Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrial Epigenetics in Age-Related Mitochondrial Dysfunction
The hundreds of mitochondria present in every cell in the body undertake the essential duty of producing chemical energy store molecules, adenosine triphosphate (ATP), used to power the cell. With age, mitochondria become less efficient and more damaged, generating oxidative stress and triggering inflammation while producing less ATP than is optimal. This is thought to be a major contribution to degenerative aging, though as for all contributions to aging, it requires a highly targeted way to improve mitochondrial function in order to determine just how important it is. That highly targeted therapy doesn't yet exist in a u...
Source: Fight Aging! - September 15, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Times They Are A-Changing … .Fast
By KIM BELLARD
If you have been following my Twitter – oops, I mean “X” – feed lately, you may have noticed that I’ve been emphasizing The Coming Wave, the new book from Mustafa Suleyman (with Michael Bhaskar). If you have not yet read it, or at least ordered it, I urge you to do so, because, frankly, our lives are not going to be the same, at all. And we’re woefully unprepared.
One thing I especially appreciated is that, although he made his reputation in artificial intelligence, Mr. Suleyman doesn’t only focus on AI. He also discusses synthetic biology, quantum computing, robotics, and new energ...
Source: The Health Care Blog - September 14, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Tech AI Kim Bellard quantum computing Smart Pills synthetic biology The Coming Wave Source Type: blogs
Reviewing Evidence for Urolithin A Supplementation
Mitochondria are the power plants of the cell, responsible for generating chemical energy store molecules to power cell processes. Urolithin A is one of a number of supplements shown to improve mitochondrial function, though as for the others it isn't all that impressive when compared to the effects of regular exercise. Nonetheless, this and other approaches to modestly attenuate age-related declines in mitochondrial function are under active development. They are not solutions to the problem of mitochondrial aging, however. For that we must look to more radical approaches to therapy, such as mitochondrial transplantation,...
Source: Fight Aging! - September 14, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Progression
The Standard of Care treatment fails. (Source: Depth-First)
Source: Depth-First - September 14, 2023 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs
Are Pharmacists Really Just Shopkeepers With A Strong Line In Pills?
This appeared
last week:
Chemists protest medicine rule change in angry walk out
Tom McIlroy Political correspondent
Sep 4, 2023 –
5.37pm
Pharmacists
have staged an angry walk-out of federal parliament, protesting the Albanese
government’s moves to allow more than 4 million consumers to buy two months’ worth of
medicine for the price of a single prescription.
Hundreds
of pharmacists were in (Source: Australian Health Information Technology)
Source: Australian Health Information Technology - September 14, 2023 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
A 40 year old with nonspecific symptoms including dizziness
.What do you notice about the ECG?There is a very short QT interval. This is often found in hypercalcemia. See Ken Grauer ' s comments below for detail.Thus, the patient ' s chemistry was done and revealed ionized hypercalcemia of 6.3 mg/dL (normal 4.4 - 5.2)Followup: he was found to have hyperparathyroidism===================================MY Comment, by KEN GRAUER, MD (9/12/2023):===================================Today ' s ECG is remarkable for an uncommon but important finding that we periodically review, because it otherwise is all-too-easy to overlook. For example — Did YO...
Source: Dr. Smith's ECG Blog - September 12, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
Wanted: Division of Pharmacology, Physiology, and Biological Chemistry Branch Chief
We’re seeking a highly qualified scientist to serve as a branch chief in our Division of Pharmacology, Physiology, and Biological Chemistry (PPBC). This is a newly created position for the Division as it reorganizes into three branches. Applicants should have significant interest and experience in the scientific areas managed by the Division, which will continue to encompass all the existing research portfolios and will generally be arranged into branches covering physiology and clinical sciences, biochemistry and molecular pharmacology, and chemistry and chemical biology. For a listing of the current scientifi...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - September 11, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Source Type: blogs
What Happens to Medicine in Your Body?
Medicines administered orally, by inhaler, and intravenously enter the stomach, lungs, and veins, respectively. They’re absorbed, then circulate throughout the body in the blood, are processed by the liver, and excreted by the kidneys and intestines. Credit: NIGMS.
Have you ever wondered what happens inside your body when you take a medicine? An area of pharmacology called pharmacokinetics is the study of precisely that. Here, we follow a medicine as it enters the body, finds its therapeutic target (also called the active site), and then eventually leaves the body.
To begin, a person takes or is given a dose of medi...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - September 11, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Common questions Medicines Miniseries Source Type: blogs
“The Greatest Scientist of All Time” says Scientific American. Who is it?
BY MIKE MAGEE
When it comes to our earthly survival as a human species, words are often under-powered and off-the-mark. Clearer concepts, definitions and terms are required for clarity. Here are five terms that are useful and worth remembering:
Planetary Boundaries
Earth Systems
Human Perturbations
Planetary Scale Destabilization
Holocene Epoch vs. Anthropogenic Epoch
These terms all tie back to a single source – a child of World War II, only seven when his home in Amsterdam was overrun by Nazis. His father was a waiter, his mother a cook in a local hospital. He’d later recall with a sh...
Source: The Health Care Blog - September 11, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Non-Health Chemistry Mike Magee Ozone Paul Crutzen Scientific American Source Type: blogs
Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The next bumper sticker: political science
As usual, Ramaswamy ' s glib slogans aren ' t self-explanatory, but I think we can figure out what he ' s pretending to be thinking about with this one:There are three branches of the U.S. government, not four.One would guess that this is a reference to the bullshit concept of the " Deep State. " What that actually means is of course the career civil service -- federal employees who don ' t get replaced wholesale every time the party in power changes, and who have legal protections to make sure that doesn ' t happen. Sometimes it also includes the military. (Sometimes it ' s the Deep State that ' s persecuting Ronald...
Source: Stayin' Alive - September 9, 2023 Category: American Health Source Type: blogs
The Way Forward for Community Health Following Pharmacy Closures
The following is a guest article by Paul Christie, Co-Founder and CEO at Tachmed
The UK’s robust and well-established pharmacy model is facing huge changes this year, as hundreds of chemists across the country are expected to shut their doors in the coming months, leading to pharmacists declaring that the model is at ‘breaking point‘.
Back in 2022, NHS data revealed the number of community pharmacies in England had dropped to its lowest figure since 2015, due to a net loss of 110 pharmacies in 2021/22.
Then in January, Lloyds pharmacy announced it was withdrawing from Sainsbury’s supermarkets – settin...
Source: EMR and HIPAA - September 8, 2023 Category: Information Technology Authors: Guest Author Tags: Health IT Company Healthcare IT Telemedicine and Remote Monitoring community health COVID Lockdowns Digital Diagnostics Healthcare RPM NHS patient data Paul Christie Pharmacies Pharmacists Self-Testing Sexual Health London Tach Source Type: blogs
Reviewing Nicotinamide Riboside as a Strategy to Increase NAD Levels
The vitamin B3 derivative nicotinamide riboside is one of the more studied ways to increase nicotinamide adenine dinucleotide (NAD) levels in aged tissues. NAD is important in mitochondrial function, but for incompletely understood reasons becomes less available with advancing age. Delivering precursors to NAD synthesis such as nicotinamide riboside can help to boost NAD levels, but researchers have failed to show that the increase in NAD levels and resulting health benefits of this sort of approach are any better than those produced by regular exercise. Clinical trials of various means of increasing NAD levels have produc...
Source: Fight Aging! - September 8, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Heart Has High Energy Needs, Making it Vulnerable to Age-Related Mitochondrial Dysfunction
Not all tissues are equal in their energy needs. The brain and more consistently active muscles, such as the heart, are at the top of the list. Energy for cell and tissue processes is provided by the chemical energy store molecule adenosine triphosphate (ATP), which is produced by mitochondria. Every cell contains hundreds of mitochondria, the descendants of ancient symbiotic bacteria now evolved to become fully integrated cell components. Mitochondria still replicate much like bacteria, each containing a small remnant circular genome. When damaged or dysfunctional, mitochondria are cleared by the complex process of mitoph...
Source: Fight Aging! - September 6, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
