Fight Aging! Newsletter, December 19th 2022
In conclusion, p16 deletion or p16 positive cell clearance could be a novel strategy preventing long term HFD-induced skin aging.
Association of LDL-Cholesterol with Mortality
https://www.fightaging.org/archives/2022/12/association-of-ldl-cholesterol-with-mortality/
Researchers here report on a study of LDL-cholesterol and mortality risk in older people. As they note, data on this topic is conflicted once one moves beyond the matter of cardiovascular disease. Over a lifetime, higher LDL-cholesterol makes it easier to reach the tipping point at which cholesterol deposited in blood vessel walls produces e...
Source: Fight Aging! - December 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Neutrophils Play a Role in the Age-Related Decline of Hematopoietic Function
Hematopoietic stem cells and progenitor cells in the bone marrow produce the red blood cells and immune cells needed for the body to function. Changes in this hematopoietic system make up one the major factors in the age-related decline of the immune system into the incapacity of immunosenescence and chronic inflammatory state known as inflammaging. There is a decline in the diversity of cell populations tasked with producing immune cells, and the types of immune cell produced shifts to favor myeloid lineages of the innate immune system over lymphoid lineages of the adaptive immune system.
The age-related decline of...
Source: Fight Aging! - December 16, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Career Conversations: Q & A with Biomolecular Engineer Markita Landry
Dr. Markita Landry. Credit: Vilcek Foundation.
“I have a hard time envisioning a career more exciting than science. It’s really magical to see an experimental result and, for a moment, be the only person in the universe to know something about the world,” says Markita Landry, Ph.D., an associate professor of chemical and biomolecular engineering at the University of California, Berkeley. In an interview, Dr. Landry shares with us her scientific journey, research with nanoparticles, and interests outside of the lab.
Q: What sparked your interest in science?
A: I was indirectly exposed to science growing up bec...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 14, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Tools and Techniques Cool Tools/Techniques Profiles Source Type: blogs
Reviewing the Role of SIRT6 in Aging
While much the history of work on sirtuins is one of disappointing results, the majority of that work involved SIRT1. Both SIRT3 and SIRT6 may be more interesting, based on animal studies conducted since the SIRT1 era. SIRT3 localizes to the mitochondria, and mitochondrial function is important in the context of aging. Researchers have shown that SIRT3 upregulation in mice improves hematopoietic stem cell function. SIRT6 upregulation, however, has been shown to modestly extend life in mice, there is a larger body of work surrounding its effects on metabolism than is the case for SIRT3, and at least one group is attempting ...
Source: Fight Aging! - December 12, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Chemistry Clicked: Two NIGMS-Funded Researchers Receive Nobel Prize
Since its creation in 1962, NIGMS has supported the work of the recipients of 94 Nobel Prizes—44 in physiology or medicine and 50 in chemistry. NIGMS-funded investigators perform cutting-edge basic research that is foundational to understanding normal life processes and disease. Such important breakthroughs in chemistry and biology often fuel more focused research that, years later, leads to important medical advances or products such as medicines or biotechnology tools.
Credit: Niklas Elmehed.
The most recent NIGMS-supported Nobel laureates are Carolyn R. Bertozzi, Ph.D., the Anne T. and Robert M. Bass Professor in...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 7, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Tools and Techniques Cool Tools/Techniques Nobel Prize Profiles Source Type: blogs
Fight Aging! Newsletter, December 5th 2022
In conclusion, the PAAIs examined (i.e. mTOR loss of function, Ghrhr loss of function, intermittent fasting-based version of dietary restriction) often influenced age-sensitive traits in a direct way and not by slowing age-dependent change. Previous studies often failed to include young animals subjected to PAAI to account for age-independent PAAI effects. However, any study not accounting for such age-independent intervention effects will be prone to overestimate the extent to which an intervention delays the effects of aging on the phenotypes studied. This can result in a considerable bias of our view on how modifiable a...
Source: Fight Aging! - December 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Vascular Smooth Muscle Cells Become Prone to Altered Behavior with Age
The altered signaling environment in aged tissue produces changes in cell behavior, some of which is adaptive and helpful, and some of which is maladaptive and harmful. In some cases the same process can be one or the other depending on context. Cellular senescence, for example, is helpful in the contexts of cancer suppression and regeneration from injury, but only up until the point at which senescent cells are no longer removed as rapidly as they are created, at which point their continued, unrelenting pro-growth, pro-inflammatory signaling contributes to many of the forms of tissue dysfunction observed in aging.
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Source: Fight Aging! - December 2, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
When Does the Heart Become Larger versus Smaller in Old Age?
As you may know, the aging heart often exhibits ventricular hypertrophy, an enlargement and weakening of the muscle. This appears driven in large part by the increased burden of cellular senescence in later life, given reversal of hypertrophy observed after senolytic treatment in old animals. This hypertrophy can also be thought as a downstream consequence of hypertension, but biology is rarely so simple as to have a single line of cause and effect. As noted in this paper, people lose muscle mass and strength with age, leading to the weakness and frailty of sarcopenia. The heart is a muscle, and a shrinking of that muscle ...
Source: Fight Aging! - November 30, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Arguing for Well Explored Approaches to Slow Aging to Not In Fact Slow Aging
In conclusion, the PAAIs examined (i.e. mTOR loss of function, Ghrhr loss of function, intermittent fasting-based version of dietary restriction) often influenced age-sensitive traits in a direct way and not by slowing age-dependent change. Previous studies often failed to include young animals subjected to PAAI to account for age-independent PAAI effects. However, any study not accounting for such age-independent intervention effects will be prone to overestimate the extent to which an intervention delays the effects of aging on the phenotypes studied. This can result in a considerable bias of our view on how modifiable a...
Source: Fight Aging! - November 28, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Advocating for Glutathione Upregulation as a Basis for Therapy
You might recall a recent small clinical trial in which oral supplementation with large amounts of glutathione precursors produced improvements in health in older adults, the size of the outcome surprisingly large for a treatment based on supplements. Here, researchers enthusiastically advocate for glutathione upregulation, reversing the normal age-related decline in glutathione levels, as a basis for improving the health of older people and slowing the onset of age-related degeneration.
Many local and systemic diseases especially diseases that are leading causes of death globally like chronic obstructive pulmona...
Source: Fight Aging! - November 28, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 28th 2022
This study explored whether determining the gain or loss of specific taxa represent a more precise metric of healthy/unhealthy aging than summary microbiome statistics, such as diversity and uniqueness. We analyzed microbiome diversity and four measures of microbiome uniqueness in 21,000 gut microbiomes for their relationship with aging and health. We show that diversity and uniqueness measures are not synonymous; uniqueness is not a uniformly desirable feature of the aging microbiome, nor is it an accurate biomarker of healthy aging. Different measures of uniqueness show different associations with diversity and with mark...
Source: Fight Aging! - November 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Exploring the Role of Somatic Mosaicism in Human Biology
In this Director ’s message, Dr. Gordon introduces the Somatic Mosaicism across Human Tissues (SMaHT) Network—an NIH-wide initiative that aims to transform our understanding of how somatic mosaicism in human cells influences biology and disease. (Source: NIMH Directors Blog)
Source: NIMH Directors Blog - November 22, 2022 Category: Psychiatry Authors: National Institute of Mental Health Source Type: blogs
The Realization that Developing Rejuvenation Therapies is the Most Useful Thing One Can Do with Great Wealth
A core point regarding wealth, realized by many but only acted on by a few to date, is that being the wealthiest individual in the graveyard begins to look very foolish in an era in which research and development is producing the basis for rejuvenation therapies. Historically, people traded time for wealth. Now, we enter the start of the era in which people can trade wealth for time. Fortunately, this is a collaborative venture: no-one wins on their own. Either sufficient funding is devoted to the right projects in rejuvenation biotechnology, and all humanity benefits as a result, or we as a society collectively fail to ac...
Source: Fight Aging! - November 22, 2022 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Winter Short: Mitochondria, Platelets, Golgi, & Green Pens TAPP 127
Episode 127 is one of ourwinter shorts, where I replay interesting segments from previous episodes. In this one, you ' ll hear about the role ofplatelets in immunity, how theGolgi apparatus gets its weird shape, exactlyhow hot mitochondria get, and why we may want to consider marking assignments and tests with agreen pen, rather than a red one.00:00 | Introduction01:07 | Mitochondria02:29 | Platelets07:15 | Sponsored by AAA, HAPI, and HAPS08:49 | Golgi Apparatus13:51 | Green Pens16:20 | Staying Connected ★ If you cannot see or activate the audio player, go to:theAPprofessor.org/podcast-episode-127.html🏅...
Source: The A and P Professor - November 18, 2022 Category: Physiology Authors: Kevin Patton Source Type: blogs
Our Plants Should Be Plants
BY KIM BELLARD
It seems like most of my healthcare Twitter buddies are enjoying themselves at HLTH2022, so I don’t suppose it much matters what I write about, because they’ll all be too busy to read it anyway. That’s too bad, because I was sparked by an article on one of my favorite topics: synthetic biology.
Elliot Hershberg, a Ph.D. geneticist who describes his mission as “to accelerate the Century of Biology,” has a great article on his Substack: Atoms are local. The key insight for me was his point that, while we’ve been recognizing the power of biology, we’ve been going about it ...
Source: The Health Care Blog - November 15, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Public Health HLTH2022 Industrialization Kim Bellard synthetic biology Source Type: blogs
