Wanted: Division for Research Capacity Building Director
With the departure of Ming Lei, a search is open for an outstanding candidate to serve as director of our Division for Research Capacity Building (DRCB).
DRCB seeks to enhance the research, research training, research infrastructure, and faculty development of institutions in states and jurisdictions that have historically received low levels of NIH support. DRCB is thus responsible for both broadening the distribution of NIH biomedical research funding and supporting NIGMS’ commitment to developing a diverse biomedical research workforce. DRCB manages a number of highly impactful initiatives, including the I...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - November 28, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Research Capacity Building Source Type: blogs
The Amaranth Foundation on Bottlenecks in Aging Research
The Amaranth Foundation is one of a small number of organizations created by high net worth individuals to accelerate progress towards the development of therapies to treat aging, picking and choosing research programs and biotech startups to fund based on the founders' understanding of the science and favored goals. Amaranth has a strong focus on neuroscience, for example. The Amaranth pitch on the importance of focusing on bottlenecks in the research and development process is a more general call to action, however, and an interesting take on how best philanthropic organizations should direct their efforts in order to sp...
Source: Fight Aging! - November 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Learning from Laron Syndrome
The longest lived mice are still those engineered to lack functional growth hormone or growth hormone receptor. That record was established more than 20 years ago, and remains in place even as an energetic research and development community focused on treating aging as a medical condition has come into being. In part this is the case because research has largely focused on approaches known to produce lesser effects on aging in mice, such as the discovery of small molecules that mimic portions of the calorie restriction response. In part it is because the pace of development in the life sciences is ever slower than we would...
Source: Fight Aging! - November 23, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 20th 2023
In this study, we attempted to further explain the role, exact mechanism and target of ICA in treating AD from the ferroptosis perspective. We found that ICA could improve the neurobehavioral, memory, and motor abilities of AD mice. It could lower the ferroptosis level and enhance the resistance to oxidative stress. After inhibition of MDM2, ICA could no longer improve the cognitive ability of AD mice, nor could it further inhibit ferroptosis. Network pharmacological analysis revealed that MDM2 might be the target of ICA action.
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Particulate Air Pollution and Its Effects on the Mechan...
Source: Fight Aging! - November 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What Can Be Learned About Energy Metabolism and Longevity from Birds?
Here find an interesting commentary on some of the evolved genetic differences between mammals and birds, with a focus on genes relevant to energy metabolism - and potentially to species longevity. Larger animals live longer, but birds tend to be long-lived for their size. This is also the case for some bat species. It is thought that adaptations to energy metabolism needed to support the very energy-intensive activity of flight are involved in this increased longevity, providing resilience as a side effect.
The details have yet to be mapped in any comprehensive way, but studies such as today's open access example a...
Source: Fight Aging! - November 17, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Cardiovascular Aging Correlates with Brain Aging
Many large epidemiological studies demonstrate a correlation between cardiovascular aging and the risk of suffering cognitive decline and dementia. The population size of such studies has increased in recent years with the advent of sizable national databases, such as the UK Biobank. Today's open access paper focuses on one specific aspect of cardiovascular aging, the onset of atrial fibrillation, irregular heartbeats that can be accompanied by palpitations and other worrying sensations. Atrial fibrillation can arise in combination with many of the features of cardiovascular aging, and one might argue that data on time of ...
Source: Fight Aging! - November 15, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
State of the lab 10 and 11 - the first years at ETH Zurich
Yet another lake by a mountain in SwitzerlandThis blog post is part of a(nearly) yearly series on running a research group in academia. This post summarizes years 10 and 11, the first 2 years after moving to ETH Zurich. It also marks the end of the first decade as a research group leader, which is meaningful only because we have ten fingers and use 10 as a base for counting but I digress. There has been a lot to adapt to in moving to a new country including all the basics of moving, re-building the group and starting teaching. It was a lot easier than the first time around since I didn ' t have to set up the group from zer...
Source: Evolution of Cellular Networks - November 13, 2023 Category: Cytology Tags: academia state of the lab Source Type: blogs
Fight Aging! Newsletter, November 13th 2023
This study investigated the correlation among muscle strength, working memory (WM), and cortical hemodynamics during the N-back task of memory performance, and further explored whether cortical hemodynamics during N-back task mediated the relationship between muscle strength and WM performance. We observed that muscle strength (particularly grip strength) predicted WM of older adults in this cross-sectional study, which validated our hypothesis and expanded on previous research findings. Studies demonstrated that grip strength predicted executive function decline in patients with mild cognitive impairment. Other cross-sect...
Source: Fight Aging! - November 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Protected: Invasive species in the UK
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Source: David Bradley Sciencebase - Songs, Snaps, Science - November 10, 2023 Category: Science Authors: David Bradley Tags: Biology Environment Science Source Type: blogs
Invasive species in the UK
Invasive species, a term referring to non-native species introduced to new environments, often establish self-sustaining populations with negative impacts on local ecosystems, economies, or human health.
These invaders, encompassing plants, animals, fungi, or microorganisms (refer to the foot of this article for examples), typically arrive due to human activities such as trade, travel, or intentional release. In rare cases, invasive species might reach the UK through natural avenues, such as animal migration or wind dispersal. Climate change exacerbates the situation, creating new ecological niches due to shifts in tempera...
Source: David Bradley Sciencebase - Songs, Snaps, Science - November 10, 2023 Category: Science Authors: David Bradley Tags: Biology Environment Science Source Type: blogs
An Evolutionary Model in Which Aging is Selected
The present consensus on the evolution of aging is that it is an inevitable side effect of natural selection - aging isn't selected for per se, it is a byproduct. Evolution favors reproduction earlier in life rather than later in life, particularly in environments with high mortality due to disease or predation, and thus there is little pressure to select for mutations that enhance long-term maintenance of the body and brain. Looking at the examples of biology around us, the outcome of this process is near always biological systems that fail over time, in which their structure is optimized for early life success at the cos...
Source: Fight Aging! - November 7, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
PhaseV Raises $15 Million to Push the Boundaries of ML for Clinical Trial Optimization
Clinical Trial Platform Uncovers Hidden Signals and Optimizes Next Steps for More Adaptive, Successful, and Efficient Clinical Trials
PhaseV, a pioneer in causal machine learning (ML) technology that optimizes clinical trial design and analysis, announced today that it has raised $15 million in funding, led by Viola Ventures and Exor Ventures, including participation from LionBird and a group of prominent angel investors.
A recent Deloitte study estimates the average cost of developing a single new drug at $2.3 billion in 2022, with an average 7.1-year deployment time. Moreover, the vast majority of drug candidates do...
Source: EMR and HIPAA - November 7, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Deloitte Dr. Brad Carlin Dr. Dan Goldstaub Dr. David Perry Dr. Howard Trachtman Dr. Marcia Levenstein Dr. Miriam Kidron Dr. Murray B. Urowitz Dr. Raviv Pryluk Dr. Sofia Vilar Elad Berkman Exor Vent Source Type: blogs
A Popular Science View of Negligible Senescence in the Animal Kingdom
Some animals, even mammals such as the naked mole-rat, show few signs of degenerative aging across a life span, a state known as negligible senescence. Such species typically live considerably longer than their more evidently aging near relative species. There isn't any one path to negligible senescence, as demonstrated by the wide variety of ecological niches containing species found to be negligibly senescence. Can we learn from their biochemistry to find ways to meaningfully extend the healthy human life span? Undoubtedly so in the very long term, at the point at which the cutting edge of research is building entirely n...
Source: Fight Aging! - November 6, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Understanding RNA-Modifying Enzymes: Q & A With Jeffrey Mugridge
Credit: Courtesy of Jeffrey Mugridge.
“One of the best aspects of research is the excitement of discovery, being the first person in the world to know a small detail about the system you’re studying,” says Jeffrey Mugridge, Ph.D., an assistant professor of chemistry and biochemistry at the University of Delaware in Newark. We talked with Dr. Mugridge about how a pet store job sparked his early interest in science, why he decided to change his career trajectory after graduate school, and what he believes is key to being a successful researcher.
Q: How did you first become interested in science?
A: ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - October 25, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Profiles RNA Source Type: blogs
How to Determine If NIGMS Might Fund Your Research
This post is the first in a series outlining NIGMS research priorities, funding opportunities, and the grant application process for those not familiar with our Institute and its programs. We encourage you to share this series with others in your network, and to sign up to receive all future Feedback Loop posts delivered straight to your inbox.
We receive many questions from prospective applicants about getting NIGMS funding for their research: How do I know if my research fits within the scientific interests of NIGMS? What grant programs does the Institute offer? What are NIGMS’ research priorities? Whom do I tal...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - October 19, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Funding Opportunities Research Administration Resources NIGMS Grant Basics Submitting an Application Source Type: blogs
