High-dimensional immune profiling using mass cytometry reveals IL-17A-producing γδ T cells as biomarkers in patients with T-cell-activated idiopathic severe aplastic anemia
Int Immunopharmacol. 2023 Dec;125(Pt B):111163. doi: 10.1016/j.intimp.2023.111163. Epub 2023 Nov 15.ABSTRACTSevere aplastic anemia (SAA) is a bone marrow failure syndrome characterized by activated T cells. Features of T-cell activation in the pathophysiology of SAA remain unknown. To understand T cell activation states, we investigated the atlas of peripheral immune cells and the secreted cytokine network with single cell mass cytometry analysis. We found decreased γδ T-cell frequencies in all patients with SAA, together with a significantly increased proportion of interleukin (IL)-17A-producing cell subsets. Cytokine n...
Source: International Immunopharmacology - November 17, 2023 Category: Allergy & Immunology Authors: Jianwei Wang Ruiqing Zhou Limei Zhong Yinchun Chen Xiaojun Wu Liping Huang Yan Tian Wenjian Mo Shunqing Wang Yufeng Liu Source Type: research
Bone marrow plasma metabonomics of idiopathic acquired aplastic anemia patients using 1H nuclear magnetic resonance spectroscopy
ConclusionThe study highlights the significant metabolic alterations in the BM plasma of AA patients which may have implication in the disease pathobiology.Graphical Abstract (Source: Metabolomics)
Source: Metabolomics - November 17, 2023 Category: Biology Source Type: research
Comparison of stem cell transplantation using unrelated, haploidentical, and sibling donors for patients with acquired severe aplastic anemia : A single center, retrospective, cohort study
The preferred donor (haploidentical vs. matched unrelated donor) choice in patients with acquired severe aplastic anemia (SAA) who lack a human leukocyte antigen (HLA)-matched sibling donors (MSDs) and fail upfront immunosuppressive treatment (IST) therapy is unknown. We retrospectively investigated SAA patients (n=58) who underwent allogeneic stem cell transplantation (allo-SCT) between January 2012 and October 2022. The 5-year overall survival (OS) (87.5% ± 11.7% vs. 98.0% ± 6.5% vs. 83.3% ± 7.6%, respectively, p= 0.926) and 5-year failure-free survival (FFS) (60.0% ± 18.2% vs. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - November 14, 2023 Category: Hematology Authors: Weijia Fu, Su Gao, Yanrong Luo, Li Chen, Jie Chen, Lei Gao, Libing Wang, Lili Xu, Yang Wang, Ziwei Wang, Wenqin Yue, Hui Cheng, Gusheng Tang, Jianmin Wang, Jianmin Yang, Xiong Ni Source Type: research
Reference guide for the diagnosis of adult primary immune thrombocytopenia, 2023 edition
Int J Hematol. 2023 Nov 13. doi: 10.1007/s12185-023-03672-1. Online ahead of print.ABSTRACTPrimary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia due to accelerated platelet destruction and impaired platelet production. Diagnosis of ITP is still challenging because ITP has been diagnosed by exclusion. Exclusion of thrombocytopenia due to bone marrow failure is especially important in Japan because of high prevalence of aplastic anemia compared to Western countries. Hence, we propose a new diagnostic criteria involving the measurement of plasma thrombopoietin (TPO) levels ...
Source: International Journal of Hematology - November 13, 2023 Category: Hematology Authors: Hirokazu Kashiwagi Masataka Kuwana Mitsuru Murata Naoki Shimada Toshiro Takafuta Jun Yamanouchi Hisashi Kato Takaaki Hato Yoshiaki Tomiyama Committee for Reference Guide for diagnosis of adult ITP Research Team for Coagulopathy and Other Intractable Disea Source Type: research
Reference guide for the diagnosis of adult primary immune thrombocytopenia, 2023 edition
Int J Hematol. 2023 Nov 13. doi: 10.1007/s12185-023-03672-1. Online ahead of print.ABSTRACTPrimary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia due to accelerated platelet destruction and impaired platelet production. Diagnosis of ITP is still challenging because ITP has been diagnosed by exclusion. Exclusion of thrombocytopenia due to bone marrow failure is especially important in Japan because of high prevalence of aplastic anemia compared to Western countries. Hence, we propose a new diagnostic criteria involving the measurement of plasma thrombopoietin (TPO) levels ...
Source: International Journal of Hematology - November 13, 2023 Category: Hematology Authors: Hirokazu Kashiwagi Masataka Kuwana Mitsuru Murata Naoki Shimada Toshiro Takafuta Jun Yamanouchi Hisashi Kato Takaaki Hato Yoshiaki Tomiyama Committee for Reference Guide for diagnosis of adult ITP Research Team for Coagulopathy and Other Intractable Disea Source Type: research
Reference guide for the diagnosis of adult primary immune thrombocytopenia, 2023 edition
Int J Hematol. 2023 Nov 13. doi: 10.1007/s12185-023-03672-1. Online ahead of print.ABSTRACTPrimary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia due to accelerated platelet destruction and impaired platelet production. Diagnosis of ITP is still challenging because ITP has been diagnosed by exclusion. Exclusion of thrombocytopenia due to bone marrow failure is especially important in Japan because of high prevalence of aplastic anemia compared to Western countries. Hence, we propose a new diagnostic criteria involving the measurement of plasma thrombopoietin (TPO) levels ...
Source: International Journal of Hematology - November 13, 2023 Category: Hematology Authors: Hirokazu Kashiwagi Masataka Kuwana Mitsuru Murata Naoki Shimada Toshiro Takafuta Jun Yamanouchi Hisashi Kato Takaaki Hato Yoshiaki Tomiyama Committee for Reference Guide for diagnosis of adult ITP Research Team for Coagulopathy and Other Intractable Disea Source Type: research
Reference guide for the diagnosis of adult primary immune thrombocytopenia, 2023 edition
Int J Hematol. 2023 Nov 13. doi: 10.1007/s12185-023-03672-1. Online ahead of print.ABSTRACTPrimary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia due to accelerated platelet destruction and impaired platelet production. Diagnosis of ITP is still challenging because ITP has been diagnosed by exclusion. Exclusion of thrombocytopenia due to bone marrow failure is especially important in Japan because of high prevalence of aplastic anemia compared to Western countries. Hence, we propose a new diagnostic criteria involving the measurement of plasma thrombopoietin (TPO) levels ...
Source: International Journal of Hematology - November 13, 2023 Category: Hematology Authors: Hirokazu Kashiwagi Masataka Kuwana Mitsuru Murata Naoki Shimada Toshiro Takafuta Jun Yamanouchi Hisashi Kato Takaaki Hato Yoshiaki Tomiyama Committee for Reference Guide for diagnosis of adult ITP Research Team for Coagulopathy and Other Intractable Disea Source Type: research
Reference guide for the diagnosis of adult primary immune thrombocytopenia, 2023 edition
Int J Hematol. 2023 Nov 13. doi: 10.1007/s12185-023-03672-1. Online ahead of print.ABSTRACTPrimary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia due to accelerated platelet destruction and impaired platelet production. Diagnosis of ITP is still challenging because ITP has been diagnosed by exclusion. Exclusion of thrombocytopenia due to bone marrow failure is especially important in Japan because of high prevalence of aplastic anemia compared to Western countries. Hence, we propose a new diagnostic criteria involving the measurement of plasma thrombopoietin (TPO) levels ...
Source: International Journal of Hematology - November 13, 2023 Category: Hematology Authors: Hirokazu Kashiwagi Masataka Kuwana Mitsuru Murata Naoki Shimada Toshiro Takafuta Jun Yamanouchi Hisashi Kato Takaaki Hato Yoshiaki Tomiyama Committee for Reference Guide for diagnosis of adult ITP Research Team for Coagulopathy and Other Intractable Disea Source Type: research
HLA class I allele loss and bone marrow transplantation outcomes in immune aplastic anemia
Immune aplastic anemia (AA) is T-cell-mediated bone marrow failure,1 which can be managed through hematopoietic stem cell transplantation (HSCT) or immunosuppressive therapy (IST) based on patient age and availability of an appropriate donor.2,3 (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - November 13, 2023 Category: Hematology Authors: Yoshitaka Zaimoku, Takamasa Katagiri, Noriharu Nakagawa, Tatsuya Imi, Hiroyuki Maruyama, Hiroyuki Takamatsu, Ken Ishiyama, Hirohito Yamazaki, Toshihiro Miyamoto, Shinji Nakao Source Type: research
Irisin protected hemopoietic stem cells and improved outcome of severe bone marrow failure
The objective of this study was to investigate potential therapeutic effect of irisin, a molecule involved in adipose tissue transition, on AA mouse model. Our results showed that the concentration of irisin in serum was lower in AA patients than in healthy controls, suggesting a role of irisin in the pathogenesis of AA. In the AA mice, irisin administration prolonged the survival rate, prevented or attenuated peripheral pancytopenia, and preserved HPSC in the BM. Moreover, irisin also markedly reduced BM adipogenesis. In vitro results showed that irisin increased both cell proliferation and colony numbers of HPSC. Further...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 12, 2023 Category: Drugs & Pharmacology Authors: Hui Li Dexiao Kong Yi Zhao Xia Liu Fang Xiao Xiaoyan Li Jianting Hu Yingjie Chen Shengli Li Baozhu Wang Yuan Chen Yang Jiang Xiaoli Liu Xiumei Feng Yanan Guo Xiaoli Feng Jing Ren Fang Wang Ying Han William Donelan Lijun Yang Dawei Xu Dongqi Tang Chengyun Source Type: research
Irisin protected hemopoietic stem cells and improved outcome of severe bone marrow failure
The objective of this study was to investigate potential therapeutic effect of irisin, a molecule involved in adipose tissue transition, on AA mouse model. Our results showed that the concentration of irisin in serum was lower in AA patients than in healthy controls, suggesting a role of irisin in the pathogenesis of AA. In the AA mice, irisin administration prolonged the survival rate, prevented or attenuated peripheral pancytopenia, and preserved HPSC in the BM. Moreover, irisin also markedly reduced BM adipogenesis. In vitro results showed that irisin increased both cell proliferation and colony numbers of HPSC. Further...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 12, 2023 Category: Drugs & Pharmacology Authors: Hui Li Dexiao Kong Yi Zhao Xia Liu Fang Xiao Xiaoyan Li Jianting Hu Yingjie Chen Shengli Li Baozhu Wang Yuan Chen Yang Jiang Xiaoli Liu Xiumei Feng Yanan Guo Xiaoli Feng Jing Ren Fang Wang Ying Han William Donelan Lijun Yang Dawei Xu Dongqi Tang Chengyun Source Type: research
Interleukin-6 and interleukin-8 levels in children with aplastic anemia and its correlation with disease severity and response to immunosuppressive therapy
Conclusions: Children with AA had higher IL-6 and IL-8 levels than normal age- and sex-matched controls. Increased levels were linked to the severity of the condition, suggesting that IL may have a role in AA. IL levels can be monitored in AA patients during IST, which can assist in predicting response to IST.
Résumé
Contexte: L'anémie aplastique (AA) est une affection peu fréquente caractérisée par une pancytopénie et une moelle osseuse hypocellulaire. Il a été démontré que l�...
Source: Annals of African Medicine - November 9, 2023 Category: African Health Authors: Anurag Singh Sharvan Kumar Bhargawa Geeta Yadav Rashmi Kushwaha Shailendra Prasad Verma Tanya Tripathi Uma Shankar Singh Anil Kumar Tripathi Source Type: research
Minor GPI(-) granulocyte populations in aplastic anemia and healthy individuals derived from a few PIGA-mutated hematopoietic stem progenitor cells
Blood Cancer Journal, Published online: 08 November 2023; doi:10.1038/s41408-023-00932-5Minor GPI(-) granulocyte populations in aplastic anemia and healthy individuals derived from a few PIGA-mutated hematopoietic stem progenitor cells (Source: Blood Cancer Journal)
Source: Blood Cancer Journal - November 8, 2023 Category: Hematology Authors: Hiroki Mizumaki Dung Cao Tran Kohei Hosokawa Kazuyoshi Hosomichi Yoshitaka Zaimoku Hiroyuki Takamatsu Hirohito Yamazaki Ken Ishiyama Rena Yamazaki Hiroshi Fujiwara Atsushi Tajima Shinji Nakao Source Type: research
Reduced regulatory effects of bone marrow-derived mesenchymal stem cells on activated T lymphocytes and Th1/Th2 cytokine secretion in children with aplastic anemia
AbstractAcquired aplastic anemia (AA) is a recognized immune-mediated disorder and abnormally activated T lymphocyte-mediated bone marrow destruction is considered to be its main pathogenesis. Whether abnormal activation of T lymphocytes would also damage bone marrow-derived MSCs remains to be further studied. The aim of this study was to analyze the extent of T lymphocyte activation and the levels of Th1/Th2 cytokines of AA patients, and to explore the immunomodulatory effects of BM-MSCs on IL-2-stimulated T lymphocyte activation and cytokine production in vitro by means of transwell co-culture assay and flow cytometry me...
Source: Clinical and Experimental Medicine - November 6, 2023 Category: Research Source Type: research
