Rapid onsite detection of piper yellow mottle virus infecting black pepper by recombinase polymerase amplification-lateral flow assay (RPA-LFA)
J Virol Methods. 2023 Feb 21;315:114695. doi: 10.1016/j.jviromet.2023.114695. Online ahead of print.ABSTRACTPiper yellow mottle virus (PYMoV) is a pararetrovirus associated with stunt disease in black pepper. As the primary spread of the virus occurs through vegetative propagation, effective diagnostics are required for the production of virus-free plants. Currently available assays are time-consuming, require expensive equipment, and are not suitable for on-site detection. In the present study, two rapid assays based on the recombinase polymerase amplification (RPA) coupled with lateral flow assay (LFA) using (i) 6-carbox...
Source: Journal of Virological Methods - February 23, 2023 Category: Virology Authors: M Greeshma A I Bhat A Jeevalatha Source Type: research
Synthesis, characterization, and assessment of chitosan-nanomatrix enriched with antifungal formulation against biodeterioration of active ingredients of selected herbal raw materials
Int J Biol Macromol. 2023 Feb 13:123684. doi: 10.1016/j.ijbiomac.2023.123684. Online ahead of print.ABSTRACTAflatoxin B1 (AFB1), a potent natural group 1 carcinogen produced by Aspergillus flavus is considered an unavoidable toxic contaminant of herbal raw materials, which often deteriorates their active ingredients making them less effective and hazardous during their formulation in herbal drugs. The present investigation reports the antifungal (0.5 μl/ml) and AFB1 inhibitory (0.4 μl/ml) effects of the developed formulation CIM based on a mixture of essential oils (Carum carvi, and Illicium verum), and methyl anthranila...
Source: International Journal of Biological Macromolecules - February 15, 2023 Category: Biochemistry Authors: Vishal Gupta Prem Pratap Singh Bhanu Prakash Source Type: research
Synthesis, characterization, and assessment of chitosan-nanomatrix enriched with antifungal formulation against biodeterioration of active ingredients of selected herbal raw materials
Int J Biol Macromol. 2023 Feb 13:123684. doi: 10.1016/j.ijbiomac.2023.123684. Online ahead of print.ABSTRACTAflatoxin B1 (AFB1), a potent natural group 1 carcinogen produced by Aspergillus flavus is considered an unavoidable toxic contaminant of herbal raw materials, which often deteriorates their active ingredients making them less effective and hazardous during their formulation in herbal drugs. The present investigation reports the antifungal (0.5 μl/ml) and AFB1 inhibitory (0.4 μl/ml) effects of the developed formulation CIM based on a mixture of essential oils (Carum carvi, and Illicium verum), and methyl anthranila...
Source: International Journal of Biological Macromolecules - February 15, 2023 Category: Biochemistry Authors: Vishal Gupta Prem Pratap Singh Bhanu Prakash Source Type: research
A review on multi-therapeutic potential of (-)-cubebin: experimental evidences
Nat Prod Res. 2023 Feb 12:1-12. doi: 10.1080/14786419.2023.2177849. Online ahead of print.ABSTRACTLignans are a large category of polyphenolic compounds that have low molecular weight and are widely distributed in the plant kingdom. They have been recognized for their potential antioxidizing and antiproliferative action. One of the most important lignans is cubebin which is abundantly isolated from the leaves and seeds of Piper cubeba and Piper nigrum. Cubebin possesses numerous biological actions such as antileukemic, trypanocidal, antimycobacterial, analgesic, anti-inflammatory, histamine antagonist, antifungal, and anti...
Source: Natural Product Research - February 12, 2023 Category: Biochemistry Authors: Neetu Agrawal Deepika Goyal Ahsas Goyal Source Type: research
A review on multi-therapeutic potential of (-)-cubebin: experimental evidences
Nat Prod Res. 2023 Feb 12:1-12. doi: 10.1080/14786419.2023.2177849. Online ahead of print.ABSTRACTLignans are a large category of polyphenolic compounds that have low molecular weight and are widely distributed in the plant kingdom. They have been recognized for their potential antioxidizing and antiproliferative action. One of the most important lignans is cubebin which is abundantly isolated from the leaves and seeds of Piper cubeba and Piper nigrum. Cubebin possesses numerous biological actions such as antileukemic, trypanocidal, antimycobacterial, analgesic, anti-inflammatory, histamine antagonist, antifungal, and anti...
Source: Natural Product Research - February 12, 2023 Category: Biochemistry Authors: Neetu Agrawal Deepika Goyal Ahsas Goyal Source Type: research
Molecules, Vol. 28, Pages 1264: Edible Plant Extracts against Aedes aegypti and Validation of a Piper nigrum L. Ethanolic Extract as a Natural Insecticide
This study screened the larvicidal and pupicidal activity of common edible plant extracts. Piper nigrum L. (black pepper) extract production was optimized using accelerated solvent extraction (ASE) and validated following regulatory requirements using HPLC-PDA analytical methodology to quantify its major component–piperine. Larvicidal activity was determined for the standardized P. nigrum fruit ethanol extract (LC50 1.1 µg/mL) and piperine standard (LC50 19.0 µg/mL). Furthermore, 9-day residual activity was determined for the extract (4 µg/mL) and piperine (60 &am...
Source: Molecules - January 28, 2023 Category: Chemistry Authors: Lais Silva Morais Jo ão Paulo Barreto Sousa Carolina Melo Aguiar Ciro Martins Gomes Daniel Pecoraro Demarque Lorena Carneiro Albernaz Laila Salmen Espindola Tags: Article Source Type: research
A new lignan (Polonilignan) and inhibitors of nitric oxide production from Penicillium polonicum, an endophytic fungi of Piper nigrum
Chem Biodivers. 2023 Jan 20. doi: 10.1002/cbdv.202200840. Online ahead of print.ABSTRACTInhibiting nitric oxide (NO) or its production is found to be of therapeutic benefit. To discover natural small molecule inhibitors of NO production, a bioassay- and LC-MS-guided chemical investigation was done on the metabolites of endophytic fungus isolated from fresh Piper nigrum fruits. The isolated pure strain was identified as Penicillium polonicum by 16S rDNA sequence comparison. The culture broth extract of P. polonicum (EEPP) exhibited a significant reduction of NO production (Griess method) in LPS-stimulated RAW 264.7 cells (P...
Source: Chemistry and Biodiversity - January 20, 2023 Category: Biochemistry Authors: Pragya Paramita Pal Sajeli A Begum Ameer Basha S Hiroshi Araya Yoshinori Fujimoto Source Type: research
A new lignan (Polonilignan) and inhibitors of nitric oxide production from Penicillium polonicum, an endophytic fungi of Piper nigrum
Chem Biodivers. 2023 Jan 20. doi: 10.1002/cbdv.202200840. Online ahead of print.ABSTRACTInhibiting nitric oxide (NO) or its production is found to be of therapeutic benefit. To discover natural small molecule inhibitors of NO production, a bioassay- and LC-MS-guided chemical investigation was done on the metabolites of endophytic fungus isolated from fresh Piper nigrum fruits. The isolated pure strain was identified as Penicillium polonicum by 16S rDNA sequence comparison. The culture broth extract of P. polonicum (EEPP) exhibited a significant reduction of NO production (Griess method) in LPS-stimulated RAW 264.7 cells (P...
Source: Chemistry and Biodiversity - January 20, 2023 Category: Biochemistry Authors: Pragya Paramita Pal Sajeli A Begum Ameer Basha S Hiroshi Araya Yoshinori Fujimoto Source Type: research
Chemical profile and biological activities of fungal strains isolated from Piper nigrum roots: Experimental and computational approaches
Chem Biodivers. 2022 Dec 23. doi: 10.1002/cbdv.202200456. Online ahead of print.ABSTRACTThe current report describes the chemical investigation and biological activity of extracts produced by three fungal strains Fusarium oxysporum, Penicillium simplicissimum, and Fusarium proliferatum isolated from the roots of Piper nigrum L. growing in Vietnam. These fungi were namely determined by morphological and DNA analyses. GC-MS identification revealed that the EtOAc extracts of these fungi were associated with the presence of saturated and unsaturated fatty acids. These EtOAc extracts showed cytotoxicity towards cancer cell line...
Source: Chemistry and Biodiversity - December 23, 2022 Category: Biochemistry Authors: Nguyen Dinh Luyen Le Mai Huong Nguyen Thi Thu Ha Nguyen Thanh Tra Le Thi Tu Anh Nguyen Van Tuyen Katalin Posta Son The Ninh Hai Pham-The Source Type: research
Chemical profile and biological activities of fungal strains isolated from Piper nigrum roots: Experimental and computational approaches
Chem Biodivers. 2022 Dec 23. doi: 10.1002/cbdv.202200456. Online ahead of print.ABSTRACTThe current report describes the chemical investigation and biological activity of extracts produced by three fungal strains Fusarium oxysporum, Penicillium simplicissimum, and Fusarium proliferatum isolated from the roots of Piper nigrum L. growing in Vietnam. These fungi were namely determined by morphological and DNA analyses. GC-MS identification revealed that the EtOAc extracts of these fungi were associated with the presence of saturated and unsaturated fatty acids. These EtOAc extracts showed cytotoxicity towards cancer cell line...
Source: Cancer Control - December 23, 2022 Category: Cancer & Oncology Authors: Nguyen Dinh Luyen Le Mai Huong Nguyen Thi Thu Ha Nguyen Thanh Tra Le Thi Tu Anh Nguyen Van Tuyen Katalin Posta Son The Ninh Hai Pham-The Source Type: research
Chemical profile and biological activities of fungal strains isolated from Piper nigrum roots: Experimental and computational approaches
Chem Biodivers. 2022 Dec 23. doi: 10.1002/cbdv.202200456. Online ahead of print.ABSTRACTThe current report describes the chemical investigation and biological activity of extracts produced by three fungal strains Fusarium oxysporum, Penicillium simplicissimum, and Fusarium proliferatum isolated from the roots of Piper nigrum L. growing in Vietnam. These fungi were namely determined by morphological and DNA analyses. GC-MS identification revealed that the EtOAc extracts of these fungi were associated with the presence of saturated and unsaturated fatty acids. These EtOAc extracts showed cytotoxicity towards cancer cell line...
Source: Chemistry and Biodiversity - December 23, 2022 Category: Biochemistry Authors: Nguyen Dinh Luyen Le Mai Huong Nguyen Thi Thu Ha Nguyen Thanh Tra Le Thi Tu Anh Nguyen Van Tuyen Katalin Posta Son The Ninh Hai Pham-The Source Type: research
Black Pepper < em > (Piper nigrum) < /em > for Tobacco Withdrawal: A Case Report
Case Rep Psychiatry. 2022 Dec 9;2022:5908769. doi: 10.1155/2022/5908769. eCollection 2022.NO ABSTRACTPMID:36530582 | PMC:PMC9757938 | DOI:10.1155/2022/5908769 (Source: Case Reports in Psychiatry)
Source: Case Reports in Psychiatry - December 19, 2022 Category: Psychiatry Authors: Jeremy Weleff Samyukta Dore Akhil Anand Brian S Barnett Source Type: research
Black Pepper < em > (Piper nigrum) < /em > for Tobacco Withdrawal: A Case Report
Case Rep Psychiatry. 2022 Dec 9;2022:5908769. doi: 10.1155/2022/5908769. eCollection 2022.ABSTRACTTobacco use continues to be one of humanity's most significant public health concerns, causing more than 8-million deaths annually. Existing treatments for tobacco use disorder are limited in efficacy and there is a strong need for identifying effective novel treatments. Small clinical trials indicate that black pepper (Piper nigrum) essential oil may be helpful for treating nicotine withdrawal and craving. However, we are unaware of any cases reporting the use of black pepper for these purposes in nonresearch settings. Here w...
Source: Case Reports in Psychiatry - December 19, 2022 Category: Psychiatry Authors: Jeremy Weleff Samyukta Dore Akhil Anand Brian S Barnett Source Type: research
