Comparison of the solid-phase red cell adherence assay and tube method for detection and identification of red blood cell antibodies
CONCLUSIONS: To our knowledge, this is the first robust, 15-year study comparing methodologic sensitivity to detect clinically significant alloantibodies. The incidence of discordant results between PEG-IAT and the solid-phase technique was low. Among discordant samples, anti-Jka was commonly detected using the solid-phase method but not with the PEG-IAT. In contrast, anti-E was commonly detected by PEG-IAT but not by the solid-phase method.PMID:38607807 | DOI:10.1093/ajcp/aqae035 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 12, 2024 Category: Pathology Authors: Mohamed Abdelmonem Alex Dussaq Kathy Papakonstantino Muharrem Yunce Mrigender Singh Virk Source Type: research
Comparison of the solid-phase red cell adherence assay and tube method for detection and identification of red blood cell antibodies
CONCLUSIONS: To our knowledge, this is the first robust, 15-year study comparing methodologic sensitivity to detect clinically significant alloantibodies. The incidence of discordant results between PEG-IAT and the solid-phase technique was low. Among discordant samples, anti-Jka was commonly detected using the solid-phase method but not with the PEG-IAT. In contrast, anti-E was commonly detected by PEG-IAT but not by the solid-phase method.PMID:38607807 | DOI:10.1093/ajcp/aqae035 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 12, 2024 Category: Pathology Authors: Mohamed Abdelmonem Alex Dussaq Kathy Papakonstantino Muharrem Yunce Mrigender Singh Virk Source Type: research
Prognostic Utility of a Novel Prognostic Model Consisting of Age, CRP, Ki67, and POD24 in Patients with Angioimmunoblastic T-Cell Lymphoma
AbstractTo find the independent factors affecting the prognosis of AITL patients, establish a novel predictive model, and stratify the prognosis of AITL patients. We retrospectively analyzed the clinical data of 86 patients diagnosed with AITL in the First Affiliated Hospital of Wenzhou Medical University from December 2010 to March 2022. The clinical features, recurrence time, and death time of patients were collected and analyzed statistically. The median age of our patients was 68 years old, and the male-to-female ratio was 2.2: 1. There are differences between males and females in ECOG PS score (p = 0.037), β2 m...
Source: Indian Journal of Hematology and Blood Transfusion - April 12, 2024 Category: Hematology Source Type: research
Bile Acid –Targeted Hyaluronic Acid Nanoparticles for Enhanced Oral Absorption of Deferoxamine
AbstractPatients with β-thalassemia and sickle cell disease often rely on blood transfusions which can lead to hemochromatosis and chronic oxidative stress in cells and tissues. Deferoxamine (DFO) is clinically approved to treat hemochromatosis but is suboptimal to patients due to its poor pharmacokinetics which require s long-term infusion regimens. Although the oral route is preferable, DFO has limited oral bioavailability. Studies have shown that hyaluronic acid (HA) and bile acid (BA) can enhance the oral absorption of poorly absorbed drugs. To improve upon the oral delivery of DFO, we report on the synthesis a nd cha...
Source: The AAPS Journal - April 12, 2024 Category: Drugs & Pharmacology Source Type: research
Prognostic Significance of T-Cells and Macrophages in the Tumour Microenvironment of Nodal DLBCL
AbstractRevised International Prognostic (R-IPI) score is used widely for risk stratification of DLBCL cases, yet some patients belonging to same risk category tend to exhibit different outcomes. The role of T-cells and macrophages in prognostication of lymphomas has been a point of interest of late. We aimed to study the association of FOXP3 positive T-regulatory cells, cytotoxic T-cells and macrophages with the immunophenotypic subtypes, clinicopathological characteristics, treatment response and survival in nodal diffuse large B-cell lymphoma (DLBCL) patients. The clinicopathological and treatment data of 83 DLBCL patie...
Source: Indian Journal of Hematology and Blood Transfusion - April 12, 2024 Category: Hematology Source Type: research
Cesarean hysterectomy for placenta accreta spectrum: Surgeon specialty-specific assessment
CONCLUSION: These data suggest that patient characteristics and surgical procedures related to cesarean hysterectomy for placenta accreta spectrum differ based on surgeon specialty. Gynecologic oncologists appear to manage more severe forms of placenta accreta spectrum. Regardless of surgeon's specialty, surgical morbidity of cesarean hysterectomy for placenta accreta spectrum is significant.PMID:38603956 | DOI:10.1016/j.ygyno.2024.04.004 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 11, 2024 Category: Cancer & Oncology Authors: Koji Matsuo Yongmei Huang Shinya Matsuzaki Andrew Vallejo Joseph G Ouzounian Lynda D Roman Fady Khoury-Collado Alexander M Friedman Jason D Wright Source Type: research
Postoperative long ‑term outcomes of acute normovolemic hemodilution in pancreatic cancer: A propensity score matching analysis
In conclusion, while ANH was not as harmful as ABT, it exhibited potentially more negative effects on long-term postoperative outcomes in PDAC than STD.PMID:38601182 | PMC:PMC11005082 | DOI:10.3892/ol.2024.14369 (Source: Oncology Letters)
Source: Oncology Letters - April 11, 2024 Category: Cancer & Oncology Authors: Taiichi Wakiya Keinosuke Ishido Norihisa Kimura Hayato Nagase Taishu Kanda Shunsuke Kubota Hiroaki Fujita Yoshiya Takahashi Takeshi Yamamoto Kohei Chida Junichi Saito Kazuyoshi Hirota Kenichi Hakamada Source Type: research
Cesarean hysterectomy for placenta accreta spectrum: Surgeon specialty-specific assessment
CONCLUSION: These data suggest that patient characteristics and surgical procedures related to cesarean hysterectomy for placenta accreta spectrum differ based on surgeon specialty. Gynecologic oncologists appear to manage more severe forms of placenta accreta spectrum. Regardless of surgeon's specialty, surgical morbidity of cesarean hysterectomy for placenta accreta spectrum is significant.PMID:38603956 | DOI:10.1016/j.ygyno.2024.04.004 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 11, 2024 Category: Cancer & Oncology Authors: Koji Matsuo Yongmei Huang Shinya Matsuzaki Andrew Vallejo Joseph G Ouzounian Lynda D Roman Fady Khoury-Collado Alexander M Friedman Jason D Wright Source Type: research
Cesarean hysterectomy for placenta accreta spectrum: Surgeon specialty-specific assessment
CONCLUSION: These data suggest that patient characteristics and surgical procedures related to cesarean hysterectomy for placenta accreta spectrum differ based on surgeon specialty. Gynecologic oncologists appear to manage more severe forms of placenta accreta spectrum. Regardless of surgeon's specialty, surgical morbidity of cesarean hysterectomy for placenta accreta spectrum is significant.PMID:38603956 | DOI:10.1016/j.ygyno.2024.04.004 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 11, 2024 Category: Cancer & Oncology Authors: Koji Matsuo Yongmei Huang Shinya Matsuzaki Andrew Vallejo Joseph G Ouzounian Lynda D Roman Fady Khoury-Collado Alexander M Friedman Jason D Wright Source Type: research
Novel definition of textbook outcome in biliary system cancers and its influence on patients' survival and quality of life
ConclusionsThe novel definition of textbook outcome was able to address the specific nature of recovery after resection of biliary system cancers. Expanding the scope of textbook outcome and addressing the influence on survival and quality of life provides a comprehensive concept able to reflect physical, psychological and functioning enhancements in patients recovery. (Source: Cancer Medicine)
Source: Cancer Medicine - April 11, 2024 Category: Cancer & Oncology Authors: Manar Mikhail Atyah,
Li Xu,
Zhiying Yang Tags: RESEARCH ARTICLE Source Type: research
Symptomatic corpus luteum hemorrhage in adolescent females with ITP
Conclusion: CLH could potentially pose a significant complication in the context of adolescent females with ITP, requiring a strong index of suspicion to direct expedient therapy.What is Known:• Immune thrombocytopenia is typically associated with minor bleeding tendency.• Corpus luteum hemorrhage is generally asymptomatic; however, in women with bleeding disorders, it has the potential to result in substantial intra-abdominal bleeding.What is New:• Corpus luteum hemorrhage leading to intra-abdominal bleeding is a potential severe complication of immune thrombocytopenia in adolescent females. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - April 11, 2024 Category: Pediatrics Source Type: research
MiR-34c-5p Inhibition Affects Bax/Bcl2 Expression and Reverses Bortezomib Resistance in Multiple Myeloma Cells
This study aimed to determine the expression profile of XBP1, hsa-miR-34c-5p, hsa-miR-214, and hsa-miR-30c-2* in resistant and sensitive multiple myeloma cell lines to a proteasome inhibitor, bortezomib. After establishing bortezomib-resistant cells, the expression level of XBP1, hsa-miR-214, hsa-miR-34c-5p, and hsa-miR-30c-2* in both cell lines were assessed by qRT-PCR. Hsa-miR-34c-5p was suppressed to study its effect on the expression profile of Bax/Bcl-2. Statistical analysis was done by t-test in two clinically resistant and sensitive cells to bortezomib. MTT assay confirmed the creation of the resistant cell line. Th...
Source: Indian Journal of Hematology and Blood Transfusion - April 11, 2024 Category: Hematology Source Type: research
Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort Study
CONCLUSIONS Among lung transplant recipients, PGD, ICU days, need for mechanical ventilation and ECMO support, and total composite events were significantly greater in patients who received blood transfusion perioperatively.PMID:38590090 | DOI:10.12659/AOT.943652 (Source: Annals of Transplantation)
Source: Annals of Transplantation - April 9, 2024 Category: Transplant Surgery Authors: Atif S Siddiqui Jawairia Shakil Source Type: research
