A Look at the Research Yet to be Accomplished for Cellular Senescence
In conclusion, although several clinical trials targeting SnCs are ongoing, various questions about the biology of SnCs remain open, resulting in a gap between molecular and cellular data. Concerning the need, initiatives such as SenNet aiming to create openly accessible atlases of SnCs should contribute enormously to the area. Advances in understanding the subcellular structure, the heterogeneity, and the dynamics of SnCs require the integration of molecular and cellular techniques with data analysis packages to evaluate high throughput evidence from microscopy and flow cytometry. It is also necessary to develop new equip...
Source: Fight Aging! - April 10, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Technobabble To English: A Buzzword Guide For Medical AI And Digital Health
Navigating AI in medicine and digital health can feel like ordering a coffee at that new hipster café downtown: exciting yet slightly overwhelming with a menu that seems to be in a different language. A while ago we published a buzzword dictionary to help you decode the most frequently repeated terms. Back then artificial intelligence and machine learning were rarely heard exotic expressions, but as quite a few years have passed, a whole new set of mambo-jambo emerged, waiting to be explained.
You’re probably sick of hearing the latest digital health buzzwords without any actual context, so let’s translat...
Source: The Medical Futurist - April 4, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF Artificial Intelligence in Medicine buzzword AI in medicine generative AI in medicine Source Type: blogs
Interview with Stefany Shaheen: Revolutionizing diabetes care through cell therapies
I had the extraordinary opportunity to chat with Stefany Shaheen, the Chief Strategy Officer of Advanced Regenerative Manufacturing Institute (ARMI) and BioFab USA, about the transformative potential of cell therapies for individuals living with diabetes. Stefany shared her remarkable journey, insights on cell therapies’ current status, approval challenges, and how the diabetes community can contribute to advancing research in this field.
A few months before this discussion with Stefany, I had the opportunity to hear Dean Kamen speak at the recent ...
Source: Scott's Diabetes Blog - April 1, 2024 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
Fight Aging! Newsletter, April 1st 2024
This study supports the proposed model that aging-related loss of colonic crypt epithelial cell AMP gene expression can promote increased relative abundances of Gn inflammaging-associated bacteria and gene expression markers of colonic inflammaging. These data may support new targets for aging-related therapies based on intestinal genes and microbiomes.
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A Skeptical View of the Role of Nuclear DNA Damage in Aging
https://www.fightaging.org/archives/2024/03/a-skeptical-view-of-the-role-of-nuclear-dna-damage-in-aging/
It is evident and settled that stochastic nuclear DNA damag...
Source: Fight Aging! - March 31, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Long and Tortured History of Alpha-Synuclein and Parkinson ’s Disease
This study tracks the decades-long journey to harness alpha-synuclein as a treatment for Parkinson’s disease. Steven Zecola an activist who tracks Parkinson’s research and was on THCB last month discussing it, offers three key changes needed to overcome the underlying challenges.
A Quick Start for Alpha-Synuclein R&D
In the mid-1990’s, Parkinson’s patient advocacy groups had become impatient by the absence of any major therapeutic advances in the 25 years since L-dopa had been approved for Parkinson’s disease (PD).
The Director of National Institute of Neurological Disorders and Stroke (NINDS) se...
Source: The Health Care Blog - March 29, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Medical Practice Parkinson's Disease Steven Zecola Source Type: blogs
Investigating the Primary Cilium: Q & A With Xuecai Ge
Credit: Courtesy of Dr. Xuecai Ge.
The brain is a large and complex organ, but some very small structures guide its development. Xuecai Ge, Ph.D., an associate professor of molecular and cell biology at the University of California, Merced (UC Merced), has devoted her career to understanding one of these structures called the primary cilium. In an interview, Dr. Ge shared how her childhood experience inspired her to study science and what makes the primary cilium fascinating.
Q: How did you first become interested in science?
A: When I was a little kid, my mom was a primary care doctor, and I saw her treat patients...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 27, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Cellular Processes Profiles Source Type: blogs
More Commentary on the Role of PF4 in Reducing Brain Inflammation
Platelets in the blood are not just involved in clotting. Near every aspect of our biology has evolved many different functions, and the complexity of our biochemistry is still far from fully explored. Increased platelet factor 4 (PF4) shows up as a feature in a number of different interventions known to reduce inflammation in the aging brain. Researchers are now moving in the direction of developing therapies for neurodegenerative conditions based on the upregulation of PF4 or the delivery of recombinant PF4.
Platelets are a component of blood best known for their role in clotting, but research in recent years ha...
Source: Fight Aging! - March 27, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 25th 2024
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology.
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Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length
https://www.fightaging.org/archives/2024/03/interesting-insight-into-the-relationship-between-t...
Source: Fight Aging! - March 24, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Microplastics, Major Problem
By KIM BELLARD
It’s been almost four years since I first wrote about microplastics; long story short, they’re everywhere. In the ground, in the oceans (even at the very bottom), in the atmosphere. More to the point, they’re in the air you breathe and in the food you eat. They’re in you, and no one thinks that is a good thing. But we’re only starting to understand the harm they cause.
The Washington Post recently reported:
Scientists have found microplastics — or their tinier cousins, nanoplastics — embedded in the human placenta, in blood, in the heart and in the liver and bowels. In one re...
Source: The Health Care Blog - March 19, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Kim Bellard Microplastics Source Type: blogs
Calorie Restriction Induces Plasminogen Production to Protect Muscle Tissue
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology.
Link: https://doi.org/10.1016/j.celrep.2024.113881 (Source: Fight Aging!)
Source: Fight Aging! - March 18, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Will Americans Get PBM Reform in 2024? Maybe, But Many Things Need to Happen I Order to Get There. On the Upside: Insulin Has Opted Out of PBM Sales.
At the core of this post is a YouTube video which can be viewed in the middle of this blog post. The subject is about whether we ' ll get much-needed legislation passed into law to reform corrupt Pharmacy Benefit Managers (PBMs) which we know with absolute certainty were at fault for runaway insulin prices. At least that was true until March 2023, when the three largest insulin manufacturers, starting withLilly, followed byNovo Nordisk and shortly thereafter,Sanofi all announced major insulin list price reductions in the range of 70% to 78%. Think about that for a second: Imagine being able to instantly...
Source: Scott's Web Log - March 17, 2024 Category: Endocrinology Tags: 2024 Congress insulin prices PBM rebates reform Source Type: blogs
Will Americans Get PBM Reform in 2024? Maybe, But Many Things Need to Happen In Order to Get There. On the Upside: Insulin Has Opted Out of PBM Sales.
At the core of this post is a YouTube video which can be viewed in the middle of this blog post. The subject is about whether we ' ll get much-needed legislation passed into law to reform corrupt Pharmacy Benefit Managers (PBMs) which we know with absolute certainty were at fault for runaway insulin prices. At least that was true until March 2023, when the three largest insulin manufacturers, starting withLilly, followed byNovo Nordisk and shortly thereafter,Sanofi all announced major insulin list price reductions in the range of 70% to 78%. Think about that for a second: Imagine being able to instantly...
Source: Scott's Web Log - March 17, 2024 Category: Endocrinology Tags: 2024 Congress insulin prices PBM rebates reform Source Type: blogs
What Scares Healthcare Like EVs Scare Detroit
By KMI BELLARD
I’m thinking about electric vehicles (EVs)…and healthcare.
Now, mind you, I don’t own an EV. I’m not seriously thinking about getting one (although if I’m still driving in the 2030’s I expect it will be in one). To be honest, I’m not really all that interested in EVs. But I am interested in disruption, so when Robinson Meyer warned in The New York Times “China’s Electric Vehicles Are Going to Hit Detroit Like a Wrecking Ball,” he had my attention. And when on the same day I also read that Apple was cancelling its decade-long effort to build an EV, I was definitely paying attention.
...
Source: The Health Care Blog - March 6, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Health Tech Biden Detroit EVs Hospitals Kim Bellard Source Type: blogs
Blackbird Health Raises $17 Million Series A to Expand Access to Integrated, Technology-Backed Youth Mental Health Model
Blackbird Health Leverages a Neuroscience-Driven, “Understanding-First” Care Model to Take the Trial and Error out of Pediatric, Adolescent, and Young-Adult Mental Health Diagnosis and Treatment
Blackbird Health, a neuroscience-led and technology-backed youth mental health provider, announced today it raised $17 million in series A funding. The round was led by Define Ventures and also included participation from Frist Cressey Ventures and GreyMatter. Blackbird has raised nearly $23 million to date.
Blackbird Health is a mental health company for kids and young adults struggling with social, emotional, devel...
Source: EMR and HIPAA - March 4, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Amy Edgar Blackbird Health Chirag Shah Define Ventures Dr. Matt Keener Frist Cressey Ventures GreyMatter Health IT Funding Health IT Fundings Health IT Investment Tom Peterson Source Type: blogs
Fight Aging! Newsletter, March 4th 2024
In conclusion, HSV (but not CMV) infection may be indicative of doubled dementia risk.
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Increased Dietary Leucine Activates mTOR Signaling in Macrophages, Accelerating Atherosclerosis
https://www.fightaging.org/archives/2024/02/increased-dietary-leucine-activates-mtor-signaling-in-macrophages-accelerating-atherosclerosis/
Leucine is an essential amino acid, only obtained from the diet rather than synthesized by our cells. Leucine supplementation has been proposed as a way to slow the loss of muscle mass with age, as leucine processing becomes dysregulated with aging in a way...
Source: Fight Aging! - March 3, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
