Fight Aging! Newsletter, June 19th 2023
In conclusion, among Swedish middle-aged subjects, nearly two-thirds showed complete fatty degeneration of thymus on CT.
Age-Related Dysfunction of Water Homeostasis
https://www.fightaging.org/archives/2023/06/age-related-dysfunction-of-water-homeostasis/
Dehydration can be an issue in older people. As in every complex system in the body, the mechanisms by which hydration is regulated become dysfunctional with advancing age. Researchers here look at the brain region responsible for regulating some of the response to dehydration, cataloging altered gene expression in search of the more important mechan...
Source: Fight Aging! - June 18, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Career Conversations: Q & A With Physiologist Elimelda Moige Ongeri
Credit: Courtesy of Dr. Elimelda Moige Ongeri.
A career path in science is rarely clear cut and linear, which Elimelda Moige Ongeri, Ph.D., can attest adds to its excitement. She went from working in animal reproductive biology to studying proteins involved in inflammation and tissue injury. Dr. Ongeri is also currently dean of the Hairston College of Health and Human Sciences and professor of physiology at North Carolina Agricultural and Technical State University (NC A&T) in Greensboro. In this interview, she shares details of her career, including a change in research focus to human physiology; her goals for the f...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 14, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Proteins Source Type: blogs
Against Prioritizing Environmentalism Over Human Health
It is fair to say that the mainstream of environmentalism prioritizes conservation of the environment over human comfort and health. Environmental concerns are high on the list of objections raised against treating aging as a medical condition, because most people believe that this will lead to a larger population, and also believe that population increases cannot occur without degrading the environment. Both of those beliefs are false, the latter evidently so given the improvements in the environment created since the 1950s, over a period of considerable population growth. Models strongly suggest that the future is one in...
Source: Fight Aging! - June 12, 2023 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
“We Are Electric” by Sally Adee: Medgadget Interviews the Author
The human body has a deep connection with electricity. The transmission of electrical impulses is responsible for the movement of our limbs, the functioning of our organs, and the formation and recall of memories. The signatures of the various electrical signals emanating from our body can be telltale signs of our health, and a jolt of electricity can literally bring us back from the brink of death.
But while these things have long been known about the electricity constantly coursing through our bodies, what has more recently been discovered is the role that “bioelectricity” plays in the formation of our bod...
Source: Medgadget - June 12, 2023 Category: Medical Devices Authors: Scott Jung Tags: Education etc. Exclusive Source Type: blogs
Fight Aging! Newsletter, June 12th 2023
In this study, we investigated the effect of NXP032 on neurovascular stabilization through the changes of PECAM-1, PDGFR-β, ZO-1, laminin, and glial cells involved in maintaining the integrity of the blood-brain barrier (BBB) in aged mice. NXP032 was orally administered daily for 8 weeks. Compared to young mice and NXP032-treated mice, 20-month-old mice displayed cognitive impairments in Y-maze and passive avoidance tests. NXP032 treatment contributed to reducing the BBB damage by attenuating the fragmentation of microvessels and reducing PDGFR-β, ZO-1, and laminin expression, thereby mitigating astrocytes and microglia ...
Source: Fight Aging! - June 11, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Can You Run In Marathons With Hypertension?
Marathons and hypertension: Understand the risks, learn how to stay safe while running, and explore alternative activities to keep your heart healthy and thriving.
Quick Summary
Marathons pose risks for individuals with hypertension: The intense physical exertion can lead to sudden increases in blood pressure, dehydration, irregular heart rhythms, and strain on the kidneys, potentially causing serious complications like heart attacks or strokes.
Safety measures for hypertensive individuals: If participating in a marathon, monitor blood pressure regularly, follow a supervised training regimen, stay hydrated, w...
Source: The EMT Spot - June 10, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Summary of responses to request for examples of data sets of microbial genomes with associated phenotypic data
So last week I posted a question to many different places as follows:Wanted - dataset(s) to test bacterial genome analysis / annotation methods. Ideally has many genomes from collection of [interesting] bacteria with associated experimental phenotypes / metadata.On Linked In:Jonathan Jacobs: "All the reference genomes in the ATCC Genome Portal are freely available for non-commercial research purposes. They are also fully authenticated and traceable to physical production lots in our biorepository, and produced under ISO quality management. I ’m biased, but I think we’re producing the quality microbial genomes I’ve ev...
Source: The Tree of Life - June 10, 2023 Category: Microbiology Source Type: blogs
Senescent Cells Appear Involved in Graft-Versus-Host Disease
Now that increasing attention is given to senescent cells in the biology of aging, their involvement in a wide range of conditions has been uncovered. The transient creation of senescent cells is a part of wound healing, a process that is harmed by the growing burden of lingering senescent cells that occurs with advancing age, and the inability of the aged immune system to remove these cells in a timely fashion. Given the role in wound healing, is perhaps not surprising to find senescent cells involved in graft-versus-host disease following surgical transplantation of tissue. Senolytic therapies may prove to be useful here...
Source: Fight Aging! - June 9, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Dancing Organelles, AI Resources, Distracting Animations, Timed Tests & Micro-credentials | TAPP 138
In Episode 138 ofThe A&P Professor podcast for anatomy& physiology faculty, host Kevin Patton discusses somenew thinking about organelle function, whydecorative animations are not a good idea in our teaching slides, news aboutWendy Riggs and the 2023 HAPS President ' s Medal, why Idon ' t like timed tests, resources forAI in the curriculum, and whymicro-credentials are our friends. With all that, how is that we left out any mention ofcarbaminohemoglobin?00:00 | Introduction00:50 | Wendy Riggs Wins Big04:173 | Curricular Resources for AI08:55 | Timed Online Tests24:12 | Micro-credentials for Professional Develo...
Source: The A and P Professor - June 9, 2023 Category: Physiology Authors: Kevin Patton Source Type: blogs
The Promise of Regenerative Medicine
Is is now going on three decades since the first flush of excitement for regenerative medicine in the form of stem cell therapies. Unfortunately, producing meaningful, reliable regeneration with cell therapies turned out to be a great deal harder then hoped. It is still not a solved problem, outside a few narrow applications. In the intervening time, the field of regenerative medicine has expanded considerably beyond cell therapies, now of many varieties, to encompass approaches such as immune modulation and reprogramming native cell behavior. As today's commentary notes, there is still no magic button to turn on regenerat...
Source: Fight Aging! - June 8, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, June 5th 2023
In conclusion, higher BMR might reduce lifespan. The underlying pathways linking to major causes of death and relevant interventions warrant further investigation.
Betting Against Progress Turns Out Poorly, But Can Work in the Short Term in a Slow Field
https://www.fightaging.org/archives/2023/06/betting-against-progress-turns-out-poorly-but-can-work-in-the-short-term-in-a-slow-field/
Setting oneself up as a spokesperson for "we will not achieve this goal", as the fellow noted here is choosing to do, is a bet against technological progress. A glance at any few decade period in the past two hundred yea...
Source: Fight Aging! - June 4, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Raised Basal Metabolic Rate Correlates with Reduced Life Expectancy in Humans
In conclusion, higher BMR might reduce lifespan. The underlying pathways linking to major causes of death and relevant interventions warrant further investigation. (Source: Fight Aging!)
Source: Fight Aging! - May 31, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Investigating Bacteria ’ s CRISPR Defense System to Improve Human Health
Credit: Adrian Sanchez Gonzales.
The earliest Andrew Santiago-Frangos, Ph.D., remembers being interested in science was when he was about 8 years old. He was home sick and became engrossed in a children’s book that explained how some bacteria and viruses cause illness. To this day, his curiosity about bacteria persists, and he’s making discoveries about CRISPR—a system that helps bacteria defend against viruses—as a postdoctoral researcher and NIGMS-funded Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) scholar at Montana State University (MSU) in Bozeman.
Becoming a Biologist...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - May 31, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Bacteria Cellular Processes COVID-19 DNA Profiles Source Type: blogs
Fight Aging! Newsletter, May 29th 2023
In this study, we used a Drosophila model to understand the role of the dec2P384R mutation on animal health and elucidate the mechanisms driving these physiological changes. We found that the expression of the mammalian dec2P384R transgene in fly sleep neurons was sufficient to mimic the short sleep phenotype observed in mammals. Remarkably, dec2P384Rmutants lived significantly longer with improved health despite sleeping less. In particular, dec2P384R mutants were more stress resistant and displayed improved mitochondrial fitness in flight muscles. Differential gene expression analyses went on to reveal several altered tr...
Source: Fight Aging! - May 28, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Doubt, Deferral, and Destiny
Five years ago, if you told me that I would be an entering MD/PhD student, I’d be elated, but if you had told me two years ago — I’d laugh and call you a liar. It’s strange that along my journey to medical school and physician-scientist training, there was such a low point, but one that many medical students can relate to: impostor syndrome during the application cycle.
I had been working toward this point throughout college, and before I started writing my applications, I felt reasonably confident in my goal to become a physician-scientist studying cancer biology. Yet the writing process brought my doubts, ...
Source: Academic Medicine Blog - May 25, 2023 Category: Universities & Medical Training Authors: Laura Siegel Tags: imposter syndrome Source Type: blogs
