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Molecules, Vol. 27, Pages 6403: Spices Volatilomic Fingerprinting & mdash;A Comprehensive Approach to Explore Its Authentication and Bioactive Properties
This study aimed to establish the volatilomic fingerprint of six of the most consumed spices all over the world (saffron (Crocus sativus L.), cinnamon (Cinnamomum verum), cumin (Cuminum cyminum L.), black pepper, (Piper nigrum L.), sweet paprika (Capsicum annuum L.), and curry (a mix of different herbs and spices)). Based on headspace solid phase microextraction (HS-SPME) followed by gas chromatography-mass spectrometry (GC-MS) analysis, this is a powerful strategy to explore and establish the spice&rsquo;s volatile pattern and unravel the potential health benefits related to the most important VOMs identified in e...
Source: Molecules - September 28, 2022 Category: Chemistry Authors: Sergio Izcara Rosa Perestrelo Sonia Morante-Zarcero Isabel Sierra Jos é S. Câmara Tags: Article Source Type: research

The genotoxic, cytotoxic and growth regulatory effects of plant secondary metabolite β-caryophyllene on polyphagous pest Spodoptera litura (Fabricius) (Lepidoptera: Noctuidae)
Toxicon. 2022 Sep 24:S0041-0101(22)00275-6. doi: 10.1016/j.toxicon.2022.09.016. Online ahead of print.ABSTRACTUse of secondary metabolites as an alternative to organic pesticides is an eco-friendly and safe strategy in pest management. β-caryophyllene [(1R,4E,9S)-4,11,11-trimethyl-8-methylene bicyclo [7.2.0]undec-4-ene], a natural sesquiterpene is found as an essential oil in many plants like Syzygium aromaticum, Piper nigrum, Cannabis sativa. The present study aims at exploring the insecticidal, genotoxic and cytotoxic potential of β-caryophyllene against common cutworm Spodoptera litura (Fab.), a major polyphagous pest...
Source: Toxicon - September 27, 2022 Category: Toxicology Authors: Evani Mahajan Sumit Singh None Diksha Sanehdeep Kaur Satwinder Kaur Sohal Source Type: research

Fumigant and contact toxicities of individual and additive combinations of biorational-essential oils for control of rice weevil ( < em > Sitophilus oryzae) < /em >
Nat Prod Res. 2022 Sep 21:1-5. doi: 10.1080/14786419.2022.2125967. Online ahead of print.ABSTRACTFumigant and contact activity of individual and combination of EOs (cumin seed and black pepper oil) were conducted against rice weevil (Sitophilus oryzae). Cumin seed and black pepper oil individually exhibited 100% insecticidal activity (Contact and Fumigant) against S. oryzae at 24 and 168 h of exposure in the absence and presence of food, respectively. Overall, differential insect mortality rates were observed with individual EOs; however, cumin seed EO showed higher insecticidal activity in both fumigant and contact bioass...
Source: Natural Product Research - September 21, 2022 Category: Biochemistry Authors: Archana V Remesh C S Vivek Babu Source Type: research

Coexistence of Riehl's Melanosis, Lupus Erythematosus and Thyroiditis in a Patient
CONCLUSION: RM could be a skin manifestation of autoimmunity. Coexistence of RM, lupus erythematosus and thyroiditis in the same patient is rare and has never been reported.PMID:36105748 | PMC:PMC9467848 | DOI:10.2147/CCID.S376614 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - September 15, 2022 Category: Dermatology Authors: Kuan Lai Xinyao Zheng Shanshan Wei Huifeng Zhou Xuedan Zeng Guixin Liang Zhiwen Zhang Wenjing Zhang Source Type: research

Molecules, Vol. 27, Pages 5990: Chemical Profiling, Formulation Development, In Vitro Evaluation and Molecular Docking of Piper nigrum Seeds Extract Loaded Emulgel for Anti-Aging
We report a stable emulgel of 4% Piper nigrum extract (PNE) prepared using 80% ethanol. The PNE-loaded formulation had an antioxidant activity of 84% and tyrosinase inhibition was 82%. Prepared formulation rendered spherical-shaped globules with high zeta potential (&minus;45.5 mV) indicative of a stable system. Total phenolic contents were 58.01 mg GAE/g of dry extract whereas total flavonoid content was 52.63 mg QE/g of dry extract. Sun protection factor for PNE-loaded emulgel was 7.512 and formulation was stable without any evidence of physical and chemical changes following 90 days of storage. Gas chromatograph...
Source: Molecules - September 14, 2022 Category: Chemistry Authors: Muhammad Yousuf Haji Muhammad Shoaib Khan Fatima Rasool Kashif ur Rehman Khan Faisal Usman Bilal Ahmad Ghalloo Muhammad Umair Ahmad O. Babalghith Muhammad Kamran Rana Muhammad Aadil Soad K. Al Jaouni Samy Selim Sameh A. Korma Carlos Adam Conte-Junior Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5965: Comparative Quantification of the Phenolic Compounds, Piperine Content, and Total Polyphenols along with the Antioxidant Activities in the Piper trichostachyon and P. nigrum
mmed Alessa India is the largest producer in the world of black pepper and it is the center of origin for Piper. The present study gives a comparative account of the chemical composition of the Piper nigrum and its wild putative parent the P. trichostachyon. Microextractions were performed and the quantification of six phenolic compounds (namely epicatechin, gallic acid, catechol, chlorogenic acid, caffeic acid, and catechin), piperine from leaves, petioles, and the fruits of both the species, were accomplished using the RP-UFLC system. The polyphenols (phenolic, flavonoid) and their antioxidant activities were also es...
Source: Molecules - September 13, 2022 Category: Chemistry Authors: Jameel Mohammed Al-Khayri Vinayak Upadhya Sandeep Ramachandra Pai Poornananda Madhava Naik Muneera Qassim Al-Mssallem Fatima Mohammed Alessa Tags: Article Source Type: research

Changes in the genomes and methylomes of three Salmonella enterica serovars after long-term storage in ground black pepper
Low moisture foods (LMFs) have traditionally been recognized as safe for consumption, as most bacteria require higher water content to grow. However, outbreaks due to LMF foods are increasing, and the microbial pathogen Salmonella enterica is frequently implicated. S. enterica can survive in LMFs for years, but few serovars have been studied, and the mechanisms which underlie this longevity are not well understood. Here, we determine that S. enterica serovars S. Tennessee, S. Anatum, and S. Reading but not S. Oranienburg can survive in the ground black pepper for 6 years. S. Reading was not previously associated with any L...
Source: Frontiers in Microbiology - September 9, 2022 Category: Microbiology Source Type: research

A Unifying Perspective in Blunting the Limited Oral Bioavailability of Curcumin: A Succinct Look
CONCLUSION: In light of current challenges, the major concern pertaining to poor systemic bioavailability of curcumin, its improvement especially in combination with piperine, and necessity of additional research in this setting are together described in this review. Besides, the recent advances on the potential therapeutic rationale and efficacy of curcumin-piperine combination, a promising duo, against various pathologic conditions are delineated.PMID:36017834 | DOI:10.2174/1389200223666220825101212 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 26, 2022 Category: Drugs & Pharmacology Authors: Pitchai Balakumar Taha Alqahtani Ali Alqahtani R Sulochana Lakshmiraj Gurfateh Singh Mani Rupeshkumar A Thangathirupathi Karupiah Sundram Source Type: research