Do dogs live in a black and white world?
As a child, I remember my mother telling me something she learned when she was an eye nurse – dogs are colourblind. Now, if I remember rightly, she didn’t mean they could only see in black and white as research in the 1940s had suggested, but that they had limited receptivity to the full colour palate. They were red-green colourblind, like some boys and men. The issue came up after they tested us boys at school for colour blindness with those spotty number colour charts. The red colour of our lab’s collar would’ve looked grey to her However, proof that the canine world isn’t monochrome didn...
Source: David Bradley Sciencebase - Songs, Snaps, Science - October 11, 2023 Category: Science Authors: David Bradley Tags: Biology Source Type: blogs

Is a dog ’ s life monochrome?
Do dogs live in a black-and-white world? As a child, I remember my mother telling me something she learned when she was an eye nurse – dogs are colourblind. Now, if I remember rightly, she didn’t mean they could only see in black and white as research in the 1940s had suggested, but that they had limited receptivity to the full colour palate. They were red-green colourblind, like some boys and men. The issue came up after they tested us boys at school for colour blindness with those spotty number colour charts. The red colour of our lab’s collar would’ve looked grey to her However, proof that the ca...
Source: David Bradley Sciencebase - Songs, Snaps, Science - October 11, 2023 Category: Science Authors: David Bradley Tags: Biology Source Type: blogs

Fight Aging! Newsletter, October 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Dublin Longevity Declaration
Aubrey de Grey and Brian Kennedy are prominent scientists in the longevity community who take very different approaches to the problem of human aging. They recently collaborated to write the Dublin Longevity Declaration, now posted online and signed by some of the leading figures in the aging research field, as well as fellow travelers in the longevity industry, founders of biotech companies attempting to implement interventions to treat aging. We live in a world in which the opportunity to produce actual, real, working rejuvenation therapies exists, but too few people believe this to be true. There is too little funding d...
Source: Fight Aging! - October 3, 2023 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs

Fight Aging! Newsletter, October 2nd 2023
In conclusion, we identified several candidate genes that may confer cancer resistance in cetaceans, providing a new avenue for further research into the mechanisms of lifespan extension. « Back to Top A Relationship Between the Gut Microbiome and Bone Density https://www.fightaging.org/archives/2023/09/a-relationship-between-the-gut-microbiome-and-bone-density/ Changes in the gut microbiome take place with advancing age, an increase in populations that provoke chronic inflammation, a reduction in the populations producing beneficial metabolites. Even only considering rising levels of in...
Source: Fight Aging! - October 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Droplet Battery Harnesses Ionic Gradients for Bioelectronic Implants
Researchers at Oxford University have developed a tiny battery that can power small implantable devices, such as drug delivery technologies. The new battery is inspired by the ionic gradients that electric eels use to generate electricity. It involves tiny droplets of a conductive hydrogel that are placed near each other. Each droplet has a different ionic concentration, meaning that ions will flow from high concentration droplets to low concentration droplets. When the researchers connect electrodes to this chain of droplets they can harness the energy generated by this ion gradient in the form of electricity. The researc...
Source: Medgadget - September 29, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Surgery Oxford Source Type: blogs

Notes on My Meningioma and Gamma Knife Treatment
So - yesterday I had Gamma Knife treatment at UC Davis for a posterior fossa meningioma that was first found by MRI about 6 years ago. I am going to be collecting my various posts here on the saga. I am also going to post separate posts here about the saga but just wanted to collect some of the other posts for now.Day 1 - September 27, 2023.Posted to many social media channels about my treatment with updates and other details and also got lots and lots and lots of support.Here are some of the posts. LinkedIn Facebook Instagram View this post on InstagramA post shared by Jonathan Eisen (@phylogenomics)View th...
Source: The Tree of Life - September 29, 2023 Category: Microbiology Source Type: blogs

A View of Aging Centered Around the Capacity for Hormesis
It is not too far from the truth to say that everyone in the field of aging research has their own theory of aging. Enormous amounts of data exists, measurements of near every aspect of cellular biochemistry, to note the ways in which these aspects change with age, yet we lack the framework to link all of the data together, to firmly state what is important and what is not, what is cause, what is consequence, and how exactly the network of age-related changes are linked to one another. Aging is a dark forest in which the boundaries are well mapped, but only a few of the interior features have been well explored. So ...
Source: Fight Aging! - September 28, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Money Is a Psychedelic Too
Money is actually psychedelic. Let me ‘splain… Money isn’t as intense as the psychedelics you put directly into your body – physical consumption changes the intentionality – but money still behaves very much as a psychedelic substance. Money responds powerfully to set and setting, the set being your mindset and the setting behind the environment of other relationships that you bring to your interactions with money. When this realization popped in, I asked my higher self if this was true, and he said, “Bingo! Indeed it is.” I see this very clearly in my own relationship with money as it...
Source: Steve Pavlina's Personal Development Blog - September 27, 2023 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Abundance Creating Reality Source Type: blogs

Diversity Supplement Program Paves the Way for Talented Researchers
“I hope that one day I’m able to increase our understanding of evolution, and I also hope to increase access to research. I want others to know that this space is open to people who look like me, who come from disadvantaged backgrounds, and who are underrepresented in the sciences,” says Nkrumah Grant, Ph.D., a postdoctoral research associate (postdoc) in microbiology and molecular genetics at Michigan State University (MSU) in East Lansing. Dr. Grant’s work receives support from the NIGMS Diversity Supplement Program (DSP), which is designed to improve the recruitment and training of promising researchers from ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - September 27, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Diseases Microbes Profiles Training Source Type: blogs

Fight Aging! Newsletter, September 25th 2023
In conclusion, this individual patient data meta-analysis of longitudinal cohort studies found that antihypertensive use was associated with decreased dementia risk compared with individuals with untreated hypertension through all ages in late life. Individuals with treated hypertension had no increased risk of dementia compared with healthy controls. « Back to Top Results from Human Clinical Trials Do Not Support Metformin as a Longevity Drug https://www.fightaging.org/archives/2023/09/results-from-human-clinical-trials-do-not-support-metformin-as-a-longevity-drug/ The SENS Research Fou...
Source: Fight Aging! - September 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Sanger DNA sequencing services
 Sanger DNA Sequencing ServicesSo I posted a request to multiple social media sites:Question - are there good / cheap services out there to do Sanger sequencing (e.g., for 16S / ITS for taxonomic identification of cultures)? The local Sanger operation we were using shut down.I posted to the following sites:FacebookLinkedIn TwitterBlue SkyMastodonThese are the places that were recommended the mostGENEWIZ from AzentaUC BerkeleyQuintaraEurofinsMcLabThese had single suggestionsMacrogene MR DNA Integrated Genomics Functional Bio U Az. CosmosIDLaragenRetrogenIMRFunctional BiosciencesThese are h...
Source: The Tree of Life - September 21, 2023 Category: Microbiology Source Type: blogs

Many Researchers and Companies Will Aim to Produce Small Molecule Reprogramming Therapies
The typical path for any program in biomedical research and development is to first demonstrate interesting results in animal studies using forms of genetic engineering or gene therapy, and then find small molecules that adjust the same mechanism. Small molecules are never as good as genetic manipulations, the size of the effect is always smaller, usually much smaller, and there are inevitably side-effects. Small molecule development is much easier to conduct, however, more familiar to investors and regulators and program managers, a well-trodden path. Thus while the future of medicine is gene therapy, in search of large e...
Source: Fight Aging! - September 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

In Other Words: Sandboxes Aren ’t Just for Kids
Did you know that kids aren’t the only ones playing around in sandboxes? The term sandbox may evoke a childhood memory of sensory play, but it’s also used to describe a virtual environment where someone can learn from digital products. Credit: NIGMS. High quantities of data that can be hard to manage, store, and understand are increasingly driving biomedical research. Scientists need access to high-performance computer infrastructure along with bioinformatics tools to do cutting-edge research, but often these resources are out of reach for smaller institutions. Cloud computing can provide access to top-of-the...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - September 20, 2023 Category: Research Authors: Chrissa Chverchko Tags: Tools and Techniques Bioinformatics Computational Biology Cool Tools/Techniques In Other Words Source Type: blogs

Aging Rate Indicators as Speedometers for Aging Research
Is it possible to measure the pace of aging at any given moment? Are there biomarkers that reveal not the biological age of the individual, but rather how fast that biological age is changing? The field is presently focused on developing measures of biological age, such as the extensive work on epigenetic clocks. Some information about pace of aging might be inferred from whether biological age is higher or lower than chronological age, assuming a biological age measurement that is actually accurate, something that still a topic for contention. But that doesn't say anything about the momentary pace of aging at any given ti...
Source: Fight Aging! - September 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs