Senescent Human Lung Fibroblasts Produce Lung Fibrosis when Transplanted into Mice
From the evidence accumulated to date in animal models and studies of human tissue, it seems clear that senescent cells play an important role in the development of fibrosis in a variety of tissues. Fibrosis is a dysfunction of normal tissue maintenance processes, an excessive deposition of collagen extracellular matrix that is disruptive to tissue structure and function. Senescent cells secrete signals that encourage both growth and inflammation, and that sort of signaling sustained for the long term may be necessary for the development of fibrosis. Many age-related fibrotic diseases exist, in lungs, liver, and heart for ...
Source: Fight Aging! - July 21, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Reviewing What is Known of the Biochemistry of Klotho Relevant to Effects on Life Span
Increased klotho expression increases longevity in mice, while reduced klotho expression accelerates aging. The most well studied effects of klotho on organ function involve the kidney and brain, where in both cases it appears protective via a number of different mechanisms. Unfortunately, klotho expression declines with age. Whether treating humans with therapies that increase levels of klotho will produce effects that are as large as those observed in mice remains to be seen. Programs that might lead to treatments remain at a preclinical stage of development, though recently advanced to the point of testing in non-human ...
Source: Fight Aging! - July 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Short-Term Economic Argument for Undertaking Efforts to Treat Aging as a Medical Condition
The primary economic argument presently made for treating aging as a medical condition emerges from the fact that medical spending and medical research is largely entwined with government in much of the world; it is increasingly a public purse, not a collection of private purses. Politicians and bureaucrats care (to some degree) about avoiding the looming financial implosion that will result when present unsustainable spending policies run head-on into the demographic transition to a society in which an ever-larger proportion of people are old, suffering from age-related disease, and many of their expenses paid via entitle...
Source: Fight Aging! - July 20, 2023 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Reduced APRT Expression Extends Life in Killifish
Researchers here note that reducing APRT expression affects extends life in short-lived killifish via mechanisms likely related to the calorie restriction response. This regulation of the pace of aging in response to nutrient availability is arguably the most well studied aspect of the biology of aging, but the production of calorie restriction mimetic strategies (such as this one) seems unlikely to result in meaningful therapies for humans. Short-lived species exhibit a much greater extension of life span in response to a low calorie diet than occurs in long-lived species like our own. Mice can live as much as 40% longer ...
Source: Fight Aging! - July 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
SENS Research Foundation 2023 Annual Report
The SENS Research Foundation has released its 2023 annual report. This is one of the few non-profit organizations focused on advancing the state of research and development of rejuvenation therapies. It exists in the same family tree as the Methuselah Foundation and LEV Foundation, and all three now have somewhat different areas of focus within the same broad outline. In comparison to the SENS Research Foundation, the Methuselah Foundation gives more attention to tissue engineering, while LEV Foundation is presently investigating combinations of potential rejuvenation therapies in animal models, a sorely neglected area of ...
Source: Fight Aging! - July 18, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Pre-A & P: A Refresher for Student Success in Anatomy & Physiology | TAPP 140
In episode 140, we introduce the development of thepre-A&P course and theA&P1 Supplement course. These coursesaddress the challenges faced by A&P students and improve theirreadiness and comprehension. In this first of two episodes, we focus on the pre-A&P course. It focuses on filling subject knowledge gaps with 10 modules and cumulative tests. Student surveys and studies show its effectiveness inachieving higher grades in the A&P 1 course. Implementing these nontraditional coursesrequires collaboration and support from advisors and faculty members. Together, we aim tobridge the gap in subject pre...
Source: The A and P Professor - July 18, 2023 Category: Physiology Authors: Kevin Patton Source Type: blogs
Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.
Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease
https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/
With the caveat that mouse models of Alzheimer'...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Developing a Recellularization Approach to Produce Thymic Tissue
The thymus produces the T cells that make up the adaptive immune system, but the organ atrophies with age, contributing to the age-related decline of immune function. A popular science article here comments on a new biotech company seeking to produce thymus tissue for transplantation from decellularized donor tissues. This builds upon work of recent years that improves the understanding of the stem cell and progenitor cell populations that give rise to thymic tissue. Given that understanding, it should be possible to take decellularized thymic tissue and repopulate it with patient-derived cells, or from novel universal cel...
Source: Fight Aging! - July 14, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Towards Depletion of Microglia as a Treatment for Alzheimer's Disease
In recent years, increasing attention has been given to the role of microglia in neurodegenerative conditions. Microglia are innate immune cells of the central nervous system, analogous to macrophages elsewhere in the body, but which also participate in the organization of synaptic connections in addition to the other roles one might expect from immune cells. Microglia in the aging brain become more inflammatory and overactive with age. Some become senescent. This contributes to the chronic inflammation of brain tissue observed in older individuals, and which contributes to the onset and progression of neurodegenerative co...
Source: Fight Aging! - July 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 10th 2023
In conclusion, the examination of the GBA can aid in understanding the etiology and development of NDs, which may benefit the improvement of clinical treatments for these disorders and ND interventions. This review indicates existing knowledge about the involvement of microbiota present in the gut in NDs and potential treatment options.
The Aging of the Enteric Nervous System
https://www.fightaging.org/archives/2023/07/the-aging-of-the-enteric-nervous-system/
The enteric nervous system is the nervous system of the intestines, and likely an important part of the relationship between the gut microbiome ...
Source: Fight Aging! - July 9, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Defining the Longevity Industry to Exclude Those Who Circumvent Rigorous Clinical Trials
As the longevity industry grows, the need for investment grows with it. A big leap in funding is needed to move from preclinical to clinical development, and ever more companies are arriving at the point of making that transition. Raising the few million dollars in seed funding needed for a small lab team to produce proof of principle studies to demonstrate that a novel therapy works in mice is a very different prospect in comparison to raising tens of millions of dollars to conduct GMP manufacturing and phase II clinical trials in humans, never mind the even larger sums needed for later phase III trials. The types of inve...
Source: Fight Aging! - July 7, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Building a Digital Immune System
Credit: Courtesy of Dr. Tomas Helikar.
The power of computer code has been a longtime fascination for Tomas Helikar, Ph.D., a professor of biochemistry at the University of Nebraska-Lincoln (UNL). In college, when he learned he could use that power to help researchers better understand biology and improve human health, Dr. Helikar knew he’d found his ideal career. Since then, he’s built a successful team of scientists studying the ways we can use mathematical models in biomedical research, such as creating a digital replica of the immune system that could predict how a patient will react to infectious microorganisms ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 28, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Tools and Techniques Bioinformatics Computational Biology Cool Tools/Techniques Modeling Profiles Source Type: blogs
Fight Aging! Newsletter, June 26th 2023
This study explored the association between different cooking fuel types and the risk of cancer and all-cause mortality among seniors constructing Cox regression models. Data were obtained by linking waves of 6, 7, and 8 of the Chinese Longitudinal Healthy Longevity Survey, which included a total of 7,269 participants who were 65 years old and over. Cooking fuels were categorized as either biomass, fossil, or clean fuels. And the effects of switching cooking fuels on death risk were also investigated using Cox regression models.
The results indicate that, compared with the users of clean fuels, individuals using bio...
Source: Fight Aging! - June 25, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Concept of Immune Resilience and Its Relevance to Degenerative Aging
The aging of the immune system is widely considered a progressive loss of functional capacity, such as the ability to effectively destroy pathogens and errant cells (known as immunosenescence), coupled to rising levels of unresolved, chronic inflammation (known as inflammaging). In today's open access paper, the authors are more interested in how well the immune system brings itself back to an equilibrium state following the disruptions of an inflammatory response. They call this capacity for restoration "immune resilience". In this framework, aging brings a loss of the ability to restore normality to the immune system fol...
Source: Fight Aging! - June 23, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Is Alzheimer's Disease Primarily a Result of Infection-Driven Inflammation?
Many diseases of aging are strongly associated with chronic inflammation, and inflammatory signaling is involved in disease pathology. Unresolved low-grade inflammatory signaling and excessive immune system activation increases with advancing age, producing the state of immune dysfunction known as inflammaging. Many different factors contribute to this chronic inflammation of aging. They include the presence of lingering senescent cells that actively produce inflammatory secretions, as well as mitochondrial dysfunction resulting in mislocated mitochondrial DNA fragments that can cause an innate inflammatory response. It is...
Source: Fight Aging! - June 22, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
