Copulation of < em > Ixodes ricinus < /em > males and females on the host and its potential impact on pathogen transmission
CONCLUSIONS: By increasing the feeding dynamics in females, the copulation of I. ricinus males with females attached to the host's skin may stimulate pathogen replication in tick tissues and migration from the gut to the salivary glands. Further investigations of the I. ricinus copulation on the host on female feeding and pathogen transmission may contribute to the elucidation of the eco-epidemiology of tick-borne diseases transmitted by this tick species.PMID:38153063 | DOI:10.26444/aaem/174105 (Source: Annals of Agricultural and Environmental Medicine : AAEM)
Source: Annals of Agricultural and Environmental Medicine : AAEM - December 28, 2023 Category: Environmental Health Authors: Weronika Buczek Alicja Buczek Marek Asman Katarzyna Bartosik Source Type: research
Copulation of < em > Ixodes ricinus < /em > males and females on the host and its potential impact on pathogen transmission
CONCLUSIONS: By increasing the feeding dynamics in females, the copulation of I. ricinus males with females attached to the host's skin may stimulate pathogen replication in tick tissues and migration from the gut to the salivary glands. Further investigations of the I. ricinus copulation on the host on female feeding and pathogen transmission may contribute to the elucidation of the eco-epidemiology of tick-borne diseases transmitted by this tick species.PMID:38153063 | DOI:10.26444/aaem/174105 (Source: Annals of Agricultural and Environmental Medicine : AAEM)
Source: Annals of Agricultural and Environmental Medicine : AAEM - December 28, 2023 Category: Environmental Health Authors: Weronika Buczek Alicja Buczek Marek Asman Katarzyna Bartosik Source Type: research
Copulation of < em > Ixodes ricinus < /em > males and females on the host and its potential impact on pathogen transmission
CONCLUSIONS: By increasing the feeding dynamics in females, the copulation of I. ricinus males with females attached to the host's skin may stimulate pathogen replication in tick tissues and migration from the gut to the salivary glands. Further investigations of the I. ricinus copulation on the host on female feeding and pathogen transmission may contribute to the elucidation of the eco-epidemiology of tick-borne diseases transmitted by this tick species.PMID:38153063 | DOI:10.26444/aaem/174105 (Source: Annals of Agricultural and Environmental Medicine : AAEM)
Source: Annals of Agricultural and Environmental Medicine : AAEM - December 28, 2023 Category: Environmental Health Authors: Weronika Buczek Alicja Buczek Marek Asman Katarzyna Bartosik Source Type: research
Rituximab leading to an atypical presentation of neuroborreliosis and false negative serology
Pract Neurol. 2023 Dec 22:pn-2023-003976. doi: 10.1136/pn-2023-003976. Online ahead of print.ABSTRACTTwo patients, recently treated with the B-cell-depleting monoclonal antibody, rituximab, had 2-3 months of progressive systemic symptoms; comprehensive investigations did not clarify the diagnosis. Transient radicular pain at disease onset had suggested neuroborreliosis, but seronegativity and an atypical clinical course made this unlikely. However, PCR identified Borrelia burgdorferi DNA in cerebrospinal fluid, establishing the diagnosis of neuroborreliosis. Both the clinical picture and the laboratory findings can be atyp...
Source: Practical Neurology - December 22, 2023 Category: Neurology Authors: Åslaug Rudjord Lorentzen Kristine Karlsrud Berg Unn Lj østad Source Type: research
Rituximab leading to an atypical presentation of neuroborreliosis and false negative serology
Pract Neurol. 2023 Dec 22:pn-2023-003976. doi: 10.1136/pn-2023-003976. Online ahead of print.ABSTRACTTwo patients, recently treated with the B-cell-depleting monoclonal antibody, rituximab, had 2-3 months of progressive systemic symptoms; comprehensive investigations did not clarify the diagnosis. Transient radicular pain at disease onset had suggested neuroborreliosis, but seronegativity and an atypical clinical course made this unlikely. However, PCR identified Borrelia burgdorferi DNA in cerebrospinal fluid, establishing the diagnosis of neuroborreliosis. Both the clinical picture and the laboratory findings can be atyp...
Source: Practical Neurology - December 22, 2023 Category: Neurology Authors: Åslaug Rudjord Lorentzen Kristine Karlsrud Berg Unn Lj østad Source Type: research
Rituximab leading to an atypical presentation of neuroborreliosis and false negative serology
Pract Neurol. 2023 Dec 22:pn-2023-003976. doi: 10.1136/pn-2023-003976. Online ahead of print.ABSTRACTTwo patients, recently treated with the B-cell-depleting monoclonal antibody, rituximab, had 2-3 months of progressive systemic symptoms; comprehensive investigations did not clarify the diagnosis. Transient radicular pain at disease onset had suggested neuroborreliosis, but seronegativity and an atypical clinical course made this unlikely. However, PCR identified Borrelia burgdorferi DNA in cerebrospinal fluid, establishing the diagnosis of neuroborreliosis. Both the clinical picture and the laboratory findings can be atyp...
Source: Practical Neurology - December 22, 2023 Category: Neurology Authors: Åslaug Rudjord Lorentzen Kristine Karlsrud Berg Unn Lj østad Source Type: research
Rituximab leading to an atypical presentation of neuroborreliosis and false negative serology
Pract Neurol. 2023 Dec 22:pn-2023-003976. doi: 10.1136/pn-2023-003976. Online ahead of print.ABSTRACTTwo patients, recently treated with the B-cell-depleting monoclonal antibody, rituximab, had 2-3 months of progressive systemic symptoms; comprehensive investigations did not clarify the diagnosis. Transient radicular pain at disease onset had suggested neuroborreliosis, but seronegativity and an atypical clinical course made this unlikely. However, PCR identified Borrelia burgdorferi DNA in cerebrospinal fluid, establishing the diagnosis of neuroborreliosis. Both the clinical picture and the laboratory findings can be atyp...
Source: Practical Neurology - December 22, 2023 Category: Neurology Authors: Åslaug Rudjord Lorentzen Kristine Karlsrud Berg Unn Lj østad Source Type: research
Rituximab leading to an atypical presentation of neuroborreliosis and false negative serology
Pract Neurol. 2023 Dec 22:pn-2023-003976. doi: 10.1136/pn-2023-003976. Online ahead of print.ABSTRACTTwo patients, recently treated with the B-cell-depleting monoclonal antibody, rituximab, had 2-3 months of progressive systemic symptoms; comprehensive investigations did not clarify the diagnosis. Transient radicular pain at disease onset had suggested neuroborreliosis, but seronegativity and an atypical clinical course made this unlikely. However, PCR identified Borrelia burgdorferi DNA in cerebrospinal fluid, establishing the diagnosis of neuroborreliosis. Both the clinical picture and the laboratory findings can be atyp...
Source: Practical Neurology - December 22, 2023 Category: Neurology Authors: Åslaug Rudjord Lorentzen Kristine Karlsrud Berg Unn Lj østad Source Type: research
Rituximab leading to an atypical presentation of neuroborreliosis and false negative serology
Pract Neurol. 2023 Dec 22:pn-2023-003976. doi: 10.1136/pn-2023-003976. Online ahead of print.ABSTRACTTwo patients, recently treated with the B-cell-depleting monoclonal antibody, rituximab, had 2-3 months of progressive systemic symptoms; comprehensive investigations did not clarify the diagnosis. Transient radicular pain at disease onset had suggested neuroborreliosis, but seronegativity and an atypical clinical course made this unlikely. However, PCR identified Borrelia burgdorferi DNA in cerebrospinal fluid, establishing the diagnosis of neuroborreliosis. Both the clinical picture and the laboratory findings can be atyp...
Source: Practical Neurology - December 22, 2023 Category: Neurology Authors: Åslaug Rudjord Lorentzen Kristine Karlsrud Berg Unn Lj østad Source Type: research
Rituximab leading to an atypical presentation of neuroborreliosis and false negative serology
Pract Neurol. 2023 Dec 22:pn-2023-003976. doi: 10.1136/pn-2023-003976. Online ahead of print.ABSTRACTTwo patients, recently treated with the B-cell-depleting monoclonal antibody, rituximab, had 2-3 months of progressive systemic symptoms; comprehensive investigations did not clarify the diagnosis. Transient radicular pain at disease onset had suggested neuroborreliosis, but seronegativity and an atypical clinical course made this unlikely. However, PCR identified Borrelia burgdorferi DNA in cerebrospinal fluid, establishing the diagnosis of neuroborreliosis. Both the clinical picture and the laboratory findings can be atyp...
Source: Practical Neurology - December 22, 2023 Category: Neurology Authors: Åslaug Rudjord Lorentzen Kristine Karlsrud Berg Unn Lj østad Source Type: research
Rituximab leading to an atypical presentation of neuroborreliosis and false negative serology
Pract Neurol. 2023 Dec 22:pn-2023-003976. doi: 10.1136/pn-2023-003976. Online ahead of print.ABSTRACTTwo patients, recently treated with the B-cell-depleting monoclonal antibody, rituximab, had 2-3 months of progressive systemic symptoms; comprehensive investigations did not clarify the diagnosis. Transient radicular pain at disease onset had suggested neuroborreliosis, but seronegativity and an atypical clinical course made this unlikely. However, PCR identified Borrelia burgdorferi DNA in cerebrospinal fluid, establishing the diagnosis of neuroborreliosis. Both the clinical picture and the laboratory findings can be atyp...
Source: Practical Neurology - December 22, 2023 Category: Neurology Authors: Åslaug Rudjord Lorentzen Kristine Karlsrud Berg Unn Lj østad Source Type: research
Differential transcriptome response of blood brain barrier spheroids to neuroinvasive Neisseria and Borrelia
ConclusionThe self-assembling spheroids were used to perceive the BBB response to neuroinvasive pathogens - Neisseria and Borrelia. Compromised integrity of spheroids during Neisseria and Borrelia infection as opposed to its intactness and non-adherence of E. coli (non-neuroinvasive) denotes the pathogen dependent fate of BBB. Genes categorized into various biological functions indicated weakened barrier properties of BBB and heightened innate immune response. Inverse expression of 48% genes commonly identified during Neisseria and Borrelia infection exemplifies unique response of BBB to varying neuropathogens. (Source: Fr...
Source: Frontiers in cellular and infection microbiology - December 19, 2023 Category: Microbiology Source Type: research
Diversity and host specificity of Borrelia burgdorferi ’s outer surface protein C (ospC) alleles in synanthropic mammals, with a notable ospC allele U absence from mixed infections
Infection and Immunity, Ahead of Print. (Source: Infection and Immunity)
Source: Infection and Immunity - December 15, 2023 Category: Infectious Diseases Authors: Scarlet A. ShifflettFrancisco C. FerreiraJulia Gonz álezAlvaro ToledoDina M. FonsecaVincenzo A. Ellis1Department of Entomology and Wildlife Ecology, University of Delaware, Newark, Delaware, USA2Center for Vector Biology, Department of Entomology, Rutger Source Type: research
In silico epitope prediction of Borrelia burgdorferi sensu lato antigens for the detection of specific antibodies
In this study, in silico B-cell epitope mapping was performed to determine the theoretical diagnostic potential of selected B. burgdorferi s.l. proteins (BB0108, BB0126, BB0298, BB0689, BB0323, FliL, PstS, SecD, EF-Tu). Bioinformatics software predicted 35 conserved linear and 30 conformational epitopes with the degree of identity among B. burgdorferi s.l. of at least 85%, which may prove to be useful in the development of a new tool for the diagnosis of Lyme disease.PMID:38070727 | DOI:10.1016/j.jim.2023.113596 (Source: Journal of Immunological Methods)
Source: Journal of Immunological Methods - December 9, 2023 Category: Allergy & Immunology Authors: Weronika Gr ąźlewska Karolina So łowińska Lucyna Holec-G ąsior Source Type: research
In silico epitope prediction of Borrelia burgdorferi sensu lato antigens for the detection of specific antibodies
In this study, in silico B-cell epitope mapping was performed to determine the theoretical diagnostic potential of selected B. burgdorferi s.l. proteins (BB0108, BB0126, BB0298, BB0689, BB0323, FliL, PstS, SecD, EF-Tu). Bioinformatics software predicted 35 conserved linear and 30 conformational epitopes with the degree of identity among B. burgdorferi s.l. of at least 85%, which may prove to be useful in the development of a new tool for the diagnosis of Lyme disease.PMID:38070727 | DOI:10.1016/j.jim.2023.113596 (Source: Journal of Immunological Methods)
Source: Journal of Immunological Methods - December 9, 2023 Category: Allergy & Immunology Authors: Weronika Gr ąźlewska Karolina So łowińska Lucyna Holec-G ąsior Source Type: research
