What does the ECG show in this patient with chest pain, hypotension, dyspnea, and hypoxemia?
Written by Pendell Meyers, with some edits by SmithA man in his 40s with many comorbidities presented to the ED with chest pain, hypotension, dyspnea, and hypoxemia.The bedside echo showed a large RV (Does this mean there is a pulmonary embolism as the etiology?)Here is his triage ECG:What do you think? Lots of info here.The rhythm is 2:1 atrial flutter.  The flutter waves can conceal or mimic ischemic repolarization findings, but here I don ' t see any obvious findings of OMI or subendocardial ischemia.The QRS is around 100 msec wide (narrow), but with very abnormal morphology including a large R-wave in V1, dee...
Source: Dr. Smith's ECG Blog - August 14, 2023 Category: Cardiology Authors: Pendell Source Type: blogs

Fight Aging! Newsletter, May 22nd 2023
Conclusions to be Drawn A High Fat Diet Accelerates Atherosclerosis Less Directly than One Might Suspect How to Construct Measures of Biological Age A Long-Term Comparison of Metformin in Diabetics with Non-Diabetic Controls In Search of Distinctive Features of the Gut Microbiome in Long-Lived Individuals Greater Fitness in Humans Implies a Younger Epigenome and Transcriptome Intestinal Barrier Dysfunction as a Feature of Aging in Many Species NAFLD as an Age-Related Condition Towards Sensory Hair Cell Regeneration in the Inner Ear Raised Leve...
Source: Fight Aging! - May 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Senescent Cells Contribute to the Harms Caused by Aged Blood
The present state of parabiosis studies demonstrates that diluting blood in old animals produces improved health, whether this is achieved using saline or young blood. Thus we expect there to be few beneficial factors in young blood, and many harmful factors in old blood. So far there has been mixed or little benefit noted in studies in which young plasma is transfused into old recipients, but dilution appears more promising. As noted here, the growing burden of senescent cells in aged tissue is a significant source of those harmful factors. Senescent cells are very active, generating a mix of factors known as the s...
Source: Fight Aging! - May 15, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Bonus Features – February 12, 2023 – Epic tops Best in KLAS for 13th straight year, 89% of healthcare finance leaders remain confident in 2023, and more
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job. News The Biden Administration announced the latest initiatives in the reignited Cancer Moonshot program. One initiative of interest to the healthcare IT community is CancerX, a public-private innovation partnership to develop to...
Source: EMR and HIPAA - February 12, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT AdvancedMD Alloantibody Exchange Beacon Health System Best in KLAS Biden Biofourmis Brooke Bowers Cancer Moonshot CareCloud CHG Healthcare CIvitas Clean Air CMS Complete Care David Feinberg DexCare DrFirst Source Type: blogs

Danger Alert: A.I. Is Writing Content, But It ’s Lying – Let Us Show You How
There is a growing number of A.I. text generators around the web, offering more or less the same.  You give a brief of your planned content and maybe some keywordsSet the parameters, like the language, the tone of the text and the creativity levelHit enterVoila, you get your blog post/article/marketing copy/whatever Isn’t it amazing? Writing a good text takes effort, so outsourcing it to A.I. could save us a ton of time in researching and crafting content.  Before you quickly lay off all your writers, let me show through a few examples of why trusting A.I. with content is dangerous as of now. TLDR spoiler: it ...
Source: The Medical Futurist - November 15, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Artificial Intelligence in Medicine AI AI text generator synthetic media AI in heaalthcare Source Type: blogs

Danger Alert: AI Is Writing Content, But It ’s Lying – Let Us Show You How
There is a growing number of AI text generators around the web, offering more or less the same.  You give a brief of your planned content and maybe some keywordsSet the parameters, like the language, the tone of the text and the creativity levelHit enterVoila, you get your blog post/article/marketing copy/whatever Isn’t it amazing? Writing a good text takes effort, so outsourcing it to AI could save us a ton of time in researching and crafting content.  Before you quickly lay off all your writers, let me show through a few examples of why trusting A.I. with content is dangerous as of now. TLDR spoiler: it is l...
Source: The Medical Futurist - November 15, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Artificial Intelligence in Medicine AI AI text generator synthetic media AI in heaalthcare Source Type: blogs

Fight Aging! Newsletter, July 25th 2022
This study further demonstrates that AMD is not a single condition or an isolated disease, but is often a signal of systemic malfunction which could benefit from targeted medical evaluation in addition to localized eye care." Microglia in the Aging Brain, Both Protective and Harmful https://www.fightaging.org/archives/2022/07/microglia-in-the-aging-brain-both-protective-and-harmful/ A growing body of evidence implicates the changing behavior of microglia in the aging of the brain and onset of neurodegeneration. Microglia are analogous to macrophages, innate immune cells unique to the central nervous sys...
Source: Fight Aging! - July 24, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Whole Blood Exchange and the Peripheral Amyloid Sink Hypothesis
Today I'll point out an interesting study in mice that is based on the peripheral amyloid sink view of Alzheimer's disease. Researchers repeatedly replaced the blood in Alzheimer's model mice, that exhibit high levels of amyloid-β in the brain, with blood from normal mice. The result was less amyloid-β in the brain and better cognitive function. While one does always need to begin these discussions by noting that mouse models of Alzheimer's disease are very artificial constructs, in that mice do not naturally develop the condition, and thus the models are all some form of genetic dysfunction that generates a particular p...
Source: Fight Aging! - July 22, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, February 28th 2022
In conclusion, as BMI and waist circumference are related to elevations of immune markers in the IL-6 pathway, chronic inflammation might be an important mediator of the relationship between BMI and frailty. Fat Tissue Becomes Dysfunctional with Age as Mitochondria Falter https://www.fightaging.org/archives/2022/02/fat-tissue-becomes-dysfunctional-with-age-as-mitochondria-falter/ Mitochondria are effectively power plants, hundreds of them working in every cell to produce chemical energy store molecules to power cellular processes. Mitochondrial function declines with age, unfortunately, for underlying r...
Source: Fight Aging! - February 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Converting Donor Organs to a Universal Blood Type
The publicity materials here discuss an intriguing approach to reducing the issues of rejection associated with organ transplantation. Some of the underlying mechanisms relate to incompatible blood types. It is possible to perfuse an extracted organ with enzymes that convert the biochemistry associated with blood type to blood type O, which is compatible with other types. The result is an organ that can be transplanted with greater safety. Blood type is determined by the presence of antigens on the surface of red blood cells - type A blood has the A antigen, type B has the B antigen, type AB blood has both antigen...
Source: Fight Aging! - February 25, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Can patients just say no to treatment?
When can a patient say“yes” or“no” to a recommended colonoscopy? A blood transfusion? A COVID vaccine? As 2022 opens, health officials predict a tsunami of new coronavirus cases worldwide due to the Omicron and Delta variants. For more than a year, official messaging has been that vaccination is the way out of theRead more …Can patients just say no to treatment? originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 19, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/charles-hebert" rel="tag" > Charles Hebert, MD < /a > < /span > Tags: Physician COVID Source Type: blogs

Epidemics and pandemics (2): AIDS
Just over 40 years ago, in June 1981, a paper appeared in Morbidity and Mortality Weekly Report (MMWR) describing an opportunistic lung infection in otherwise healthy gay men.  The lung condition was pneumocystis pneumonia, and this was the first description of what came to be known as AIDS.  That first description, first article, was a case series, of five people, and therefore not evidence from particularly high up the traditional evidence pyramid.  I may have pointed this out to students when discussing evidence based practice and that pyramid.There is more about this inthis post from Circulatin...
Source: Browsing - December 29, 2021 Category: Databases & Libraries Tags: AIDS Source Type: blogs

Microfluidic Photoreactor for Neonatal Jaundice
Researchers at the Oregon State University College of Engineering have developed a microfluidic photoreactor that is intended to treat severe cases of neonatal jaundice. Jaundice is caused by an excess of a pigment called bilirubin, which can be difficult to excrete due to underlying conditions in many neonates. In severe cases, newborns may need multiple blood transfusions, which is resource and labor intensive, and can come with risks. This system could help avoid such procedures, and involves passing the blood of the newborn through a microfluidic device, where an LED helps to break the bilirubin down into more easily e...
Source: Medgadget - December 8, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Pediatrics Source Type: blogs

Catheter-Deliverable Biomaterial Sealants: Interview with Natalie Artzi, Co-founder of BioDevek
BioDevek, a medtech company based in Cambridge, Massachusetts, has developed a biomaterial adhesive that acts to seal internal wounds and incisions. The material is designed to be sprayed through a catheter, and the primary application for the technology so far is to act as a sealant following colonic polyp resection. At present, following polyp resection, surgeons can use polyp clips to seal the resection site, which can hamper wound healing, or use no sealant at all, leading to an open wound that comes with a risk of bleeding or other complications. This can lead to additional surgeries to correct the issue and is inc...
Source: Medgadget - November 30, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive GI Materials Plastic Surgery BioDevek Source Type: blogs

Fight Aging! Newsletter, October 11th 2021
In conclusion, this study examined how age and the process of aging are associated with changes in the microbiome of the small intestine, using validated sampling and processing techniques. The most significant differences are higher relative abundance of the phylum Proteobacteria and decreased relative abundance of Bacteroidetes in older subjects when compared to the youngest group. The higher relative abundance of Proteobacteria appeared to affect other duodenal microbial taxa, leading to decreased microbial diversity and increased relative abundance of coliforms and of anaerobic bacteria. The small intestine is vital to...
Source: Fight Aging! - October 10, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs