Fight Aging! Newsletter, January 1st 2024
Discussion of What is Need to Speed the Pace at which Drugs to Treat Aging Arrive in the Clinic
Cellular Senescence in the Aging Brain, a Contributing Cause of Cognitive Decline
Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Blunt Thoughts on Calculating the Revealed Value of Human Life
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
Towards Adjustment of the Gut Microbiome to Slow Aging
Gene Therapy Enhances Object Recognition Memory in Young and Old Mice
Benefits of Sem...
Source: Fight Aging! - December 31, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
The market has been in the doldrums and it has been a tough year for fundraising, both for non-profits and biotech startups. The conferences have exhibited more of an academic focus as companies tightened belts and postponed investment rounds, while investors stayed home. Not that this halts the flow of hype for some projects, and nor has it slowed media commentary on the longevity industry as it presently stands. A few of the articles in that commmentary are even interesting to read! The field has grown and is more mature now than has ever been the case. Biotech of all forms is a challenging field with a high failure rate...
Source: Fight Aging! - December 29, 2023 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Ring In the New Year With Basic Research
Empowering basic biomedical research, which focuses on understanding how living systems work, is one of NIGMS’ main goals. This type of research not only helps us learn how our bodies and those of other organisms function but also lays the foundation for advances in disease diagnosis, treatment, and prevention.
We’re excited to see what the upcoming year has in store for the field! In preparation, we’re highlighting what NIGMS-supported scientists had to say in 2023 about the many merits of basic research. Also check out the links to the Biomedical Beat posts that feature them if you haven’t already.
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Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 27, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Scientific Process Source Type: blogs
The surprising science of gratitude: How it boosts your well-being
I have never been a very touchy-feely person. I was trained as a biologist and chemist, then went to medical school where more science on top of science was aimed at me like a gushing firehose. I learned to put science and evidence first and to try in my practice of medicine to use only
Read more…
The surprising science of gratitude: How it boosts your well-being originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 25, 2023 Category: General Medicine Authors: Greg Smith, MD Tags: Physician Psychiatry Source Type: blogs
Seeking Success in Science Through NIH-Funded Training
Credit: Courtesy of Hasset Nurelegne.
“What’s great about a career in research is that there are so many paths you can take. I get so excited for the future when I think about all the open doors ahead of me,” says Hasset Nurelegne, a senior at Emory University in Atlanta, Georgia. Hasset is majoring in neuroscience and behavioral biology (NBB) as well as English.
Since her first year on campus, Hasset has been an active participant in an NIGMS-funded program at Emory that aims to develop a diverse pool of scientists, the Initiative for Maximizing Student Development (IMSD) (which is now just for graduate student...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 20, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Training Source Type: blogs
Fight Aging! Newsletter, December 18th 2023
In conclusion, given the relative safety and the favourable effects of aspirin, its use in cancer seems justified, and ethical implications of this imply that cancer patients should be informed of the present evidence and encouraged to raise the topic with their healthcare team.
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Aged Transplant Organs Cause Harm to Younger Recipients
https://www.fightaging.org/archives/2023/12/aged-transplant-organs-cause-harm-to-younger-recipients/
Old tissues are dysfunctional in ways that young tissues are not. This has always been known in the context of organ transplants, but absent me...
Source: Fight Aging! - December 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Looking for Evidence of Antagonistic Pleiotropy in Human Data
The dominant view of the evolution of aging is that it emerges from what is known as antagonistic pleiotropy, a term used to describe a mechanism that is initially helpful but later harmful. Mutations that help early life reproductive fitness will be selected even if they cause later harm, as a greater chance of earlier reproduction tends to win out over a greater chance of sustained reproduction over time. Natural selection thus tends to produce biological systems that invest little in long-term maintenance and sustainability. Aging is the result.
In 1957, evolutionary biologist George Williams proposed that gene...
Source: Fight Aging! - December 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Dissecting the Kenhub Atlas: Insights from Editor Mike Pascoe | TAPP 144
Mike Pascoe joins host Kevin Patton in Episode 144 to chat about Mike ' s experience in editing the newKenhub Atlas of Human Anatomy. We gobehind the scenes to see how this new kind of anatomy atlas was developed. Let ' s see how those decisions get made and how thelearning perspective gets incorporated into anatomy manuals. And we explorediverse representation in anatomy images and why we won ' t find anyeponyms in this atlas. We also have a brief remembrance of our friendDavid Allard.00:00 | Introduction00:45 | Remembering David Allard04:25 | Introducing Mike Pascoe06:12 | A New Take on the Human Atlas19:0...
Source: The A and P Professor - December 14, 2023 Category: Physiology Authors: Kevin Patton Source Type: blogs
Science Snippet: Zooming In on Nanoparticles
Nanoparticles come in many different shapes and configurations. Credit: Adapted from Stevens, et. al., under Creative Commons License 4.0.
Nanoparticles may sound like gadgets from a science fiction movie, but they exist in real life. They’re particles of any material that are less than 100 nanometers (one-billionth of a meter) in all dimensions. Nanoparticles appear in nature, and humans have, mostly unknowingly, used them since ancient times. For example, hair dyeing in ancient Egypt involved lead sulfite nanoparticles, and artisans in the Middle Ages added gold and silver nanoparticles to stained-glass windows. Over...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 13, 2023 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Tools and Techniques Cool Tools/Techniques Cool Videos Medicines Science Snippet Source Type: blogs
From Xenobots to Anthrobots
By KIM BELLARD
There were many things I could have written bout this week – e.g., in A.I., in quantum computing, even “transparent wood” — but when I saw some news about biological robots, I knew I had my topic.
The news comes from researchers at Tufts University and Harvard’s Wyss Institute. Their paper appeared in Advanced Science, introducing “a spheroid-shaped multicellular biological robot (biobot) platform” that they fondly dubbed “Anthrobots.” Importantly, the Anthrobots are made from human cells.
Let’s back up. In 2020, senior researcher Michael Levin, Ph.D., who holds positions at ...
Source: The Health Care Blog - December 13, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Biological Robots Kim Bellard Source Type: blogs
A bird ’ s eye view
Birds have incredible visual systems. This is especially true of the birds of prey, the raptors, which includes the hawks, falcons, eagles, buzzards, harriers, owls, and others.
Red Kite staring at me from its perch atop a conifer
Unlike many other types of birds, the raptors have binocular vision, their eyes face forward, like ours, which means they have a 3D view of the world ahead of them. This allows them to pinpoint prey incredibly well even from great distances as is the case with the Peregrine Falcon. That species, and others, also have two fovea, the most sensitive regions of the light-sensitive retinas at the back...
Source: David Bradley Sciencebase - Songs, Snaps, Science - December 7, 2023 Category: Science Authors: David Bradley Tags: Biology Birds Source Type: blogs
Fight Aging! Newsletter, December 4th 2023
This study produced a great deal of data that continues to be mined for insights into human aging and effects of calorie restriction in a long-lived species such as our own, to contrast with the sizable effects on health and longevity in short-lived species such as mice.
In particular, and the topic for today, cellular senescence and its role in degenerative aging has garnered far greater interest in the research community in the years since the CALERIE study took place. Thus in today's open access paper, scientists examine CALERIE study data to find evidence for calorie restriction to reduce the burden of cellular ...
Source: Fight Aging! - December 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Can you try these two questions on Amyloid ?
Is it a physiological molecule ?
1.Yes, It is a physiological molecule.
2.No, Amyloid is always pathological.
Where does it gets deposited ?
A .Extracellular*
B. Intracellular
C. Both
Answer : Q 1: A / Q 2: C. It is indeed a physiological molecule in small amounts that help carry hormones across the blood. In pathology, it accumulates in huge amounts. It is a disorder of protein folding, making them thick, stiff , sheets of peptide, hence mis-behaving with adjacent cells, injuring them in the process. This is responsible for the systemic nature of disorder right from the brain to peripheral nerves, H...
Source: Dr.S.Venkatesan MD - December 1, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Alzheimer disease amyloidosis ttr amyloid what is amyloid Source Type: blogs
Intestinal Inflammation Increases with Age, and is Greater Still in Patients with Alzheimer's Disease
16s rRNA sequencing allows the microbial populations resident in the gut to be catalogued in detail: which species are present, and relative numbers by species. In the years since this assay became cheap, reliable, and readily available, researchers have built increasingly large human gut microbiome databases from samples obtained over the course of epidemiological studies. The research community has found that the gut microbiome exhibits characteristic differences in older people, marked by a growth in populations of inflammatory microbes and a loss of those species that produce beneficial metabolites. Further, some age-r...
Source: Fight Aging! - November 29, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Making Microprotein Discoveries With Alan Saghatelian
Credit: Courtesy of Dr. Alan Saghatelian.
“There aren’t many professions that can provide this much opportunity for learning, especially when it comes to understanding how our bodies work. I really love what I do—I wouldn’t trade it for anything,” says Alan Saghatelian, Ph.D., a professor in the Clayton Foundation Laboratories for Peptide Biology at the Salk Institute for Biological Studies in La Jolla, California. From studying new facts and experimental techniques to adopting new ways of thinking, researchers never stop learning, and Dr. Saghatelian credits his love for learning and exploring as reasons why h...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - November 29, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Profiles Proteins Source Type: blogs
