A Microbial Metabolite can Harm Dopaminergenic Neurons
The standard view of Parkinson's disease is that misfolding of α-synuclein occurs in the gut or brain, and then spreads in a prion-like manner to cause widespread dysfunction and cell death throughout the brain. The most vulnerable cells are dopaminergic neurons, and their destruction causes the most evident symptoms of the disease. Some people have a greater risk of Parkinson's disease than others. The most studied vulnerabilities are genetic variants that appear to make dopaminergic neurons even more vulnerable to stress. Environmental factors may also attack this population of neurons: here, researchers note that a soi...
Source: Fight Aging! - October 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Just say no
I just finished reading Dopesick, by Beth Macy. You don ' t need to take my word that it ' s worth your while, the book was a huge bestseller. However, it does have a fairly narrow focus. It tells the story of the opioid epidemic largely within the confines of a region of rural Virginia, but this is a disaster of national scope that manifests somewhat differently in different places. Here ' s the really sad news: source:U.S. Department of Health and Human Services I know it ' s a little small but you can see it full size if you click the link. The short version of the story is that deaths from opioid ...
Source: Stayin' Alive - October 17, 2023 Category: American Health Source Type: blogs
How Do Medicines Work?
Credit: iStock.
What we put into our bodies can affect how they function and what they do. For example, a sugary snack will probably make you feel differently than a high-protein meal. Similarly, different medicines elicit different responses in your body, and pharmacologists try to fine-tune each medicine to balance the desired (on-target) with the undesired (off-target) effects—a branch of pharmacology called pharmacodynamics.
Most medicines work by binding to a molecular target, usually proteins like receptors or enzymes, and either blocking or supporting its activity, which results in their therapeutic effects.
...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - October 16, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Common questions Medicines Miniseries Source Type: blogs
Why Antidepressants Take 28 Days To Start Working (M)
The study may partly explain how antidepressants really work -- since there is little evidence for the 'chemical imbalance' theory. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - October 15, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Antidepressants subscribers-only Source Type: blogs
Fight Aging! Newsletter, October 16th 2023
In conclusion, a number of studies have shown that CD4+ Treg cells are crucial in the maintenance of peripheral tolerance and have an important role in the control of atherosclerosis-related inflammation. Therefore, Treg cells are a promising target of major research efforts focused on immune-modulating therapies against atherosclerosis. Developing anti-atherosclerotic Treg-based therapies faces challenges. However, rapid progress in genetic, epigenetic, and molecular aspects of cellular immunology gives hope for a fast-track solution.
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Delivering Senolytic Nanoparticles to Atheroscle...
Source: Fight Aging! - October 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Grandpa, What Did You Do at the Atom Bomb Factory?
First in a series investigating what exactly my grandfather did at the Hanford Engineer works. (Source: Depth-First)
Source: Depth-First - October 14, 2023 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs
The “Green Pope” Loves Science and Is Cautious of AI
By MIKE MAGEE
By all accounts, they were mutually supportive. He was three years older and the chief scientific adviser to the world’s most powerful religious leader. The Scientific American called him “the greatest scientist of all time,” and not because he won the Nobel Prize in Chemistry a decade earlier for explaining the nuts and bolts of ozone formation. It was his blunt truthfulness and ecological advocacy that earned the organization’s respect.
Paul Crutzan is no longer alive. He died on February 4, 2021 in Mainz, Germany at the age of 87. What attracted the 86 year old “Green Pope” to Paul were t...
Source: The Health Care Blog - October 11, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Climate Change Mike Magee Pope Francis Source Type: blogs
Lollipop Puts the Fun in Saliva Collection
Researchers at the University of Washington have developed a technique to make saliva collection for diagnostic purposes a little less disgusting and a little more fun and pleasant. Saliva collection often acts as a less invasive alternative than throat swabs in the detection of a variety of pathogens, such as that causing streptococcal soar throat (strep throat). However, manually collecting the right amount of saliva is pretty gross. In an effort to streamline this process, and make it more appealing to both adults and children, these researchers have developed a new solution. The CandyCollect is a specially designed lol...
Source: Medgadget - October 11, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Materials Medicine Source Type: blogs
A Novel Approach to Exploiting the Peculiar Biochemistry of Senescent Cells to Produce a Highly Targeted Senolytic
Senolytic drugs selectively destroy senescent cells. First generation senolytic drugs generally target apoptosis-resistance mechanisms and have off-target effects, though these appear quite acceptable in the case of dasatinib and quercetin, given the potential benefits. Nonetheless, researchers are expending a great deal of effort to search for ways to produce far more selective targeting of senescent cells. One example is the category of prodrugs that are only transformed into their cytotoxic form via the activity of β-galactosidase, upregulated in senescent cells. Another type of prodrug employs iron metabolism peculiar...
Source: Fight Aging! - October 11, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How I Bought and Estimated the Purity of Sodium Dichloroacetate
Trust, but verify. On second thought, just verify. (Source: Depth-First)
Source: Depth-First - October 10, 2023 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs
Claira Sohn Cultivates Neurons and Diversity in the STEM Community
Credit: Courtesy of Claira Sohn.
Claira Sohn credits her grandfather with sparking her interest in science. Although he never studied science at a 4-year university due to financial limitations, he took many community college classes and worked in chemistry labs developing products such as hair dyes and dissolvable stitches. “Every morning, my grandfather would take me to school, and we’d stop to get orange juice and a cookie and talk about science. When I was in elementary school, he bought me a book about quantum mechanics written for kids,” she says. “He inspired me to ask questions and encouraged me to go to ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - October 4, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Diseases Profiles Training Source Type: blogs
Beware Oncologists Bearing Hope
Why interpretations from this special breed of doctor should be considered carefully. (Source: Depth-First)
Source: Depth-First - October 4, 2023 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs
What happened to the chemical pathologist?
During my early years as a pediatric hospitalist in the U.K. during the ’80s, a figure that loomed large was the chemical pathologist (CP). The CP was the guardian of the laboratory, and every hospital had one. This fearsome beast was approached with trepidation, as the outcome was likely to be a unique but bruising
Read more…
What happened to the chemical pathologist? originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - October 1, 2023 Category: General Medicine Authors: Martin C. Young, MD Tags: Conditions Pathology Source Type: blogs
Fight Aging! Newsletter, October 2nd 2023
In conclusion, we identified several candidate genes that may confer cancer resistance in cetaceans, providing a new avenue for further research into the mechanisms of lifespan extension.
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A Relationship Between the Gut Microbiome and Bone Density
https://www.fightaging.org/archives/2023/09/a-relationship-between-the-gut-microbiome-and-bone-density/
Changes in the gut microbiome take place with advancing age, an increase in populations that provoke chronic inflammation, a reduction in the populations producing beneficial metabolites. Even only considering rising levels of in...
Source: Fight Aging! - October 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
