In the Long Run, Even Baseline Humans Will Live for a Very, Very Long Time
It is at present somewhat out of style to point out that, yes, obviously, it will be possible in the future to ensure that humans live for a very, very long time. That will be true for even baseline humans lacking all of the various genetic modifications one might propose a future scientific community to be capable of, modifications to introduce the numerous distinct forms of resilience to the mechanisms of mammalian aging exhibited by naked mole-rats, whales, elephants, bats and so forth. Control over aging is a subset of control over molecules and their positions. To be as reductionist as possible, degenerative aging is ...
Source: Fight Aging! - August 9, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
cGAS-STING Signalling Drives Age-Related Chronic Inflammation
The reaction of the innate immune system to damage characteristic of aging biology drives a great deal of age-related chronic inflammation. For example, mislocalized mitochondrial DNA arises as a consequence of age-related mitochondrial dysfunction, and can trigger innate immune sensors that evolved to detect bacterial DNA. Here, researchers look more closely at one of the important signaling pathways involved in the maladaptive innate immune response to damage and dysfunction in aging cells.
Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated impairment and disease. Multiple ...
Source: Fight Aging! - August 9, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Blood Protein Signature of Increased Dementia Risk
The search for ways to determine whether someone is in the very early stages of developing dementia overlaps with the development of means to determine biological age. The first step in both cases is to gather a sizable database of omics data, usually from blood samples. Once that data is in hand, why not try to achieve both goals? Alzheimer's disease and other neurodegenerative conditions may exhibit years to decades of slow development prior to evident symptoms, and those underlying processes will show up given the right measurements. The research noted here is one example of the exploration of biomarkers that is present...
Source: Fight Aging! - August 8, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Biomaterial Injection Combines T Cell and Cancer Vaccine Treatments
Researchers at the Harvard Wyss Institute have developed an anti-cancer biomaterial treatment that combines adoptive T cell therapy and cancer vaccine technology to treat solid tumors. The researchers have called their technique SIVET, which is short for “synergistic in situ vaccination enhanced T cell”. The approach combines local delivery of cytotoxic T cells with longer lasting cancer vaccine technology that engages with the immune system more broadly for long lasting anticancer action. The researchers hope that the technology could lead to improvements in efficacy for immune therapies in treating solid tumors.
A...
Source: Medgadget - August 7, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Oncology harvard wyssinstitute Source Type: blogs
Imaging Technique Reveals Living Brain Tissue in its Complexity
Researchers at the Institute of Science and Technology Austria have developed a brain imaging technique called Live Information Optimized Nanoscopy Enabling Saturated Segmentation (LIONESS). The method lets the researchers create high-resolution 3D images of living brain tissue that reveal its cellular complexity, and even how it changes over time, allowing for monitoring of neural plasticity.
The technique relies on deep learning approaches that help to refine the image quality and also to distinguish cellular structures within this dense and highly complex tissue. The approach can provide unprecedented detail of li...
Source: Medgadget - August 7, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Neurology Neurosurgery Radiology istaustria Source Type: blogs
Population Health Management: SDOH Challenges and Solutions
Conclusion
SDOH data collection has its challenges. The first step is to convince organizations and policymakers of its utility and promise to offer whole-person care. Without SDOH, providers are only taking in a fraction of their patient’s health. Therefore, the dismissal of SDOH only widens health disparity gaps and fuels a cycle of reduced patient engagement.
However, the use of focused SDOH benchmarking, routine screening assessments, and robust analytics tools can help organizations take steps toward greater health equity. This gives each patient the potential to achieve and maintain optimal physical hea...
Source: The Health Care Blog - August 7, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Arcadia Population Health Management SDoH Source Type: blogs
Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
« Back to Top
Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seem...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Investigating the Secrets of Cancer-Causing Viruses
Credit: Courtesy of Dr. Mandy Muller.
While she was in graduate school, Mandy Muller, Ph.D., became intrigued with viruses that are oncogenic, meaning they can cause cancer. At the time, she was researching human papillomaviruses (HPVs), which can lead to cervical and throat cancer, among other types. Now, as an assistant professor of microbiology at the University of Massachusetts (UMass) Amherst, Dr. Muller studies Kaposi sarcoma-associated herpesvirus (KSHV), which causes the rare AIDS-associated cancer Kaposi sarcoma.
A Continental Change
Dr. Muller has come a long way, both geographically and professionally, s...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - August 1, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Infectious Diseases Microbes Profiles RNA Viruses Source Type: blogs
Altered Mitochondrial Calcium Metabolism is a Major Factor in Inflammaging
In this study, we report a surprising discovery that mitochondrial Ca2+ (mCa2+) uptake capacity in macrophages drops significantly with age. This amplifies cytosolic Ca2+ (cCa2+) signaling and promotes NF-κB activation, rendering the macrophages prone to chronic low-grade inflammatory output at baseline and hyper-inflammatory when stimulated. Although mitochondrial dysfunction has long been a suspected driver of aging, our study pinpoints the mitochondrial calcium uniporter (MCU) complex as a keystone molecular apparatus that links age-related changes in mitochondrial physiology to macrophage-mediated inflammation.
...
Source: Fight Aging! - August 1, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 31st 2023
In conclusion, an SBP level below 130 mmHg was found to be associated with longevity among older women. The longer SBP was controlled at a level between 110 and 130 mmHg, the higher the survival probability to age 90. Preventing age-related rises in SBP and increasing the time with controlled BP levels constitute important measures for achieving longevity.
« Back to Top (Source: Fight Aging!)
Source: Fight Aging! - July 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Play
I came downstairs yesterday morning and looked out the window, to see a doe and two fawns grazing on my lawn. Evidently they were finding something worth eating among the crabgrass. But the fawns weren ' t all that interested in breakfast. They ' d nibble a bit then gambol -- i.e. jump around -- singly or together. They ' d nuzzle the mother briefly, and she might nuzzle them back. At one point they both suddenly ran off into the woods. She just waited patiently until they came running back. They seemed to be testing or teasing her. Of course at some point she ' s going to have to let them go, but not yet. What I find...
Source: Stayin' Alive - July 25, 2023 Category: American Health Source Type: blogs
Lobbying Efforts for the Development of Means to Treat Aging are at a Very Early Stage
That so many people turn their hand to lobbying government is a sad statement of the character of our era. Those engaged in getting things done start to feel, at some level of funding, that lobbying is a necessary defense on the one hand, against Big Pharma entities who will use regulators to impede and coerce competition, and on the other hand a way to access greater funding and publicity. The trough of public funds is ever an attractive proposition, and never as easy to access without tainting everything involved as people would like to think it is. A world with smaller, less powerful governments would be a world in whic...
Source: Fight Aging! - July 24, 2023 Category: Research Authors: Reason Tags: Politics and Legislation Source Type: blogs
Responses to requests for suggestions for quiet air filter for daughter's California dorm room
So I posted a request for suggestions on various social media sites:" Wanted - recommendations for good / not too expensive / not too loud air filter to get my daughter for her for a small dorm room in California (and thus to filter out pathogens, allergens and smoke ...) "I am going to compile responses here
TwitterWanted - recommendations for good / not too expensive / not too loud air filter to get my daughter for her for a small dorm room in California (and thus to filter out pathogens, allergens and smoke ...)— Jonathan Eisen (@phylogenomics)July 23, 2023
Mastodon
Facebook
--------
This is from ...
Source: The Tree of Life - July 23, 2023 Category: Microbiology Source Type: blogs
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Consciously Exploring Your Relationship with Drugs
Humanity has a complex, long-term relationship with a wide variety of drugs. In this article let’s delve into your personal relationship with drugs, how you frame them, and how you might upgrade these relationships to be more conscious and aligned with your path of self-development. Let’s include common drug sources like coffee, tea, and chocolate too, so this will be very inclusive.
My purpose here isn’t to encourage or discourage you from using any particular substances but rather to invite you to take a more conscious and honest look at your current frames, attitudes, biases, and behaviors, and dete...
Source: Steve Pavlina's Personal Development Blog - July 21, 2023 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Creating Reality Emotions Health Lifestyle Relationships Values Source Type: blogs
