making significant changes to your diet. After all, managing hypertension is an individual journey,...
Source: The EMT Spot - June 18, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs

poem
 Taylor SwiftAt the Taylor Swift show in PittsburghMost of the restrooms were reserved femaleWhen I finally found a men ’s roomIt was near empty and very cleanAs I pissed a pleasant tropical fragrance Wafted around me in heady swirls.It struck me the pains we take to mitigateThe foul, the ugly, the reeking, the distastefulMy own piss, via complex chemical reactionsWith the lime green slab at the baseWas creating a Costa Rican faunaOf sweet citrusy florality It ’s just piss, I thoughtIt ’s just me and my own pissI didn ’t need this Funeral home perfumes, deodorants and antiperspirantsThe way we d...
Source: Buckeye Surgeon - June 18, 2023 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs

Physical and Cognitive Impairments
My symptoms get much worse after brain surgery. (Source: Depth-First)
Source: Depth-First - June 17, 2023 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs

Of moths and box
This is a female Box-tree Moth. They were inadvertently brought into the UK in 2007 on imported, exotic Box plants. They are spreading rapidly and I see lots in Cottenham. I don’t think they’ve got as far north as Ely yet, but it’s only a matter of time. Female Box-tree Moths lack the male’s hair pencil at the end of the abdomen The female lays her eggs on Box plants and her larvae will ravage the plant, you’ll see the damage pretty quickly. In their native environment the moths are kept in check somewhat by the ecosystem itself, but that doesn’t happen here. I have warned people not to ...
Source: David Bradley Sciencebase - Songs, Snaps, Science - June 16, 2023 Category: Science Authors: David Bradley Tags: Lepidoptera Source Type: blogs

Career Conversations: Q & A With Physiologist Elimelda Moige Ongeri
Credit: Courtesy of Dr. Elimelda Moige Ongeri. A career path in science is rarely clear cut and linear, which Elimelda Moige Ongeri, Ph.D., can attest adds to its excitement. She went from working in animal reproductive biology to studying proteins involved in inflammation and tissue injury. Dr. Ongeri is also currently dean of the Hairston College of Health and Human Sciences and professor of physiology at North Carolina Agricultural and Technical State University (NC A&T) in Greensboro. In this interview, she shares details of her career, including a change in research focus to human physiology; her goals for the f...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 14, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Proteins Source Type: blogs

Fight Aging! Newsletter, June 12th 2023
In this study, we investigated the effect of NXP032 on neurovascular stabilization through the changes of PECAM-1, PDGFR-β, ZO-1, laminin, and glial cells involved in maintaining the integrity of the blood-brain barrier (BBB) in aged mice. NXP032 was orally administered daily for 8 weeks. Compared to young mice and NXP032-treated mice, 20-month-old mice displayed cognitive impairments in Y-maze and passive avoidance tests. NXP032 treatment contributed to reducing the BBB damage by attenuating the fragmentation of microvessels and reducing PDGFR-β, ZO-1, and laminin expression, thereby mitigating astrocytes and microglia ...
Source: Fight Aging! - June 11, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Towards Small Molecules that Induce Expression of Reprogramming Factor OCT4
Reprogramming involves inducing expression of reprogramming factors, canonically OSKM (OCT4, SOX2, KLF4, and MYC), the Yamanaka factors. When expressed for a sufficiently long time, a period of days to weeks, some fraction of OSKM-expressing cells dedifferentiate into induced pluripotent stem cells (iPSCs). Before that happens, however, beneficial epigenetic changes occur, resetting a cell to a more youthful pattern of gene expression, resulting in improvements such as restored mitophagy and mitochondrial function. The present focus of the industry is to find a way to safely apply transient exposure to reprogramming factor...
Source: Fight Aging! - June 7, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

The G-Word
I finally get a name for my attacker. (Source: Depth-First)
Source: Depth-First - June 7, 2023 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs

Urine Test for Parkinson ’s Disease
Scientists at Purdue University have developed a urine test for early-stage Parkinson’s disease. The technology involves isolating extracellular vesicles of neural origin from urine samples and then assessing the proteins within the vesicles to detect biomarkers of the disease. The researchers have called their technology “EVtrap” (Extracellular Vesicles total recovery and purification) and it involves using magnetic beads to concentrate extracellular vesicles in urine, before subsequent proteomics analysis. The goal of the technique is to detect levels of LRRK2 (leucine-rich repeat kinase 2) proteins and related dow...
Source: Medgadget - June 6, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Medicine Neurology parkinson's purdue Source Type: blogs