Synthesis of eugenol derivatives and evaluation of their antifungal activity against Fusarium solani f. sp. piperis.
CONCLUSION: The results suggest that 4 is a potential candidate for use in the design of new and effective compounds that could control this pathogen. PMID: 32242782 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 3, 2020 Category: Drugs & Pharmacology Authors: Maximino SC, Dutra JAP, Rodrigues RP, de Cássia Ribeiro Gonçalves R, de Morais PAB, Ventura JA, Schuenck RP, Júnior VL, Kitagawa RR, de Souza Borges W Tags: Curr Pharm Des Source Type: research

Comparative study of the bioactive compounds, flavours and minerals present in black pepper before and after removing the outer skin
Publication date: Available online 31 March 2020Source: LWTAuthor(s): Joon-Goo Lee, Dae-Won Kim, Youngjae Shin, Young-Jun Kim (Source: LWT Food Science and Technology)
Source: LWT Food Science and Technology - April 1, 2020 Category: Food Science Source Type: research

Understanding the Intrinsic Fluorescence of Piperine in Microheterogeneous Media: Partitioning and Loading Studies
This study explores the intrinsic fluorescence of piperine in different microheterogeneous media (i.e. dimyristoylphosphatidylcholine (DMPC) small unilamellar vesicles... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - April 1, 2020 Category: Chemistry Authors: sanchari debnath Source Type: research

Structural characterization of chitosan nanoparticle loaded with Piper nigrum essential oil for biological efficacy against the stored grain pest control
Publication date: Available online 21 March 2020Source: Pesticide Biochemistry and PhysiologyAuthor(s): Vallavan Rajkumar, Chinappan Gunasekaran, Jayaraman Dharmaraj, Panneerselvam Chinnaraj, Cheruvathur Amita Paul, Inbaraj Kanithachristy (Source: Pesticide Biochemistry and Physiology)
Source: Pesticide Biochemistry and Physiology - March 23, 2020 Category: Biochemistry Source Type: research

Synergistic antibacterial, antifungal and antioxidant efficacy of cinnamon and clove essential oils in combination.
Abstract The present investigation aimed to evaluate antibacterial, antifungal and antioxidant efficacy of essential oils of three commonly used spices (black pepper, cinnamon and clove) in combination along with chemical characterization and toxicity evaluation. Among the possible combinations tested, cinnamon/clove oil combination showed synergistic antibacterial activity against foodborne bacteria Staphylococcus aureus, Listeria monocytogenes, Salmonella typhimurium and Pseudomonas aeruginosa and synergistic antifungal activity against Aspergillus niger as well as synergistic antioxidant potential in DPPH radic...
Source: Archives of Microbiology - March 17, 2020 Category: Microbiology Authors: Purkait S, Bhattacharya A, Bag A, Chattopadhyay RR Tags: Arch Microbiol Source Type: research

The Effect of Piperine on Oral Absorption of Cannabidiol following Acute vs. Chronic Administration.
Abstract The piperine is an alkaloid naturally found mostly in black pepper with a myriad of pharmacological attributes. The most far reaching indication of piperine is its use as an absorption enhancer, with supportive data regarding piperine's ability to inhibit first pass effect mechanisms. However, alongside these findings, the role of piperine as an absorption enhancer is undermined with publications stating an effect of a metabolic inducer. The aim of this commentary is to investigate the effect of repeated administration of piperine on oral absorption of cannabidiol (CBD), compared to single dose administra...
Source: European Journal of Pharmaceutical Sciences - March 17, 2020 Category: Drugs & Pharmacology Authors: Izgelov D, Domb AJ, Hoffman A Tags: Eur J Pharm Sci Source Type: research

An evidence-based review of medicinal plants used in traditional Persian medicine for treatment of osteoarthritis.
Abstract Osteoarthritis (OA) is known to be the leading cause of pain and disability in the elderly. The prevalence of this disease in adults over 60 years was 9.6% in men and 18% in women. The therapeutic goals of this disease generally include pain relief with the least side effects, improvement of articular function and improvement of life, in which pharmacological and non-pharmacological treatments are performed in different protocols. Due to the common side effects of pain relievers and complaints after invasive joint surgeries, there is a growing interest in the use of Traditional and Complementary protocols...
Source: Current Drug Discovery Technologies - March 15, 2020 Category: Drugs & Pharmacology Authors: Karami S, Shamshiri S, Abdollahi M, Rahimi R Tags: Curr Drug Discov Technol Source Type: research

[ASAP] Alkaloids from Black Pepper ( < italic toggle="yes" > Piper nigrum < /italic > L.) Exhibit Anti-Inflammatory Activity in Murine Macrophages by Inhibiting Activation of NF-?B Pathway
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.9b07754 (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - February 18, 2020 Category: Food Science Authors: Heying Pei †§, Linlin Xue†§, Minghai Tang†, Huan Tang†, Shuang Kuang†, Lun Wang†‡, Xu Ma†, Xiaoying Cai†, Yan Li†‡, Min Zhao†, Aihua Peng†, Haoyu Ye*†, and Lijuan Chen*† Source Type: research

Preparation, characterization and antimicrobial activity of polyvinyl alcohol/gum arabic/chitosan composite films incorporated with black pepper essential oil and ginger essential oil.
In this study, biocomposite films based on polyvinyl alcohol (PVA), gum arabic (GA) and chitosan (CS) incorporated with BPEO and GEO were fabricated by solvent casting method. FTIR, XRD, SEM and DSC were performed with mechanical and antimicrobial properties of PVA/GA/CS films with and without BPEO and GEO. The BPEO-PVA/GA/CS film showed heterogeneous rough surface with cavities containing entrapment of BPEO droplets, whereas, the GEO-PVA/GA/CS film showed heterogeneous rough surface with coarseness due to the incorporation of respective EOs. The BPEO and GEO incorporated PVA/GA/CS films were considerable resistant to brea...
Source: International Journal of Biological Macromolecules - February 18, 2020 Category: Biochemistry Authors: Amalraj A, Haponiuk JT, Thomas S, Gopi S Tags: Int J Biol Macromol Source Type: research

Selective in vivo molecular and cellular biocompatibility of black peppercorns by piperine-protein intrinsic atomic interaction with elicited oxidative stress and apoptosis in zebrafish eleuthero embryos.
This study investigates the in vivo selective molecular biocompatibility of its seed cover (SC) and seed core (SP) powder extract using embryonic zebrafish model. Gas chromatography mass spectrometry (GCMS) analysis of the extract prepared by grinding showed presence of different components with "piperine" as principle component. Biocompatibility analysis showed dose and time dependent selective effect of SC and SP with LC50 of 30.4 μg/ml and 35.6 μg/ml, respectively on survivability, hatching and heartbeat rate in embryonic zebrafish. Mechanistic investigation elucidated it as effect of accumulat...
Source: Ecotoxicology and Environmental Safety - February 13, 2020 Category: Environmental Health Authors: Patel P, Panda PK, Kumari P, Singh PK, Nandi A, Mallick MA, Das B, Suar M, Verma SK Tags: Ecotoxicol Environ Saf Source Type: research

Evaluation of the antioxidant and antidiabetic potential of the Poly Herbal Formulation. Identification of bioactive factors.
CONCLUSION: In conclusion, it could be reasoned that due to the nearness of antioxidant components, the PHF has good potential in the administration of hyperglycemia, diabetes and the related state of oxidative stress. This study shows that PHF is superior to individual plant extracts, supporting the conventional PHF concept. PMID: 32031078 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 9, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Encapsulation of the black pepper (Piper nigrum L.) essential oil by lactoferrin-sodium alginate complex coacervates: Structural characterization and simulated gastrointestinal conditions
Publication date: Available online 4 February 2020Source: Food ChemistryAuthor(s): Lívia Pinto Heckert Bastos, Carlos Henrique Corrêa dos Santos, Mario Geraldo de Carvalho, Edwin Elard Garcia-RojasAbstractBlack pepper essential oil (EO) was encapsulated by complex coacervation with lactoferrin and sodium alginate using transglutaminase as a cross-linking agent. The encapsulation efficiency varied from 31.66 to 84.48%. Chemical and morphological characteristics suggest that the EO was encapsulated in a lactoferrin/sodium alginate shell. The chemical composition of the encapsulated EO was identified by gas chrom...
Source: Food Chemistry - February 7, 2020 Category: Food Science Source Type: research

Antioxidant and anti-glycation potential of green pepper (Piper nigrum): optimization of β-cyclodextrin-based extraction by response surface methodology
Publication date: Available online 23 January 2020Source: Food ChemistryAuthor(s): Leonardo Cristian Favre, Guido Rolandelli, Ndumiso Mshicileli, Lusani Norah Vhangani, Cristina dos Santos Ferreira, Jessy van Wyk, María del Pilar BueraAbstractGreen pepper (Piper nigrum) presents high levels of functional compounds, with antioxidant and anti-glycation properties. Thus, the optimization of the β-cyclodextrin-based extraction of functional compounds from green pepper through Response Surface Methodology was performed. The optimum extraction conditions were assessed by optimizing total polyphenolic content (TP...
Source: Food Chemistry - January 24, 2020 Category: Food Science Source Type: research

Rational design of ultra-small photoluminescent copper nano-dots loaded PLGA micro-vessels for targeted co-delivery of natural piperine molecules for the treatment for epilepsy
This study was illustrating that Piperine loaded CuQDs@HA/PLGA nanostructures exhibit improved neuroprotection and encourage the activation of astrocytes in chemical kindling model of epilepsy. This proposed material could be a novel and effective therapeutic platform for the targeted drug delivery systems.Graphical Abstract (Source: Journal of Photochemistry and Photobiology B: Biology)
Source: Journal of Photochemistry and Photobiology B: Biology - January 24, 2020 Category: Speech-Language Pathology Source Type: research

Analysis and Reduction of Heterocyclic Amines and Cholesterol Oxidation Products in Chicken by Controlling Flavorings and Roasting Condition
The objectives of this study were to evaluate analysis of HAs and COPs in raw, boiled and roasted chicken by QuEChERS coupled with UPLC-MS/MS and GC-MS, respectively, and study their formation as affected by different flavorings (red pepper, black pepper, rosemary, soy sauce) and roasting methods (fan oven and superheated steam oven). Results showed that the average recovery respectively ranged from 54.1–109.3% and 65.1–116.6% for 20 HAs and from 87.9–102.8% and 87.5–101.3% for 7 COPs in the skin and meat portions of boiled chicken breast, while the coefficient of variation (CV) of the intra-day and...
Source: Food Research International - January 19, 2020 Category: Food Science Source Type: research

Self-stick adhesive made with black pepper derivative adjusts to many tastes
UV light tunes properties of pressure-sensitive biobased adhesive (Source: Chemical and Engineering News)
Source: Chemical and Engineering News - January 15, 2020 Category: Chemistry Authors: Fernando Gomolln-Bel, special to C&EN Source Type: research

Multi-Element Evaluation in Black Pepper (Piper nigrum L.) According to the Processing
In this study, concentrations of the elements As, Cd, Co, Cu, Fe, Mn, Mo, Ni, Pb, Se, V and Zn was determined in samples of black peppercorn (n = 25) and ground black pepper (n = 25) to verify how processing affects element concentrations. The elements were determined by inductively coupled plasma mass spectrometry and flame atomic absorption spectrometry. A principal component analysis showed that Fe, Pb and V was influenced by the processing and ground black pepper samples showed higher levels for these elements than black peppercorn. Although specific legislation for spices is not available in Brazil, results indicated ...
Source: Journal of the Brazilian Chemical Society - January 11, 2020 Category: Chemistry Source Type: research

A rapid HPTLC method to estimate piperine in Ayurvedic formulations
ConclusionThis method can be successfully employed for standardization and quantitative analysis of piperine in Ayurvedic formulations (churnas) and also be helpful to clinicians and pharmacists to draw significant role of piperine present in all these samples. (Source: Journal of Ayurveda and Integrative Medicine)
Source: Journal of Ayurveda and Integrative Medicine - December 28, 2019 Category: Complementary Medicine Source Type: research

Major, minor and trace element concentrations in spices and aromatic herbs from Sicily (Italy) and Mahdia (Tunisia) by ICP-MS and multivariate analysis
Publication date: Available online 26 December 2019Source: Food ChemistryAuthor(s): Angela Giorgia Potortì, Giuseppe Daniel Bua, Vincenzo Lo Turco, Asma Ben Tekaya, Asma Beltifa, Hedi Ben Mansour, Giacomo Dugo, Giuseppa Di BellaAbstractElement contents in different types of spices and aromatic herbs collected from Italy and Tunisia were evaluated. The aim was to evaluate: the possible differences and/or similarities among the analyzed samples; if it is possible related the samples to their geographical origins; the nutritional quality and the potential health risks. Potassium, Ca, Mg and Ni were low in laurel and ro...
Source: Food Chemistry - December 27, 2019 Category: Food Science Source Type: research

Black pepper (Piper nigrum L.) associated endophytic Pseudomonas putida BP25 alters root phenotype and induces defense in rice (Oryza sativa L.) against blast disease incited by Magnaporthe oryzae
This study explains endophyte P. putida BP25 induced root phenotypic alteration in rice along with its potential to exploit as alternate for blast management.Graphical abstract (Source: Biological Control)
Source: Biological Control - December 27, 2019 Category: Biology Source Type: research

[ASAP] A Rapid Non-Targeted Method for Detecting the Adulteration of Black Pepper with a Broad Range of Endogenous and Exogenous Material at Economically Motivating Levels Using Micro-ATR-FT-MIR Imaging
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.9b03865 (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - December 24, 2019 Category: Food Science Authors: Jean-Louis Lafeuille* †, Aline Fre´gie`re-Salomon†, Alexandre Michelet‡, and Karen L. Henry§ Source Type: research

Efficacy of low energy electron beam on microbial decontamination of spices
This study suggests the low energy e-beam as an alternative technology for the currently used highly penetrating ionising irradiation to eliminate microbial contamination of spices. (Source: Radiation Physics and Chemistry)
Source: Radiation Physics and Chemistry - December 22, 2019 Category: Physics Source Type: research

Encapsulation of black pepper (Piper nigrum L.) essential oil with gelatin and sodium alginate by complex coacervation
This study aimed to analyze the composition of black pepper EO, determining the most appropriate conditions for the formation of the complex between gelatin and sodium alginate. Further, we also encapsulated the black pepper EO. The main terpene identified in black pepper EO was β-caryophyllene. The ratio of 6:1 (gelatin/sodium alginate) at pH 4.0 was the ideal condition. The encapsulation efficiency varied from 49.13 to 82.36%, and the chemical composition of the encapsulated EO was identified by Gas Chromatography (GC). GC analysis indicated good core protection with the materials used. These biopolymers can serve a...
Source: Food Hydrocolloids - December 20, 2019 Category: Food Science Source Type: research

Effect of processing on microbial safety of wild pepper (Piper borbonense) from Reunion Island
Publication date: Available online 18 December 2019Source: Food ControlAuthor(s): Mathieu Weil, Fabienne Remize, Noel Durand, Pascaline Alter, Mathilde Hoarau, Jean Christophe MeileAbstractThe management of microbial contamination is an important issue in spice trade. For common domesticated black pepper (Piper spp.), the control relies mainly on post-process decontamination. The aim of the present study was to examine microbial contamination of wild pepper (Piper borbonense) from Reunion Island and investigate the effects of different processing paths on microbiological quality and fungal ecology. The fresh pepper microbi...
Source: Food Control - December 19, 2019 Category: Food Science Source Type: research

Development and validation of an analytical method for the analysis of Sterigmatocystin in roasted coffee beans and black pepper using liquid chromatography-tandem mass spectrometry
. (Source: Food Additives and Contaminants Part A)
Source: Food Additives and Contaminants Part A - December 19, 2019 Category: Food Science Authors: Stephen W. C. Chung Andy H. T. Wu Source Type: research

Molecules, Vol. 24, Pages 4587: Kleeb Bua Daeng, a Thai Traditional Herbal Formula, Ameliorated Unpredictable Chronic Mild Stress-Induced Cognitive Impairment in ICR Mice
it Anake Kijjoa Thai traditional herbal formula &amp;lsquo;&amp;rsquo;Kleeb Bua Daeng (KBD)&amp;rsquo;&amp;rsquo;consists of a 1:1:1 ratio (dry weight) of three medicinal plants: Piper nigrum fruit, the aerial part of Centella asiatica and the petals of Nelumbo nucifera. Oral administration of KBD to unpredictable chronic mild stress (UCMS) mice significantly improved their cognitive function caused by chronic mild stress. Daily administration of KBD significantly decreased the serum corticosterone (CORT) and malondialdehyde (MDA) levels but increased the catalase and superoxide dismutase activities i...
Source: Molecules - December 14, 2019 Category: Chemistry Authors: Juthamart Maneenet Supawadee Daodee Orawan Monthakantirat Chantana Boonyarat Charinya Khamphukdee Pakakrong Kwankhao Supaporn Pitiporn Suresh Awale Yaowared Chulikhit Anake Kijjoa Tags: Article Source Type: research

Quality Variation and standardization of black pepper (Piper nigrum): A comparative geographical evaluation based on instrumental and metabolomics analysis.
CONCLUSION: The samples were properly standardized and effectively differentiated in terms of quality and biological activities using fast and reliable tools, however it certainly does not mean that a particular geographical region is more better or productive in terms of herbal products. PMID: 31813159 [PubMed - as supplied by publisher] (Source: Biomedical Chromatography : BMC)
Source: Biomedical Chromatography : BMC - December 8, 2019 Category: Biomedical Science Authors: Ahmad R, Ahmad N, Amir M, AlJhisi F, Alamer MH, Al-Shaban HR, Alsadah ZA, Alsultan BM, Aldawood NA, Chathoth S, Almofty SA Tags: Biomed Chromatogr Source Type: research

Development and validation of an analytical method for the analysis of Sterigmatocystin in roasted coffee beans and black pepper using liquid chromatography-tandem mass spectrometry
. (Source: Food Additives and Contaminants Part A)
Source: Food Additives and Contaminants Part A - December 7, 2019 Category: Food Science Authors: Stephen W. C. Chung Andy H. T. Wu Source Type: research

4-Coumarate:coenzyme A ligase isoform 3 from Piper nigrum (Pn4CL3) catalyzes the CoA thioester formation of 3,4-methylenedioxycinnamic and piperic acids.
Abstract Black pepper, dried green fruit of Piper nigrum L., is a household spice most popular in the world. Piperine, the pungency compound of black pepper, is proposed to partially arise from phenylpropanoid pathway. In the biosynthesis of piperine, 4-coumarate:CoA ligase (4CLs) must play a pivotal role in activating intermediate acids to corresponding CoA thioesters to serve as substrates. Based on transcriptome data, we isolated three P. nigrum 4CL isoforms (Pn4CL1, -2, and -3) from unripe peppercorn. These Pn4CLs were expressed in E. coli for in-vitro enzyme assay with putative substrates, namely cinnamic, co...
Source: The Biochemical Journal - November 25, 2019 Category: Biochemistry Authors: Jin Z, Wungsintaweekul J, Kim SH, Kim JH, Shin Y, Ro DK, Kim SU Tags: Biochem J Source Type: research

Molecules, Vol. 24, Pages 4244: Volatiles of Black Pepper Fruits (Piper nigrum L.)
Setzer Black pepper (Piper nigrum) is historically one of the most important spices and herbal medicines, and is now cultivated in tropical regions worldwide. The essential oil of black pepper fruits has shown a myriad of biological activities and is a commercially important commodity. In this work, five black pepper essential oils from eastern coastal region of Madagascar and six black pepper essential oils from the Amazon region of Brazil were obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry. The major components of the essential oils were &amp;alpha;-pinene, sabinene, &a...
Source: Molecules - November 21, 2019 Category: Chemistry Authors: Dosoky Satyal Barata da Silva Setzer Tags: Article Source Type: research

Evaluation of antiplasmodial properties in 15 selected traditional medicinal plants from India
The objective of this study was to evaluate the in vitro antiplasmodial properties against malaria parasite in 15 plants mentioned in Indian traditional medicine texts.MethodsIn vitro antiplasmodial activity of methanolic extracts obtained from Indian traditional medicinal plants was evaluated on Plasmodium falciparum of FCK2 and INDO strains using schizont maturation inhibition assay and parasite lactate dehydrogenase inhibition assay.ResultsMethanolic extracts of Adhatoda zeylanica, Embelia ribes, Piper nigrum and Plumbago zeylanica exhibited more than 50% inhibition in both the stains in schizont maturation inhibition a...
Source: Journal of Integrative Medicine - November 12, 2019 Category: Complementary Medicine Source Type: research

Meta-analysis of the influence of phytobiotic (pepper) supplementation in broiler chicken performance
AbstractThe aim of the study is to use meta-analytical procedure to resolve uncertainty, identify knowledge gaps, and create new insights using published data on the phytobiotic effect of dietary pepper intervention on daily feed intake (DFI), average daily gain (ADG), and feed conversion ratio (FCR) in broiler chickens. The authors accessed AGORA, Scopus, ScienceDirect, and Google Scholar databases for primary studies published between 2011 and 2018 using combinations of different search terms. Fifteen studies were included to assess phytobiotic effect of pepper on DFI, FCR, and ADG in broiler chickens. Random-effects mod...
Source: Tropical Animal Health and Production - November 9, 2019 Category: Veterinary Research Source Type: research

Molecules, Vol. 24, Pages 4030: Evaluation of the Anti-Diabetic Activity of Some Common Herbs and Spices: Providing New Insights with Inverse Virtual Screening
In this study, a library of over 2300 compounds derived from 30 common herbs and spices were screened in silico with the DIA-DB web server against 18 known diabetes drug targets. Over 900 compounds from the herbs and spices library were observed to have potential anti-diabetic activity and liquorice, hops, fennel, rosemary, and fenugreek were observed to be particularly enriched with potential anti-diabetic compounds. A large percentage of the compounds were observed to be potential polypharmacological agents regulating three or more anti-diabetic drug targets and included compounds such as achillin B from yarrow, asparasa...
Source: Molecules - November 7, 2019 Category: Chemistry Authors: Andreia S.P. Pereira Antonio J. Banegas-Luna Jorge Pe ña-García Horacio P érez-Sánchez Zeno Apostolides Tags: Article Source Type: research

Electrochemical Quantification of Piperine in Black Pepper
Publication date: Available online 24 October 2019Source: Food ChemistryAuthor(s): Yuanzhe Wang, Lifu Chen, Korbua Chaisiwamongkhol, Richard G ComptonAbstractA simple, rapid method of the detection of piperine in black pepper is reported using a voltammetric sensor based on a glassy carbon electrode (GC) with analysis following a short one-step extraction using ethanol. The method is based on a novel potential sweep designed to maximise signal sizes and shown with context of the present analytical challenge to be essential for gathering data allowing the construction of a linear calibration curve for the analysis in the re...
Source: Food Chemistry - October 25, 2019 Category: Food Science Source Type: research

Antifungal efficacy of spice extracts against Candida albicans: An in vitro study
The objective of this study was (1) to evaluate the antifungal activity of black pepper, bay leaf, cinnamon, and cumin against C. albicans and (2) to determine the minimum inhibitory concentration (MIC) of spice extracts against C. albicans. Materials and Methods: Spices obtained from the local market were dried and powdered. Solvent extracts were obtained by maceration with methanol followed by filtration and evaporation. The antifungal efficacy was assessed using cup-plate diffusion method followed by the determination of MIC by serial tube dilution technique. Statistical analysis was done using one-way analysis of varia...
Source: Indian Journal of Community Medicine - September 25, 2019 Category: International Medicine & Public Health Authors: Pooja Latti Subramaniam Ramanarayanan GM Prashant Source Type: research

Analysis of chemical components and biological activities of essential oils from black and white pepper (Piper nigrum L.) in five provinces of southern China
Publication date: January 2020Source: LWT, Volume 117Author(s): Yong-xin Li, Chi Zhang, Shenyuan Pan, Lei Chen, Man Liu, Kunlong Yang, Xiaobin Zeng, Jun TianAbstractThe chemical composition and antioxidant and antifungal activities of hydro-distilled essential oils (EOs) in black and white Piper nigrum L were evaluated in the present study. Hydro-distilled EOs obtained from black and white P. nigrum L from five areas of China was analyzed by gas chromatography-mass spectrometry (GC-MS). Nineteen compounds were identified, accounting for 98.20–99.35% of the oils. Chemical variation in the oils was estimated using sys...
Source: LWT Food Science and Technology - September 22, 2019 Category: Food Science Source Type: research

Piperine ameliorates the severity of fibrosis via inhibition of TGF ‑β/SMAD signaling in a mouse model of chronic pancreatitis.
Piperine ameliorates the severity of fibrosis via inhibition of TGF‑β/SMAD signaling in a mouse model of chronic pancreatitis. Mol Med Rep. 2019 Sep 02;: Authors: Choi JW, Lee SK, Kim MJ, Kim DG, Shin JY, Zhou Z, Jo IJ, Song HJ, Bae GS, Park SJ Abstract Chronic pancreatitis (CP) is characterized by recurrent pancreatic injury, resulting in inflammation and fibrosis. Currently, there are no drugs for the treatment of pancreatic fibrosis associated with CP. Piperine, a natural alkaloid found in black pepper, has been reported to show anti‑inflammatory, anti‑oxidative, and antitumor activities....
Source: Molecular Medicine Reports - September 7, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Comparative transcriptome analysis reveals the signal proteins and defence genes conferring foot rot (Phytophthora capsici sp. nov.) resistance in black pepper (Piper nigrum L.)
This study had the objective to identify the candidate genes involved in the foot rot field tolerance of black pepper through comparative transcriptome analysis. P. capsici tolerant/moderately resistant cultivar IISR-Shakthi and susceptible cultivar IISR-Subhakara were artificially inoculated under controlled conditions and mRNAs were isolated from the leaves of treated and control plants at 0, 2, 4, 6, 12, 24, 48 h after inoculation. Transcriptome profiles were compared using DD-RT PCR on cDNA fragments and differentially expressed bands were sequenced. Sequence analysis revealed the involvement of signal proteins and d...
Source: Physiological and Molecular Plant Pathology - August 31, 2019 Category: Molecular Biology Source Type: research

Bioactive compounds from Piper nigrum —A new hope for vitiligo treatment?
This study, being consistent with previous related research showed that Piper nigrum (black pepper) (PN) and its main alkaloid, piperine, promote melanocyte proliferation in vivo. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Essential oils disrupt steroidogenesis in a feto-placental co-culture model
Publication date: Available online 16 August 2019Source: Reproductive ToxicologyAuthor(s): Debbie Yancu, Thomas SandersonAbstractWe determined whether 5 common essential oils (basil, fennel seed, orange, black pepper and sage) interfered with feto-placental steroidogenesis in a co-culture model composed of fetal-like adrenocortical (H295R) and placental trophoblast-like (BeWo) cells. After a 24 h exposure, only basil and fennel seed oil significantly increased hormone concentrations of estradiol, estrone, dehydroepiandrosterone (DHEA), androstenedione, progesterone, and estriol. Basil and fennel seed oil were shown ...
Source: Reproductive Toxicology - August 17, 2019 Category: Toxicology Source Type: research

Fast quantitative detection of black pepper and cumin adulterations by near-infrared spectroscopy and multivariate modeling
Publication date: January 2020Source: Food Control, Volume 107Author(s): Amanda Beatriz Sales de Lima, Acsa Santos Batista, Josane Cardim de Jesus, Jaqueline de Jesus Silva, Antônia Cardoso Mendes de Araújo, Leandro Soares SantosAbstractSpices are high value-added ingredients that are part of a complex supply chain susceptible to a variety of fraudulent actions which requires fast and efficient quality control. The study developed methods for detection of non-targeted and targeted adulteration in black pepper and cumin powder by addition of starch cassava and corn flour (5%–50%) using NIRs associated wit...
Source: Food Control - August 6, 2019 Category: Food Science Source Type: research

Subject Profile Assessment of Cases Recommended with Nutritional Supplement Containing Red Yeast Rice, Grape Seed Extract and Black Pepper Extract: A Prospective, Multicentric, Post-marketing Study.
Authors: Shah S, Rajagopal N, Shah B, Biswas AD, Hiremath J, Bansal R Abstract Objective: To assess the profile and general health indices in subjects prescribed with a nutritional supplement containing red yeast rice, grape seed extract and black pepper extract (NS-YGP; PreLipid®; Abbott Healthcare Pvt. Ltd.) in routine clinical setting in India. Methods: In this prospective, postmarketing observational study, consecutive subjects recommended NS-YG at their outpatient department were recruited from 39 sites in India. The primary outcome of interest was to identify the profiles of subjects recommended with ...
Source: Journal of the Association of Physicians of India - July 20, 2019 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Reduced Systemic and Brain Exposure with Inhibited Liver Metabolism of Carbamazepine After Its Long-Term Combination Treatment with Piperine for Epilepsy Control in Rats
In conclusion, single-dose cotreatment of CBZ and piperine did not result in any significant PK or pharmacodynamic interactions, where as their long-term cotreatment could lead to inhibited liver metabolism and the markedly reduced systemic and brain exposure of CBZ and CBZE. (Source: The AAPS Journal)
Source: The AAPS Journal - July 18, 2019 Category: Drugs & Pharmacology Source Type: research

Prebiotic Potential of Culinary Spices Used to Support Digestion and Bioabsorption.
Authors: Peterson CT, Rodionov DA, Iablokov SN, Pung MA, Chopra D, Mills PJ, Peterson SN Abstract Although the impact of medicinal and culinary herbs on health and disease has been studied to varying extents, scarcely little is known about the impact of these herbs on gut microbiota and how such effects might contribute to their health benefits. We applied in vitro anaerobic cultivation of human fecal microbiota followed by 16S rRNA sequencing to study the modulatory effects of 4 culinary spices: Curcuma longa (turmeric), Zingiber officinale (ginger), Piper longum (pipli or long pepper), and Piper nigrum (black pep...
Source: Evidence-based Complementary and Alternative Medicine - July 11, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Piperine-loaded nanoparticles with enhanced dissolution and oral bioavailability for epilepsy control.
Abstract Piperine, an alkaloid from black pepper, has demonstrated beneficial effects in central nervous system, especially in epilepsy control. However, its therapeutic application remains limited due to the low aqueous solubility of piperine. Thus, the present study aimed to formulate piperine into a more solubilized form to enhance its oral bioavailability and facilitate its development as a potential anti-epileptic treatment. The nanoprecipitation method was applied to prepare piperine nanoparticles, which were then examined under transmission electron microscopy. A spherical nanosized particle was obtained wi...
Source: European Journal of Pharmaceutical Sciences - July 7, 2019 Category: Drugs & Pharmacology Authors: Ren T, Hu M, Cheng Y, Shek TL, Xiao M, Ho NJ, Zhang C, Leung SSY, Zuo Z Tags: Eur J Pharm Sci Source Type: research

Piperine: role in prevention and progression of cancer.
Abstract Cancer is among the leading causes of death worldwide. Several pharmacological protocols have been developed in order to block tumor progression often showing partial efficacy and severe counterproductive effects. It is now conceived that a healthy lifestyle coupled with the consumption of certain phytochemicals can play a protective role against tumor development and progression. According to this vision, it has been introduced the concept of "chemoprevention". This term refers to natural agents with the capability to interfere with the tumorigenesis and metastasis, or at least, attenuate the c...
Source: Molecular Biology Reports - July 4, 2019 Category: Molecular Biology Authors: Zadorozhna M, Tataranni T, Mangieri D Tags: Mol Biol Rep Source Type: research

Effect of mild steaming treatment on the inactivation of Salmonella, Listeria monocytogenes, Escherichia coli O157:H7 and their surrogates on black peppercorns
Publication date: Available online 25 June 2019Source: Food ControlAuthor(s): Zijin Zhou, Sophie Zuber, Matteo Campagnoli, Thierry Putallaz, Frank Devlieghere, Mieke UyttendaeleAbstractThe microbial safety of black peppercorns (Piper nigrum L.) has raised concerns due to increasing numbers of reported foodborne outbreaks and food safety alerts. To avoid quality degradation caused by excessive thermal processing, mild steaming treatments (
Source: Food Control - June 26, 2019 Category: Food Science Source Type: research

An endophytic Pseudomonas sp. of Piper tuberculatum promotes growth on Piper nigrum through increase of root biomass production
Publication date: Available online 24 June 2019Source: Physiological and Molecular Plant PathologyAuthor(s): Angelo Cleiton da Costa Pereira, Gledson Luiz Salgado de Castro, Paulo Canas Rodrigues, Gisele Barata Silva, Danyllo Amaral de Oliveira, Cláudia Regina Batista de SouzaAbstractMicroorganisms that can positively influence plants have emerged as a powerful tool for sustainable agriculture. Previous studies identified a Pseudomonas sp. (Pt13) associated with the roots of Piper tuberculatum, a member of the Piperaceae occurring in the Amazon region with known resistance to infection by Fusarium solani f. sp. pipe...
Source: Physiological and Molecular Plant Pathology - June 25, 2019 Category: Molecular Biology Source Type: research

CDK2 and Bcl-xL inhibitory mechanisms by docking simulations and anti-tumor activity from piperine enriched supercritical extract.
Abstract Supercritical fluid technologies offer an innovative method for food industry and drug discovery from natural sources. The aim of the study is to investigate the anti-tumor activity of piperine rich extract by supercritical fluid (SFE) from black pepper (Piper nigrum). In silico docking simulations predicted anti-tumor molecular mechanism and protein-piperine hydrophobic interactions, showing hydrogen bonds between piperine and residue Ser5 inside the ATP binding site in CDK2. Moreover, piperine interacts with peptide substrate residue Lys8 inside its binding site in Cyclin A molecule. Other predicted int...
Source: Food and Chemical Toxicology - June 25, 2019 Category: Food Science Authors: Grinevicius VMAS, Andrade KS, Mota NSRS, Bretanha LC, Felipe KB, Ferreira SRS, Pedrosa RC Tags: Food Chem Toxicol Source Type: research

Incidence and levels of Alternaria mycotoxins in spices and herbs produced worldwide and commercialized in Lebanon
This study provide large information on the natural occurrence of Alternaria mycotoxins in spices and herbs useful for the human exposure assessment and future regulation. (Source: Food Control)
Source: Food Control - June 20, 2019 Category: Food Science Source Type: research