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Erythema Migrans Caused by Borrelia spielmanii, France
We describe a rare case of early Lyme borreliosis in France caused by Borrelia spielmanii, which manifested as a large erythema chronicum migrans rash. The patient completely recovered after a 15-day course of amoxicillin. Absence of pathognomonic signs prevented distinguishing B. spielmanii from other etiologies as cause in this case-patient.PMID:37877610 | DOI:10.3201/eid2911.230149 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - October 25, 2023 Category: Infectious Diseases Authors: Pascal Del Giudice Fabienne Freychet Lora Kopec Florence Fenollar Carole Eldin Marine Velin Thomas Hubiche Didier Raoult Oleg Mediannikov Source Type: research

Autogenous reproduction by Ornithodoros turicata (Ixodida: Argasidae) females and vertical transmission of the tick-borne pathogen Borrelia turicatae (Spirochaetales: Borreliaceae )
In this report, we collected ticks from a park within a neighborhood of Austin, TX. They were reared to adulthood, and male ticks were individually housed with females. We observed autogenous reproduction, which is the ability to produce eggs without the need for a blood meal, and further investigated vertical transmission of B. turicatae by quantifying filial infection rates in a cohort of progeny ticks. These results indicate that O. turicata transovarially transmits B. turicatae during autogenous reproduction and further signify the tick as a natural reservoir of the spirochetes. IMPORTANCE Previous research has implica...
Source: Applied and Environmental Microbiology - October 25, 2023 Category: Microbiology Authors: Serhii Filatov Aparna Krishnavajhala Job E Lopez Source Type: research

Adiponectin in the mammalian host influences ticks ’ acquisition of the Lyme disease pathogen Borrelia 
by Xiaotian Tang, Yongguo Cao, Carmen J. Booth, Gunjan Arora, Yingjun Cui, Jaqueline Matias, Erol Fikrig Arthropod-borne pathogens cause some of the most important human and animal infectious diseases. Many vectors acquire or transmit pathogens through the process of blood feeding. Here, we report adiponectin, the most abundant adipocyte-derived hormone circulating in human blood, directly or indirectly inhibits acquisition of the Lyme disease agent,Borrelia burgdorferi, byIxodes scapularis ticks. Rather than altering tick feeding or spirochete viability, adiponectin or its associated factors induces host histamine releas...
Source: PLoS Biology: Archived Table of Contents - October 20, 2023 Category: Biology Authors: Xiaotian Tang Source Type: research

Structure of the Borrelia burgdorferi ATP-dependent metalloprotease FtsH in its functionally relevant hexameric form
Biochim Biophys Acta Proteins Proteom. 2023 Oct 16:140969. doi: 10.1016/j.bbapap.2023.140969. Online ahead of print.ABSTRACTATP-dependent proteases FtsH are conserved in bacteria, mitochondria, and chloroplasts, where they play an essential role in degradation of misfolded/unneeded membrane and cytosolic proteins. It has also been demonstrated that the FtsH homologous protein BB0789 is crucial for mouse and tick infectivity and in vitro growth of the Lyme disease-causing agent Borrelia burgdorferi. This is not surprising, considering B. burgdorferi complex life cycle, residing in both in mammals and ticks, which requires a...
Source: Biochimica et Biophysica Acta - October 18, 2023 Category: Biochemistry Authors: Kalvis Brangulis Laura Drunka Inara Akopjana Kaspars Tars Source Type: research

Immune checkpoint inhibitor-induced neurotoxicity is not associated with seroprevalence of neurotropic infections
ConclusionPrevious viral, bacterial and protozoal neurotropic infections appear not to be associated with the development of neurological irAEs in melanoma patients who underwent therapy with ICI across 3 countries. Further efforts are needed to unravel the factors underlying neurological irAEs in order to identify risk factors for these toxicities, especially with the increasing use of ICI in earlier stage disease. (Source: Cancer Immunology, Immunotherapy)
Source: Cancer Immunology, Immunotherapy - October 14, 2023 Category: Cancer & Oncology Source Type: research

Insight into the dynamics of the Ixodes ricinus nymphal midgut proteome
In this study, we used a label-free quantitative approach to perform a novel dynamic proteomic analysis of the midgut of Ixodes ricinus nymphs, covering their development from unfed to pre-moult stages. We identified 1,534 I. ricinus-specific proteins with a relatively low proportion of host proteins. This proteome dataset, which was carefully examined by manual scrutiny, allowed precise annotation of proteins important for blood meal processing and their dynamic changes during nymphal ontogeny. We focused on midgut molecules related to lipid hydrolysis, storage, and transport, opening an yet unexplored avenue for studying...
Source: Molecular and Cellular Proteomics : MCP - October 13, 2023 Category: Molecular Biology Authors: Tereza Kozelkov á Filip Dy čka Stephen Lu Veronika Urbanov á Helena Frantov á Daniel Sojka Radek Šíma Martin Horn Jan Perner Petr Kop áček Source Type: research

Pathogenicity and virulence of Borrelia burgdorferi
Volume 14, Issue 1, December 2023 . (Source: Virulence)
Source: Virulence - October 10, 2023 Category: Virology Authors: Martin StrnadNatalie RudenkoRyan O.M. Regoa Biology Centre CAS, Institute of Parasitology, České Budějovice, Czech Republicb Faculty of Science, University of South Bohemia, Branišovská, Czech Republic Source Type: research

Possible effect of mutations on serological detection of Borrelia burgdorferi sensu stricto ospC major groups: An in-silico study
This study explored the hypothesis that serological test sensitivity decreases as genetic similarity of ospC major groups (MGs) of infecting strains, and ospC A (the MG in the strain B31 used to prepare antigen for serodiagnosis assays) decreases. We used a previously published microarray dataset to compare serological reactivity to ospC A (measured as pixel intensity) versus reactivity to 22 other ospC MGs, within a population of 55 patients diagnosed by two-tier serological testing usingB.burgdorferi s.s. strain B31 as antigen, in which the ospC MG is OspC A. The difference in reactivity of sera to ospC A and reactivity ...
Source: PLoS One - October 10, 2023 Category: Biomedical Science Authors: Samir Mechai Source Type: research

Erythema Migrans Caused by Borrelia spielmanii, France
P. del Giudice et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - October 5, 2023 Category: Infectious Diseases Source Type: research

Borrelia burgdorferi Infection-Induced Persistent IgM Secretion Controls Bacteremia, but Not Bacterial Dissemination or Tissue Burden
J Immunol. 2023 Oct 2:ji2300384. doi: 10.4049/jimmunol.2300384. Online ahead of print.ABSTRACTInfection with Borrelia burgdorferi causes Lyme disease in humans. In small rodents, the natural reservoir species of this spirochete, infections lead to only modest disease manifestations, despite causing persistence infection. Although B cell responses are central for controlling bacterial tissue burden and disease manifestations, they lack classical aspects of T-dependent responses, such as sustained IgG affinity maturation and longevity, corresponding with a rapid collapse of germinal centers. Instead, the Ab response is chara...
Source: Journal of Immunology - October 2, 2023 Category: Allergy & Immunology Authors: Christine J Hastey Kimberly J Olsen Rebecca A Elsner Sophia Mundigl Giang Vu Vi Tran Stephen W Barthold Nicole Baumgarth Source Type: research