Mentoring Month: NIGMS-Funded Researchers Make Mentoring Meaningful
Mentoring is a vital part of training the next generation of scientists. Through a variety of programs ranging from the undergraduate to faculty levels, NIGMS fosters the training and the development of a strong and diverse biomedical research workforce. To celebrate National Mentoring Month, we’re highlighting a few of the many NIGMS-funded researchers who emphasize being great mentors. Check out the snapshots of our interviews with these mentors to see what they think about mentoring and to access and read their full stories. Dr. Julia Bohannon. Credit: Vanderbilt University Medical Center. Scientist Studie...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 11, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist STEM Education Profiles Research Roundup Training Source Type: blogs

Pharma – 2023 Health IT Predictions
As we head into 2023, we wanted to kick off the new year with a series of 2023 Health IT predictions.  We asked the Healthcare IT Today community to submit their predictions and we received a wide ranging set of responses that we grouped into a number of themes.  Check out our communities predictions below and be sure to add your own thoughts and/or places you disagree with these predictions in the comments and on social media. Check out our community’s pharma predictions. Jesse Cugliotta, Global Industry GTM Lead, Healthcare & Life Sciences at Snowflake Industry investments in data platforms to enable decentra...
Source: EMR and HIPAA - January 9, 2023 Category: Information Technology Authors: John Lynn Tags: Health IT Company Healthcare IT 2023 Health IT Predictions Abrpo BrainCheck Doceree Harshit Jain Ian Chen Jesse Cugliotta Kimberly Powell Lance Hill Lauren Ohlsson Mike Montalto NVIDIA Ofer Sharon OncoHost PathAI Pharma Source Type: blogs

More Popular Science Commentary on the Longevity Industry
It is interesting to see the present state of popular science commentary on efforts to treat aging as a medical condition, given the recollection of widespread skepticism and mockery even as recently as a decade ago. The large-scale funding, many serious research programs, and dozens of new biotech companies are ensuring that the popular science press at least does its homework on the science underlying the prospects for human rejuvenation before committing an opinion to paper. Today's bootstrapping era of progress is very different from the turn of the century, a great deal more is being accomplished, but these are still ...
Source: Fight Aging! - January 9, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, January 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Stage is Set for More Rapid Progress Towards Human Longevity in the Next Decade
Today's popular science article is a tour of a few of the higher profile lines of research and development relevant to treating aging as a medical condition. The state of the field has changed greatly over the last decade, not least of these changes being a vast increase in the funding devoted to clinical translation of age-slowing and rejuvenation therapies. Cynically, I suspect that it is the funding that ensures that the popular science press takes a more respectful tone than they did ten years ago. It is much harder to advance (in writing!) a knee-jerk dismissal of a field of science when billions of dollars of funding...
Source: Fight Aging! - January 6, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

Friday Feature: Highlands Latin School
Colleen HroncichPublic school teacher turned homeschooler turned education entrepreneur. We ’re seeing this more and more these days, but it isn’t as new of a phenomenon as many might think. The lateCheryl Lowe, founder of Memoria Press and Highlands Latin School in Louisville, KY, is a perfect example.Cheryl received her bachelor ’s degree in chemistry and master’s in biology; she taught chemistry and geometry in a public high school before having children. She taught her sons to read before they started school, but she wasn ’t satisfied with the well‐​regarded public or private schools they e...
Source: Cato-at-liberty - January 6, 2023 Category: American Health Authors: Colleen Hroncich Source Type: blogs

Shawn Drew Gaillard to Direct GMCDB
I’m pleased to announce the selection of Shawn Drew Gaillard, Ph.D., as the new director of our Division of Genetics and Molecular, Cellular, and Developmental Biology (GMCDB). Shawn has been the acting director of the Division since February 2022. She will begin in this new role on January 15. Shawn joined GMCDB as chief of the Developmental and Cellular Processes Branch in 2019, overseeing grants focused on organismal response to environmental stressors. Prior to this role, she was the research training officer at the National Institute of Allergy and Infectious Diseases, and before that, she was a program director in ...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - January 4, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Director’s Messages Job Announcements NIGMS Staff News Source Type: blogs

A Tale of Tails: How Reptile Regeneration Could Help Humans
Dr. Thomas Lozito. Credit: Chris Shinn for USC Health Advancement Communications. “I’ve always been interested in science and in lizards. I got my first pet lizard when I was around 4 years old, and it was love at first sight,” says Thomas Lozito, Ph.D., who now studies the creatures as an assistant professor of orthopaedic surgery, stem cell biology, and regenerative medicine at the University of Southern California (USC) in Los Angeles. During his childhood, Dr. Lozito turned his parents’ house into a “little zoo” of lizards and amphibians. He sneaked lizards into his dorm room as a college student at Jo...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 4, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Injury and Illness Cool Creatures Profiles Regeneration Research Organisms Wound Healing Source Type: blogs

Discussing the Target Cells for Allotopic Expression of Mitochondrial DNA
The Strategies for Engineered Negligible Senescence (SENS) view of the relevance of mitochondrial DNA damage to aging is that certain types of damage, large deletions for example, can produce pathological mitochondria that are both broken and able to outcompete their peers. Clones of the original damaged mitochondrion take over a cell, turning it into an exporter of large amounts of damaging reactive molecules. Only a small number of cells are affected by this type of damage in aged tissues, but it doesn't take that many cells acting in this way to produce pervasive changes to the signaling environment, as well as signific...
Source: Fight Aging! - January 3, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

P2Y6R Inhibition as a Strategy to Reduce Age-Related Memory Loss
Memory is in some way encoded in the synaptic connections between neurons, with the precise details yet to be determined. Destruction of synapses is a characteristic of neurodegenerative conditions involving loss of memory. Researchers here identify a regulatory receptor that controls the removal of synapses by the innate immune cells known as microglia in the brains of mice. Blocking the activity of this receptor reduces age-related memory loss in mice, suggesting that this aspect of aging is largely a matter of inappropriate microglial activity, destroying synapses that should remain intact. Removal of synapses i...
Source: Fight Aging! - January 2, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

What is Known of Anti-Cancer Mechanisms in Longer-Lived Species
Risk of cancer is a function of cell numbers and division rates, but also of the efficiency of cancer suppression mechanisms. In order for a species to evolve a longer life span, cancer suppression must improve. In order for a species to evolve a larger body mass, cancer suppression must improve. As this paper notes, comparatively little is definitively known of the anti-cancer strategies of various long-lived mammals. Elephants duplicate the tumor suppressor gene TP53, but that doesn't occur in other large and long-lived species, so it is likely that each species takes its own path. It is far too early to say whether what...
Source: Fight Aging! - January 2, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules. MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/ Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, pro...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Conservative View of Aging Research and Development of Treatments Targeting Mechanisms of Aging
A present, the conservative scientific viewpoint on aging is that significant progress has been made in understanding how to produce therapies that might target mechanisms of aging, but these are still very early days in both (a) understanding in detail how those mechanisms give rise to the observed outcomes in aging, and (b) the development of age-slowing and rejuvenating therapies. It is most likely the case that more could be accomplished than is presently being accomplished, given greater will and funding. But the creation of a new field of medicine is a slow process, proceeding incrementally, taking years to convince ...
Source: Fight Aging! - December 27, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Netflix for Drugs?
By KIM BELLARD A relative — obviously overestimating my healthcare expertise — asked my thoughts on The New York Times article Can a Federally Funded ‘Netflix Model’ Fix the Broken Market for Antibiotics? I had previously skimmed the article and was vaguely aware of the Pasteur Act that it discusses, but, honestly, my immediate reaction to the article was, gosh, that may not be a great analogy: do people realize what a tough year Netflix has had? I have to admit that I tend to stay away from writing about Big Pharma and prescription drugs, mainly because, in a US healthcare system that seems to pride i...
Source: The Health Care Blog - December 21, 2022 Category: Consumer Health News Authors: matthew holt Tags: The Business of Health Care Congress Kim Bellard Netflix Pharma Pharmaceutical industry Source Type: blogs

Well, this is about as scammy / spammy as a journal can get ... putting me on an editorial board I did not agree to be on ...
 So I got an email this AM from "Microorganisms Editorial Office "Dear Prof. Dr. Eisen,We are pleased to inform you that your information has been announced on the webpage of our journal ' s board.Please check that all of your information is correct here:https://www.mdpi.com/journal/microorganismsCool. Cool. Except I never agreed to be on their editorial board. And yet there I am on their web site.https://www.mdpi.com/journal/microorganisms/editors?page_no=3No MDPI Microoorganisms. This is not OK.  -------- This is from the" Tree of Life Blog " of Jonathan Eisen, an evolutionary biologist and Open Access ad...
Source: The Tree of Life - December 19, 2022 Category: Microbiology Source Type: blogs