Surveillance for Lyme Disease After Implementation of a Revised Case Definition - United States, 2022
MMWR Morb Mortal Wkly Rep. 2024 Feb 15;73(6):118-123. doi: 10.15585/mmwr.mm7306a1.ABSTRACTLyme disease, a tickborne zoonosis caused by certain species of Borrelia spirochetes, is the most common vectorborne disease in the United States. Approximately 90% of all cases are reported from 15 high-incidence jurisdictions in the Northeast, mid-Atlantic, and upper-Midwest regions. After the implementation of a revised surveillance case definition in 2022, high-incidence jurisdictions report cases based on laboratory evidence alone, without need for additional clinical information. In 2022, 62,551 Lyme disease cases were reported ...
Source: MMWR Morb Mortal Wkl... - February 15, 2024 Category: Epidemiology Authors: Kiersten J Kugeler Austin Earley Paul S Mead Alison F Hinckley Source Type: research
Surveillance for Lyme Disease After Implementation of a Revised Case Definition - United States, 2022
MMWR Morb Mortal Wkly Rep. 2024 Feb 15;73(6):118-123. doi: 10.15585/mmwr.mm7306a1.ABSTRACTLyme disease, a tickborne zoonosis caused by certain species of Borrelia spirochetes, is the most common vectorborne disease in the United States. Approximately 90% of all cases are reported from 15 high-incidence jurisdictions in the Northeast, mid-Atlantic, and upper-Midwest regions. After the implementation of a revised surveillance case definition in 2022, high-incidence jurisdictions report cases based on laboratory evidence alone, without need for additional clinical information. In 2022, 62,551 Lyme disease cases were reported ...
Source: MMWR Morb Mortal Wkl... - February 15, 2024 Category: Epidemiology Authors: Kiersten J Kugeler Austin Earley Paul S Mead Alison F Hinckley Source Type: research
The major epidemiologic, microbiologic, immunologic, and clinical aspects of Lyme disease that form the basis for a newly developed vaccine that may become available soon for human use
Working together, two major pharmaceutical companies have developed a Lyme disease vaccine consisting of recombinant-derived outer surface protein A (OspA) of the etiologic agent Borrelia burgdorferi. Multiple clinical trials have shown the vaccine to have good safety and efficacy results, and it is hoped that it would become available for human use at least by the year 2025 after receiving approval from the U.S. Food and Drug Administration. There are still challenges left to ensure that the vaccine has, at most, minimal side effects. Also, because the previously developed Lyme disease vaccine was discontinued in 2002 aft...
Source: Frontiers in Immunology - February 14, 2024 Category: Allergy & Immunology Source Type: research
High Prevalence of Borrelia burgdorferi Antibodies in Jaworzno, Poland: A Retrospective Study Revealing Endemic Lyme Borreliosis
CONCLUSIONS The ELISA method obtained similar values for positive, negative, and equivocal results in the serological test. This was reflected in the survey conducted on residents who reported a tick bite and later received a positive result in the ELISA test as well as an approximate time between the bite and removal of the tick.PMID:38327041 | PMC:PMC10863337 | DOI:10.12659/MSM.943203 (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 8, 2024 Category: Research Authors: Barbara Kole żyńska Krzysztof Solarz Weronika Wieczorek Dorota Sagan Dariusz Boro ń Rafa ł Staszkiewicz Dawid Soba ński Tomasz Sirek Anna Janik Piotr Łojko Beniamin Oskar Grabarek Source Type: research
Dysautonomia following Lyme disease: a key component of post-treatment Lyme disease syndrome?
Dysautonomia, or dysfunction of the autonomic nervous system (ANS), may occur following an infectious insult and can result in a variety of debilitating, widespread, and often poorly recognized symptoms. Dysautonomia is now widely accepted as a complication of COVID-19 and is an important component of Post-Acute Sequelae of COVID-19 (PASC or long COVID). PASC shares many overlapping clinical features with other infection-associated chronic illnesses including Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Post-Treatment Lyme Disease Syndrome (PTLDS), suggesting that they may share common underlying mechani...
Source: Frontiers in Neurology - February 8, 2024 Category: Neurology Source Type: research
Evolutionary dynamics and geographical dispersal of Borrelia lusitaniae
ConclusionThe results of this study can provide beneficial information about the potential for further spread of B. lusitaniae in Europe and North Africa and estimation of necessity for the development of strategies to monitor and control Lyme borreliosis. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - February 6, 2024 Category: Microbiology Source Type: research
Lyme Disease Models of Tick-Mouse Dynamics with Seasonal Variation in Births, Deaths, and Tick Feeding
Bull Math Biol. 2024 Jan 31;86(3):25. doi: 10.1007/s11538-023-01248-y.ABSTRACTLyme disease is the most common vector-borne disease in the United States impacting the Northeast and Midwest at the highest rates. Recently, it has become established in southeastern and south-central regions of Canada. In these regions, Lyme disease is caused by Borrelia burgdorferi, which is transmitted to humans by an infected Ixodes scapularis tick. Understanding the parasite-host interaction is critical as the white-footed mouse is one of the most competent reservoir for B. burgdorferi. The cycle of infection is driven by tick larvae feedin...
Source: Bulletin of Mathematical Biology - January 31, 2024 Category: Bioinformatics Authors: Kateryna Husar Dana C Pittman Johnny Rajala Fahad Mostafa Linda J S Allen Source Type: research
Exploring the relationship of supernumerary recurrent renal calculi formation and tick-borne infections: a case report
A 51-year-old male with a history of Cacchi-Ricci disease and long-standing infection with various species of Borrelia, Babesia, and Bartonella presented with recurrent symptoms of right-sided flank pain. Numerous renal calculi were identified on imaging. The etiology of the calculi had not been previously elucidated. Symptoms intermittently date back to 2002 when uric acid stones were identified. Subsequent calculi analysis revealed calcium oxalate stones. Despite the commonality of nephrolithiasis in patients with Cacchi-Ricci disease, the extreme number of calculi and recurrent presentation of symptoms persisted despite...
Source: Frontiers in cellular and infection microbiology - January 26, 2024 Category: Microbiology Source Type: research
Borrelia turicatae from Ticks in Peridomestic Setting, Camayeca, Mexico
Emerg Infect Dis. 2024 Feb;30(2):380-383. doi: 10.3201/eid3002.231053.ABSTRACTWe conducted surveillance studies in Sinaloa, Mexico, to determine the circulation of tick-borne relapsing fever spirochetes. We collected argasid ticks from a home in the village of Camayeca and isolated spirochetes. Genomic analysis indicated that Borrelia turicatae infection is a threat to those living in resource-limited settings.PMID:38270112 | PMC:PMC10826751 | DOI:10.3201/eid3002.231053 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - January 25, 2024 Category: Infectious Diseases Authors: Edwin V ázquez-Guerrero Alexander R Kneubehl Patricio Pellegrini-Hern ández Jos é Luis González-Quiroz Mar ía Lilia Domínguez-López Aparna Krishnavajhala Paulina Estrada-de Los Santos J Antonio Ibarra Job E Lopez Source Type: research
Highly heterogenous humoral immune response in Lyme disease patients revealed by broad machine learning-assisted antibody binding profiling with random peptide arrays
This study was designed to perform a broad profiling of the entire repertoire of circulating antibodies in human sera at the single-individual level using planar arrays of short linear peptides with random sequences. The peptides sample sparsely, but uniformly the entire combinatorial sequence space of the same length peptides for profiling the humoral immune response to a B.burg. infection and compare them with other diseases with etiology similar to LD and healthy controls.ResultsThe study revealed substantial variability in antibody binding profiles between individual LD patients even to the same antigen (VlsE protein) ...
Source: Frontiers in Immunology - January 22, 2024 Category: Allergy & Immunology Source Type: research
Borrelia nietonii sp. nov.: Relapsing Fever Spirochetes Transmitted By the Tick Ornithodoros hermsi Designated Previously as Borrelia hermsii Genomic Group II
Vector-Borne and Zoonotic Diseases, Ahead of Print. (Source: Vector-Borne and Zoonotic Diseases)
Source: Vector-Borne and Zoonotic Diseases - January 22, 2024 Category: Infectious Diseases Authors: Tom G. Schwan Sandra J. Raffel Stacy M. Ricklefs Daniel P. Bruno Craig Martens Source Type: research
Borrelia turicatae from Ticks in Peridomestic Setting, Camayeca, Mexico
E. V ázquez-Guerrero et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - January 18, 2024 Category: Infectious Diseases Source Type: research
Vector competence of Ixodes ricinus instars for the transmission of Borrelia burgdorferi sensu lato in different small mammalian hosts
Many pathogens and parasites can infect multiple host species, and the competence of different hosts as pathogen reservoirs is key to understanding their epidemiology. Small mammals are important hosts for the... (Source: Parasites and Vectors)
Source: Parasites and Vectors - January 18, 2024 Category: Microbiology Authors: Lars K. Linds ø, Hildegunn Viljugrein and Atle Mysterud Tags: Research Source Type: research
Molecular identification of Borrelia and SFG Rickettsia spp. in hard ticks parasitizing domestic and wild animals in southeastern Spain
This study increases the knowledge about the presence ofBorrelia spp. DNA and SFGRickettsia spp. DNA in different hard tick species from this geographical area. (Source: Veterinary Research Communications)
Source: Veterinary Research Communications - January 17, 2024 Category: Veterinary Research Source Type: research
Diagnosis of neuroborreliosis in the context of local seroprevalence: A chart review study and a methodological overview
CONCLUSION: Our results suggest that recombinant antigen-based two-tier serology from solely the sera might have sufficient positive predictive value to verify NB in young individuals with characteristic anamnestic data in our region. When parallel serum-CSF testing is warranted, AI should have priority. IgG and albumin concentrations in the both serum and the CSF, the potential time of exposure and the nature and duration of symptoms form the bare minimal set of data for conclusive testing.PMID:38174513 | DOI:10.4103/0972-9062.374040 (Source: Journal of Vector Borne Diseases)
Source: Journal of Vector Borne Diseases - January 4, 2024 Category: Infectious Diseases Authors: Andr ás Baráth M ónika Révész M árton Gönczi Gabriella Bek ő Andr ás Zóka Source Type: research
