Clinical study on combined " lanzhou prescription " for the treatment of " syndrome of heat-toxin congestion and excessiveness " in children with acute aplastic anemias
Conclusion: Compared with immunosuppressive therapy, lanzhou prescription plus or minus combined with immunosuppressive therapy can alleviate the clinical symptoms and signs of children more effectively, obviously improve the Traditional Chinese Medicine symptoms of children, and help bone marrow hematopoietic stem cells gradually restore hematopoietic function.Keywords: Acute aplastic anemia in children; Lanzhou prescription; Traditional Chinese medicine combined with Western medicine; Clinical research. (Source: African Health Sciences)
Source: African Health Sciences - July 13, 2023 Category: African Health Authors: Niancheng Yu, Hong Huang, Fang Wu Source Type: research

Optimizing diagnostic methods and stem cell transplantation outcomes in pediatric bone marrow failure: a 50-year single center experience
Conclusion: Unbiased protocolized in-depth diagnostic strategies are crucial to increase the frequency of identifiable causes within the heterogeneous group of pediatric BMF. A comprehensive approach to identify the cause of BMF can prevent treatment delay and be useful to tailor treatment and follow-up protocols.What is Known:• Irreversible BMF in pediatric patients can be caused by a wide spectrum of underlying diseases including (pre)malignant disease, IBMFS and AA. Identifying the exact underlying cause of BMF is crucial for tailored therapy, however often challenging and time-consuming.• Frontline allogeneic HSCT ...
Source: European Journal of Pediatrics - July 13, 2023 Category: Pediatrics Source Type: research

T memory stem cell characteristics in autoimmune diseases and their promising therapeutic values
Memory T cells are conventionally subdivided into T central memory (TCM) and T effector memory (TEM) cells. However, a new subset of memory T cells named T memory stem cell (TSCM) cells has been recognized that possesses capabilities of both TCM and TEM cells including lymphoid homing and performing effector roles through secretion of cytokines such as interleukin-2 (IL-2) and interferon-gamma (IFN-γ). The TSCM subset has some biological properties including stemness, antigen independency, high proliferative potential, signaling pathway and lipid metabolism. On the other hand, memory T cells are considered one of the prin...
Source: Frontiers in Immunology - July 11, 2023 Category: Allergy & Immunology Source Type: research

TERC haploid cell reprogramming: a novel therapeutic strategy for aplastic anemia
In this study, we summarized the effects of TERC haploid cell reprogramming on telomere length and the correlation between this alteration and the pathogenesis of AA; by investigating the role of cell reprogramming in AA, we aimed to identify novel diagnostic indicators and therapeutic strategies for patients with AA.PMID:37424004 | DOI:10.1186/s10020-023-00691-w (Source: Molecular Medicine)
Source: Molecular Medicine - July 9, 2023 Category: Molecular Biology Authors: Xinyu Tang Ruirong Xu Yan Wang Kaiqing Chen Siyuan Cui Source Type: research

Exploration of risk factors of platelet transfusion refractoriness and its impact on the prognosis of hematopoietic stem cell transplantation: a retrospective study of patients with hematological diseases
In conclusion, we found that splenomegaly and JAK gene mutation were independent risk factors for PTR in patients with hematological diseases. A history of PTR prior to allo-HSCT indicates a poor prognosis.PMID:37409458 | DOI:10.1080/09537104.2023.2229905 (Source: Platelets)
Source: Platelets - July 6, 2023 Category: Hematology Authors: Xiaofei Song Jiaqian Qi Xueqian Li Meng Zhou Jingyi He Tiantian Chu Yue Han Source Type: research