Molecules, Vol. 28, Pages 5587: Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer
Brasil
André Salim Khayat
Gastric cancer is one of the most frequent types of neoplasms worldwide, usually presenting as aggressive and difficult-to-manage tumors. The search for new structures with anticancer potential encompasses a vast research field in which natural products arise as promising alternatives. In this scenario, piperine, an alkaloid of the Piper species, has received attention due to its biological activity, including anticancer attributes. The present work proposes three heating-independent, reliable, low-cost, and selective methods for obtaining piperine from Piper nigrum L. (Black pepper). Elect...
Source: Molecules - July 22, 2023 Category: Chemistry Authors: Ingryd Nayara de Farias Ramos Monique Feitosa da Silva Jefferson Marcio Sanches Lopes Jordy Neves Cruz Fabrine Silva Alves Jos é de Arimatéia Rodrigues do Rego Marcondes Lima da Costa Paulo Pimentel de Assump ção Davi do Socorro Barros Brasil Andr é Tags: Article Source Type: research
An eco-friendly one-pot extraction process for curcumin and its bioenhancer, piperine from edible plants in exosome-like nanovesicles
Green Chem., 2023, Accepted Manuscript DOI: 10.1039/D3GC01287E, PaperMeghana N Kumar, Sreeram Peringattu Kalarikkal, Cathrine MS Bethi, Sukriti Narendra Singh, Narayanan Janakiraman, Gopinath M. Sundaram Curcumin has been extensively studied for its medicinal benefits, though its therapeutic use is limited by a lack of aqueous solubility and bioavailability. Piperine from black pepper is known to... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Green Chem. latest articles)
Source: RSC - Green Chem. latest articles - July 19, 2023 Category: Chemistry Authors: Meghana N Kumar Source Type: research
Piper nigrum extract suppresses tumor growth and enhances the antitumor immune response in murine models of breast cancer and melanoma
AbstractAlthough the antitumor effect ofP. nigrum has been widely studied, research related to its possible immunomodulatory effects is relatively scarce. Here, the antitumor and immunomodulatory activity of an ethanolic extract ofP. nigrum were evaluated in the murine models of 4T1 breast cancer and B16-F10 melanoma. In vitro evaluations showed that theP. nigrum extract has cytotoxic activity, induces apoptotic cell death, and has a pro-oxidant effect in both cell lines, but it regulates glucose uptake differently in both lines, decreasing it in 4T1 but not in B16-F10.P. nigrum extract significantly reduced tumor size in ...
Source: Cancer Immunology, Immunotherapy - July 18, 2023 Category: Cancer & Oncology Source Type: research
Effects of black pepper and turmeric powder on growth performance, gut health, meat quality, and fatty acid profile of Japanese quail
This study investigated the effects of dietary supplementation of black pepper and turmeric powder, separately or in combination, on the growth performance, gastrointestinal microbiota population, intestinal morphology, serum biochemical parameters, meat quality, and meat fatty acid profile in Japanese quails. Five hundred-day-old mixed-sex Japanese quail chicks were randomly assigned to one of five treatments: a control diet (CON); CON +0.2% antibiotic flavomycin as an antibiotic growth promoter (AGP); CON +0.5% turmeric powder (TUP); CON +0.5% black pepper powder (BPP); and CON +0.5% TUP, and 0.5% BPP (MIX). The findings...
Source: Frontiers in Physiology - July 11, 2023 Category: Physiology Source Type: research
Thermal desorption direct analysis in real ‐time high‐resolution mass spectrometry and machine learning allow the rapid authentication of ground black pepper and dried oregano: A proof‐of‐concept study
In this study, TD-DART-HRMS's utility for establishing spice authenticity was examined. To this aim, we directly analyzed authentic (typical) and adulterated (atypical) samples of ground black pepper and dried oregano in positive and negative ion modes. We analyzed a set of authentic ground black pepper samples (n = 14) originating from Brazil, Sri Lanka, Madagascar, Ecuador, Vietnam, Costa Rica, Indonesia, Cambodia, and adulterated samples (n = 25) consisting of mixtures of ground black pepper with this spice's nonfunctional by-products (pinheads or spent) or with different exogenous materials (olive kernel, green...
Source: Journal of Mass Spectrometry - July 4, 2023 Category: Chemistry Authors: Carmela Zacometti,
Andrea Massaro,
Tommaso Gioia,
Stephane Lefevre,
Aline Fr égière‐Salomon,
Jean‐Louis Lafeuille,
Ingrid Fiordaliso Candalino,
Michele Suman,
Roberto Piro,
Alessandra Tata Tags: RESEARCH ARTICLE Source Type: research
Evaluation of Curcumin-Piperine Supplementation in COVID-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial
CONCLUSION: The study results showed that short-term curcumin-piperine supplementation significantly decreased CRP, AST, and increased hemoglobin in COVID-19 patients admitted to the ICU. Based on these promising findings, curcumin appears to be a complementary treatment option for COVID-19 patients, although some parameters were not affected by the intervention.PMID:37378780 | DOI:10.1007/978-3-031-28012-2_22 (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - June 28, 2023 Category: Research Authors: Gholamreza Askari Mohammad Bagherniya Zahra Kiani Babak Alikiaii Mahdiye Mirjalili Mehrnaz Shojaei Shirin Hassanizadeh Mahdi Vajdi Awat Feizi Muhammed Majeed Amirhossein Sahebkar Source Type: research
Spices and Biomarkers of COVID-19: A Mechanistic and Therapeutic Perspective
Adv Exp Med Biol. 2023;1412:375-395. doi: 10.1007/978-3-031-28012-2_20.ABSTRACTIn the face of the COVID-19 pandemic, many people around the world have increased their healthy behaviors to prevent transmission of the virus and potentially improve their immune systems. Therefore, the role of diet and food compounds such as spices with bioactive and antiviral properties may be important in these efforts. In this chapter, we review the efficacy of spices such as turmeric (curcumin), cinnamon, ginger, black pepper, saffron, capsaicin, and cumin by investigating the effects of these compounds of COVID-19 disease severity biomark...
Source: Advances in Experimental Medicine and Biology - June 28, 2023 Category: Research Authors: Masha Shirani Shokoofeh Talebi Mehrnaz Shojaei Gholamreza Askari Mohammad Bagherniya Paul C Guest Thozhukat Sathyapalan Amirhossein Sahebkar Source Type: research
Evaluation of Curcumin-Piperine Supplementation in COVID-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial
CONCLUSION: The study results showed that short-term curcumin-piperine supplementation significantly decreased CRP, AST, and increased hemoglobin in COVID-19 patients admitted to the ICU. Based on these promising findings, curcumin appears to be a complementary treatment option for COVID-19 patients, although some parameters were not affected by the intervention.PMID:37378780 | DOI:10.1007/978-3-031-28012-2_22 (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - June 28, 2023 Category: Research Authors: Gholamreza Askari Mohammad Bagherniya Zahra Kiani Babak Alikiaii Mahdiye Mirjalili Mehrnaz Shojaei Shirin Hassanizadeh Mahdi Vajdi Awat Feizi Muhammed Majeed Amirhossein Sahebkar Source Type: research
Spices and Biomarkers of COVID-19: A Mechanistic and Therapeutic Perspective
Adv Exp Med Biol. 2023;1412:375-395. doi: 10.1007/978-3-031-28012-2_20.ABSTRACTIn the face of the COVID-19 pandemic, many people around the world have increased their healthy behaviors to prevent transmission of the virus and potentially improve their immune systems. Therefore, the role of diet and food compounds such as spices with bioactive and antiviral properties may be important in these efforts. In this chapter, we review the efficacy of spices such as turmeric (curcumin), cinnamon, ginger, black pepper, saffron, capsaicin, and cumin by investigating the effects of these compounds of COVID-19 disease severity biomark...
Source: Advances in Experimental Medicine and Biology - June 28, 2023 Category: Research Authors: Masha Shirani Shokoofeh Talebi Mehrnaz Shojaei Gholamreza Askari Mohammad Bagherniya Paul C Guest Thozhukat Sathyapalan Amirhossein Sahebkar Source Type: research
Evaluation of Curcumin-Piperine Supplementation in COVID-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial
CONCLUSION: The study results showed that short-term curcumin-piperine supplementation significantly decreased CRP, AST, and increased hemoglobin in COVID-19 patients admitted to the ICU. Based on these promising findings, curcumin appears to be a complementary treatment option for COVID-19 patients, although some parameters were not affected by the intervention.PMID:37378780 | DOI:10.1007/978-3-031-28012-2_22 (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - June 28, 2023 Category: Research Authors: Gholamreza Askari Mohammad Bagherniya Zahra Kiani Babak Alikiaii Mahdiye Mirjalili Mehrnaz Shojaei Shirin Hassanizadeh Mahdi Vajdi Awat Feizi Muhammed Majeed Amirhossein Sahebkar Source Type: research
Spices and Biomarkers of COVID-19: A Mechanistic and Therapeutic Perspective
Adv Exp Med Biol. 2023;1412:375-395. doi: 10.1007/978-3-031-28012-2_20.ABSTRACTIn the face of the COVID-19 pandemic, many people around the world have increased their healthy behaviors to prevent transmission of the virus and potentially improve their immune systems. Therefore, the role of diet and food compounds such as spices with bioactive and antiviral properties may be important in these efforts. In this chapter, we review the efficacy of spices such as turmeric (curcumin), cinnamon, ginger, black pepper, saffron, capsaicin, and cumin by investigating the effects of these compounds of COVID-19 disease severity biomark...
Source: Advances in Experimental Medicine and Biology - June 28, 2023 Category: Research Authors: Masha Shirani Shokoofeh Talebi Mehrnaz Shojaei Gholamreza Askari Mohammad Bagherniya Paul C Guest Thozhukat Sathyapalan Amirhossein Sahebkar Source Type: research
Evaluation of Curcumin-Piperine Supplementation in COVID-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial
CONCLUSION: The study results showed that short-term curcumin-piperine supplementation significantly decreased CRP, AST, and increased hemoglobin in COVID-19 patients admitted to the ICU. Based on these promising findings, curcumin appears to be a complementary treatment option for COVID-19 patients, although some parameters were not affected by the intervention.PMID:37378780 | DOI:10.1007/978-3-031-28012-2_22 (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - June 28, 2023 Category: Research Authors: Gholamreza Askari Mohammad Bagherniya Zahra Kiani Babak Alikiaii Mahdiye Mirjalili Mehrnaz Shojaei Shirin Hassanizadeh Mahdi Vajdi Awat Feizi Muhammed Majeed Amirhossein Sahebkar Source Type: research
Spices and Biomarkers of COVID-19: A Mechanistic and Therapeutic Perspective
Adv Exp Med Biol. 2023;1412:375-395. doi: 10.1007/978-3-031-28012-2_20.ABSTRACTIn the face of the COVID-19 pandemic, many people around the world have increased their healthy behaviors to prevent transmission of the virus and potentially improve their immune systems. Therefore, the role of diet and food compounds such as spices with bioactive and antiviral properties may be important in these efforts. In this chapter, we review the efficacy of spices such as turmeric (curcumin), cinnamon, ginger, black pepper, saffron, capsaicin, and cumin by investigating the effects of these compounds of COVID-19 disease severity biomark...
Source: Advances in Experimental Medicine and Biology - June 28, 2023 Category: Research Authors: Masha Shirani Shokoofeh Talebi Mehrnaz Shojaei Gholamreza Askari Mohammad Bagherniya Paul C Guest Thozhukat Sathyapalan Amirhossein Sahebkar Source Type: research
Evaluation of Curcumin-Piperine Supplementation in COVID-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial
CONCLUSION: The study results showed that short-term curcumin-piperine supplementation significantly decreased CRP, AST, and increased hemoglobin in COVID-19 patients admitted to the ICU. Based on these promising findings, curcumin appears to be a complementary treatment option for COVID-19 patients, although some parameters were not affected by the intervention.PMID:37378780 | DOI:10.1007/978-3-031-28012-2_22 (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - June 28, 2023 Category: Research Authors: Gholamreza Askari Mohammad Bagherniya Zahra Kiani Babak Alikiaii Mahdiye Mirjalili Mehrnaz Shojaei Shirin Hassanizadeh Mahdi Vajdi Awat Feizi Muhammed Majeed Amirhossein Sahebkar Source Type: research
