Investigation of the potential of Brevibacillus spp. for the biosynthesis of nonribosomally produced bioactive compounds by combination of genome mining with MALDI-TOF mass spectrometry
The biosynthetic potential of 11 Brevibacillus spp. strains was investigated by combination of genome mining with mass spectrometric analysis using MALDI-TOF mass spectrometry. These endophytic, plant associated Brevibacillus strains were isolated from crop plants, such as coffee and black pepper, in Vietnam. Draft genomes of these strains were available. They were classified (a) by comparison with type strains and a collection of genome-sequenced Brevibacillus spp. deposited in the NCBI data base as well as (b) by construction of a phylogenetic tree from the core sequences of publicly available genomes of Brevibacillus st...
Source: Frontiers in Microbiology - December 14, 2023 Category: Microbiology Source Type: research
Nanoemulsion-integrated gelatin/bacterial cellulose nanofibril-based multifunctional film: Fabrication, characterization, and application
Int J Biol Macromol. 2023 Nov 27:128341. doi: 10.1016/j.ijbiomac.2023.128341. Online ahead of print.ABSTRACTThe current requirements of food safety regulations and the environmental impact stemming from plastic packaging can only be addressed by developing suitable bio-nanocomposite films. Therefore, this study is dedicated to the fabrication of multifunctional film composed of gelatin, bacterial cellulose nanofibrils (BCNF), and black pepper essential oil nanoemulsion (BPEONE) and application for duck meat preservation. BCNF was prepared through ultrasonication of cellulose derived from Komagataeibacter xylinus. BPEONE ob...
Source: International Journal of Biological Macromolecules - November 29, 2023 Category: Biochemistry Authors: Dev Raj Acharya Siyu Liu Hongyun Lu Dafaallah Albashir Pankaj Koirala Ying Shi Qihe Chen Source Type: research
Molecules, Vol. 28, Pages 7748: Chemical Composition of Essential Oils and Supercritical Carbon Dioxide Extracts from Amomum kravanh, Citrus hystrix and Piper nigrum & lsquo;Kampot & rsquo;
In this study, the chemical composition of essential oils (EOs) and supercritical CO2 extracts from all three species was determined using GC-MS, with two columns of different polarity (HP-5/DB-HeavyWAX). Differences between the chemical profile of the EOs and CO2 extracts were observed for all species. The greatest difference was detected in A. kravanh EO containing mainly eucalyptol (78.8/72.6%), while the CO2 extract was rich in fatty acids (13/55.92%) and long-chain alkanes (25.55/9.54%). Furthermore, the results for the CO2 extract of this species differed, where tricosane (14.74%) and oleic acid (29.26%) were the mai...
Source: Molecules - November 24, 2023 Category: Chemistry Authors: Vihanova Katerina Urbanova Klara Nguon Samnang Kokoska Ladislav Tags: Article Source Type: research
Novel applications of black pepper essential oil as an antioxidant agent in sodium caseinate and chitosan based active edible films
Int J Biol Macromol. 2023 Nov 11:128045. doi: 10.1016/j.ijbiomac.2023.128045. Online ahead of print.ABSTRACTIn the current study, sodium caseinate and chitosan-based composite edible films were developed with the incorporation of black pepper (Piper nigrum) essential oil (BPO) in various concentrations (0.05, 0.1 and 0.15 %) for potential food packaging applications. The chemical composition of BPO was determined using GCMS and the major compound detected were β-Caryophyllene, Limonene, β-Phellandren, Pinene, Copaene and α-humulene. The addition of BPO resulted in an increase in the thickness, EAB, WVP, moisture content...
Source: International Journal of Biological Macromolecules - November 13, 2023 Category: Biochemistry Authors: Saurabh Bhatia Yasir Abbas Shah Ahmed Al-Harrasi Muhammad Jawad Esra Koca Levent Yurdaer Aydemir Source Type: research
Novel applications of black pepper essential oil as an antioxidant agent in sodium caseinate and chitosan based active edible films
Int J Biol Macromol. 2023 Nov 11:128045. doi: 10.1016/j.ijbiomac.2023.128045. Online ahead of print.ABSTRACTIn the current study, sodium caseinate and chitosan-based composite edible films were developed with the incorporation of black pepper (Piper nigrum) essential oil (BPO) in various concentrations (0.05, 0.1 and 0.15 %) for potential food packaging applications. The chemical composition of BPO was determined using GCMS and the major compound detected were β-Caryophyllene, Limonene, β-Phellandren, Pinene, Copaene and α-humulene. The addition of BPO resulted in an increase in the thickness, EAB, WVP, moisture content...
Source: International Journal of Biological Macromolecules - November 13, 2023 Category: Biochemistry Authors: Saurabh Bhatia Yasir Abbas Shah Ahmed Al-Harrasi Muhammad Jawad Esra Koca Levent Yurdaer Aydemir Source Type: research
Biodegradation of the methylenedioxyphenyl group in piperine and its derivatives: discovery of a novel methylenetransferase in an actinomycete
This study provides new insights into the unique functions of GcvT members and the piperine metabolism in nature.IMPORTANCEPepper is a spice that has been used worldwide since the Age of Discovery. The substance that is responsible for the spiciness in pepper is piperine, a type of alkaloid. It has never been reported how piperine is degraded by microorganisms. In this study, we discovered a bacterium in the soil that is capable of catabolizing piperine as its sole nitrogen source. Furthermore, we discovered the enzyme involved in piperine metabolism. This enzyme decomposed the methylenedioxyphenyl group, which is the comm...
Source: Applied and Environmental Microbiology - October 24, 2023 Category: Microbiology Authors: Pu Jian Takuto Kumano Mio Kimura Makoto Kurisaki Yoshiteru Hashimoto Michihiko Kobayashi Source Type: research
Biodegradation of the methylenedioxyphenyl group in piperine and its derivatives: discovery of a novel methylenetransferase in an actinomycete
This study provides new insights into the unique functions of GcvT members and the piperine metabolism in nature.IMPORTANCEPepper is a spice that has been used worldwide since the Age of Discovery. The substance that is responsible for the spiciness in pepper is piperine, a type of alkaloid. It has never been reported how piperine is degraded by microorganisms. In this study, we discovered a bacterium in the soil that is capable of catabolizing piperine as its sole nitrogen source. Furthermore, we discovered the enzyme involved in piperine metabolism. This enzyme decomposed the methylenedioxyphenyl group, which is the comm...
Source: Applied and Environmental Microbiology - October 24, 2023 Category: Microbiology Authors: Pu Jian Takuto Kumano Mio Kimura Makoto Kurisaki Yoshiteru Hashimoto Michihiko Kobayashi Source Type: research
Significant Advancement in Various Synthetic Strategies and Pharmacotherapy of Piperine Derivatives: A Review
CONCLUSION: This review article provides a thorough examination of piperine and the source plant. The best extraction technique for the extraction of piperine and the synthesis of its analogs with various biological activities, including antihypertensive, antidiabetic, insecticidal, antibacterial, and antibiotic properties, are covered in the article. This review aims to provide an updated analysis of the literature on the synthesis of piperine analogs.PMID:37828679 | DOI:10.2174/0115680266256255231009075303 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - October 13, 2023 Category: Chemistry Authors: Sagar Joshi None Salahuddin Avijit Mazumder Rajnish Kumar Km Shabana Sonakshi Tyagi Kavita Rana Mohamed Jawed Ahsan Mohammad Shahar Yar Arvind Arya Navneet Khurana Source Type: research
Significant Advancement in Various Synthetic Strategies and Pharmacotherapy of Piperine Derivatives: A Review
CONCLUSION: This review article provides a thorough examination of piperine and the source plant. The best extraction technique for the extraction of piperine and the synthesis of its analogs with various biological activities, including antihypertensive, antidiabetic, insecticidal, antibacterial, and antibiotic properties, are covered in the article. This review aims to provide an updated analysis of the literature on the synthesis of piperine analogs.PMID:37828679 | DOI:10.2174/0115680266256255231009075303 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - October 13, 2023 Category: Chemistry Authors: Sagar Joshi None Salahuddin Avijit Mazumder Rajnish Kumar Km Shabana Sonakshi Tyagi Kavita Rana Mohamed Jawed Ahsan Mohammad Shahar Yar Arvind Arya Navneet Khurana Source Type: research
Significant Advancement in Various Synthetic Strategies and Pharmacotherapy of Piperine Derivatives: A Review
CONCLUSION: This review article provides a thorough examination of piperine and the source plant. The best extraction technique for the extraction of piperine and the synthesis of its analogs with various biological activities, including antihypertensive, antidiabetic, insecticidal, antibacterial, and antibiotic properties, are covered in the article. This review aims to provide an updated analysis of the literature on the synthesis of piperine analogs.PMID:37828679 | DOI:10.2174/0115680266256255231009075303 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - October 13, 2023 Category: Chemistry Authors: Sagar Joshi None Salahuddin Avijit Mazumder Rajnish Kumar Km Shabana Sonakshi Tyagi Kavita Rana Mohamed Jawed Ahsan Mohammad Shahar Yar Arvind Arya Navneet Khurana Source Type: research
The potential of a combination of pungent spices as a novel supplement in gilthead seabream (Sparus aurata) diets to aid in the strategic use of fish oil in aquafeeds: a holistic perspective
In conclusion, the supplementation of gilthead seabream diets with pungent spices at an inclusion of 0.1% was beneficial to enhance growth performance and feed utilization; reduce fat accumulation in the visceral cavity, liver, and intestine; and improve the fish health status and condition. Results suggest that the tested supplement can be used as part of a nutritional strategy to promote a more judicious use of fish oil in fish diets due to its decreasing availability and rising costs. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - September 25, 2023 Category: Allergy & Immunology Source Type: research
Enhanced anticancer activity of piperine: Structural optimization and chitosan-based microgels with boosted drug delivery
Int J Biol Macromol. 2023 Sep 20:127019. doi: 10.1016/j.ijbiomac.2023.127019. Online ahead of print.ABSTRACTAs a plant-derived drug, piperine possesses therapeutic efficacy for many diseases, but its inherent low solubility and bioavailability have greatly limited its clinical use. Herein, we extracted piperine from black pepper, optimized the structure of piperine to prepare various derivatives, and then explored the anticancer activity of these derivatives. Piperine and its derivatives have high anticancer selectivity against 4T1 cells, exhibiting obvious anticancer properties even at a low concentration of 100 μg/mL. F...
Source: International Journal of Biological Macromolecules - September 22, 2023 Category: Biochemistry Authors: Xuejiao Wang Jiangbin Wang Helin Li Source Type: research
Enhanced anticancer activity of piperine: Structural optimization and chitosan-based microgels with boosted drug delivery
Int J Biol Macromol. 2023 Sep 20:127019. doi: 10.1016/j.ijbiomac.2023.127019. Online ahead of print.ABSTRACTAs a plant-derived drug, piperine possesses therapeutic efficacy for many diseases, but its inherent low solubility and bioavailability have greatly limited its clinical use. Herein, we extracted piperine from black pepper, optimized the structure of piperine to prepare various derivatives, and then explored the anticancer activity of these derivatives. Piperine and its derivatives have high anticancer selectivity against 4T1 cells, exhibiting obvious anticancer properties even at a low concentration of 100 μg/mL. F...
Source: International Journal of Biological Macromolecules - September 22, 2023 Category: Biochemistry Authors: Xuejiao Wang Jiangbin Wang Helin Li Source Type: research
Subunit-specific inhibition of BK channels by piperine
In this study, we have investigated the pharmacological effects of piperine on various BK channel subunit compositions (BKα, BKαβ1,4, BKαγ1,3) expressed in HEK293T cells. Piperine in zero Ca2+ reversibly inhibited currents from the pore-forming BKα channels in a dose-dependent manner with an IC50 of 4.8μM. Elevating the internal Ca2+ concentration from 0μM to 100μM significantly attenuated the inhibitory effects of piperine on BKα channels. The mutation G311S in the pore domain failed to alter the modulatory effects of piperine, whereas deletion of the entire cytoplasmic domain from BKα channels ablated its inhi...
Source: Biophysical Journal - September 13, 2023 Category: Physics Authors: Aravind Kshatri Belinda Rivero-P érez Teresa Giraldez Source Type: research
Subunit-specific inhibition of BK channels by piperine
In this study, we have investigated the pharmacological effects of piperine on various BK channel subunit compositions (BKα, BKαβ1,4, BKαγ1,3) expressed in HEK293T cells. Piperine in zero Ca2+ reversibly inhibited currents from the pore-forming BKα channels in a dose-dependent manner with an IC50 of 4.8μM. Elevating the internal Ca2+ concentration from 0μM to 100μM significantly attenuated the inhibitory effects of piperine on BKα channels. The mutation G311S in the pore domain failed to alter the modulatory effects of piperine, whereas deletion of the entire cytoplasmic domain from BKα channels ablated its inhi...
Source: Biophysical Journal - September 13, 2023 Category: Physics Authors: Aravind Kshatri Belinda Rivero-P érez Teresa Giraldez Source Type: research
