Synthesized pyrrole ester ameliorates adjuvant ‑induced arthritis in Wistar rats by alleviating inflammation and downregulating the pro‑inflammatory cytokines
In this study, pyrrole ester (AU-5) was designed, synthesized and evaluated for ant-arthritic activity in adjuvant-induced arthritis Wistar rats. The synthesized pyrrole ester (AU-5) was administered in three selected doses (20, 10 and 5 mg/kg) to the arthritic-induced model. The administered ester significantly inhibited the increase in arthritis index, paw and ankle joint swelling compared to the arthritic control group. Similarly, the treated rats exhibited a remarkable increase in body weight increase, improved haematological, biochemical, histopathological and radiological parameters. Moreover, the excess production...
Source: Inflammopharmacology - April 29, 2024 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 29, Pages 2019: Microencapsulation of Essential Oils Using Faba Bean Protein and Chia Seed Polysaccharides via Complex Coacervation Method
Kurek
The aim of this study was to develop microcapsules containing juniper or black pepper essential oils, using a combination of faba bean protein and chia seed polysaccharides (in ratios of 1:1, 1:2, 2:1). By synergizing these two polymers, our goal was to enhance the efficiency of essential oil microencapsulation, opening up various applications in the food industry. Additionally, we aimed to investigate the influence of different polymer mixing ratios on the properties of the resulting microcapsules and the course of the complex coacervation process. To dissolve the essential oils and limit their evaporation, soyb...
Source: Molecules - April 27, 2024 Category: Chemistry Authors: Alicja Napi órkowska Arkadiusz Szpicer El żbieta Górska-Horczyczak Marcin Andrzej Kurek Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1611: An Overview of the Spices Used for the Prevention and Potential Treatment of Gastric Cancer
We present the potential molecular mechanisms responsible for the effectivity of a given seasoning substance and their impact on GC cells. We discuss their potential effects on proliferation, apoptosis, and migration. For most of the spices discussed, we also outline the unavailability and side effects of their use. (Source: Cancers)
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Katarzyna Kostelecka Łukasz Bryliński Olga Komar Justyna Michalczyk Agata Mi łosz Jan Bi łogras Filip Woli ński Alicja Forma Jacek Baj Tags: Review Source Type: research
Two pairs of bioactive cyclohexene alkaloid enantiomers from the roots of Piper nigrum
. (Source: Journal of Asian Natural Products Research)
Source: Journal of Asian Natural Products Research - April 10, 2024 Category: Complementary Medicine Authors: Zhi-Yong XuNing-Ning DuChang-Sheng LaXiao-Xiao HuangShao-Jiang SongKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Engineering Research Center of Natural Medicine Active Molecule Research & Development, Key Source Type: research
Network pharmacology and experimental insights into STAT3 inhibition by novel isoxazole derivatives of piperic acid in triple negative breast cancer
Fitoterapia. 2024 Mar 26:105927. doi: 10.1016/j.fitote.2024.105927. Online ahead of print.ABSTRACTSTAT3 is a crucial member within a family of seven essential transcription factors. Elevated STAT3 levels have been identified in various cancer types, notably in breast cancer (BC). Consequently, inhibiting STAT3 is recognized as a promising and effective strategy for therapeutic intervention against breast cancer. We herein synthesize a library of isoxazole (PAIs) from piperic acid [2E, 4E)-5-(2H-1,3-Benzodioxol-5-yl) penta-2,4-dienoic acid] on treatment with propargyl bromide followed by oxime under prescribed reaction cond...
Source: Fitoterapia - March 28, 2024 Category: Biochemistry Authors: G N Yatoo Basharat A Bhat None Zubaid-Ul-Khazir Mohammad Asif Sajad A Bhat Farhana Gulzar Fehmida Rashied Abdul Haleem Wani Ishfaq Ahmed Sajad Majeed Zargar Mushtaq A Mir Javid A Banday Source Type: research
Network pharmacology and experimental insights into STAT3 inhibition by novel isoxazole derivatives of piperic acid in triple negative breast cancer
Fitoterapia. 2024 Mar 26;175:105927. doi: 10.1016/j.fitote.2024.105927. Online ahead of print.ABSTRACTSTAT3 is a crucial member within a family of seven essential transcription factors. Elevated STAT3 levels have been identified in various cancer types, notably in breast cancer (BC). Consequently, inhibiting STAT3 is recognized as a promising and effective strategy for therapeutic intervention against breast cancer. We herein synthesize a library of isoxazole (PAIs) from piperic acid [2E, 4E)-5-(2H-1,3-Benzodioxol-5-yl) penta-2,4-dienoic acid] on treatment with propargyl bromide followed by oxime under prescribed reaction ...
Source: Fitoterapia - March 28, 2024 Category: Biochemistry Authors: G N Yatoo Basharat A Bhat None Zubaid-Ul-Khazir Mohammad Asif Sajad A Bhat Farhana Gulzar Fehmida Rashied Abdul Haleem Wani Ishfaq Ahmed Sajad Majeed Zargar Mushtaq A Mir Javid A Banday Source Type: research
Piperine attenuates hepatic ischemia/reperfusion injury via suppressing the TLR4 signaling cascade in mice
In this study, the mice were administered piperine (30 mg/kg) intragastric administration before surgery. After 24 h of hepatic ischemia-reperfusion, liver histopathological evaluation, serum transaminase measurements, and TUNEL analysis were performed. The infiltration of inflammatory cells and production of inflammatory mediators in the liver tissue were determined by immunofluorescence and immunohistochemical staining. The protein levels of toll-like receptor 4 (TLR4) and related proteins such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), interleukin-1 receptor-associated kinase 1 (IRAK1), ...
Source: Transplant Immunology - March 14, 2024 Category: Transplant Surgery Authors: Lidan Zhang Ge Kuang Xia Gong Rui Huang Zizuo Zhao Yan Li Jingyuan Wan Bin Wang Source Type: research
Piperine attenuates hepatic ischemia/reperfusion injury via suppressing the TLR4 signaling cascade in mice
In this study, the mice were administered piperine (30 mg/kg) intragastric administration before surgery. After 24 h of hepatic ischemia-reperfusion, liver histopathological evaluation, serum transaminase measurements, and TUNEL analysis were performed. The infiltration of inflammatory cells and production of inflammatory mediators in the liver tissue were determined by immunofluorescence and immunohistochemical staining. The protein levels of toll-like receptor 4 (TLR4) and related proteins such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), interleukin-1 receptor-associated kinase 1 (IRAK1), ...
Source: Transplant Immunology - March 14, 2024 Category: Transplant Surgery Authors: Lidan Zhang Ge Kuang Xia Gong Rui Huang Zizuo Zhao Yan Li Jingyuan Wan Bin Wang Source Type: research
Piperine attenuates hepatic ischemia/reperfusion injury via suppressing the TLR4 signaling cascade in mice
In this study, the mice were administered piperine (30 mg/kg) intragastric administration before surgery. After 24 h of hepatic ischemia-reperfusion, liver histopathological evaluation, serum transaminase measurements, and TUNEL analysis were performed. The infiltration of inflammatory cells and production of inflammatory mediators in the liver tissue were determined by immunofluorescence and immunohistochemical staining. The protein levels of toll-like receptor 4 (TLR4) and related proteins such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), interleukin-1 receptor-associated kinase 1 (IRAK1), ...
Source: Transplant Immunology - March 14, 2024 Category: Transplant Surgery Authors: Lidan Zhang Ge Kuang Xia Gong Rui Huang Zizuo Zhao Yan Li Jingyuan Wan Bin Wang Source Type: research
Piperine attenuates hepatic ischemia/reperfusion injury via suppressing the TLR4 signaling cascade in mice
In this study, the mice were administered piperine (30 mg/kg) intragastric administration before surgery. After 24 h of hepatic ischemia-reperfusion, liver histopathological evaluation, serum transaminase measurements, and TUNEL analysis were performed. The infiltration of inflammatory cells and production of inflammatory mediators in the liver tissue were determined by immunofluorescence and immunohistochemical staining. The protein levels of toll-like receptor 4 (TLR4) and related proteins such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), interleukin-1 receptor-associated kinase 1 (IRAK1), ...
Source: Transplant Immunology - March 14, 2024 Category: Transplant Surgery Authors: Lidan Zhang Ge Kuang Xia Gong Rui Huang Zizuo Zhao Yan Li Jingyuan Wan Bin Wang Source Type: research
Phytochemistry and pharmacology of Piper nigrum
AbstractBlack pepper (Piper nigrum) has been used as an antidote for cough, cold, dyspnoea, throat illnesses, intermittent fever, dysentery, stomach ache, worms, and piles in traditional medicine. It is also used as an anti-inflammatory, antipyretic, and to treat epilepsy and snakebite. Black pepper is a common spice in Asian cuisine, and it has applications in traditional medicine, perfumes, preservatives, and pesticides. Piperine, an alkaloid, increases the therapeutic efficacy of a variety of medications, vaccines, and nutrients by increasing bioavailability by blocking several digestive enzymes. Piperine also promotes ...
Source: Comparative Clinical Pathology - March 7, 2024 Category: Pathology Source Type: research
Determination of higenamine in common natural spices by ultrahigh ‐performance liquid chromatography–tandem mass spectrometry
In this study, a comprehensive and systematic analysis of the HG content in five batches of samples from each of the 48 natural spices selected for this investigation was conducted using UPLC–MS/MS technology. Method validation was carried out in accordance with the ICH Analytical Procedu res and Methods Validation for Drugs and Biologics Guidance, and the experimental results demonstrated that the method provided appropriate sensitivity, precision, stability, linearity, and accuracy. HG was detected for the first time inHouttuynia cordata,Zingiber officinale,Cinnamomum cassia,Stevia rebaudiana,Piper nigrum,Siraitia gros...
Source: Drug Testing and Analysis - March 5, 2024 Category: Drugs & Pharmacology Authors: Jinming Du,
Xuefen Li,
Wenyi Tian,
Chengjun Guo Tags: SHORT COMMUNICATION Source Type: research
Tegumental surface change in Paramphistomum epiclitum caused by Bombax ceiba flowers and black pepper seed extract
This study compares the tegumental surface change of Paramphistomum epiclitum as a response to ethanolic extracts of Bombax ceiba flowers and black pepper seeds. Adult flukes were subjected to various concentrations of crude extracts, including 12.5, 25, 50, 100, and 200 μg/mL for 12, 18, and 24 h incubation. Scanning electron microscopy (SEM) exhibited that the ethanolic extracts of both Bombax ceiba flowers and black pepper seeds caused tegumental surface changes in adult P. epiclitum. Based on the results, Bombax ceiba flower extract has anthelmintic activity, compared with black pepper seed extract, towards adult P. e...
Source: Experimental Parasitology - March 2, 2024 Category: Parasitology Authors: Kulvadee Dolsophon Sirapat Nak-On Thapana Chontananarth Source Type: research
Molecules, Vol. 29, Pages 947: Chemical Composition of Piper nigrum L. Cultivar Guajarina Essential Oils and Their Biological Activity
veira
Eloisa Helena de Aguiar Andrade
The essential oils and aroma derived from the leaves (L), stems (St), and spikes (s) of Piper nigrum L. cv. Guajarina were extracted; the essential oils were extracted using hydrodistillation (HD), and steam distillation (SD), and the aroma was obtained by simultaneous distillation and extraction (SDE). Chemical constituents were identified and quantified using GC/MS and GC-FID. Preliminary biological activity was assessed by determining the toxicity against Artemia salina Leach larvae, calculating mortality rates, and determining lethal concentration values (LC50). The predomina...
Source: Molecules - February 21, 2024 Category: Chemistry Authors: Bruna de Souza Feitosa Oberdan Oliveira Ferreira Celeste de Jesus Pereira Franco Himani Karakoti Ravendra Kumar Marcia Moraes Cascaes Rahul D. Jawarkar Suraj N. Mali Jorddy Neves Cruz Ilmarina Campos de Menezes Mozaniel Santana de Oliveira Eloisa Helena d Tags: Article Source Type: research
