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Traditional Chinese medicine for treating aplastic anemia
This article reviews the potential mechanism of traditional Chinese medicine or its active ingredients in the treatment of AA. These include improving the bone marrow microenvironment, regulating immunity, and affecting the fate of hematopoietic stem cells. This provides useful information for further treatment of AA with integration of traditional Chinese and Western medicine and the development of new treatment strategies.PMID:38022904 | PMC:PMC10679336 | DOI:10.3389/jpps.2023.11863 (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - November 29, 2023 Category: Drugs & Pharmacology Authors: Jing Guan YiHui Zhao Ting Wang Rong Fu Source Type: research

Traditional Chinese medicine for treating aplastic anemia
This article reviews the potential mechanism of traditional Chinese medicine or its active ingredients in the treatment of AA. These include improving the bone marrow microenvironment, regulating immunity, and affecting the fate of hematopoietic stem cells. This provides useful information for further treatment of AA with integration of traditional Chinese and Western medicine and the development of new treatment strategies.PMID:38022904 | PMC:PMC10679336 | DOI:10.3389/jpps.2023.11863 (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - November 29, 2023 Category: Drugs & Pharmacology Authors: Jing Guan YiHui Zhao Ting Wang Rong Fu Source Type: research

Mass cytometric analysis unveils a disease-specific immune cell network in the bone marrow in acquired aplastic anemia
In this study, we applied high-dimensional mass cytometry on bone marrow aspirates of AA patients pre-ATG, AA patients post-ATG and healthy donors to decipher which immune cells may be implicated in the pathogenesis of AA. We show that the bone marrow of AA patients features an immune cell composition distinct from healthy donors, with significant differences in the myeloid, B-cell, CD4+ and CD8+ T-cells lineages. Specifically, we discovered that AA pre-ATG is characterized by a disease-specific immune cell network with high frequencies of CD16+ myeloid cells, CCR6++ B-cells, Th17-like CCR6+ memory CD4+ T-cells, CD45RA+CCR...
Source: Frontiers in Immunology - November 29, 2023 Category: Allergy & Immunology Source Type: research

High-dimensional immune profiling using mass cytometry reveals IL-17A-producing γδ T cells as biomarkers in patients with T-cell-activated idiopathic severe aplastic anemia
Int Immunopharmacol. 2023 Nov 15;125(Pt B):111163. doi: 10.1016/j.intimp.2023.111163. Online ahead of print.ABSTRACTSevere aplastic anemia (SAA) is a bone marrow failure syndrome characterized by activated T cells. Features of T-cell activation in the pathophysiology of SAA remain unknown. To understand T cell activation states, we investigated the atlas of peripheral immune cells and the secreted cytokine network with single cell mass cytometry analysis. We found decreased γδ T-cell frequencies in all patients with SAA, together with a significantly increased proportion of interleukin (IL)-17A-producing cell subsets. Cy...
Source: International Immunopharmacology - November 17, 2023 Category: Allergy & Immunology Authors: Jianwei Wang Ruiqing Zhou Limei Zhong Yinchun Chen Xiaojun Wu Liping Huang Yan Tian Wenjian Mo Shunqing Wang Yufeng Liu Source Type: research