Commentary on Gaps in the Knowledge of Aging
There are any number of sizable gaps in the understanding of how aging progresses at the detail level, which processes are more or less important, the direct of causation for many different interactions, and so forth. Aging is very complex because a living organism is very complex. Even simply causes produce complex outcomes when operating in a complex system. The same sizable gaps in understanding exist when we ask how and why aging evolved to be near universal across the tree of life, given that physical immortality appears possible for lower animals, and for much the same reasons. The evolutionary landscape is a complic...
Source: Fight Aging! - January 23, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
HDL dysfunction & It ’ s clinical Implication
High-density lipoproteins (HDLs) represent a class of lipids, very heterogeneous in structure, composition, and biological functions .The density is between 1.063 to 1.210. It has at least 5 sub-types. Normal HDL level in blood should be above 35mg (50-60mg Ideal). When it goes beyond 60 there is not much benefit to accrue and also some surprise findings are there.(Article will be linked)
We know ,HDL carries free cholesterol from peripheral cells, including macrophages and endothelial cells. After reaching the liver, HDL receptors in the hepatocellular surface, metabolize it into bile acid or neutral lipids, which are ...
Source: Dr.S.Venkatesan MD - January 21, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Novel Proteomic Aging Clock
By now there are most likely dozens of published aging clocks constructed from various omics databases. The proliferation of new clocks isn't helping to solve the fundamental problem with this approach to assessing biological age, which is that the predicted biological age produced by a clock isn't actionable, as no-one yet understands how the clocks relate to causative processes of aging. Thus factions within the research community are arguing for standardization to a single clock, followed by focused effort on understand how those clock measurements relate to underlying processes of aging.
Using a large proteomi...
Source: Fight Aging! - January 19, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Wanted: Division of Genetics and Molecular, Cellular, and Developmental Biology Program Directors
We’re seeking two highly qualified scientists to serve as program directors in the Genetic Mechanisms Branch (GMB) and the Developmental and Cellular Processes Branch (DCPB) of our Division of Genetics and Molecular, Cellular, and Developmental Biology (GMCDB).
GMCDB supports research grants focused on understanding the structure and function of cells and cellular components and the cellular and molecular mechanisms that underlie inheritance, gene expression, and development. All prospective candidates should have expertise in the mechanism and regulation of genetics including basic molecular processes, cellular biolo...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - January 17, 2024 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Source Type: blogs
Wanted: Biomedical Technology and Bioinformatics and Computational Biology Program Directors
We’re recruiting accomplished scientists for program officer positions in the Division of Biophysics, Biomedical Technology, and Computational Biosciences (BBCB). The selected candidates will be responsible for scientific and administrative management of a portfolio of research grants, and will stimulate, plan, advise, direct, and evaluate program activities related to their field of expertise.
One program officer position is in the Biomedical Technology Branch (BTB), which supports the development and optimization of innovative NIGMS’ mission-relevant technologies and tools to advance biomedical research....
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - January 17, 2024 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Source Type: blogs
Research Organism Superheroes: Fruit Flies
Credit: iStock.
Those pesky little bugs flying around the overripe bananas in your kitchen may hold the key to understanding something new about how our bodies work. That’s right, the fruit fly (Drosophila melanogaster) is a widely used research organism in genetics because of its superpower of reproducing quickly with similar genes to people.
Researchers have been studying fruit flies for over a century for many reasons. First, they’re easy to please—just keep them at room temperature and feed them corn meal, sugar, and yeast (or those bananas on your counter!). Second, they reproduce more quickly and have shor...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 17, 2024 Category: Research Authors: Chrissa Chverchko Tags: STEM Education Tools and Techniques Cool Creatures Research Organisms Source Type: blogs
What ’ s in a name?
What names we give the flora and fauna. Names are critical for scientific discourse and general conversation alike. They can be weird and wonderful, informative, confusing, hilarious even, and sometimes baffling. While common, or vernacular, names vary wildly, science, of course, has a relatively standardised method of naming living things. The common format, which is often colloquially known as the Latin name, is to have the species in a genus, a family group, and then to follow that genus name with the species name.
For example, in the UK, we might talk of the Snowdrop, or the Common Snowdrop. This delicate plant with wh...
Source: David Bradley Sciencebase - Songs, Snaps, Science - January 16, 2024 Category: Science Authors: David Bradley Tags: Biology Science Source Type: blogs
Healthcare AI Regulations and Ethics – 2024 Health IT Predictions
As we kick off 2024, we wanted to start the new year with a series of 2024 Health IT predictions. We asked the Healthcare IT Today community to submit their predictions and we received a wide ranging set of responses that we grouped into a number of themes. In fact, we got so many that we had to narrow them down to just the best and most interesting. Check out our community’s predictions below and be sure to add your own thoughts and/or places you disagree with these predictions in the comments and on social media.
All of this year’s 2024 health IT predictions (updated as they’re shared):
John and ...
Source: EMR and HIPAA - January 12, 2024 Category: Information Technology Authors: John Lynn Tags: AI/Machine Learning Ambulatory C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System LTPAC Regulations 2024 Health IT Predictions Alison Sloane Anika Heavener ArentFox Schiff LLP athenahealth Barnes & Thornb Source Type: blogs
Wanted: Chemistry and Chemical Biology Program Director
We’re seeking a highly qualified scientist to serve as a program director in our Division of Pharmacology, Physiology, and Biological Chemistry (PPBC). This is a newly created position for the Division as it reorganizes into three Branches. Applicants should have significant interest and experience in the scientific areas comprising the newly formed Chemistry and Chemical Biology Branch. The purpose of the Branch is to foster meritorious research in chemical biology, synthetic biology, chemical catalysis and synthesis, carbohydrate chemistry, natural products, bioinorganic chemistry, and metabolic engineering. We seek...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - January 10, 2024 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Source Type: blogs
RISE-ing Stars From Northern Arizona University
Chantel Tsosie at her college graduation, wearing her Tribe’s formal, traditional rug dress that her grandmother made. Credit: Courtesy of Chantel Tsosie.
“Science is for everyone. It’s in everything. It exists in cultures everywhere,” says Chantel Tsosie, a master’s student in the NIGMS-supported Research Initiative for Scientific Enhancement (RISE) program at Northern Arizona University (NAU) in Flagstaff. The program aims to prepare a diverse group of students for research careers through culturally relevant support, hands-on research experiences, and a tailored curriculum.
Chantel started her bachelor’...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 10, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Training Source Type: blogs
Fight Aging! Newsletter, January 8th 2024
This study examined whether the local injection of the supernatant of activated PRP (saPRP) into the salivary gland (SG) could help prevent aging-induced SG dysfunction and explored the mechanisms responsible for the protective effects on the SG hypofunction.
Human salivary gland epithelial cells (hSGEC) were treated with saPRP or PRP after senescence through irradiation. The significant proliferation of hSGEC was observed in saPRP treated group compared to irradiation only group and irradiation + PRP group. Cellular senescence, apoptosis, and inflammation were significantly reduced in the saPRP group.
Th...
Source: Fight Aging! - January 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
3 Things Transhumanism Can Give To Healthcare
Imagine a future where aging is not a fate but a solvable puzzle, reshaping the very fabric of medical science. This is what transhumanism aims for. Although this goal is surely too ambitious, we might learn a thing or two from this futuristic movement.
What is transhumanism?
Transhumanism is the position that humans should be permitted to use technology to modify and enhance human cognition and bodily function, expanding abilities and capacities beyond current biological constraints.
It is a philosophical and social movement, with not only technological aspirations. It is also an approach to exp...
Source: The Medical Futurist - January 4, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF transhumanism Source Type: blogs
Is Alternative Splicing a Meaningful Cause of Degenerative Aging, or Largely a Downstream Side-Effect?
A gene sequence consists of a mix of shorter sequences, only some of which are used to manufacture the protein encoded in that gene. Exon sequences are included and intron sequences are excluded. Nothing is ever quite that simple, of course, but changes in which exons and introns end up in a protein enable multiple proteins to be produced from a single gene sequence. Sometimes this is an accident, assome genes are prone to accidental production of truncated or extended proteins that are toxic. Sometimes this is an evolutionary reuse in which a gene produces several different vital proteins with quite different functions.
...
Source: Fight Aging! - January 3, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Four years - 1461 straight days - of iNaturalist observations
Well, today is a big day I guess. I just posted an observation to iNaturalist of a hummingbird in my backyard.https://www.inaturalist.org/observations/195397005Not that big a deal unless you are living in some place where it is really cold and you are jealous we have hummingbirds in our yard in Davis, California on December 31.But the context here is important.This entry completes a somewhat crazy run. I have made iNaturalist observations every day for the last four years. That is, every day for the last 1461 days. It all started in January 2020. Before the pandemic reared its ugly head. I decided it mi...
Source: The Tree of Life - December 31, 2023 Category: Microbiology Source Type: blogs
