Exercise and Alternative Mechanisms of Telomerase
Discussion on the canonical and extra-telomeric roles of telomerase are presented, followed by a detailed summary of the evidence on how exercise influences telomerase. Finally, the potential cell signalling underpinning the exercise-induced modulation of telomerase are discussed with directions for future research.
Link: https://doi.org/10.1111/acel.13836 (Source: Fight Aging!)
Source: Fight Aging! - April 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Impaired Melanocyte Stem Cell Migration Implicated in Hair Graying
Reading around the present state of research into the aging of skin and hair provides interesting insights into the gap between knowledge and understanding in complex biological systems. At this point, there is no complete understanding as to how skin and hair age, even while there is an enormous amount of data on the cellular biology and behavior on all of the different cell types involved. This is a microcosm of the bigger picture of aging in general: while well-researched lists of fundamental forms of damage and change exist, showing exactly how those processes interact to produce the decline of a larger system remains ...
Source: Fight Aging! - April 25, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, April 24th 2023
In this study, researchers show that mice lacking a functional ATF4 gene show little to no loss of grip strength and treadmill performance into late life; it is quite an impressive effect size. Assessments of muscle biochemistry do show age-related declines, but to a lesser degree than the controls. How ATF4 knockout functions to produce this outcome is an interesting question. The researchers point out a range of possible downstream and upstream targets that have been implicated in the regulation of muscle growth, but it will clearly require further work to identify the important mechanisms involved.
Aging slowly...
Source: Fight Aging! - April 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Wanted: Biophysics Branch Chief
We’re seeking a highly qualified scientist to serve as a branch chief in our Division of Biophysics, Biomedical Technology, and Computational Biosciences (BBCB). Applicants should have interest and experience in the scientific areas managed by the Biophysics Branch. Position responsibilities include scientific and administrative planning, managing, and evaluating activities of the Branch; optimizing Branch procedures; and overseeing grant portfolio activities of Branch program directors. The branch chief will also manage a research grant portfolio and will work closely with the Bioinformatics and Computational Biology a...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - April 20, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Source Type: blogs
Career Conversations: Q & A With Polymer Chemist Frank Leibfarth
Credit: Courtesy of Dr. Frank Leibfarth.
“I love that you can change the molecular-level structure of a material, then pull it, bend it, or twist it and see firsthand how the molecular changes you introduced influence its stretchiness or bendiness,” says Frank Leibfarth Ph.D., an associate professor of chemistry at the University of North Carolina (UNC) at Chapel Hill. In an interview, Dr. Leibfarth shares with us his scientific journey, his use of chemistry to tackle challenges in human health and sustainability, and his beliefs on what makes a career in science exciting.
Q: What led you to study chemistry?
...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - April 19, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Tools and Techniques Cool Tools/Techniques Profiles Source Type: blogs
Preparing For AI-Driven Medicine: 6 Crucial Questions For Tomorrow ’ s Doctors
This article will discuss some critical questions that medical professionals must be able to answer in order to navigate the AI revolution successfully.
1. Do you know enough about AI?
As a medical student or a young doctor, it is crucial to have a fundamental understanding of AI, its applications, and potential implications. The Medical Futurist’s paper, A short guide for medical professionals in the era of artificial intelligence provides a high-level overview of AI, its definitions, methods, levels, dangers, and advantages.
To stay relevant in the evolving healthcare landscape, medical professionals shoul...
Source: The Medical Futurist - April 18, 2023 Category: Information Technology Authors: Andrea Koncz Tags: Artificial Intelligence in Medicine Medical education AI digital health Source Type: blogs
An Overview of Early Work on the mTOR Inhibitor Rapamycin
The path to understanding that pharmacological inhibition of mTOR replicates some of the calorie restriction response to cause a slowing of aging started with studies of rapamycin. The primary mechanism of interest is upregulation of autophagy, a cellular housekeeping mechanism that is involved in a range of interventions that slow aging in short-lived species. Other mechanisms may well turn out to be involved, as altering metabolism is a complex business and still incompletely understood.
The various mTOR inhibitors are collectively one of the most studied, and arguably best of the existing approaches to alter meta...
Source: Fight Aging! - April 17, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, April 10th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 9, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Flawed Software Framing of Programmed Aging
The hypothesis that aging is a genetic program that is to some degree selected has always been a vocal minority view in the research community. There are just as many quite diverse theories of programmed aging as there are more mainstream evolutionary theories of aging that orbit the concept of antagonistic pleiotropy, the idea that lesser selection pressure in late life, because early reproduction means greater evolutionary fitness, allows for the evolution of mechanisms that are beneficial in youth and harmful in late life. There is even a fusion of the two sides: the hyperfunction theory of programmed aging suggests tha...
Source: Fight Aging! - April 5, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Accelerating Personalized Health With Healthcare Digital Twins
The following is a guest article by Steve Lazer, Global Healthcare & Life Sciences CTO at Dell Technologies.
One rapidly advancing trend in healthcare and life sciences is the shift from inefficient, expensive physical models to digital models tested in the virtual world. This is especially critical when time to value and cost are of the essence, as in the case of a global pandemic. One way to address this challenge, is to create a digital replica of a physical system or environment, accumulate data with sensors and collectors to monitor performance, and identify anomalies and trends to predict problems before they oc...
Source: EMR and HIPAA - April 4, 2023 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Analytics/Big Data C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Artificial Intelligence Dell Technologies Digital Twin Consortium Digital Twins Healthcare AI Healthcare Digital Twins Source Type: blogs
I Have No Mouth, Yet Still I Scream
BY KIM BELLARD
In light of the recent open letter from AI leaders for a moratorium on AI development, I’m declaring a temporary moratorium on writing about it too, although I doubt either one will last long (and this week’s title is, if you hadn’t noticed, an homage to Harlan Ellison’s classic dystopian AI short story). Instead, this week I want to write about plants. Specifically, the new research that suggests that plants can, in their own way, scream.
Bear with me.
To be fair, the researchers don’t use the word “scream;” they talk about “ultrasonic airborne sounds,” but just about every ac...
Source: The Health Care Blog - April 4, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Non-Health Kim Bellard Microbiome Plants Source Type: blogs
Responses to question about functional annotation of metagenomic reads
Posted a question to a few placesHi. We would like to functionally annotate some metagenomic sequencing reads without doing any assembly or binning or read mapping to reference genomes. Just annotate by searching things like nr, PFAM, COGs, etc. Anyone know of tools that do this?— Jonathan Eisen (@phylogenomics)March 29, 2023Humann suggestion fraggenescan on the raw reads, then use hmmer w/ pfam-A or kegg hmm.EggNog MapperMGRASThttp://mgrast.orgMetawrapYooseph approachhttps://pubmed.ncbi.nlm.nih.gov/27400380/https://pubmed.ncbi.nlm.nih.gov/27585568/mi-faserhttps://bromberglab.org/project/mifaser/ …MGXhttps://micr...
Source: The Tree of Life - April 4, 2023 Category: Microbiology Source Type: blogs
Fight Aging! Newsletter, April 3rd 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Age-Related Impairment of Angiogenesis Impacts Proficient Regeneration in Zebrafish
Zebrafish are one of the few vertebrate species capable of repeatedly regenerating major tissue loss without scarring. This ability is impacted by aging, however, as noted here. Researchers find that the age-related loss of angiogenesis capacity impairs regeneration. It is known that capillary density declines with age, hand in hand with impaired angiogenesis, and it is hypothesized that the consequent reduced delivery of oxygen and nutrients is an important contribution to many aspects of aging.
Impaired wound healing is associated with aging and has significant effects on human health on an individual level, but...
Source: Fight Aging! - March 28, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 27th 2023
This study has potentially significant implications in the field of OA as it provides a novel strategy for OA treatment.
A Vicious Cycle of Heart Failure and Dementia
https://www.fightaging.org/archives/2023/03/a-vicious-cycle-of-heart-failure-and-dementia/
The end of life is not pretty. The body is a failing machine of many complex essential parts, and the failures cascade and feed into one another as it breaks down. There is pain, loss of capacity, loss of the self as the brain runs down. There is a tendency to paper over the ugly reality in public discussion, to not talk about the facts of the matter...
Source: Fight Aging! - March 26, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
