The Mitochondrial Permeability Transition Pore and Loss of Mitochondrial Membrane Potential in Aging
This open access review paper discusses what is known of the role of the mitochondrial permeability transition pore in the age-related decrease of mitochondrial membrane potential. This measure is a lens through which one can view the growing dysfunction of mitochondria with advancing age. Every cell contains hundreds of mitochondria, producing chemical energy store molecules, ATP, to power cellular processes. Reduced rates of ATP production lead to cell and tissue dysfunction. This is thought to be an important contribution to degenerative aging, though exactly how it arises from causative mechanisms, such as mitochondria...
Source: Fight Aging! - August 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How the 3 laws of thermodynamics illuminate the pathways of health care and AI
This article unveils these connections, offering a physician’s insights into the applications of these principles in patient care, medical innovation, and the integration of
Read more…
How the 3 laws of thermodynamics illuminate the pathways of health care and AI originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 21, 2023 Category: General Medicine Authors: Harvey Castro, MD, MBA Tags: Tech Health IT Source Type: blogs
Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
George
Coming to terms with a disease that can change who you are. (Source: Depth-First)
Source: Depth-First - August 19, 2023 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs
Associations Between the Lipidome and Epigenetic Aging
The body contains hundreds of different types of lipid molecules, participating in cellular metabolism in ways that are just as complex and relevant to health as the activities of other biomolecules. In the context of aging, this broad range of lipids are perhaps understudied in comparison to levels and roles of proteins and patterns of gene expression. The situation is much the same, however: researchers can readily and cost-effectively amass a vast amount of data, but the analysis of this data lags far behind the accumulation of ever more and ever larger omics databases. It is ever unclear as to whether any particular as...
Source: Fight Aging! - August 18, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Celebrating 10 Years of Biomedical Beat
This August marks 10 years of the blog! Throughout the past decade, we’ve brought you blog posts that explore basic science topics, quiz your knowledge, showcase cool images, and more! Some of our most-read favorites include:
We’ve also interviewed over a hundred NIGMS-funded scientists about their research, mentorship, and careers. To celebrate 10 years, we went back to two of the first researchers featured on the blog to see what they’re up to now.
Exploring Enzymes With Dr. Emily Scott
Credit: University of Michigan.
Around the time we first fe...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - August 16, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Molecular Structures Cool Tools/Techniques Profiles Research Roundup RNA Source Type: blogs
Predicting Mildly Age-Slowing Drugs will be a Focus of Future Research
It is clear that new ways of analyzing large amounts of data via machine learning will be used extensively in the near future in the field of aging research, employed to speed up the process of finding new drug targets and small molecules that might alter metabolism to slightly slow aging. This will no doubt be a sizable component of the longevity industry, if we judge the near future by the present distribution of companies and efforts. I can't say that I think that is likely to produce sizable benefits in aging humans, however, when compared to the rational design of therapies to specifically repair underlying causes of ...
Source: Fight Aging! - August 16, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Glycogen Phosphorylase Inhibition Improves Cognitive Function in Old Mice Only
Today's open access paper provides an interesting example of a pharmacological strategy that is beneficial to specific aspects of memory function in old mice, but detrimental to that same function in young mice. This is certainly possible, as the biochemistry of cells and tissues is nothing if not exceedingly complex, but this outcome tends to be unusual. More commonly, a therapy targeting causative mechanisms of aging, one that improves function in aged individuals, will do little to nothing for younger individuals, but will not be actively harmful.
Here, clearly, the biochemistry of memory formation changes in mea...
Source: Fight Aging! - August 15, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
What Is Pharmacology?
Credit: iStock.
Pharmacology is the study of how molecules, such as medicines, interact with the body. Scientists who study pharmacology are called pharmacologists, and they explore the chemical properties, biological effects, and therapeutic uses of medicines and other molecules. Their work can be broken down into two main areas:
Pharmacokinetics is the study of how the body acts on a medicine, including its processes of absorption, distribution, metabolism, and excretion (ADME).
Pharmacodynamics is the study of how a medicine acts in the body—both on its intended target and throughout all the organs and tissue...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - August 14, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Common questions Genomics Medicines Miniseries Source Type: blogs
Fight Aging! Newsletter, August 14th 2023
This study demonstrates just how vital the thymus is to maintaining adult health."
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Does Amyloid-β Aggregation Cause Broad Disruption of Proteostasis?
https://www.fightaging.org/archives/2023/08/does-amyloid-%ce%b2-aggregation-cause-broad-disruption-of-proteostasis/
Researchers here speculate on the ability of insoluble amyloid-β aggregates to be broadly disruptive of the solubility of many other proteins, and thus disruptive to cell and tissue function. Is this important in aging? The evidence here shows the existence of the mechanism in a lower species, but that doesn't ...
Source: Fight Aging! - August 13, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senomorphic Development to Reduce the Senescence Associated Secretory Phenotype
The burden of cellular senescence increases with age, perhaps largely because the immune system becomes less able to remove senescent cells in a timely fashion. Lingering senescent cells are significantly harmful even when making up one percent or less of all cells in a tissues. This is because cells in a senescent state vigorously generate a mix of pro-growth, pro-inflammatory signals, the senescence-associated secretory phenotype (SASP). The SASP changes cell behavior for the worse, encourages chronic inflammation, and induces nearby cells to also become senescent. This is actively disruptive to tissue function, and cont...
Source: Fight Aging! - August 11, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Chemoradiotherapy
Undergoing a chemical and radiological exorcism. (Source: Depth-First)
Source: Depth-First - August 11, 2023 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs
Copper Keeps Us Going
Copper pipes, copper wires, copper…food? Copper is not only a useful metal for conducting electricity, but it’s also an essential element we need in our bodies for a variety of important activities—from metabolizing iron to pigmenting skin. (Source: Biomedical Beat Blog - National Institute of General Medical Sciences)
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - August 9, 2023 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Molecular Structures Cellular Processes Element Proteins Source Type: blogs
Donate to Support a Study of Allotopic Expression for the COX2 Mitochondrial Gene
Mitochondria, hundreds to a cell, are evolved descendants of the ancient bacteria that became symbiotic with the first, primitive cells. Mitochondria still behave a great deal like bacteria, in that they fuse together, replicate, carry a small circular genome, the mitochondrial DNA and promiscuously swap component parts. While the primary role of mitochondria is the generation of adenosine triphosphate (ATP), a chemical energy store used to power cell processes, they are also well integrated cellular components in a broader sense, influential in a range of fundamental cellular activities.
Mitochondrial DNA is a lot ...
Source: Fight Aging! - August 7, 2023 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
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Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seem...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
