The Interaction of Borrelia burgdorferi with Human Dendritic Cells: Functional Implications
J Immunol. 2023 Jul 5:ji2300235. doi: 10.4049/jimmunol.2300235. Online ahead of print.ABSTRACTDendritic cells bridge the innate and adaptive immune responses by serving as sensors of infection and as the primary APCs responsible for the initiation of the T cell response against invading pathogens. The naive T cell activation requires the following three key signals to be delivered from dendritic cells: engagement of the TCR by peptide Ags bound to MHC molecules (signal 1), engagement of costimulatory molecules on both cell types (signal 2), and expression of polarizing cytokines (signal 3). Initial interactions between Bor...
Source: Journal of Immunology - July 5, 2023 Category: Allergy & Immunology Authors: Maria Gutierrez-Hoffmann Jinshui Fan Robert N O'Meally Robert N Cole Liliana Florea Corina Antonescu C Conover Talbot Eleni Tiniakou Erika Darrah Mark J Soloski Source Type: research
The Interaction of Borrelia burgdorferi with Human Dendritic Cells: Functional Implications
J Immunol. 2023 Jul 5:ji2300235. doi: 10.4049/jimmunol.2300235. Online ahead of print.ABSTRACTDendritic cells bridge the innate and adaptive immune responses by serving as sensors of infection and as the primary APCs responsible for the initiation of the T cell response against invading pathogens. The naive T cell activation requires the following three key signals to be delivered from dendritic cells: engagement of the TCR by peptide Ags bound to MHC molecules (signal 1), engagement of costimulatory molecules on both cell types (signal 2), and expression of polarizing cytokines (signal 3). Initial interactions between Bor...
Source: Journal of Immunology - July 5, 2023 Category: Allergy & Immunology Authors: Maria Gutierrez-Hoffmann Jinshui Fan Robert N O'Meally Robert N Cole Liliana Florea Corina Antonescu C Conover Talbot Eleni Tiniakou Erika Darrah Mark J Soloski Source Type: research
Utility of Borrelia-specific IgM and IgG antibody titer determinations during a 12-year period – results from a clinical laboratory in Northern Sweden
Interpretation of serological findings in suspected Lyme borreliosis (LB) is challenging and IgM reactivities may have low predictive value. Therefore, if used indiscriminately, there is a risk for incorrect diagnosis of LB. To evaluate the usefulness of IgM titer determination, we performed a study of the prevalence of Borrelia-specific antibodies in serological samples from patients with suspected LB analyzed during the period 2010 - 2021 at the University Hospital of Umeå in Sweden. In total, 19,335 samples had been analyzed for the presence of IgG and IgM antibodies. Overall, there were higher percentages of IgM posit...
Source: Frontiers in cellular and infection microbiology - July 3, 2023 Category: Microbiology Source Type: research
Borrelia Burgdorferi, a Root Cause of Inflammatory Bowel Disease: A Case Report of Successful Treatment and Remission
CONCLUSIONS: Lyme disease should be recognized as a potential trigger of autoimmune conditions, especially Crohn's disease. This underlying cause is novel to the literature and may help many patients obtain the proper diagnosis so that curative treatment may be received.PMID:37392196 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - July 1, 2023 Category: Complementary Medicine Authors: Elliot Dinetz Yusuf Saleeby Source Type: research
Borrelia Burgdorferi, a Root Cause of Inflammatory Bowel Disease: A Case Report of Successful Treatment and Remission
CONCLUSIONS: Lyme disease should be recognized as a potential trigger of autoimmune conditions, especially Crohn's disease. This underlying cause is novel to the literature and may help many patients obtain the proper diagnosis so that curative treatment may be received.PMID:37392196 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - July 1, 2023 Category: Complementary Medicine Authors: Elliot Dinetz Yusuf Saleeby Source Type: research
Borrelia Burgdorferi, a Root Cause of Inflammatory Bowel Disease: A Case Report of Successful Treatment and Remission
CONCLUSIONS: Lyme disease should be recognized as a potential trigger of autoimmune conditions, especially Crohn's disease. This underlying cause is novel to the literature and may help many patients obtain the proper diagnosis so that curative treatment may be received.PMID:37392196 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - July 1, 2023 Category: Complementary Medicine Authors: Elliot Dinetz Yusuf Saleeby Source Type: research
Borrelia Burgdorferi, a Root Cause of Inflammatory Bowel Disease: A Case Report of Successful Treatment and Remission
CONCLUSIONS: Lyme disease should be recognized as a potential trigger of autoimmune conditions, especially Crohn's disease. This underlying cause is novel to the literature and may help many patients obtain the proper diagnosis so that curative treatment may be received.PMID:37392196 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - July 1, 2023 Category: Complementary Medicine Authors: Elliot Dinetz Yusuf Saleeby Source Type: research
Borrelia Burgdorferi, a Root Cause of Inflammatory Bowel Disease: A Case Report of Successful Treatment and Remission
CONCLUSIONS: Lyme disease should be recognized as a potential trigger of autoimmune conditions, especially Crohn's disease. This underlying cause is novel to the literature and may help many patients obtain the proper diagnosis so that curative treatment may be received.PMID:37392196 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - July 1, 2023 Category: Complementary Medicine Authors: Elliot Dinetz Yusuf Saleeby Source Type: research
Borrelia Burgdorferi, a Root Cause of Inflammatory Bowel Disease: A Case Report of Successful Treatment and Remission
CONCLUSIONS: Lyme disease should be recognized as a potential trigger of autoimmune conditions, especially Crohn's disease. This underlying cause is novel to the literature and may help many patients obtain the proper diagnosis so that curative treatment may be received.PMID:37392196 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - July 1, 2023 Category: Complementary Medicine Authors: Elliot Dinetz Yusuf Saleeby Source Type: research
Borrelia Burgdorferi, a Root Cause of Inflammatory Bowel Disease: A Case Report of Successful Treatment and Remission
CONCLUSIONS: Lyme disease should be recognized as a potential trigger of autoimmune conditions, especially Crohn's disease. This underlying cause is novel to the literature and may help many patients obtain the proper diagnosis so that curative treatment may be received.PMID:37392196 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - July 1, 2023 Category: Complementary Medicine Authors: Elliot Dinetz Yusuf Saleeby Source Type: research
Borrelia Burgdorferi, a Root Cause of Inflammatory Bowel Disease: A Case Report of Successful Treatment and Remission
CONCLUSIONS: Lyme disease should be recognized as a potential trigger of autoimmune conditions, especially Crohn's disease. This underlying cause is novel to the literature and may help many patients obtain the proper diagnosis so that curative treatment may be received.PMID:37392196 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - July 1, 2023 Category: Complementary Medicine Authors: Elliot Dinetz Yusuf Saleeby Source Type: research
Borrelia Burgdorferi, a Root Cause of Inflammatory Bowel Disease: A Case Report of Successful Treatment and Remission
CONCLUSIONS: Lyme disease should be recognized as a potential trigger of autoimmune conditions, especially Crohn's disease. This underlying cause is novel to the literature and may help many patients obtain the proper diagnosis so that curative treatment may be received.PMID:37392196 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - July 1, 2023 Category: Complementary Medicine Authors: Elliot Dinetz Yusuf Saleeby Source Type: research
Borrelia Burgdorferi, a Root Cause of Inflammatory Bowel Disease: A Case Report of Successful Treatment and Remission
CONCLUSIONS: Lyme disease should be recognized as a potential trigger of autoimmune conditions, especially Crohn's disease. This underlying cause is novel to the literature and may help many patients obtain the proper diagnosis so that curative treatment may be received.PMID:37392196 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - July 1, 2023 Category: Complementary Medicine Authors: Elliot Dinetz Yusuf Saleeby Source Type: research
Prevalence of pathogens in sympatric < em > Ixodes ricinus < /em > and < em > Dermacentor reticulatus < /em > ticks in Eastern Poland and their potential impact on oral-anal contacts between ticks
CONCLUSIONS: The study suggests that tick-borne pathogens may have influenced the sexual behaviour of their vectors. The oral-anal contacts between I. ricinus and D. reticulatus ticks are probably stimulated by Bb and/or Rs. The presence of five pathogens and numerous co-infections in the analysed ticks indicates a risk of various human infectious diseases in the study region. Further studies are required to clarify the implications of oral-anal interspecific tick interactions.PMID:37387375 | DOI:10.26444/aaem/167427 (Source: Annals of Agricultural and Environmental Medicine : AAEM)
Source: Annals of Agricultural and Environmental Medicine : AAEM - June 30, 2023 Category: Environmental Health Authors: Weronika Buczek Alicja Buczek Joanna Witecka Marek Asman Source Type: research
Impact of tick-borne pathogens on the health risk of soldiers
Ann Agric Environ Med. 2023 Jun 26;30(2):211-216. doi: 10.26444/aaem/159702. Epub 2023 Feb 9.ABSTRACTINTRODUCTION AND OBJECTIVE: Vector diseases are common in Europe, including Poland. Every year, 77,000 Europeans are infected with transmissive diseases as a result of contact with infected vectors. In Poland, ticks are vectors of great epidemiological importance. The most important etiological factors causing disease in humans and transmitted by ticks include bacteria of the genus Borrelia and the species Francisella tularensis, Anaplasma phagophytophilum and Coxiella burnetii; as well as tick-borne encephalitis viruses. T...
Source: Annals of Agricultural and Environmental Medicine : AAEM - June 30, 2023 Category: Environmental Health Authors: Anna Borecka Ma łgorzata Szczypek Agata Pabin Krzysztof Kowalczuk Ewelina Maculewicz Source Type: research
