Spices and Biomarkers of COVID-19: A Mechanistic and Therapeutic Perspective
Adv Exp Med Biol. 2023;1412:375-395. doi: 10.1007/978-3-031-28012-2_20.ABSTRACTIn the face of the COVID-19 pandemic, many people around the world have increased their healthy behaviors to prevent transmission of the virus and potentially improve their immune systems. Therefore, the role of diet and food compounds such as spices with bioactive and antiviral properties may be important in these efforts. In this chapter, we review the efficacy of spices such as turmeric (curcumin), cinnamon, ginger, black pepper, saffron, capsaicin, and cumin by investigating the effects of these compounds of COVID-19 disease severity biomark...
Source: Advances in Experimental Medicine and Biology - June 28, 2023 Category: Research Authors: Masha Shirani Shokoofeh Talebi Mehrnaz Shojaei Gholamreza Askari Mohammad Bagherniya Paul C Guest Thozhukat Sathyapalan Amirhossein Sahebkar Source Type: research
Evaluation of Curcumin-Piperine Supplementation in COVID-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial
CONCLUSION: The study results showed that short-term curcumin-piperine supplementation significantly decreased CRP, AST, and increased hemoglobin in COVID-19 patients admitted to the ICU. Based on these promising findings, curcumin appears to be a complementary treatment option for COVID-19 patients, although some parameters were not affected by the intervention.PMID:37378780 | DOI:10.1007/978-3-031-28012-2_22 (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - June 28, 2023 Category: Research Authors: Gholamreza Askari Mohammad Bagherniya Zahra Kiani Babak Alikiaii Mahdiye Mirjalili Mehrnaz Shojaei Shirin Hassanizadeh Mahdi Vajdi Awat Feizi Muhammed Majeed Amirhossein Sahebkar Source Type: research
Spices and Biomarkers of COVID-19: A Mechanistic and Therapeutic Perspective
Adv Exp Med Biol. 2023;1412:375-395. doi: 10.1007/978-3-031-28012-2_20.ABSTRACTIn the face of the COVID-19 pandemic, many people around the world have increased their healthy behaviors to prevent transmission of the virus and potentially improve their immune systems. Therefore, the role of diet and food compounds such as spices with bioactive and antiviral properties may be important in these efforts. In this chapter, we review the efficacy of spices such as turmeric (curcumin), cinnamon, ginger, black pepper, saffron, capsaicin, and cumin by investigating the effects of these compounds of COVID-19 disease severity biomark...
Source: Advances in Experimental Medicine and Biology - June 28, 2023 Category: Research Authors: Masha Shirani Shokoofeh Talebi Mehrnaz Shojaei Gholamreza Askari Mohammad Bagherniya Paul C Guest Thozhukat Sathyapalan Amirhossein Sahebkar Source Type: research
Synthesis and evaluation of Piperine analogs as thioredoxin reductase inhibitors to cause oxidative stress-induced cancer cell apoptosis
Bioorg Chem. 2023 May 6;138:106589. doi: 10.1016/j.bioorg.2023.106589. Online ahead of print.ABSTRACTInhibiting thioredoxin reductase (TrxR) to disrupt the redox equilibrium and induce tumor cell apoptosis is a significant tumor therapeutic strategy. Piperine, a natural product from black pepper, has been demonstrated to suppress tumor cell proliferation by enhancing reactive oxygen species (ROS), subsequently leading to cell death. However, the development of Piperine as an active molecule is hampered by its weak cytotoxicity. To develop a compound with higher activity, we synthesized 22 Piperine analogs and evaluated the...
Source: Bioorganic Chemistry - June 15, 2023 Category: Chemistry Authors: Miao Zhong Lingzhen Chen Yue Tao Jintao Zhao Bingbing Chang Fang Zhang Jingwen Tu Wenqing Cai Baoxin Zhang Source Type: research
Synthesis and evaluation of Piperine analogs as thioredoxin reductase inhibitors to cause oxidative stress-induced cancer cell apoptosis
Bioorg Chem. 2023 May 6;138:106589. doi: 10.1016/j.bioorg.2023.106589. Online ahead of print.ABSTRACTInhibiting thioredoxin reductase (TrxR) to disrupt the redox equilibrium and induce tumor cell apoptosis is a significant tumor therapeutic strategy. Piperine, a natural product from black pepper, has been demonstrated to suppress tumor cell proliferation by enhancing reactive oxygen species (ROS), subsequently leading to cell death. However, the development of Piperine as an active molecule is hampered by its weak cytotoxicity. To develop a compound with higher activity, we synthesized 22 Piperine analogs and evaluated the...
Source: Bioorganic Chemistry - June 15, 2023 Category: Chemistry Authors: Miao Zhong Lingzhen Chen Yue Tao Jintao Zhao Bingbing Chang Fang Zhang Jingwen Tu Wenqing Cai Baoxin Zhang Source Type: research
Separation of 90Nb from bulk yttrium target using two food derived alkaloids
AbstractnatY was irradiated with 34 MeV α-particles to produce90Nb. Separation of90Nb from bulk yttrium target was carried out using two naturally occurring alkaloids namely caffeine extracted from black tea leaves and piperine extracted from black pepper, both of which are commonly used in everyday household. In both the cases, SLX was opted as caffeine was insoluble in 2 M Na2SO4 and piperine in HCl of varying concentration.90Nb was preferentially extracted by caffeine and piperine precipitate and bulk yttrium remained in supernatant. DFT calculations suggest the preferential binding of90Nb to different binding site...
Source: Journal of Radioanalytical and Nuclear Chemistry - June 14, 2023 Category: Nuclear Medicine Source Type: research
The potential role of Piper guineense (black pepper) in managing geriatric brain aging: a review
(Source: Critical Reviews in Food Science and Nutrition)
Source: Critical Reviews in Food Science and Nutrition - June 2, 2023 Category: Nutrition Authors: Ademuyiwa, Oluwaseun Hannah Fasogbon, Beatrice Mofoluwaso Adebo, Oluwafemi Ayodeji Source Type: research
Piperine ameliorates psoriatic skin inflammation by inhibiting the phosphorylation of STAT3
Int Immunopharmacol. 2023 Apr 28;119:110221. doi: 10.1016/j.intimp.2023.110221. Online ahead of print.ABSTRACTPsoriasis is a common chronic inflammatory skin disease that is easy to relapse and difficult to cure. Piperine is the main alkaloid extracted from black pepper, and its role in psoriasis has not been previously reported. We identified that piperine ameliorated M5-induced psoriatic skin lesions. Furthermore, piperine alleviated psoriasis pathological features including epidermal hyperplasia and inflammatory cell infiltration, decreased the expression of psoriasis-characteristic cytokines, chemokines and proteins in...
Source: International Immunopharmacology - April 30, 2023 Category: Allergy & Immunology Authors: Hui Lu Hongjian Gong Juan Du Wenqi Gao Jia Xu Xiaonan Cai Yuan Yang Han Xiao Source Type: research
Piperine ameliorates psoriatic skin inflammation by inhibiting the phosphorylation of STAT3
Int Immunopharmacol. 2023 Apr 28;119:110221. doi: 10.1016/j.intimp.2023.110221. Online ahead of print.ABSTRACTPsoriasis is a common chronic inflammatory skin disease that is easy to relapse and difficult to cure. Piperine is the main alkaloid extracted from black pepper, and its role in psoriasis has not been previously reported. We identified that piperine ameliorated M5-induced psoriatic skin lesions. Furthermore, piperine alleviated psoriasis pathological features including epidermal hyperplasia and inflammatory cell infiltration, decreased the expression of psoriasis-characteristic cytokines, chemokines and proteins in...
Source: International Immunopharmacology - April 30, 2023 Category: Allergy & Immunology Authors: Hui Lu Hongjian Gong Juan Du Wenqi Gao Jia Xu Xiaonan Cai Yuan Yang Han Xiao Source Type: research
Effect of Piper nigrum, Thymus vulgaris and Syzigiuim aromaticum essential oils on the microbiological and sensory quality of Pork sausages during preservation
The use of essentials oils (EOs) as alternative of nitrites and nitrates in sausages will be proposed in this study. For this purpose, the minimal inhibitory concentration (MIC) of white Piper nigrum of Penja, Thymus vulgaris and Syzigiuim aromaticum EOs were determined in vitro against Escherichia coli ATCC25922, Salmonella enteritidis 155A and Staphylococcus aureus NCTC10652. It follows fr... (Source: African Journal of Microbiology Research)
Source: African Journal of Microbiology Research - April 27, 2023 Category: Microbiology Source Type: research
New natural pro-inflammatory cytokines (TNF- α, IL-6 and IL-1β) and iNOS inhibitors identified from Penicillium polonicum through in vitro and in vivo studies
Int Immunopharmacol. 2023 Apr;117:109940. doi: 10.1016/j.intimp.2023.109940. Epub 2023 Mar 10.ABSTRACTOverexpression of pro-inflammatory cytokines and iNOS have been found to be concomitant with several chronic inflammatory diseases and hence targeting their inhibition would be a useful therapy for inflammation. In view of this, study on discovery of natural pro-inflammatory cytokines inhibitory lead molecules from Penicillium polonicum, an endophytic fungus isolated from the fresh fruits of Piper nigrum was performed. When the culture broth extract of P. polonicum (EEPP) was subjected to LPS-induced cytokines expression (...
Source: International Immunopharmacology - April 4, 2023 Category: Allergy & Immunology Authors: Pragya Paramita Pal Ahil Sajeli Begum S Ameer Basha Hiroshi Araya Yoshinori Fujimoto Source Type: research
New natural pro-inflammatory cytokines (TNF- α, IL-6 and IL-1β) and iNOS inhibitors identified from Penicillium polonicum through in vitro and in vivo studies
Int Immunopharmacol. 2023 Apr;117:109940. doi: 10.1016/j.intimp.2023.109940. Epub 2023 Mar 10.ABSTRACTOverexpression of pro-inflammatory cytokines and iNOS have been found to be concomitant with several chronic inflammatory diseases and hence targeting their inhibition would be a useful therapy for inflammation. In view of this, study on discovery of natural pro-inflammatory cytokines inhibitory lead molecules from Penicillium polonicum, an endophytic fungus isolated from the fresh fruits of Piper nigrum was performed. When the culture broth extract of P. polonicum (EEPP) was subjected to LPS-induced cytokines expression (...
Source: International Immunopharmacology - April 4, 2023 Category: Allergy & Immunology Authors: Pragya Paramita Pal Ahil Sajeli Begum S Ameer Basha Hiroshi Araya Yoshinori Fujimoto Source Type: research
Molecules, Vol. 28, Pages 2293: Isolation, Bioactive Potential, and Application of Essential Oils and Terpenoid-Rich Extracts as Effective Antioxidant and Antimicrobial Agents in Meat and Meat Products
avlić
Using food additives (e.g., preservatives, antioxidants) is one of the main methods for preserving meat and meat product quality (edible, sensory, and technological) during processing and storage. Conversely, they show negative health implications, so meat technology scientists are focusing on finding alternatives for these compounds. Terpenoid-rich extracts, including essential oils (EOs), are remarkable since they are generally marked as GRAS (generally recognized as safe) and have a wide ranging acceptance from consumers. EOs obtained by conventional or non-conventional methods possess different preservative ...
Source: Molecules - March 1, 2023 Category: Chemistry Authors: Branislav Šojić Sanja Milo šević Danica Savanovi ć Zoran Zekovi ć Vladimir Tomovi ć Branimir Pavli ć Tags: Review Source Type: research
Rapid onsite detection of piper yellow mottle virus infecting black pepper by recombinase polymerase amplification-lateral flow assay (RPA-LFA)
J Virol Methods. 2023 Feb 21:114695. doi: 10.1016/j.jviromet.2023.114695. Online ahead of print.ABSTRACTPiper yellow mottle virus (PYMoV) is a pararetrovirus associated with stunt disease in black pepper. As the primary spread of the virus occurs through vegetative propagation, effective diagnostics are required for the production of virus-free plants. Currently available assays are time-consuming, require expensive equipment, and are not suitable for on-site detection. In the present study, two rapid assays based on the recombinase polymerase amplification (RPA) coupled with lateral flow assay (LFA) using (i) 6-carboxyflu...
Source: Journal of Virological Methods - February 23, 2023 Category: Virology Authors: M Greeshma A I Bhat A Jeevalatha Source Type: research
Rapid onsite detection of piper yellow mottle virus infecting black pepper by recombinase polymerase amplification-lateral flow assay (RPA-LFA)
J Virol Methods. 2023 Feb 21;315:114695. doi: 10.1016/j.jviromet.2023.114695. Online ahead of print.ABSTRACTPiper yellow mottle virus (PYMoV) is a pararetrovirus associated with stunt disease in black pepper. As the primary spread of the virus occurs through vegetative propagation, effective diagnostics are required for the production of virus-free plants. Currently available assays are time-consuming, require expensive equipment, and are not suitable for on-site detection. In the present study, two rapid assays based on the recombinase polymerase amplification (RPA) coupled with lateral flow assay (LFA) using (i) 6-carbox...
Source: Journal of Virological Methods - February 23, 2023 Category: Virology Authors: M Greeshma A I Bhat A Jeevalatha Source Type: research
