Using Robots and Artificial Intelligence to Search for New Medicines
Courtesy of Dr. Adam Gormley.
Adam Gormley, Ph.D., describes himself as a creative and adventurous person—albeit, not creative in the traditional sense. “Science allows me to be creative; to me, it’s a form of art. I love being outdoors, going on sailing trips, and spending time adventuring with my family. Research is the same—it’s an adventure. My creative and adventurous sides have combined into a real love for science,” he says. Dr. Gormley currently channels his passion for science into his position as an assistant professor of biomedical engineering at Rutgers University in Piscataway, New Jersey.
Lea...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - May 24, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Tools and Techniques Bioinformatics Computational Biology Medicines Profiles Source Type: blogs
Reviewing mTOR Inhibition as a Pharmacological Strategy to Modestly Slow Aging
It is arguably the case that we should look at small molecule mTOR inhibitors, such as rapamycin and its descendant rapalog compounds, as the most effective of the calorie restriction mimetic approaches developed to date. The practice of calorie restriction, eating as much as 40% fewer calories while still obtaining optimal levels of micronutrients, produces sweeping changes to metabolism. Some of these, such as increased autophagy and other forms of cellular housekeeping, appear to be beneficial to long-term health. Keeping cells more free of damage leads to a slowing of aging.
In mice, that slowing of aging can le...
Source: Fight Aging! - May 23, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, May 22nd 2023
Conclusions to be Drawn
A High Fat Diet Accelerates Atherosclerosis Less Directly than One Might Suspect
How to Construct Measures of Biological Age
A Long-Term Comparison of Metformin in Diabetics with Non-Diabetic Controls
In Search of Distinctive Features of the Gut Microbiome in Long-Lived Individuals
Greater Fitness in Humans Implies a Younger Epigenome and Transcriptome
Intestinal Barrier Dysfunction as a Feature of Aging in Many Species
NAFLD as an Age-Related Condition
Towards Sensory Hair Cell Regeneration in the Inner Ear
Raised Leve...
Source: Fight Aging! - May 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Intestinal Barrier Dysfunction as a Feature of Aging in Many Species
One of the more noteworthy aspect of fly aging is the degree to which it is centered around intestinal dysfunction. Increasing leakage of the intestinal barrier is a feature of aging in many species, however, as noted here. When the intestinal barrier is compromised, the result is an invasion of tissues by gut microbes, provoking chronic inflammation throughout the body and further consequent dysfunction.
A major challenge in the biology of aging is to understand how specific age-onset pathologies relate to the overall health of the organism. The integrity of the intestinal epithelium is essential for the wellbein...
Source: Fight Aging! - May 17, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, May 15th 2023
In this study, we examined the average telomere length and telomerase activity, as well as the formation of telomere associated foci (TAFs) and the mRNA expression levels of the shelterin components in cultured primary cells of Spalax, a long-lived, hypoxia-tolerant, and cancer-resistant blind mole-rat species.
We showed that with cell passages, Spalax fibroblasts demonstrated significant shortening in telomere length, similar to rat cells, and in line with the processes observed earlier in tissues. We also demonstrated that the average telomere length in Spalax fibroblasts was significantly higher than the average ...
Source: Fight Aging! - May 14, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The New Alzheimer's Therapies are Not What One Would Call Successful
The first batch of immunotherapies demonstrated to be capable of clearing extracellular amyloid-β from the brain have performed poorly in late stage Alzheimer's patients. Data is beginning to emerge for their ability to modestly slow down the progression of the condition at earlier stages, however. This somewhat fits with the amyloid cascade hypothesis, in that it is evidence to support the idea that amyloid-β is no longer important to disease progression once the condition has reached the stage of becoming a feedback loop involving tau aggregation, chronic inflammation, and cell death.
Unfortunately, it isn't str...
Source: Fight Aging! - May 11, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Ianap
I am not a physicist, but I do think I have a good intuitive understanding of the state of physics and cosmology today. Rather than continue this discussion in the comments to an earlier post, I thought I ' d elevate it to the front page. I would say that a funny thing happened on the way to a Theory of Everything.The profound discoveries of the 20th Century -- relativity, quantum theory, field theories and the so-called Standard Model of particles and forces, and of course Big Bang* cosmology -- to many signaled the end of metaphysics. Mere speculation about the deep nature of the universe and first causes was obsolete. T...
Source: Stayin' Alive - May 10, 2023 Category: American Health Source Type: blogs
Fight Aging! Newsletter, May 8th 2023
In conclusion, NAT mitigated age-associated cerebral injury in mice through gut-brain axis. The findings provide novel evidence for the effect of NAT on anti-aging, and highlight the potential application of NAT as an effective intervention against age-related diseases.
Retinal Cell Reprogramming Restores Vision in Non-Human Primate Study
https://www.fightaging.org/archives/2023/05/retinal-cell-reprogramming-restores-vision-in-non-human-primate-study/
Early applications of in vivo cellular reprogramming to medicine are cautiously focused on retinal regeneration. The eye is as close to an isolated system...
Source: Fight Aging! - May 7, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Another day to think, to pause, to ponder.
Panorama of Sycamore Park and the memorial to Karim A bit over 10 years ago I wrote a blog post that I repost all the time. Entitled "A day to think, to pause, to ponder" it was posted on my dad ' s birthday and was about the pain of him dying, by suicide, when I was in college. It was meant as a sad, melancholy post but also one about the importance of compassion and how " we can all do a little bit to improve how we treat other. " When I reposted this one time a few years ago, someone asked me if I had ever met the " Compassion Guy " who frequented downtown Davis and who had a life ' s mission of getting people to t...
Source: The Tree of Life - May 5, 2023 Category: Microbiology Tags: DavisCA UCDavis Karim Majdi Abou Najm David Breaux Kimberlee Guillory compassion Source Type: blogs
Wanted: NIGMS Program Directors
We’re recruiting accomplished scientists for positions in our Division of Biophysics, Biomedical Technology, and Computational Biosciences (BBCB) and Division of Genetics and Molecular, Cellular, and Developmental Biology (GMCDB). The successful applicants will be responsible for scientific and administrative management of a portfolio of research grants and/or research training grants and career development awards, and will stimulate, plan, advise, direct, and evaluate program activities related to their field of expertise.
The two BBCB program director positions support research and training portfolios in biophys...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - May 3, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Source Type: blogs
Cuffless Blood Pressure Monitoring – Not for the Faint-of-Heart (Pun Intended)
This article will summarize these challenges and also provide optimism for the refreshingly near future. Namely, while the progress towards FDA-cleared cuffless BP monitoring may feel protracted, significant technological advances, regulatory modernization, and clinical use case validation are rapidly advancing and aligning.
Key Challenges Confronting OTC Cuffless Blood Pressure Monitoring
Scientific Risks
At the most fundamental level, the jury’s still out on whether sufficiently accurate noninvasive, cuffless, calibration-free blood pressure monitoring is physically realizable at all. Namely, “Do the laws of nature...
Source: EMR and HIPAA - May 3, 2023 Category: Information Technology Authors: Guest Author Tags: Clinical Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System Telemedicine and Remote Monitoring AliveCor Blood Pressure Blood Pressure Cuffs Blood Pressure Monitoring BP Calibration-Free Bloo Source Type: blogs
Cellular Senescence in the Aging of Bone
Senescent cells accumulate with age, and disrupt tissue function via the signaling that they generate, the senescence-associated secretory phenotype (SASP). In bone tissue, the SASP contributes to breaking the balance between the activities of osteoblast cells, constantly building bone, and osteoclast cells, constantly deconstructing bone. Osteoclast activity in older people outweighs osteoblast activity, leading to a progressive loss of bone mineral density and eventual osteoporosis.
Maintaining lifelong mobility is one aim of healthy aging that allows independence and autonomy. However, falls and fragility fract...
Source: Fight Aging! - May 2, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Reviewing Present Biomarkers of Aging
Today's open access paper, with more than 120 contributing authors, is a tour of the broad topic of biomarkers of aging, an attempt to say at least something about every aspect of cellular biochemistry and functional capacity that is either used or proposed to be used to measure biological age, from grip strength to epigenetic clocks. Biological age is in one sense an aspirational concept, a way to measure the progression of aging that will accurately reflect mortality and disease risk. In another sense, biological age is self-evidently real. Different people age at different rates, and exhibit very different risk levels f...
Source: Fight Aging! - May 1, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Deep Thought
I ' ve been doing a lot of reading lately -- history and science as well as material that ' s directly relevant to my book. Right now I ' m reading On the Origin of Time by Thomas Hertog, who was a student and then a collaborator of Stephen Hawking. I would definitely recommend it if you ' re into that sort of thing. And I ' ve read a few more books recently on physics and cosmology, as well as biology, which I can also recommend if anyone is interested..I think I get why there is so much denial of science. I forget who it was who said something to the effect that the more we know about the universe, the more pointless it ...
Source: Stayin' Alive - May 1, 2023 Category: American Health Source Type: blogs
Fight Aging! Newsletter, May 1st 2023
In conclusion, frailty progression accelerates in males with one LTCs and females with two LTCs or more. Health providers should be aware of planning a suitable intervention once the elderly have two or more health conditions.
Plasma Transfer Lowers Epigenetic Age and Mortality in Rats
https://www.fightaging.org/archives/2023/04/plasma-transfer-lowers-epigenetic-age-and-mortality-in-rats/
Plasma transfer from young to old individuals has produced mixed results in animals and little to no benefit in humans where assessed rigorously. These studies were driven by the hypothesis that young plasma contains m...
Source: Fight Aging! - April 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
