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SOHO State of the Art Updates and Next Questions: An Update on Higher Risk Myelodysplastic Syndromes
Clin Lymphoma Myeloma Leuk. 2024 Mar 18:S2152-2650(24)00113-7. doi: 10.1016/j.clml.2024.03.006. Online ahead of print.ABSTRACTHigher-risk myelodysplastic syndromes (HR-MDS) are clonal myeloid neoplasms that cause life-limiting complications from severe cytopenias and leukemic transformation. Efforts to better classify, prognosticate, and assess therapeutic responses in HR-MDS have resulted in publication of new clinical tools in the last several years. Given limited current treatment options and suboptimal outcomes, HR-MDS stands to benefit from the study of investigational agents.Higher-risk myelodysplastic syndromes (HR-...
Source: Clinical Lymphoma and Myeloma - April 9, 2024 Category: Cancer & Oncology Authors: Michael J Hochman Amy E DeZern Source Type: research

Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort Study
CONCLUSIONS Among lung transplant recipients, PGD, ICU days, need for mechanical ventilation and ECMO support, and total composite events were significantly greater in patients who received blood transfusion perioperatively.PMID:38590090 | PMC:PMC11015745 | DOI:10.12659/AOT.943652 (Source: Annals of Transplantation)
Source: Annals of Transplantation - April 9, 2024 Category: Transplant Surgery Authors: Atif S Siddiqui Jawairia Shakil Source Type: research

Is ultrafiltration volume a predictor of postoperative acute kidney injury in patients undergoing cardiopulmonary bypass?
CONCLUSION: The predictors of postoperative AKI in coronary CABG patients were the volume of UF, age, MAP, and blood transfusion during CPB.PMID:38590130 | DOI:10.1177/02676591241246081 (Source: Perfusion)
Source: Perfusion - April 9, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Hamid Gerami Javad Sajedianfard Bahram Ghasemzadeh Maryam AnsariLari Source Type: research

Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort Study
CONCLUSIONS Among lung transplant recipients, PGD, ICU days, need for mechanical ventilation and ECMO support, and total composite events were significantly greater in patients who received blood transfusion perioperatively.PMID:38590090 | DOI:10.12659/AOT.943652 (Source: Annals of Transplantation)
Source: Annals of Transplantation - April 9, 2024 Category: Transplant Surgery Authors: Atif S Siddiqui Jawairia Shakil Source Type: research

Clinicopathological and Immunophenotypic Characteristics of Series of ZNF384 Re-arranged Acute Leukemias
We present the clinic-pathological and immunophenotypic findings in a series of five cases of acute leukemia withZNF384-r reported in our Institute between September 2020 to September 2023. Notably, whileTCF3::ZNF384 fusion was the most frequently encountered abnormality, the fusion partner was not identified in two patients withZNF384-r BCP-ALL. Immunophenotypically, patients presenting as B-cell precursor acute lymphoblastic leukemia (BCP-ALL) had a distinct profile characterized by weak or absent CD10 expression and the presence of myeloid markers such as CD13/CD33. Our findings underscore the importance of recognizing ...
Source: Indian Journal of Hematology and Blood Transfusion - April 9, 2024 Category: Hematology Source Type: research