Identification of the stable and reactive metabolites of tetrahydropiperine by ultra-high-performance liquid chromatography combined with diode array detector and high-resolution mass spectrometry.

CONCLUSION: The major metabolic pathways of tetrahydropiperine were hydroxylation, dehydrogenation, methylation, GSH conjugation and glucuronidation. Tetrahydropiperine was bioactivated through ortho-quinone, Michael receptor and aldehyde intermediates. PMID: 33049799 [PubMed - as supplied by publisher]
Source: Rapid Communications in Mass Spectrometry : RCM - Category: Chemistry Authors: Tags: Rapid Commun Mass Spectrom Source Type: research