Molecules, Vol. 26, Pages 2293: Quorum Sensing and NF- κB Inhibition of Synthetic Coumaperine Derivatives from Piper nigrum
In this study, we tested 32 synthetic derivatives of coumaperine (CP), a known natural compound found in pepper (Piper nigrum), for Quorum Sensing Inhibition (QSI) and NF-κB inhibitory activities. Of the compounds tested, seven were found to have high QSI activity, three inhibited bacterial growth and five inhibited NF-κB. In addition, some of the CP compounds were active in more than one test. For example, compounds CP-286, CP-215 and CP-158 were not cytotoxic, inhibited NF-κB activation and QS but did not show antibacterial activity. CP-154 inhibited QS, decreased NF-κB activation and inhibited bacterial growth. Our ...
Source: Molecules - April 15, 2021 Category: Chemistry Authors: Yael Kadosh Subramani Muthuraman Karin Yaniv Yifat Baruch Jacob Gopas Ariel Kushmaro Rajendran Saravana Kumar Tags: Article Source Type: research
IJERPH, Vol. 18, Pages 3774: QuEChERS LC –MS/MS Screening Method for Mycotoxin Detection in Cereal Products and Spices
IJERPH, Vol. 18, Pages 3774: QuEChERS LC–MS/MS Screening Method for Mycotoxin Detection in Cereal Products and Spices
International Journal of Environmental Research and Public Health doi: 10.3390/ijerph18073774
Authors:
Licia Pantano
Ladislao La Scala
Francesco Olibrio
Francesco Giuseppe Galluzzo
Carmelo Bongiorno
Maria Drussilla Buscemi
Andrea Macaluso
Antonio Vella
We developed and validated a screening method for mycotoxin analysis in cereal products and spices. Ultra-high-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC–MS/MS) was used for the analysis. Dispersiv...
Source: International Journal of Environmental Research and Public Health - April 4, 2021 Category: Environmental Health Authors: Licia Pantano Ladislao La Scala Francesco Olibrio Francesco Giuseppe Galluzzo Carmelo Bongiorno Maria Drussilla Buscemi Andrea Macaluso Antonio Vella Tags: Article Source Type: research
Black pepper prevents anemia of inflammation by inhibiting hepcidin over-expression through BMP6-SMAD1/ IL6-STAT3 signaling pathway
Free Radic Biol Med. 2021 Mar 23:S0891-5849(21)00178-7. doi: 10.1016/j.freeradbiomed.2021.03.019. Online ahead of print.ABSTRACTHepcidin, a circulatory hepatic peptide hormone, is associated with systemic iron homeostasis. Inflammation leads to an increase in hepcidin expression, which dysregulates body iron level. The related disorder, anemia of inflammation, is the second most prevalent anemia-related disorder worldwide. In the present study, we conducted in vitro and in vivo studies to evaluate the effect of black pepper and its major alkaloid, piperine, on anemia of inflammation. The initial in vitro study using human ...
Source: Free Radical Biology and Medicine - March 27, 2021 Category: Biology Authors: Somesh Banerjee Parul Katiyar Lokesh Kumar Vijay Kumar Shashank Sagar Saini Vengadesan Krishnan Debabrata Sircar Partha Roy Source Type: research
Black pepper prevents anemia of inflammation by inhibiting hepcidin over-expression through BMP6-SMAD1/ IL6-STAT3 signaling pathway
Free Radic Biol Med. 2021 Mar 23:S0891-5849(21)00178-7. doi: 10.1016/j.freeradbiomed.2021.03.019. Online ahead of print.ABSTRACTHepcidin, a circulatory hepatic peptide hormone, is associated with systemic iron homeostasis. Inflammation leads to an increase in hepcidin expression, which dysregulates body iron level. The related disorder, anemia of inflammation, is the second most prevalent anemia-related disorder worldwide. In the present study, we conducted in vitro and in vivo studies to evaluate the effect of black pepper and its major alkaloid, piperine, on anemia of inflammation. The initial in vitro study using human ...
Source: Free Radical Biology and Medicine - March 27, 2021 Category: Biology Authors: Somesh Banerjee Parul Katiyar Lokesh Kumar Vijay Kumar Shashank Sagar Saini Vengadesan Krishnan Debabrata Sircar Partha Roy Source Type: research
Efficacy of bioagents against Pythium deliense Meurs associated with yellowing of black pepper
Arch Microbiol. 2021 Mar 10. doi: 10.1007/s00203-021-02252-3. Online ahead of print.ABSTRACTYellowing and wilting of black pepper vines is a serious concern in many black pepper growing tracts where Pythium deliense was recently emerged as a pathogen from the rhizosphere of affected vines, which is proved to be pathogenic by Koch's postulates. As a measure to manage the symptoms, bioagents were evaluated against infection by P. deliense. Among the seven bioagents tested, Trichoderma harzianum and Streptomyces albulus showed 100% inhibition in vitro followed by one Streptomyces sp. and S. rimosus (75.33%). The potential one...
Source: Archives of Microbiology - March 11, 2021 Category: Microbiology Authors: Subila Kizhakke Purayil R Suseela Bhai Source Type: research
Efficacy of bioagents against Pythium deliense Meurs associated with yellowing of black pepper
Arch Microbiol. 2021 Mar 10. doi: 10.1007/s00203-021-02252-3. Online ahead of print.ABSTRACTYellowing and wilting of black pepper vines is a serious concern in many black pepper growing tracts where Pythium deliense was recently emerged as a pathogen from the rhizosphere of affected vines, which is proved to be pathogenic by Koch's postulates. As a measure to manage the symptoms, bioagents were evaluated against infection by P. deliense. Among the seven bioagents tested, Trichoderma harzianum and Streptomyces albulus showed 100% inhibition in vitro followed by one Streptomyces sp. and S. rimosus (75.33%). The potential one...
Source: Archives of Microbiology - March 11, 2021 Category: Microbiology Authors: Subila Kizhakke Purayil R Suseela Bhai Source Type: research
[ASAP] Phytochemical Analysis and Determination of the Chemical Composition of Larvicidal Extracts of Black Pepper ( < italic toggle="yes" > Piper < /italic > < italic toggle="yes" > nigrum < /italic > L.) Waste: An Undergraduate Chemistry Experiment
Journal of Chemical EducationDOI: 10.1021/acs.jchemed.0c01106 (Source: Journal of Chemical Education)
Source: Journal of Chemical Education - March 9, 2021 Category: Chemistry Authors: Danielle R. Lucas, Thaiany S. C. Bressiani, Anne C. C. Gomes, Ingrid M. Hayashide, Naomi K. Simas, Maria F. F. Lelis, Ricardo M. Kuster, and Paulo R. G. Moura Source Type: research
Analytical method development, validation and forced degradation studies for rutin, quercetin, curcumin and piperine by RP-UFLC method
CONCLUSION: The method developed was simple, fast, accurate, sensitive and applicable for the determination of phytoconstituents in natural extracts and herbal formulations, individually or in combination and can be used as a quality control tool.PMID:33648389 | DOI:10.1080/03639045.2021.1892740 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - March 2, 2021 Category: Drugs & Pharmacology Authors: Ramaswamy Shanmugam Kuppuswamy Gowthamarajan Lalitha Priyanka Dwarampudi Mahendran Bhaskaran Madhuri Kadiyala Source Type: research
Evaluation of Enterococcus faecium NRRL B-2354 as a surrogate for Salmonella in ground black pepper at different water activities
Int J Food Microbiol. 2021 Feb 23;344:109114. doi: 10.1016/j.ijfoodmicro.2021.109114. Online ahead of print.ABSTRACTThermal inactivation kinetics of Salmonella in low moisture foods are necessary for developing proper thermal processing parameters for pasteurization. The effect of water activity on thermal inactivation kinetics of Salmonella and Enterococcus faecium NRRL B-2354 in ground black pepper has not been studied previously. Identification of a suitable surrogate assists in conducting in-plant process validations. Ground black pepper was inoculated with a 5-serotype Salmonella cocktail or E. faecium NRRL B-2354, eq...
Source: International Journal of Food Microbiology - March 2, 2021 Category: Food Science Authors: Xinyao Wei Sabrina Vasquez Harshavardhan Thippareddi Jeyamkondan Subbiah Source Type: research
Analytical method development, validation and forced degradation studies for rutin, quercetin, curcumin and piperine by RP-UFLC method
CONCLUSION: The method developed was simple, fast, accurate, sensitive and applicable for the determination of phytoconstituents in natural extracts and herbal formulations, individually or in combination and can be used as a quality control tool.PMID:33648389 | DOI:10.1080/03639045.2021.1892740 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - March 2, 2021 Category: Drugs & Pharmacology Authors: Ramaswamy Shanmugam Kuppuswamy Gowthamarajan Lalitha Priyanka Dwarampudi Mahendran Bhaskaran Madhuri Kadiyala Source Type: research
Evaluation of Enterococcus faecium NRRL B-2354 as a surrogate for Salmonella in ground black pepper at different water activities
Int J Food Microbiol. 2021 Feb 23;344:109114. doi: 10.1016/j.ijfoodmicro.2021.109114. Online ahead of print.ABSTRACTThermal inactivation kinetics of Salmonella in low moisture foods are necessary for developing proper thermal processing parameters for pasteurization. The effect of water activity on thermal inactivation kinetics of Salmonella and Enterococcus faecium NRRL B-2354 in ground black pepper has not been studied previously. Identification of a suitable surrogate assists in conducting in-plant process validations. Ground black pepper was inoculated with a 5-serotype Salmonella cocktail or E. faecium NRRL B-2354, eq...
Source: International Journal of Food Microbiology - March 2, 2021 Category: Food Science Authors: Xinyao Wei Sabrina Vasquez Harshavardhan Thippareddi Jeyamkondan Subbiah Source Type: research
Analytical method development, validation and forced degradation studies for rutin, quercetin, curcumin and piperine by RP-UFLC method
CONCLUSION: The method developed was simple, fast, accurate, sensitive and applicable for the determination of phytoconstituents in natural extracts and herbal formulations, individually or in combination and can be used as a quality control tool.PMID:33648389 | DOI:10.1080/03639045.2021.1892740 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - March 2, 2021 Category: Drugs & Pharmacology Authors: Ramaswamy Shanmugam Kuppuswamy Gowthamarajan Lalitha Priyanka Dwarampudi Mahendran Bhaskaran Madhuri Kadiyala Source Type: research
