Chemical Analysis and Classification of Black Pepper (Piper nigrum L.) based on Their Country of Origin Using Mass Spectrometric Methods and Chemometrics
Publication date: Available online 10 November 2020Source: Food Research InternationalAuthor(s): Jian Liang, Jianghao Sun, Pei Chen, Jared Frazier, Virginia Benefield, Mengliang Zhang (Source: Food Research International)
Source: Food Research International - November 10, 2020 Category: Food Science Source Type: research
Piperine: Chemical, biological and nanotechnological applications.
Abstract
Piperine (PIP) is an alkaloid present in several species of piper, mainly Piper nigrum Linn. and P. longum, among other species. The present article provides a comprehensive review of PIP research in the last years concerning its chemical properties, synthesis, absorption, metabolism, bioavailability and toxicity. The reviewed PIP literature has shown many pharmacological properties, such as antidiabetic, antidiarrheal, antioxidant, antibacterial, and anti-parasitic activity of PIP. However, its low solubility and absorption make its application challenging. This review also includes advances in t...
Source: Acta Pharmaceutica - November 7, 2020 Category: Drugs & Pharmacology Authors: Quijia CR, Araujo VH, Chorilli M Tags: Acta Pharm Source Type: research
Identification of the stable and reactive metabolites of tetrahydropiperine by ultra-high-performance liquid chromatography combined with diode array detector and high-resolution mass spectrometry.
CONCLUSION: The major metabolic pathways of tetrahydropiperine were hydroxylation, dehydrogenation, methylation, GSH conjugation and glucuronidation. Tetrahydropiperine was bioactivated through ortho-quinone, Michael receptor and aldehyde intermediates.
PMID: 33049799 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - October 13, 2020 Category: Chemistry Authors: Chen X, Li Y Tags: Rapid Commun Mass Spectrom Source Type: research
Identification of the metabolites of piperine via hepatocyte incubation and liquid chromatography combined with diode array detector and high-resolution mass spectrometry.
CONCLUSIONS: This study provided some new information on the metabolic profiles of piperine, which should be of great importance in the study of the pharmacology and toxicity of this compound.
PMID: 32929805 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - September 13, 2020 Category: Chemistry Authors: Li Y, Li M, Wang Z, Wen M, Tang J Tags: Rapid Commun Mass Spectrom Source Type: research
Effect of TRP-Stimulating Compounds to Reduce Swallowing Response Time in the Elderly: A Systematic Review
AbstractThere is still controversy on evidence supporting compounds that stimulate the transient receptor potential cation channel (TRP) receptor, which can reduce the latency of swallowing reflex. This systematic review aims to evaluate the effectiveness of TRP-stimulating compounds to reduce swallowing reflex time in the elderly. We searched the following databases: PubMed, EMBASE, OVID, Central, Scopus, ISI, CINALH, LILACS, CRD database, and Open grey until June 1st, 2019. We included randomized controlled trials (RCTs) which compared swallowing time between TRP-stimulating compounds and placebo or no treatment in popul...
Source: Dysphagia - August 30, 2020 Category: Speech-Language Pathology Source Type: research
Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins.
Abstract
Piperine is a component of Piper nigrum (Black pepper). It is well known in ayurvedic formulations. Piperine is a bioenhancer as it reduces the activity of drug-metabolizing enzymes in rodents and thereby enhancing the plasma concentrations of several drugs, including the Pglycoprotein substrates. Therefore, it is of interest to understand the molecular docking interactions of piperine with several cell cycle proteins such as Cyclin dependent kinase 2 (CDK2), Cyclin-dependent kinase 4 (CDK4), Cyclin D and Cyclin T for further consideration in drug discovery related to oral cancer.
PMID: 32...
Source: Bioinformation - August 25, 2020 Category: Bioinformatics Authors: Rekha UV, Anita M, Jayamathi G, Sadhana K, Deepa S, Hussain S, Bhuvaneswari J, Ramya V, Selvaraj J, Naveenraj NS Tags: Bioinformation Source Type: research
Influence of extractions on physicochemical characterization and bioactivity of Piper nigrum oils: Study on the non-isothermal decomposition kinetic
Publication date: Available online 17 August 2020Source: Arabian Journal of ChemistryAuthor(s): T. Thanh-Tam Huynh, Thanh-Chi Mai, Chi-Hien Dang, T. Thuy-Trang Vo, Dinh-Truong Nguyen, Van-Su Dang, Khang Duy Vu Nguyen, Vinh-Thien Tran, Thanh-Danh Nguyen (Source: Arabian Journal of Chemistry)
Source: Arabian Journal of Chemistry - August 19, 2020 Category: Chemistry Source Type: research
Acute and Subchronic Toxicity Profile of a Polyherbal Drug Used in Sri Lankan Traditional Medicine.
Authors: Liyanagamage DSNK, Jayasinghe S, Attanayake AP, Karunaratne V
Abstract
A polyherbal drug composed of leaves of Murraya koenigii L. Spreng, cloves of Allium sativum L., fruits of Garcinia quaesita Pierre, and seeds of Piper nigrum L. is a popular drug which has been used by indigenous practitioners in Sri Lanka for the treatment of diabetes mellitus and dyslipidemia. The acute toxicity assessment was conducted, following a single oral dose of 0.25-2.0 g/kg in healthy rats, and rats were observed up to 14 days. The hot water extract (1.0 g/kg) and the water : acetone extract (0.5, 1.0, and 1...
Source: Evidence-based Complementary and Alternative Medicine - August 14, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Dichloromethane extraction from Piper nigrum L. and P. longum L. to mitigate ischemic stroke by activating the AKT/mTOR signaling pathway to suppress autophagy.
In conclusion, our findings indicated that DF treatment can reduce brain damage and inhibit apoptosis and autophagy by activating the Akt-mTOR signaling pathway in ischemic stroke.
PMID: 32781091 [PubMed - as supplied by publisher] (Source: Brain Research)
Source: Brain Research - August 7, 2020 Category: Neurology Authors: Zhang Y, He Q, Yang M, Hua S, Ma Q, Guo L, Wu X, Zhang C, Fu X, Liu J Tags: Brain Res Source Type: research
Pipercyclobutanamide D, a new member of the cyclobutanamide-type alkaloid, from the roots of Piper nigrum
. (Source: Journal of Asian Natural Products Research)
Source: Journal of Asian Natural Products Research - August 2, 2020 Category: Complementary Medicine Authors: Duc Minh Nguyen Huu Phu Hoang Dang Ngoc Vinh Huynh Huu Phuc Dang Loi Vuong Thi Lien Thuong Nguyen Source Type: research
New Diesters Derived from Piperine: in silico Study and Evaluation of Their Antimicrobial Potential
Piperine, previously extracted from black pepper (Piper nigrum L.), was used as a precursor for the synthesis of twelve new diester derivatives. The final products were obtained through the bimolecular nucleophilic substitution reaction (SN2) of the alkyl 2-chloroacetates and the salt of piperic acid, obtained from the basic hydrolysis of piperine. The compounds were synthesized with yields of 55-84% and characterized by infrared spectroscopy and 1H and 13C nuclear magnetic resonance. The evaluation of the compounds ’ potential as new drug candidates was done through an in silico study of ADME properties (absorption, di...
Source: Journal of the Brazilian Chemical Society - July 27, 2020 Category: Chemistry Source Type: research
Ayurveda and Siddha systems polyherbal formulations to treat COVID-19 caused by SARS-CoV-2 and brief insight on application of Molecular Docking and SWISS Target prediction tools to study efficacy of active molecules
Ayurveda and Siddha systems are the two ancient medical systems originated in India more than 4000 years ago had given many formulary and treatment methods against influenza like infections. Kabasura churan from Siddha system and Maha sudharshan churan from the Ayurvedic system are the two major formulations a long with many other individual herbs mentioned in the texts to treat Influenza like infections. Kabasura churan and Maha Sudarshan churan both have antipyretic, analgesic and anti-inflammatory effects. Both formulations were prepared according to Siddha and Ayurvedic texts. Herbs mentioned in both formulations lik...
Source: International Journal of Phytomedicine - July 20, 2020 Category: Science Authors: Hemanth kumar Manikyam Source Type: research
Inhibitory effect of Capsicum chinense and Piper nigrum fruits, capsaicin and piperine on aflatoxins production in Aspergillus parasiticus by downregulating the expression of aflD, aflM, aflR, and aflS genes of aflatoxins biosynthetic pathway.
Abstract
Aflatoxins produced by Aspergillus parasiticus are toxic and carcinogenic metabolites. The biosynthesis of this mycotoxins is a complex process and involves at least 30 genes clustered within an approximately 82 kB gene cluster. In the present study, the effect of Capsicum chinense and Piper nigrum fruits on Aspergillus parasiticus growth and aflatoxin production were studied in relation to the expression of aflD, aflM, aflR, and aflS four; key genes of aflatoxins biosynthesis pathway. GC-EIMS analysis identified capsaicin (66,107 µg g-1) and piperine (1,138 µg g-1) as the most abundant co...
Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes - July 10, 2020 Category: Environmental Health Authors: Buitimea-Cantúa GV, Buitimea-Cantúa NE, Rocha-Pizaña MDR, Hernández-Morales A, Magaña-Barajas E, Molina-Torres J Tags: J Environ Sci Health B Source Type: research
Plant growth-promoting bacteria as potential bio-inoculants and biocontrol agents to promote black pepper plant cultivation
Publication date: Available online 8 July 2020Source: Microbiological ResearchAuthor(s): Ee Tiing Lau, Akio Tani, Choy Yuen Khew, Yee Qin Chua, Siaw San Hwang (Source: Microbiological Research)
Source: Microbiological Research - July 9, 2020 Category: Infectious Diseases Source Type: research
(-)-Kusunokinin inhibits breast cancer in N-nitrosomethylurea-induced mammary tumor rats.
In conclusion, the results suggest that 14 mg/kg of (-)-kusunokinin inhibited tumors through the reduction of signaling proteins and their downstream molecules. Therefore, (-)-kusunokinin becomes an intriguing candidate for cancer treatment as it provides a strong potency in cancer inhibition.
PMID: 32619673 [PubMed - as supplied by publisher] (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - June 29, 2020 Category: Drugs & Pharmacology Authors: Tedasen A, Dokduang S, Sukpondma Y, Lailerd N, Madla S, Sriwiriyajan S, Rattanaburee T, Tipmanee V, Graidist P Tags: Eur J Pharmacol Source Type: research
