Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
In this study, we report systemic changes in the molecular regulation of biological processes under multiple lifespan-extending interventions, by jointly leveraging systems-level analyses on two mouse liver proteomic datasets, which were generated in the NIA Longevity Consortium, and a previously published mouse liver transcriptomic dataset. Differential Rank Conservation (DIRAC) analyses of mouse liver proteomics and transcriptomics data show that mechanistically distinct lifespan-extending interventions (acarbose, 17α-estradiol, rapamycin, and calorie restriction) generally tighten the regulation of biological modules. ...
Source: Fight Aging! - August 2, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
I am 49 … not out, how about you TAVI ?
This post was written after coming across a case report Oxford medical case report.
What is the life of a prosthetic Aortic valve?
The standard answer needs to be, mechanical valves can last up to 25 years or more. But, we are in a techno-conflict era. Instead of working on the longevity of the valve, ( with concerns for long-term OAC ) we fell for the biological valves. Curiously, this has made the durability of the valve, a less relevant discussion in many centers. We get excited when some company brings out a long-lasting bio-prosthetic valve that can live up to a maximum of 15 years.
Now, ...
Source: Dr.S.Venkatesan MD - August 1, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized prosthetic aortic valve starr edwards valve tavi valve Source Type: blogs
Examining the Details of Mitochondrial Dysfunction in the Aging Mouse Heart
Every cell contains hundreds of mitochondria, hard at work to produce the chemical energy store molecule adenosine triphosphate (ATP), used to power cellular activities. Mitochondria are complex structures, the evolved descendants of ancient symbiotic bacteria that are now integrated into the cell. At their center is the electron transport chain, a collection of protein complexes that conducts the energetic chemical reactions needed to make ATP. Mitochondria bear copies of a remnant circular genome, DNA distinct from that in the cell nucleus, which encodes some of the mitochondrial proteins necessary for mitochondrial func...
Source: Fight Aging! - July 31, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, July 31st 2023
In conclusion, an SBP level below 130 mmHg was found to be associated with longevity among older women. The longer SBP was controlled at a level between 110 and 130 mmHg, the higher the survival probability to age 90. Preventing age-related rises in SBP and increasing the time with controlled BP levels constitute important measures for achieving longevity.
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Source: Fight Aging! - July 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Central Agonists For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion
In summary, central agonists, a notable class of hypertension medications, offer an alternative modality when other first-line antihypertensive treatments fail to show desired results or cause intolerable side effects.
They operate via a unique neurocentric mechanism that primarily functions centrally in the brain, impacting blood pressure regulation by decreasing systemic arterial pressure and heart rate.
Despite their potential side effects and potential for interactions with other drugs, their therapeutic utility in the context of hypertension management remains undiminished.
Moreover, certain cen...
Source: The EMT Spot - July 27, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Tumor Board
The disquieting limits to glioblastoma ' s front-line diagnostic technique. (Source: Depth-First)
Source: Depth-First - July 27, 2023 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs
Cancer Treatment Increases Biological Age
The established non-surgical forms of cancer treatment, chemotherapy and radiotherapy, induce cellular senescence via stress and damage to cells. The target for these harmful effects is the cancer, but other cells are also inevitably stressed to the point of entering a senescent state. An increased burden of senescent cells in tissues throughout the body is a feature of aging. These cells directly contribute to dysfunction of tissues and organs via secreted signals, the senescence-associated secretory phenotype (SASP). When maintained over the long term, the SASP contributes to the onset and progression of age-related cond...
Source: Fight Aging! - July 26, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Why Am I So Tired?
Circadian rhythms control the timing of many daily changes in your body. Credit: iStock.
If you struggle to wake up in time for school or work or feel drowsy during a trip abroad, your circadian rhythms may be out of sync with your environment. Circadian rhythms are your internal timekeepers, and almost all organisms, from bacteria to plants and animals, have them. You can’t see them, but you can feel their effects—they control when you get sleepy, when you wake up in the morning, and when you feel hungry. Among other signals, the brain uses sunlight to keep time.
Changing Circadian Rhythms
Exposure to ligh...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - July 26, 2023 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Biological Clocks Common questions Source Type: blogs
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Consciously Exploring Your Relationship with Drugs
Humanity has a complex, long-term relationship with a wide variety of drugs. In this article let’s delve into your personal relationship with drugs, how you frame them, and how you might upgrade these relationships to be more conscious and aligned with your path of self-development. Let’s include common drug sources like coffee, tea, and chocolate too, so this will be very inclusive.
My purpose here isn’t to encourage or discourage you from using any particular substances but rather to invite you to take a more conscious and honest look at your current frames, attitudes, biases, and behaviors, and dete...
Source: Steve Pavlina's Personal Development Blog - July 21, 2023 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Creating Reality Emotions Health Lifestyle Relationships Values Source Type: blogs
The Ambiguously Alarming Brain MRI
A close look at one reason that glioblastoma remains incurable despite decades of research. (Source: Depth-First)
Source: Depth-First - July 21, 2023 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs
Reviewing the all-in-pod heart health segment
BY ANISH KOKA
The All-in podcast is a fairly popular show that features successful silicon valley investors commenting about everything worth commenting on from politics to health. The group has good chemistry and interesting insights that breaks the mold of the usual tribal politics that controls legacy media analysis of current events.
Last week, the podcast touched on a topic I spend a fair amount of time on: Cardiology.
Brad Gerstner, who is actually a guest host for this particular episode starts off by referencing something called Heartflow to evaluate the heart that has been recommended by one of the o...
Source: The Health Care Blog - July 20, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice All-in Podcast Anish Koka Brad Gerstner cardiology Source Type: blogs
Further Work on Small Molecules that Can Induce Cell Reprogramming
In this study, we developed and utilized novel screening methods including a quantitative nucleocytoplasmic compartmentalization assay (NCC) that can readily distinguish between young, old, and senescent cells. We identify a variety of novel chemical cocktails capable of rejuvenating cells and reversing transcriptomic age to a similar extent as OSK overexpression. Thus, it is possible to reverse aspects of aging without erasing cell identity using chemical rather than genetic means. (Source: Fight Aging!)
Source: Fight Aging! - July 19, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Career Conversations: Q & A With Biomedical Engineer Elizabeth Wayne
Courtesy of Dr. Elizabeth Wayne.
“It’s so fun to try to make meaning from a confusing experimental result and talk to other scientists who are excited by the same questions you are,” says Elizabeth Wayne, Ph.D., an assistant professor of biomedical engineering and chemical engineering at Carnegie Mellon University (CMU) in Pittsburgh, Pennsylvania. We talked to Dr. Wayne about her career trajectory, research on immune cells, and belief that scientists can change the world.
Q: How did you first become interested in science?
A: I was introduced to atoms during 6th grade science class. The idea that we’re ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - July 19, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cellular Imaging Profiles Source Type: blogs
SENS Research Foundation 2023 Annual Report
The SENS Research Foundation has released its 2023 annual report. This is one of the few non-profit organizations focused on advancing the state of research and development of rejuvenation therapies. It exists in the same family tree as the Methuselah Foundation and LEV Foundation, and all three now have somewhat different areas of focus within the same broad outline. In comparison to the SENS Research Foundation, the Methuselah Foundation gives more attention to tissue engineering, while LEV Foundation is presently investigating combinations of potential rejuvenation therapies in animal models, a sorely neglected area of ...
Source: Fight Aging! - July 18, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
