In Vitro ADME, Preclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of RBx14255, a Novel Ketolide with Pharmacodynamics Against Multidrug-Resistant Bacterial Pathogens.
CONCLUSION: RBx14255 displayed significantly better pharmacodynamics which correlates with the pharmacokinetic properties against S. pneumoniae and H. influenzae as compared to telithromycin. The predicted human efficacious doses are in the range of 124-226 mg, making it amenable to oral dosage form drug in human. This could be a promising clinical candidate for future studies. PMID: 32574140 [PubMed - as supplied by publisher] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - June 25, 2020 Category: Drugs & Pharmacology Authors: Chaira T, Barman T, Samuel Raj V Tags: J Pharm Pharm Sci Source Type: research

A Simple Computational Tool for Accurate, Quantitative Prediction of One-Electron Reduction Potentials of Hypoxia-Activated Tirapazamine Analogues.
Abstract The reduction potentials of bioreductively-activated drugs represent an important design parameter to be accommodated in the course of creating lead compounds and improving the efficacy of older generation drugs.  Reduction potentials are traditionally reported as single-electron reduction potentials, E(1), measured against reference electrodes under strictly defined experimental conditions.  More recently, computational chemists have described redox properties in terms of a molecule's highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO), in electron volts (eV...
Source: J Pharm Pharm Sci - June 25, 2020 Category: Drugs & Pharmacology Authors: Elsaidi HR, Wiebe LI, Kumar P Tags: J Pharm Pharm Sci Source Type: research

Droperidol Reduces Postoperative Nausea and Vomiting and Supports the Continuation of Intravenous Patient-Controlled Analgesia with Fentanyl.
Abstract PURPOSE: To examine the impact of adding droperidol to fentanyl-based intravenous patient- controlled analgesia (IVPCA) on the discontinuation of IVPCA use due to postoperative nausea and vomiting (PONV). METHODS: Patients who underwent surgeries other than abdominal surgeries and used IVPCA between April 2014 and March 2018 were selected. Patients using IVPCA with fentanyl alone were compared to patients using droperidol added to IVPCA. Patients were allocated to one of two groups depending on the drug used for IVPCA: 1) control group, fentanyl alone; 2) droperidol group, droperidol with fentanyl. T...
Source: J Pharm Pharm Sci - June 23, 2020 Category: Drugs & Pharmacology Authors: Hirata I, Iwamoto M, Matsui H, Yoshinuma H, Funakoshi R Tags: J Pharm Pharm Sci Source Type: research

Potential Limitations of Bioluminescent Xenograft Mouse Models: A Systematic Review.
CONCLUSIONS: In general, BLI remains a valid tool for pre-clinical assessment of tumor burden. While no single factor may be identified as a general limitation, data should be interpreted with caution. PMID: 32407285 [PubMed - as supplied by publisher] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - May 16, 2020 Category: Drugs & Pharmacology Authors: Shen YT, Asthana R, Peeters C, Allen C, DeAngelis C, Piquette-Miller M Tags: J Pharm Pharm Sci Source Type: research

Importance of Therapeutic Drug Monitoring to Detect Drug Interaction between Pazopanib and Warfarin: A Case Report.
Abstract Pazopanib is an orally available multi-tyrosine kinase inhibitor and has been used to treat renal cell carcinoma (RCC). Here, we report the case of a patient with RCC with an increased prothrombin time- international normalized ratio (PT-INR) due to pazopanib therapy. In addition, we have reported the change in the blood levels of pazopanib. A 75-year-old man underwent a left nephrectomy for RCC. Four years later, his cancer recurred and pazopanib therapy was initiated. He was also taking warfarin for atrial fibrillation and his PT-INR was constant at approximately 2. His warfarin dose was reduced from 3....
Source: J Pharm Pharm Sci - May 16, 2020 Category: Drugs & Pharmacology Authors: Takasaki S, Adachi H, Kawasaki Y, Kikuchi M, Ito A, Mano N Tags: J Pharm Pharm Sci Source Type: research

Potential Application of Ionic Liquids in Pharmaceutical Dosage Forms for Small Molecule Drug and Vaccine Delivery System.
Abstract Ionic liquids are salts in which the ions are poorly coordinated, which causes them to exist in liquid form below 100°C, or at room temperature. Therefore, these are also defined as room temperature ionic liquids (RTILs). In ionic liquids, at least one ion has a delocalized charge and one component is organic, which prevents the formation of a stable solid form of crystal lattice. Physical properties of ionic liquids, such as melting point, viscosity, and solubility of starting materials and other solvents, are impacted by the substituents on the organic component and by the counterions. Many ionic li...
Source: J Pharm Pharm Sci - May 16, 2020 Category: Drugs & Pharmacology Authors: Uddin MN, Basak D, Hopefl R, Minofar B Tags: J Pharm Pharm Sci Source Type: research

Targeted Nanomedicines for Cancer Therapy, From Basics to Clinical Trials.
Abstract Traditional systemic chemotherapy involves the wide distribution of drug molecules in the body, causing toxic side effects in the healthy tissues and limiting the therapeutic dose required at the site of drug action. In order to decrease side effects and increase the drug efficacy, recent research on chemotherapy focuses on drug targeting. Targeted therapy can be achieved by several mechanisms including; 1) using an antibody as a drug that is specific to a disease biomarker, 2) using an antibody (or peptide) as a targeting agent conjugated to the drug molecule, 3) delivering the drug molecules to the targ...
Source: J Pharm Pharm Sci - May 7, 2020 Category: Drugs & Pharmacology Authors: Eskandari Z, Bahadori F, Celik B, Onyuksel H Tags: J Pharm Pharm Sci Source Type: research

Association Between Polymorphisms in Cytokine Gene and Viral Infections in Renal and Liver Transplant Recipients: A Systematic Review.
CONCLUSIONS: Cytokine gene polymorphisms IL-12B and IL-1B were found to be associated with an increased risk of infection in kidney transplants and IL-28B in liver transplant recipients. However, the small number and heterogeneity of studies limits the generalization of our results. Further research may lead to finding these associations in larger studies which perhaps improve the use of genetic testing and targeted antiviral therapy. This will further reduce the risk of viral infections associated with cytokine gene polymorphisms in post renal and liver transplant recipients. PMID: 32365304 [PubMed - as supplied by p...
Source: J Pharm Pharm Sci - May 6, 2020 Category: Drugs & Pharmacology Authors: Sakharkar P, Deb S, Mashayekhi N Tags: J Pharm Pharm Sci Source Type: research

Topical Application of Doxycycline Inhibits Th2 Cell Development Mediated by Langerhans Cells and Exerts a Therapeutic Effect on Atopic Dermatitis.
CONCLUSION: Topical application of doxycycline to AD lesions would act on both superficial S. aureus colonization and epidermal LCs, thus possibly inhibiting the development of Th2 cells in vivo, with benefits for control of acute inflammation in AD. PMID: 32338591 [PubMed - as supplied by publisher] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - April 28, 2020 Category: Drugs & Pharmacology Authors: Matsui K, Nojima Y, Kajiwara Y, Busujima K, Mori Y Tags: J Pharm Pharm Sci Source Type: research

Prevention and therapy of COVID-19 via exogenous estrogen treatment for both male and female patients.
Abstract The presented work summarizes the results of studies underlining the crucial role of estrogen receptor (ER) signaling in both innate and adaptive immune responses as well as in tissue repairing processes during respiratory virus infection. Experimental studies justify that among respiratory virus infected mice, a weaker ER signaling leads to increased morbidity and mortality in both males and females. In animal experiments, estrogen treatment silences the inflammatory reactions and decreases virus titers leading to improved survival rate; it seems to be an ideal prevention and therapy against COVID-19. We...
Source: J Pharm Pharm Sci - April 24, 2020 Category: Drugs & Pharmacology Authors: Suba Z Tags: J Pharm Pharm Sci Source Type: research

Gamma glutamyl transferase - an underestimated marker for cardiovascular disease and the metabolic syndrome.
Abstract Gamma glutamyl transferase (GGT) is an enzyme in glutathione and cysteine metabolism. GGT is a standard liver enzyme test reflecting biliary tract involvement. It also has a prooxoidant activity and a modulating influence on endothelia dysfunction. GGT is associated with the metabolic syndrome and is often elevated in patients with NAFLD. There is also a role for GGT activity in several aspects cardiovascular disease. There is an association between elevated GGT and cardiovascular mortality, atrial fibrillation, exacerbation of congestive heart failure . In addition there is an association with obstructiv...
Source: J Pharm Pharm Sci - April 21, 2020 Category: Drugs & Pharmacology Authors: Neuman MG, Malnick S, Chertin L Tags: J Pharm Pharm Sci Source Type: research

Use of Real World Data/Evidence to Inform Regulatory Decision Making.
PMID: 32311311 [PubMed - as supplied by publisher] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - April 21, 2020 Category: Drugs & Pharmacology Authors: Rwde Tags: J Pharm Pharm Sci Source Type: research

Current Drugs with Potential for Treatment of COVID-19: A Literature Review.
CONCLUSION: All examined treatments, although potentiality effective against COVID-19, need either appropriate drug development or clinical trial to be suitable for clinical use. PMID: 32251618 [PubMed - as supplied by publisher] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - April 7, 2020 Category: Drugs & Pharmacology Authors: Md Insiat Islam Rabby Tags: J Pharm Pharm Sci Source Type: research

Raman Spectroscopy for Quantitative Analysis in the Pharmaceutical Industry.
NA Abstract Raman spectroscopy is a very promising technique increasingly used in the pharmaceutical industry. Due to its development and improved instrumental versatility achieved over recent decades and through the application of chemometric methods, this technique has become highly precise and sensitive for the quantification of drug substances. Thus, it has become fundamental in identifying critical variables and their clinical relevance in the development of new drugs. In process monitoring, it has been used to highlight in-line real-time analysis, and it has been used more commonly since 2004 when the Food ...
Source: J Pharm Pharm Sci - March 5, 2020 Category: Drugs & Pharmacology Authors: Jesus JISDS, Löbenberg R, Bou-Chacra NA Tags: J Pharm Pharm Sci Source Type: research

Medicinal Plants as Potential Hemostatic Agents.
CONCLUSION: This review provides a list of medicinal plants with hemostatic activity that could be used as valuable sources of new plant-based hemostatic agents. Furthermore, this could be practical in detecting possible interactions of plants with anticoagulant, antiplatelet, fibrinolytic and antifibrinolytic medications. PMID: 32027817 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - February 7, 2020 Category: Drugs & Pharmacology Authors: Ebrahimi F, Torbati M, Mahmoudi J, Valizadeh H Tags: J Pharm Pharm Sci Source Type: research

Effects of Trough Concentration and Solute Carrier Polymorphisms on Imatinib Efficacy in Chinese Patients with Chronic Myeloid Leukemia.
CONCLUSION: Imatinib trough concentrations and SLCO1A2 -361G>A genotypes are associated with imatinib efficacy in Chinese patients with CML. PMID: 32027818 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - February 7, 2020 Category: Drugs & Pharmacology Authors: Wang Q, Jiang ZP, Zeng J, Zhu Y, Cai HL, Xiang DX, He Q, Shi XL, Zhong AN, Zhao XL, Xu P Tags: J Pharm Pharm Sci Source Type: research

CNS Penetration of Cyclophosphamide and Metabolites in Mice Bearing Group 3 Medulloblastoma and Non-Tumor Bearing Mice.
CONCLUSIONS: Future studies will explore potential mechanisms at the brain-tumor barrier to explain lower cyclophosphamide brain penetration in tumor-bearing mice. These results will be used to further investigate exposure-response relationships in medulloblastoma xenograft models. PMID: 31815662 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - December 11, 2019 Category: Drugs & Pharmacology Authors: Stewart C, Campagne O, Davis A, Zhong B, Nair S, Haberman V, T Patel Y, Janke L, F Roussel M Tags: J Pharm Pharm Sci Source Type: research

Probe Cocktail to Assess Transporter Function in Sandwich-Cultured Human Hepatocytes.
CONCLUSIONS: These data suggest that rosuvastatin and metformin can be administered as a cocktail to evaluate the function of OATP1B1, OATP1B3, BCRP, and OCT1 in SCHH, and that digoxin may not be an ideal component of such a cocktail. PMID: 31804919 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - December 6, 2019 Category: Drugs & Pharmacology Authors: Guo C, Brouwer KLR, Brouwer KR, Stewart PW, Mosley C Tags: J Pharm Pharm Sci Source Type: research

Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.
CONCLUSIONS: These data suggest that PIP5K1A and PIP5K1C could be target proteins for modulating MRP2 function, partly because of the resulting changes of the linker function of radixin. PMID: 31804920 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - December 6, 2019 Category: Drugs & Pharmacology Authors: Kawase A, Inoue Y, Hirosoko M, Sugihara Y, Shimada H, Iwaki M Tags: J Pharm Pharm Sci Source Type: research

The Interaction of PI3K Inhibition with Homologous Recombination Repair in Triple Negative Breast Cancer Cells.
CONCLUSIONS: Consequently, targeted therapies based on the interaction of PI3K inhibition with BRCA1 mutations or HR deficiency in TNBC may be a promising strategy for the treatment of patients with TNBC. PMID: 31804921 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - December 6, 2019 Category: Drugs & Pharmacology Authors: Guney Eskiler G Tags: J Pharm Pharm Sci Source Type: research

Inhibitory and Stimulatory Effects of Selective Serotonin Reuptake Inhibitors on Cytochrome P450 2D6-mediated Dopamine Formation from p-Tyramine.
CONCLUSIONS: These results suggest that the inhibition/stimulation of CYP2D6-mediated dopamine formation by these SSRIs would be affected by CYP2D6 polymorphisms in the brain. PMID: 31804922 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - December 6, 2019 Category: Drugs & Pharmacology Authors: Niwa T, Sugimoto S Tags: J Pharm Pharm Sci Source Type: research

Ergocalciferol Versus Cholecalciferol in Non-Dialysis Dependent Chronic Kidney Disease Patients: A Small Retrospective Cohort Study.
CONCLUSION: In this small pilot study, cholecalciferol treatment appeared to increase serum phosphorous concentrations compared to ergocalciferol. These observations may warrant further large-scale studies that are appropriately powered to validate such findings. PMID: 31804923 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - December 6, 2019 Category: Drugs & Pharmacology Authors: Al-Makki A, Frost K, Yun SA, Overholser B, Shepler B Tags: J Pharm Pharm Sci Source Type: research

Need for Bioequivalence Standards that Reflect the Clinical Importance of the Complex Pharmacokinetics of Paliperidone Palmitate Long-Acting Injectable Suspension.
Abstract Paliperidone palmitate is a second generation antipsychotic, approved for the treatment of schizophrenia in the form of the long-acting injectable (LAI) products INVEGA SUSTENNA® (once monthly injection) and INVEGA TRINZA® (once every 3 months injection). Paliperidone palmitate dissolves slowly after deep intramuscular injection before being hydrolyzed to paliperidone and absorbed into the systemic circulation. The pharmacokinetic (PK) profile of the INVEGA SUSTENNA® formulation is biphasic, comprised of an initial relatively fast zero-order input, which allows rapid attainment of therapeutic ...
Source: J Pharm Pharm Sci - November 16, 2019 Category: Drugs & Pharmacology Authors: Procyshyn RM, Lamoure JW, Katzman MA, Skinner PL, Sherman SE Tags: J Pharm Pharm Sci Source Type: research

A Novel Formulation Strategy to Deliver Combined DNA and VLP Based HPV Vaccine.
Abstract Human papillomaviruses (HPV) are small, double-stranded DNA viruses that cause cervical cancer, the second most lethal cancer among women in the world. Currently, two vaccines are on the market for preventing HPV-caused cervical cancers and warts. Both are virus-like particle (VLP)-based vaccines. However, these vaccines have limitations; they are costly, have an invasive route of administration, require trained personnel to administer, need cold chain storage to preserve them, and most of all, they are preventive vaccines that do not have curative effects. Therefore, it is necessary to develop therapeuti...
Source: J Pharm Pharm Sci - November 15, 2019 Category: Drugs & Pharmacology Authors: Uddin MN, Henry B, Carter KD, Roni MA, Kouzi SS Tags: J Pharm Pharm Sci Source Type: research

The Requirements for Additional Strength Biowaivers for Immediate Release Solid Oral Dosage Forms in International Pharmaceutical Regulators Programme Participating Regulators and Organisations: Differences and Commonalities.
The objective of this article is to describe the differences and commonalities in biowaivers for additional strengths of immediate release solid oral dosage forms between the participating members of the International Pharmaceutical Regulators Program (IPRP). The requirements are based on five main aspects; the pharmacokinetics of the drug substance, the manufacturing process, the qualitative and quantitative composition of the different strengths, and the comparative dissolution profiles. For the pharmacokinetic aspects, many regulators/agencies have the same requirements. All strengths must be manufactured with the same ...
Source: J Pharm Pharm Sci - October 5, 2019 Category: Drugs & Pharmacology Authors: Crane C, Santos GML, Fernandes EAF, Simon C, Tam A, Triana DG, Potthast H, Kuribayashi R, Okada Y, Myoenzono A, Calderon IO, Rodriguez Z, Jones B, Park SA, Eum SY, Rodrigues C, Van Oudsthoorn J, Nolting A, Walther C, Roost MS, Hung WY, Braddy AC, Garcia-A Tags: J Pharm Pharm Sci Source Type: research

Multitarget Therapy: An Effective and Safe Therapeutic Regimen for Lupus Nephritis.
CONCLUSIONS: Multitarget therapy is an effective and safe intervention for inducing remission in lupus nephritis patients. PMID: 31580800 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - October 5, 2019 Category: Drugs & Pharmacology Authors: Zhou T, Zhang X, Lin W, Lin S Tags: J Pharm Pharm Sci Source Type: research

Review of the cosolvency models for predicting solubility in solvent mixtures: An update.
Abstract The cosolvency models frequently used in solubility data modeling of drugs in mixed solvents were reviewed and their accuracies for calculating the solubility of solutes were briefly discussed. The models could be used either for correlation of the generated solubility data with temperature, solvent composition etc or for prediction of unmeasured solubility data using interpolation/extrapolation technique. Concerning the correlation results employing a given number of independent variables, the accuracies of the investigated models were comparable, since they could be converted to a single mathematical fo...
Source: J Pharm Pharm Sci - September 25, 2019 Category: Drugs & Pharmacology Authors: Jouyban A Tags: J Pharm Pharm Sci Source Type: research

Current prevention and potential treatment options for dengue infection.
Abstract Currently, treatments for dengue infection are only symptomatic as no antiviral agents nor vaccines are available to combat this virus. Despite challenges faced by researchers, many efforts are ongoing to reduce cases of dengue infection either by targeting the vector or the virus. Vector population is monitored and reduced by using mechanical, chemical and biological controls. Chemical control is achieved either by using synthetic or natural insecticides where the latter is more preferable. In biological control, bacteria, fungi and larvivorous fish are utilised to reduce the vector population. Moreover,...
Source: J Pharm Pharm Sci - September 22, 2019 Category: Drugs & Pharmacology Authors: Jasamai M, Yap WB, Sakulpanich A, Jaleel A Tags: J Pharm Pharm Sci Source Type: research

Changes in transporters and metabolizing enzymes in the livers of rats with bile duct ligation.
CONCLUSIONS: This study reports the comprehensive changes of transporters, metabolizing enzymes, nuclear receptors, and ezrin/radixin/moesin proteins in the livers of BDL rats. The expression levels of nuclear receptors and radixin that regulate the transcription and localization of CYP and/or transporters were decreased by BDL. PMID: 31539322 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - September 22, 2019 Category: Drugs & Pharmacology Authors: Kawase A, Kazaoka A, Yamamoto R, Minakata R, Shimada H, Iwaki M Tags: J Pharm Pharm Sci Source Type: research

Limited Sampling Strategy for the Estimation of Mycophenolic Acid and its Acyl Glucuronide Metabolite Area under the Concentration-Time Curve in Japanese Lung Transplant Recipients.
CONCLUSION: LSS using three time-point (C1, C4, and C8) provides the most reliable and accurate simultaneous estimation of the AUC0-12 of MPA and AcMPAG in Japanese lung transplant patients. PMID: 31430249 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - August 21, 2019 Category: Drugs & Pharmacology Authors: Tanaka M, Kikuchi M, Takasaki S, Hirasawa T, Sigeta K, Noda A, Akiba M, Matsuda Y, Oishi H, Sado T, Noda M, Okada Y, Mano N, Yamaguchi H Tags: J Pharm Pharm Sci Source Type: research

Developmental Expression of Monocarboxylate Transporter 1 and 4 in Rat Liver.
CONCLUSION: Our study elucidates the transcriptional and translational maturation patterns of MCT1, MCT4 and CD147 expression, with isoform- dependent differences in the liver. Changes in transporter expression during development may greatly influence drug distribution and clearance in pediatric populations. PMID: 31361594 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - July 31, 2019 Category: Drugs & Pharmacology Authors: Ng M, Louie J, Cao J, Felmlee MA Tags: J Pharm Pharm Sci Source Type: research

Comparison of Steroid Hormone Hydroxylations by and Docking to Human Cytochromes P450 3A4 and 3A5.
CONCLUSIONS: The Vmax, rather than Km values, for CYP3A5-mediated 6β-hydroxylation of three steroid hormones were different from those for CYP3A4. Molecular docking simulations could partially explain the differences in the accessibility of substrates to the heme moiety of human CYP3A molecules, resulting in the enzymatic affinity of CYP3A4 and CYP3A5. PMID: 31339834 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - July 25, 2019 Category: Drugs & Pharmacology Authors: Niwa T, Narita K, Okamoto A, Murayama N, Yamazaki H Tags: J Pharm Pharm Sci Source Type: research

Drugs Loaded into Electrospun Polymeric Nanofibers for Delivery.
l-Gómez LJ Abstract The electrospinning technique is a useful and versatile approach for conversion of polymeric solutions into continuous fibers, ranging from a few micrometers (10-100 μm) to the scale of nanometers (10- 100 nm) in diameters. This technique can be used in a vast number of polymers, in some cases after modifying them to the required properties. The high surface-to-volume ratio of the fibers can improve some processes like cell binding and proliferation, drug loading, and mass transfer processes. One of the most important and studied areas of electrospinning is in the drug delivery field,...
Source: J Pharm Pharm Sci - July 24, 2019 Category: Drugs & Pharmacology Authors: Torres-Martinez EJ, Pérez-González GL, Serrano-Medina A, Grande D, Vera-Graziano R, Cornejo-Bravo JM, Villarreal-Gómez LJ Tags: J Pharm Pharm Sci Source Type: research

Effect of Bile Duct Ligation-induced Liver Dysfunction on Methamphetamine Pharmacokinetics and Locomotor Activity in Rats.
CONCLUSIONS: In rats, liver dysfunction reduced METH clearance, increased brain METH concentrations, and enhanced METH effects on locomotor activity in a dose dependent manner. In addition, this model could be further developed to simulate the associated hepatic dysfunction of key METH abuse comorbidities for preclinical testing of novel pharmacotherapies for effectiveness and/or toxicity in vulnerable populations. PMID: 31329536 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - July 24, 2019 Category: Drugs & Pharmacology Authors: Hambuchen MD, Berquist MD, Simecka CM, McGill MR, Gunnell MG, Hendrickson HP, Owens SM Tags: J Pharm Pharm Sci Source Type: research

Prediction of Biopharmaceutical Drug Disposition Classification System (BDDCS) by Structural Parameters.
In this study, structural parameters of drugs were used to develop classification-based models for the prediction of BDDCS class. Reported BDDCS data of drugs were collected from the literature, and structural descriptors (Abraham solvation parameters and octanol-water partition coefficient (log P)) were calculated by ACD/Labs software. Data were divided into training and test sets. Classification-based models were then used to predict the class of each drug in BDDCS system using structural parameters and the validity of the established models was evaluated by an external test set. The results of this study showed that log...
Source: J Pharm Pharm Sci - July 11, 2019 Category: Drugs & Pharmacology Authors: Golfar Y, Shayanfar A Tags: J Pharm Pharm Sci Source Type: research

Inhibition of TLR4/TRIF/IRF3 Signaling Pathway by Curcumin in Breast Cancer Cells.
CONCLUSIONS: Consequently, these results demonstrated that the activation of LPS stimulated TLR4/TRIF/IRF3 signaling pathway was mediated by curcumin in breast cancer cells, in vitro. However, more studies are necessary to examine the curcumin's anti-inflammatory activities on TLR4/MyD88/NF-κB as well as other signaling pathways downstream of TLRs in breast cancer. PMID: 31287789 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - July 11, 2019 Category: Drugs & Pharmacology Authors: Güney Eskiler G, Deveci Özkan A, Kaleli S, Bilir C Tags: J Pharm Pharm Sci Source Type: research

Neuropeptide FF (FLFQPQRF-NH2) and its Fragments Bind to α2δ Subunit of Voltage-Gated Calcium Channels.
CONCLUSION: FLFQPQRF-NH2, FLFQP-NH2 and FLP-NH2 displace bound gabapentin in membrane preparations of rat cerebral cortex. Binding cooperativity was detected when GBP/FLFQP-NH2/FLP-NH2 were incubated together. These novel binding sites may provide new approaches to modulate L-type Ca2+ channels. PMID: 31287790 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - July 11, 2019 Category: Drugs & Pharmacology Authors: Skubatz H Tags: J Pharm Pharm Sci Source Type: research

The Effect of Diuretics on Patients with Heart Failure: A Network Meta-Analysis: Diuretics Effect on Heart Failure Patients.
CONCLUSION: Torasemide might be an optimal treatment for HF patients considering its comprehensive curative effect. PMID: 31287791 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - July 11, 2019 Category: Drugs & Pharmacology Authors: Zhao X, Ren Y, Li H, Liu X Tags: J Pharm Pharm Sci Source Type: research

Understanding the Role of Sodium Lauryl Sulfate on the Biorelevant Solubility of a Combination of Poorly Water-Soluble Drugs Using High Throughput Experimentation and Mechanistic Absorption Modeling.
This study investigates the influence of surfactant sodium lauryl sulfate (SLS) on the solubility of poorly-water soluble drug substances, model Compound X and Compound Y, used in a fixed dose combination oral solid dosage form. To determine the impact of SLS concentration on the solubility of compounds X and Y, we experimentally determined the critical micelle concentration (CMC) of SLS in water, simulated gastric fluid (SGF), and fed state simulated intestinal fluid (FeSSIF) in the presence of Compound X and Compound Y using UV/Visible spectrophotometry at 25°C. The aggregation of SLS was characterized by calculating...
Source: J Pharm Pharm Sci - June 21, 2019 Category: Drugs & Pharmacology Authors: Bahr MN, Modi D, Patel S, Campbell G, Stockdale G Tags: J Pharm Pharm Sci Source Type: research

Drug Targeting Strategies Based on Charge Dependent Uptake of Nanoparticles into Cancer Cells.
Abstract The aim of this review was to describe the preferred charged nano-particles (CNPs) for targeted delivery in tumor cells. Zeta Potential (ZP), which represents the surface charge of NPs was highlighted in cell entrance and interactions. In this regard, various types of endocytosis pathways which are involved in NPs' uptake were first introduced. Then, significance of positively charged NPs (PCNPs) in proton sponge effect corresponding to lysosomal escape was discussed. Cells prefer to endocyte the NPs with positive charge in passive targeting and gene delivery, while in active targeting; the charge of rece...
Source: J Pharm Pharm Sci - May 22, 2019 Category: Drugs & Pharmacology Authors: Saadat M, Zahednezhad F, Zakeri-Milani P, Reza Heidari H, Shahbazi-Mojarrad J, Valizadeh H Tags: J Pharm Pharm Sci Source Type: research

Evaluation of the Physicochemical and Biological Stability of Cetuximab under Various Stress Condition.
In conclusion, we found that all mentioned stress conditions significantly affect the bioactivity of cetuximab. Our finding highlights the importance of bioactivity evaluation of biopharmaceuticals in their quality control assessment. PMID: 31112673 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - May 22, 2019 Category: Drugs & Pharmacology Authors: Farjami A, Siahi-Shadbad M, Akbarzadehlaleh P, Roshanzamir K, Molavi O Tags: J Pharm Pharm Sci Source Type: research

Engineering Size and Structure of Particles in Novel Modified-Release Delivery Systems.
Abstract Particle engineering has become a hot topic in the field of modified-release delivery systems during last decades. It has a wide range of pharmaceutical applications and is a bridge linking between drugs and drug delivery systems. Particles are an important part of many dosage forms and viewed as a carrier of drugs. Their size, shape, crystalline form, and structure directly affect the stability and releasing pattern of drugs. Engineering size or modifying particles by forming porous, core-shell, or skeleton structures can realize the development and utilization of functionally modified release systems (i...
Source: J Pharm Pharm Sci - April 28, 2019 Category: Drugs & Pharmacology Authors: Dong Q, Zheng X, Zhou M, Wu F, Hong Y, Lin X, Shen L Tags: J Pharm Pharm Sci Source Type: research

Mining Small Routine Clinical Data: A Population Pharmacokinetic Model and Optimal Sampling Times of Capecitabine and its Metabolites.
CONCLUSIONS: Capecitabine, 5-DFUR, 5-FU and 5-FUH2 can be correctly described by the joint multicompartmental model presented in this work. The aforementioned times are optimal to maximize the information of samples. Useful knowledge can be obtained for clinical practice from small databases. PMID: 30964613 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - April 11, 2019 Category: Drugs & Pharmacology Authors: Oyaga-Iriarte E, Insausti A, Bueno L, Sayar O, Aldaz A Tags: J Pharm Pharm Sci Source Type: research

Effects of Orotic Acid-Induced Non-Alcoholic Fatty Liver on the Pharmacokinetics of Metoprolol and its Metabolites in Rats.
CONCLUSIONS: NALFD can lead to a reduction in the hepatic CLint of a drug if it is a substrate of the CYP2D subfamily. The decreased clearance may result in elevated drug concentrations and increased exposure. PMID: 30786957 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - February 23, 2019 Category: Drugs & Pharmacology Authors: Bang WS, Hwang YR, Li Z, Lee I, Kang HE Tags: J Pharm Pharm Sci Source Type: research

Evaluation of the Impact of an Inpatient Hyperglycemia Protocol on Glycemic Control.
The objective of this study was to evaluate the impact of an inpatient hyperglycemia protocol on glycemic control. METHODS: This retrospective cohort study at a large, community teaching hospital included adult patients in non-critical care units requiring insulin administration for glycemic control. The intervention examined was utilization of an inpatient hyperglycemia protocol, comprised of a computerized physician order entry order set and provider education at the time of implementation. Two cohorts, a pre-protocol implementation group and a post-protocol implementation group, were compared. The primary outcome w...
Source: J Pharm Pharm Sci - February 9, 2019 Category: Drugs & Pharmacology Authors: Ilcewicz HN, Hennessey EK, Smith CB Tags: J Pharm Pharm Sci Source Type: research

Antidepressant Use and Risk of Venous Thromboembolism: A Systematic Review and Meta-Analysis.
CONCLUSIONS: There was no association between selective serotonin reuptake inhibitor use and VTE risk. Tricyclic antidepressant may be associated with an increased VTE risk, but the quality of evidence was very low. PMID: 30660205 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - January 21, 2019 Category: Drugs & Pharmacology Authors: Wang Y, Ye Z, Liu L, Cui X Tags: J Pharm Pharm Sci Source Type: research

Lifitegrast Ophthalmic Solution 5.0% for Treatment of Dry Eye Disease: Overview of Clinical Trial Program.
Abstract Dry eye disease (DED) is a common inflammatory disorder of the ocular surface. Millions of people are affected by DED worldwide. Lifitegrast is a novel drug designed to inhibit DED-associated ocular inflammation. Four clinical trials have shown that lifitegrast is well tolerated and effective in improving symptoms and signs of DED over 12 weeks. A fifth trial showed long-term safety over 1 year. Lifitegrast has been in clinical use for more than one year in the United States and was recently approved in Canada (in December 2017). In this review, we discuss lifitegrast's novel mechanism of action and provi...
Source: J Pharm Pharm Sci - January 16, 2019 Category: Drugs & Pharmacology Authors: Chan CC, Prokopich CL Tags: J Pharm Pharm Sci Source Type: research

Novel Approaches for Efficient Delivery of Tyrosine Kinase Inhibitors.
This article reviews the recent advances in the design and development of delivery systems for TKIs. PMID: 30636671 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - January 16, 2019 Category: Drugs & Pharmacology Authors: Moradpour Z, Barghi L Tags: J Pharm Pharm Sci Source Type: research

Resveratrol Limits Lipogenesis and Enhance Mitochondrial Activity in HepG2 Cells.
CONCLUSION: This beneficial effect could be helpful in the treatment of NAFLD. PMID: 30522586 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - December 15, 2018 Category: Drugs & Pharmacology Authors: Izdebska M, Herbet M, Gawrońska-Grzywacz M, Piątkowska-Chmiel I, Korga A, Sysa M, Iwan M, Natorska-Chomicka D, Poleszak E, Wróbel A, Mandziuk S, Dudka J Tags: J Pharm Pharm Sci Source Type: research

Appropriateness of Ticagrelor Use at Initiation: A Population-Based Cohort Study.
CONCLUSIONS: A large majority of patients initiated ticagrelor appropriately. Further improvement in appropriateness may come at targeting indication for use. PMID: 30545445 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - December 15, 2018 Category: Drugs & Pharmacology Authors: Gregoire JP, Poirier P, Pérez N, Demers É, Moisan J Tags: J Pharm Pharm Sci Source Type: research