Limited Sampling Strategy for the Estimation of Mycophenolic Acid and its Acyl Glucuronide Metabolite Area under the Concentration-Time Curve in Japanese Lung Transplant Recipients.
CONCLUSION: LSS using three time-point (C1, C4, and C8) provides the most reliable and accurate simultaneous estimation of the AUC0-12 of MPA and AcMPAG in Japanese lung transplant patients. PMID: 31430249 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - August 21, 2019 Category: Drugs & Pharmacology Authors: Tanaka M, Kikuchi M, Takasaki S, Hirasawa T, Sigeta K, Noda A, Akiba M, Matsuda Y, Oishi H, Sado T, Noda M, Okada Y, Mano N, Yamaguchi H Tags: J Pharm Pharm Sci Source Type: research

Developmental Expression of Monocarboxylate Transporter 1 and 4 in Rat Liver.
CONCLUSION: Our study elucidates the transcriptional and translational maturation patterns of MCT1, MCT4 and CD147 expression, with isoform- dependent differences in the liver. Changes in transporter expression during development may greatly influence drug distribution and clearance in pediatric populations. PMID: 31361594 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - July 31, 2019 Category: Drugs & Pharmacology Authors: Ng M, Louie J, Cao J, Felmlee MA Tags: J Pharm Pharm Sci Source Type: research

Comparison of Steroid Hormone Hydroxylations by and Docking to Human Cytochromes P450 3A4 and 3A5.
CONCLUSIONS: The Vmax, rather than Km values, for CYP3A5-mediated 6β-hydroxylation of three steroid hormones were different from those for CYP3A4. Molecular docking simulations could partially explain the differences in the accessibility of substrates to the heme moiety of human CYP3A molecules, resulting in the enzymatic affinity of CYP3A4 and CYP3A5. PMID: 31339834 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - July 25, 2019 Category: Drugs & Pharmacology Authors: Niwa T, Narita K, Okamoto A, Murayama N, Yamazaki H Tags: J Pharm Pharm Sci Source Type: research

Drugs Loaded into Electrospun Polymeric Nanofibers for Delivery.
l-Gómez LJ Abstract The electrospinning technique is a useful and versatile approach for conversion of polymeric solutions into continuous fibers, ranging from a few micrometers (10-100 μm) to the scale of nanometers (10- 100 nm) in diameters. This technique can be used in a vast number of polymers, in some cases after modifying them to the required properties. The high surface-to-volume ratio of the fibers can improve some processes like cell binding and proliferation, drug loading, and mass transfer processes. One of the most important and studied areas of electrospinning is in the drug delivery field,...
Source: J Pharm Pharm Sci - July 24, 2019 Category: Drugs & Pharmacology Authors: Torres-Martinez EJ, Pérez-González GL, Serrano-Medina A, Grande D, Vera-Graziano R, Cornejo-Bravo JM, Villarreal-Gómez LJ Tags: J Pharm Pharm Sci Source Type: research

Effect of Bile Duct Ligation-induced Liver Dysfunction on Methamphetamine Pharmacokinetics and Locomotor Activity in Rats.
CONCLUSIONS: In rats, liver dysfunction reduced METH clearance, increased brain METH concentrations, and enhanced METH effects on locomotor activity in a dose dependent manner. In addition, this model could be further developed to simulate the associated hepatic dysfunction of key METH abuse comorbidities for preclinical testing of novel pharmacotherapies for effectiveness and/or toxicity in vulnerable populations. PMID: 31329536 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - July 24, 2019 Category: Drugs & Pharmacology Authors: Hambuchen MD, Berquist MD, Simecka CM, McGill MR, Gunnell MG, Hendrickson HP, Owens SM Tags: J Pharm Pharm Sci Source Type: research

Prediction of Biopharmaceutical Drug Disposition Classification System (BDDCS) by Structural Parameters.
In this study, structural parameters of drugs were used to develop classification-based models for the prediction of BDDCS class. Reported BDDCS data of drugs were collected from the literature, and structural descriptors (Abraham solvation parameters and octanol-water partition coefficient (log P)) were calculated by ACD/Labs software. Data were divided into training and test sets. Classification-based models were then used to predict the class of each drug in BDDCS system using structural parameters and the validity of the established models was evaluated by an external test set. The results of this study showed that log...
Source: J Pharm Pharm Sci - July 11, 2019 Category: Drugs & Pharmacology Authors: Golfar Y, Shayanfar A Tags: J Pharm Pharm Sci Source Type: research

Inhibition of TLR4/TRIF/IRF3 Signaling Pathway by Curcumin in Breast Cancer Cells.
CONCLUSIONS: Consequently, these results demonstrated that the activation of LPS stimulated TLR4/TRIF/IRF3 signaling pathway was mediated by curcumin in breast cancer cells, in vitro. However, more studies are necessary to examine the curcumin's anti-inflammatory activities on TLR4/MyD88/NF-κB as well as other signaling pathways downstream of TLRs in breast cancer. PMID: 31287789 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - July 11, 2019 Category: Drugs & Pharmacology Authors: Güney Eskiler G, Deveci Özkan A, Kaleli S, Bilir C Tags: J Pharm Pharm Sci Source Type: research

Neuropeptide FF (FLFQPQRF-NH2) and its Fragments Bind to α2δ Subunit of Voltage-Gated Calcium Channels.
CONCLUSION: FLFQPQRF-NH2, FLFQP-NH2 and FLP-NH2 displace bound gabapentin in membrane preparations of rat cerebral cortex. Binding cooperativity was detected when GBP/FLFQP-NH2/FLP-NH2 were incubated together. These novel binding sites may provide new approaches to modulate L-type Ca2+ channels. PMID: 31287790 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - July 11, 2019 Category: Drugs & Pharmacology Authors: Skubatz H Tags: J Pharm Pharm Sci Source Type: research

The Effect of Diuretics on Patients with Heart Failure: A Network Meta-Analysis: Diuretics Effect on Heart Failure Patients.
CONCLUSION: Torasemide might be an optimal treatment for HF patients considering its comprehensive curative effect. PMID: 31287791 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - July 11, 2019 Category: Drugs & Pharmacology Authors: Zhao X, Ren Y, Li H, Liu X Tags: J Pharm Pharm Sci Source Type: research

Understanding the Role of Sodium Lauryl Sulfate on the Biorelevant Solubility of a Combination of Poorly Water-Soluble Drugs Using High Throughput Experimentation and Mechanistic Absorption Modeling.
This study investigates the influence of surfactant sodium lauryl sulfate (SLS) on the solubility of poorly-water soluble drug substances, model Compound X and Compound Y, used in a fixed dose combination oral solid dosage form. To determine the impact of SLS concentration on the solubility of compounds X and Y, we experimentally determined the critical micelle concentration (CMC) of SLS in water, simulated gastric fluid (SGF), and fed state simulated intestinal fluid (FeSSIF) in the presence of Compound X and Compound Y using UV/Visible spectrophotometry at 25°C. The aggregation of SLS was characterized by calculating...
Source: J Pharm Pharm Sci - June 21, 2019 Category: Drugs & Pharmacology Authors: Bahr MN, Modi D, Patel S, Campbell G, Stockdale G Tags: J Pharm Pharm Sci Source Type: research

Drug Targeting Strategies Based on Charge Dependent Uptake of Nanoparticles into Cancer Cells.
Abstract The aim of this review was to describe the preferred charged nano-particles (CNPs) for targeted delivery in tumor cells. Zeta Potential (ZP), which represents the surface charge of NPs was highlighted in cell entrance and interactions. In this regard, various types of endocytosis pathways which are involved in NPs' uptake were first introduced. Then, significance of positively charged NPs (PCNPs) in proton sponge effect corresponding to lysosomal escape was discussed. Cells prefer to endocyte the NPs with positive charge in passive targeting and gene delivery, while in active targeting; the charge of rece...
Source: J Pharm Pharm Sci - May 22, 2019 Category: Drugs & Pharmacology Authors: Saadat M, Zahednezhad F, Zakeri-Milani P, Reza Heidari H, Shahbazi-Mojarrad J, Valizadeh H Tags: J Pharm Pharm Sci Source Type: research

Evaluation of the Physicochemical and Biological Stability of Cetuximab under Various Stress Condition.
In conclusion, we found that all mentioned stress conditions significantly affect the bioactivity of cetuximab. Our finding highlights the importance of bioactivity evaluation of biopharmaceuticals in their quality control assessment. PMID: 31112673 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - May 22, 2019 Category: Drugs & Pharmacology Authors: Farjami A, Siahi-Shadbad M, Akbarzadehlaleh P, Roshanzamir K, Molavi O Tags: J Pharm Pharm Sci Source Type: research

Engineering Size and Structure of Particles in Novel Modified-Release Delivery Systems.
Abstract Particle engineering has become a hot topic in the field of modified-release delivery systems during last decades. It has a wide range of pharmaceutical applications and is a bridge linking between drugs and drug delivery systems. Particles are an important part of many dosage forms and viewed as a carrier of drugs. Their size, shape, crystalline form, and structure directly affect the stability and releasing pattern of drugs. Engineering size or modifying particles by forming porous, core-shell, or skeleton structures can realize the development and utilization of functionally modified release systems (i...
Source: J Pharm Pharm Sci - April 28, 2019 Category: Drugs & Pharmacology Authors: Dong Q, Zheng X, Zhou M, Wu F, Hong Y, Lin X, Shen L Tags: J Pharm Pharm Sci Source Type: research

Mining Small Routine Clinical Data: A Population Pharmacokinetic Model and Optimal Sampling Times of Capecitabine and its Metabolites.
CONCLUSIONS: Capecitabine, 5-DFUR, 5-FU and 5-FUH2 can be correctly described by the joint multicompartmental model presented in this work. The aforementioned times are optimal to maximize the information of samples. Useful knowledge can be obtained for clinical practice from small databases. PMID: 30964613 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - April 11, 2019 Category: Drugs & Pharmacology Authors: Oyaga-Iriarte E, Insausti A, Bueno L, Sayar O, Aldaz A Tags: J Pharm Pharm Sci Source Type: research

Effects of Orotic Acid-Induced Non-Alcoholic Fatty Liver on the Pharmacokinetics of Metoprolol and its Metabolites in Rats.
CONCLUSIONS: NALFD can lead to a reduction in the hepatic CLint of a drug if it is a substrate of the CYP2D subfamily. The decreased clearance may result in elevated drug concentrations and increased exposure. PMID: 30786957 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - February 23, 2019 Category: Drugs & Pharmacology Authors: Bang WS, Hwang YR, Li Z, Lee I, Kang HE Tags: J Pharm Pharm Sci Source Type: research

Evaluation of the Impact of an Inpatient Hyperglycemia Protocol on Glycemic Control.
The objective of this study was to evaluate the impact of an inpatient hyperglycemia protocol on glycemic control. METHODS: This retrospective cohort study at a large, community teaching hospital included adult patients in non-critical care units requiring insulin administration for glycemic control. The intervention examined was utilization of an inpatient hyperglycemia protocol, comprised of a computerized physician order entry order set and provider education at the time of implementation. Two cohorts, a pre-protocol implementation group and a post-protocol implementation group, were compared. The primary outcome w...
Source: J Pharm Pharm Sci - February 9, 2019 Category: Drugs & Pharmacology Authors: Ilcewicz HN, Hennessey EK, Smith CB Tags: J Pharm Pharm Sci Source Type: research

Antidepressant Use and Risk of Venous Thromboembolism: A Systematic Review and Meta-Analysis.
CONCLUSIONS: There was no association between selective serotonin reuptake inhibitor use and VTE risk. Tricyclic antidepressant may be associated with an increased VTE risk, but the quality of evidence was very low. PMID: 30660205 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - January 21, 2019 Category: Drugs & Pharmacology Authors: Wang Y, Ye Z, Liu L, Cui X Tags: J Pharm Pharm Sci Source Type: research

Lifitegrast Ophthalmic Solution 5.0% for Treatment of Dry Eye Disease: Overview of Clinical Trial Program.
Abstract Dry eye disease (DED) is a common inflammatory disorder of the ocular surface. Millions of people are affected by DED worldwide. Lifitegrast is a novel drug designed to inhibit DED-associated ocular inflammation. Four clinical trials have shown that lifitegrast is well tolerated and effective in improving symptoms and signs of DED over 12 weeks. A fifth trial showed long-term safety over 1 year. Lifitegrast has been in clinical use for more than one year in the United States and was recently approved in Canada (in December 2017). In this review, we discuss lifitegrast's novel mechanism of action and provi...
Source: J Pharm Pharm Sci - January 16, 2019 Category: Drugs & Pharmacology Authors: Chan CC, Prokopich CL Tags: J Pharm Pharm Sci Source Type: research

Novel Approaches for Efficient Delivery of Tyrosine Kinase Inhibitors.
This article reviews the recent advances in the design and development of delivery systems for TKIs. PMID: 30636671 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - January 16, 2019 Category: Drugs & Pharmacology Authors: Moradpour Z, Barghi L Tags: J Pharm Pharm Sci Source Type: research

Resveratrol Limits Lipogenesis and Enhance Mitochondrial Activity in HepG2 Cells.
CONCLUSION: This beneficial effect could be helpful in the treatment of NAFLD. PMID: 30522586 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - December 15, 2018 Category: Drugs & Pharmacology Authors: Izdebska M, Herbet M, Gawrońska-Grzywacz M, Piątkowska-Chmiel I, Korga A, Sysa M, Iwan M, Natorska-Chomicka D, Poleszak E, Wróbel A, Mandziuk S, Dudka J Tags: J Pharm Pharm Sci Source Type: research

Appropriateness of Ticagrelor Use at Initiation: A Population-Based Cohort Study.
CONCLUSIONS: A large majority of patients initiated ticagrelor appropriately. Further improvement in appropriateness may come at targeting indication for use. PMID: 30545445 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - December 15, 2018 Category: Drugs & Pharmacology Authors: Gregoire JP, Poirier P, Pérez N, Demers É, Moisan J Tags: J Pharm Pharm Sci Source Type: research

The Use of High Sensitivity C-Reactive Protein in Cardiovascular Disease Detection.
Abstract Cardiovascular diseases (CVDs) are responsible for a high mortality rate worldwide. One of the most common causes of CVDs is vascular inflammation associated to atherosclerosis. Inflammatory biomarkers are used to assist the detection of CVDs and monitor their evaluation, prognosis and therapy implementation. C-reactive protein (CRP) is an acute phase protein produced after stimulation by pro-inflammatory cytokines. CRP is a biomarker of the inflammatory reaction and an important mediator of atherosclerosis. Given it actively contributes to the development of the atherosclerotic plaque, instability and su...
Source: J Pharm Pharm Sci - December 1, 2018 Category: Drugs & Pharmacology Authors: Castro AR, Silva SO, Soares SC Tags: J Pharm Pharm Sci Source Type: research

Progress on Active Analgesic Components and Mechanisms of Commonly Used Traditional Chinese Medicines: A Comprehensive Review.
Abstract Many clinical diseases are accompanied by the symptoms of pain, and the degree of pain is closely related to the patients' suffering. Therefore, effectively relieving pain has become one of the vital concerns of clinical treatment and analgesic drug research. Non-opioid drugs are mainly used for the clinical treatment of mild to moderate pain, whereas opioid drugs are mainly used for treating moderate to severe pain. However, opioid drugs easily elicit adverse reactions, such as gastrointestinal discomfort, addiction, dependence, and so on. Traditional Chinese medicine and its active ingredients have uniq...
Source: J Pharm Pharm Sci - November 24, 2018 Category: Drugs & Pharmacology Authors: Wang R, Han L, Gao Q, Chen D, Wang Y, Zhang X, Yu X, Zhang Y, Li Z, Bai C Tags: J Pharm Pharm Sci Source Type: research

STAT3 is involved in IL-6-Mediated Downregulation of Hepatic Transporters in Mice.
CONCLUSIONS: Our findings demonstrate that IL-6 imposes a significant downregulation of numerous ABC and SLC transporters in liver primarily through activation of the STAT3 signaling pathway. Based on time-dependent changes in transporter expression, downregulation likely occurs downstream of STAT3 activation.  As IL-6 is elevated in many diseases, understanding the underlying mechanism(s) involved in transporter dysregulation will allow us to predict potential drug-disease interactions. PMID: 30465708 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - November 24, 2018 Category: Drugs & Pharmacology Authors: Abualsunun WA, Piquette-Miller M Tags: J Pharm Pharm Sci Source Type: research

The Controversies, Challenges and Complexities of Lyme Disease: A Narrative Review.
CONCLUSION: Despite growing global incidence of the Lyme disease, treatment has not attracted pharmaceutical investment, and the evidence base and international guidelines for treatment and management of chronic Lyme continue to be conflicting and controversial. The challenges of this immune mediated tick borne disease for public health policy and clinical practice are summarised, alongside directions for future research. PMID: 30458921 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - November 22, 2018 Category: Drugs & Pharmacology Authors: Van Hout MC Tags: J Pharm Pharm Sci Source Type: research

Treating Children with ASD: The Perspective of Caregivers.
CONCLUSIONS: Better education and awareness are necessary to help ASD children and their families. Pharmacists should explore opportunities to provide better services. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 30424832 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - November 15, 2018 Category: Drugs & Pharmacology Authors: Breik N, Kuo IF, Bugden S, Moffat M, Alessi-Severini S Tags: J Pharm Pharm Sci Source Type: research

Revisiting FDA's 1995 Guidance on Bioequivalence Establishment of Topical Dermatologic Corticosteroids: New Research Based Recommendations.
CONCLUSIONS: The population ED50 estimates were influenced by both the type of population modeling methods and the distribution assumptions. We recommend updating the FDA guidance with more specific instructions related to the population approach to be used (EM-like versus FOCE-like methods) and to the normality assumptions that need to be set (ln-normal versus normal distribution). PMID: 30407906 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - November 10, 2018 Category: Drugs & Pharmacology Authors: Ozdin D, Sharma N, Lujan-Zilbermann J, Colucci P, Kanfer I, Ducharme MP Tags: J Pharm Pharm Sci Source Type: research

The Antioxidant Activity of Recombinant Rat Hepatic Fatty Acid Binding Protein T94A Variant.
Abstract PURPOSE: Liver fatty acid binding protein (FABP1) is a cytoplasmic polypeptide that transports substrates throughout the cytosol and functions as an antioxidant. A common polymorphic variant, FABP1 T94A has a minor allele frequency of 26-38%, 8.3±1.9% homozygous in the human population. The purpose of this study was to mutate and isolate recombinant rat FABP1 to the T94A variant to evaluate the mutant's antioxidant activity using in vitro studies. METHODS: Site-directed mutagenesis was used to generate a mutation in rat cDNA within a pGEX-6p-2 vector. This plasmid was transformed into competen...
Source: J Pharm Pharm Sci - November 10, 2018 Category: Drugs & Pharmacology Authors: Le T, Gong Y, Davies NM, Lillico R, Lakowski T, Roberts MS, Burczynski FJ Tags: J Pharm Pharm Sci Source Type: research

Moving towards Universal Coverage of Direct-Acting Antiviral Therapies for Hepatitis C Infection in Canada: An Environmental Scan of Canadian Provinces and International Jurisdictions.
CONCLUSION: DAAs appear to be generally accessible through public drug plans in Canada compared to other countries. PMID: 30407908 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - November 10, 2018 Category: Drugs & Pharmacology Authors: Myers S, Khosa G, Kuo IF, Janzen D, Alessi-Severini S Tags: J Pharm Pharm Sci Source Type: research

Appropriateness of Ticagrelor Use at Initiation: A Population-Based Cohort Study.
CONCLUSIONS: A large majority of patients initiated ticagrelor appropriately. Further improvement in appropriateness may come at targeting indication for use. PMID: 30384882 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - November 4, 2018 Category: Drugs & Pharmacology Authors: Gregoire JP, Poirier P, Pérez N, Demers É, Moisan J Tags: J Pharm Pharm Sci Source Type: research

Nano-sized Droplets of Self-Emulsifying System for Enhancing Oral Bioavailability of Chemotherapeutic Agent VP-16 in Rats: A Nano Lipid Carrier for BCS Class IV Drugs.
CONCLUSION: The SNEDDS formulation was able to enhance the oral bioavailability of the BCS Class IV chemotherapeutic agent VP-16 by increasing the dissolution and absorption of the drug. A good in vitro in vivo correlation was found between the in vitro dissolution and in vivo absorption data of VP-16 SNEDDS preparation. Therefore, SNEDDS formulations might be a very promising approach for BCS Class IV drugs. PMID: 30365396 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - October 28, 2018 Category: Drugs & Pharmacology Authors: Khalid N, Sarfraz M, Arafat M, Akhtar M, Löbenberg R, Ur Rehman N Tags: J Pharm Pharm Sci Source Type: research

Rh-endostatin Concomitant with Chemotherapy Versus Single Agent Chemotherapy for Treating Soft Tissue and Bone Sarcomas: A Systematic Review and Meta-Analysis.
Conclusions: Rh-endostatin combined chemotherapeutic agents significantly improved clinical efficacy compared with chemotherapeutic agents alone in treating bone and soft tissue sarcomas. Moreover, combination of rh-endostatin with chemotherapy didn't increase the incidence of AEs. But more high quality RCTs with  large  sample  size  should  be  done  in  the  future  to confirm the conclusion. PMID: 30352660 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - October 26, 2018 Category: Drugs & Pharmacology Authors: Ma Z, Guo L, Cui X, Liu H, Liu L Tags: J Pharm Pharm Sci Source Type: research

Lymphatic Drug Absorption via the Enterocytes: Pharmacokinetic Simulation, Modeling, and Considerations for Optimal Drug Development.
In this report, an in silico modeling approach was adopted to delineate the salient pharmacokinetic features of lymphatic absorption, and provide further guidance for the rationale design of drugs and drug delivery systems for lymphatic drug transport. The importance of hepatic extraction ratio, absorption lag time, lipoprotein binding, and the influence of competing portal and lymphatic pathways for systemic drug availability were explored using simulations. The degree of hepatic extraction was found to be an essential consideration when examining the influence of lymphatic uptake to overall oral drug bioavailability. Lym...
Source: J Pharm Pharm Sci - October 25, 2018 Category: Drugs & Pharmacology Authors: Brocks DR, Davies NM Tags: J Pharm Pharm Sci Source Type: research

Application of in Silico Tools in Clinical Practice using Ketoconazole as a Model Drug.
HG Abstract Hypochlorhydria is a condition where the production of hydrochloric acid in the stomach is decreased. As a result, the intragastric pH is elevated. This condition can be due to a series of causes, such as disease (gastric mucosal infection caused by Helicobacter pylori and is prominent in AIDS patients), ethnicity, age and also the use of antisecretory agents. This may significantly impact the absorption of other drugs that have pH-dependent solubility, such as ketoconazole, a weak base. Within this context, the purpose of this study was to demonstrate how GastroPlusTM - a physiological based software...
Source: J Pharm Pharm Sci - October 25, 2018 Category: Drugs & Pharmacology Authors: Silva DA, Duque MD, Davies NM, Löbenberg R, Ferraz HG Tags: J Pharm Pharm Sci Source Type: research

Positron Emission Tomography (PET) and Pharmacokinetics: Classical Blood Sampling Versus Image-Derived Analysis of [18F]FAZA and [18F]FDG in a Murine Tumor Bearing Model.
CONCLUSIONS: The present study provides a working example of the applicability of functional PET imaging as a suitable tool to determine PK parameters in small animals. The comparative analysis in the current study demonstrates that it is feasible to use [18F]FDG PET and [18F]FAZA PET in the same model to analyze their blood PK parameters, and to estimate kinetic parameters for these tracers in tumor. This non-invasive imaging-based determination of tissue kinetic parameters facilitates translation from pre-clinical to clinical phases of drug development. This article is open to POST-PUBLICATION REVIEW. Registered rea...
Source: J Pharm Pharm Sci - October 22, 2018 Category: Drugs & Pharmacology Authors: Jans HS, Yang XH, Brocks DR, Kumar P, Wuest M, Wiebe LI Tags: J Pharm Pharm Sci Source Type: research

Research on the Scientific Evolution of the Flavonoid Agathisflavone.
CONCLUSION: Although agathisflavone has been known in the literature since at least 1969, only 23 of the eligible articles found evaluated its possible therapeutic effects. The demonstrated biological activities of agathisflavone range from antiprotozoal to neurogenesis and neuroprotection, however, the molecule needs to be better studied at the in vivo and human level. PMID: 30342562 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - October 22, 2018 Category: Drugs & Pharmacology Authors: De Amorim VCM, Júnior MSO, Bastos EMS, Da Silva VDA, Costa SL Tags: J Pharm Pharm Sci Source Type: research

Cytotoxicity of Structurally Diverse Anthranoids and Correlation with Mechanism of Action and Side Effects.
Abstract The purpose of this contribution is to evaluate the cytotoxicity and apoptosis inducing ability of structurally diverse anthraquinones to establish a relationship between structure and toxicity. Besides the wide spread use of anthraquinones in pharmacological drugs for constipation and non-prescription dietary supplements for weight loss, extracts are still commercialized as crude extracts and long-term side effects are still relevant. In this work we developed a method to quantify the cascarosides isolated from Rhamnus purshiana (Cascara Sagrada) using LC-MS/MS and evaluated the effects of this extract a...
Source: J Pharm Pharm Sci - October 16, 2018 Category: Drugs & Pharmacology Authors: Demarque DP, Silva RMP, Santos LF, Leopoldino AM, Espreafico EM, Lopes NP Tags: J Pharm Pharm Sci Source Type: research

Preparation and Characterization of Spray-Dried Inhalable Powders Containing Polymeric Micelles for Pulmonary Delivery of Paclitaxel in Lung Cancer.
CONCLUSION: These results demonstrate that this novel PTX-loaded micelles embedded in dry powder inhalation aerosol platform has a great potential to be used in lung cancer treatment. PMID: 30321135 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - October 16, 2018 Category: Drugs & Pharmacology Authors: Rezazadeh M, Davatsaz Z, Emami J, Hasanzadeh F, Jahanian-Najafabadi A Tags: J Pharm Pharm Sci Source Type: research

Design and Evaluation of Gemini Surfactant-Based Lipoplexes Modified with Cell-Binding Peptide for Targeted Gene Therapy in Melanoma Model.
Conclusion The gemini surfactant-based lipoplexes modified with p18-4 peptide showed significantly higher efficiency and safety compared to the system that did not contain a cancer targeting peptide and provided evidence for their potential application to achieve targeted melanoma gene therapy. PMID: 30266136 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - October 1, 2018 Category: Drugs & Pharmacology Authors: Mohammed-Saeid W, Soudy R, Tikoo R, Kaur K, Verrall RE, Badea I Tags: J Pharm Pharm Sci Source Type: research

Targeted Nanostructured Lipid Carrier for Brain Delivery of Artemisinin: Design, Preparation, Characterization, Optimization and Cell Toxicity.
Abstract In the present study, a transferrin-conjugated nanostructured lipid carrier (TF-NLCs) for brain delivery of artemisinin (ART) was developed. ART-loaded NLCs (ART-NLCs) were prepared using solvent evaporation method and the impact of various formulation or process variables on the responses were assessed using a Taguchi design. Optimized ART-NLC was then coupled with transferrin as targeting ligand and its in vitro cytotoxicity was investigated against U-87MG brain cancer cell line. As a result, the following values are suggested by the software to prepare the optimized formulation: 20 mg Compritol®, 0...
Source: J Pharm Pharm Sci - October 1, 2018 Category: Drugs & Pharmacology Authors: Emami J, Yousefian H, Sadeghi H Tags: J Pharm Pharm Sci Source Type: research

Pharmacokinetic Variability in Pediatrics and Intensive Care: Toward a Personalized Dosing Approach.
Abstract Providing a safe and efficacious drug therapy for large and often heterogeneous populations is a challenging objective in clinical drug development and routine clinical practice. It has been known for years that the optimum dose required for many therapeutic agents among individuals is quite variable. A wide interindividual pharmacokinetic variability was described in clinically relevant populations such as pediatrics and critically ill patients. The aim of this article was to present the main individual factors influencing variability in these two populations and their applications. Growth and developmen...
Source: J Pharm Pharm Sci - September 19, 2018 Category: Drugs & Pharmacology Authors: Marsot A Tags: J Pharm Pharm Sci Source Type: research

Gorlin Syndrome Presentation and the Importance of Differential Diagnosis of Skin Cancer: A Case Report.
We describe a 68-year-old female who presented to the dermatology office with a previous history of over 30 BCCs that had been previously biopsied and/or surgically removed. However, the patient had been lost to follow up for several years and had not been seen by a skin specialist. In the interim, she had been misdiagnosed as having eczematous or psoriatic lesions by primary care providers. Patients with Gorlin syndrome are even harder to diagnose as their skin cancers often do not possess the classic features associated with a basal cell or squamous cell carcinoma. When in doubt, and especially if failing topical therapy...
Source: J Pharm Pharm Sci - September 9, 2018 Category: Drugs & Pharmacology Authors: Sangera-Grewal R, Singh Grewal P Tags: J Pharm Pharm Sci Source Type: research

Identification of Mechanism and Pathway of the Interaction between the African Traditional Medicine, Sutherlandia Frutescens, and the Antiretroviral Protease Inhibitor, Atazanavir, in Human Subjects Using Population Pharmacokinetic (PK) Analysis.
This study has highlighted the utility of population PK analyses in postulating probable mechanism(s) whereby an ATM or a herbal medicine interacts with an allopathic drug. PMID: 30158052 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - September 1, 2018 Category: Drugs & Pharmacology Authors: Muller AC, Ducharme MP, Kanfer I Tags: J Pharm Pharm Sci Source Type: research

A Case for Alpha-Lipoic Acid as an Alternative Treatment for Diabetic Polyneuropathy.
CONCLUSIONS: ALA demonstrates effectiveness in treating DPN through multiple mechanisms to modulate pathophysiology and control symptoms. In addition, ALA exhibits activity in weight management and insulin sensitivity. The use of ALA for DPN in the US is worth considering because commonly prescribed medications have unclear mechanisms, more pronounced adverse effects, and are more expensive than ALA.  Further research needs to be conducted to assess long-term efficacy of ALA in US patients. PMID: 30139425 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - August 26, 2018 Category: Drugs & Pharmacology Authors: Nguyen N, Takemoto JK Tags: J Pharm Pharm Sci Source Type: research

Pharmacokinetics of Orally Administered Poly(Ethylene Oxide)-block-Poly( ε-Caprolactone) Micelles of Cyclosporine A in Rats: Comparison with Neoral®.
Pharmacokinetics of Orally Administered Poly(Ethylene Oxide)-block-Poly(ε-Caprolactone) Micelles of Cyclosporine A in Rats: Comparison with Neoral®. J Pharm Pharm Sci. 2018;21(1s):192s-199s Authors: Binkhathlan Z, Ali R, Qamar W, Lavasanifar A Abstract PURPOSE: The aim of this study was to assess the pharmacokinetics of methoxy poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL) micellar formulation of cyclosporine A (CyA) following oral administration in rats making comparisons with its commercial microemulsion formulation, Neoral®. METHODS: PEO-b-PCL copolymer wa...
Source: J Pharm Pharm Sci - August 26, 2018 Category: Drugs & Pharmacology Authors: Binkhathlan Z, Ali R, Qamar W, Lavasanifar A Tags: J Pharm Pharm Sci Source Type: research

Therapeutic Drug Monitoring of Levetiracetam in Select Populations.
CONCLUSION: Routine TDM of levetiracetam is not recommended for all populations, however, it may be beneficial to maintain an individual therapeutic range in patients where the PK of LEV may be altered, such as in patients who are critically ill patients, pregnant, pediatrics or elderly. PMID: 30096051 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - August 12, 2018 Category: Drugs & Pharmacology Authors: Jarvie D, Mahmoud SH Tags: J Pharm Pharm Sci Source Type: research

Mast Cells Stimulated with Peptidoglycan from Staphylococcus aureus Augment the Development of Th1 Cells.
CONCLUSIONS: Colonization of S. aureus on the lesioned skin of AD patients contributes to not only an increase in the number of mast cells but also Th1 cell development mediated by mast cells in the dermis and subsequent induction of chronic inflammation, which is characterized by up-regulation of the Th1 cytokine, interferon (IFN)- g. Therefore, application of josamycin to the lesional skin of AD patients may provide relief from chronic inflammation mediated by mast cells. PMID: 30012242 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - July 19, 2018 Category: Drugs & Pharmacology Authors: Matsui K, Kanai S, Ikuta M, Horikawa S Tags: J Pharm Pharm Sci Source Type: research

Purchasing Over The Counter (OTC) Medicinal Products Containing Codeine - Easy Access, Advertising, Misuse and Perceptions of Medicinal Risk.
CONCLUSIONS: Codeine containing products are widely purchased and used in all three jurisdictions. Whilst the majority of customers appear to have some awareness and knowledge of risks, it does not materially impact on their purchasing behaviour with a substantial minority purchasing/using such products on a weekly basis. This regularity of purchase whilst indicative of the popularity of such products, may also be a potential indicator of misuse. Future research is needed in relation to cultural and gendered differences and targeted information giving and harm reduction initiatives for safe usage of these medicinal product...
Source: J Pharm Pharm Sci - July 17, 2018 Category: Drugs & Pharmacology Authors: Wells JS, Bergin M, Van Hout MC, McGuinness P, De Pleissisc J, Rich E, Dada S, Wells R, Gooney MA Tags: J Pharm Pharm Sci Source Type: research

A Combined Computer-Aided Approach to Drive the Identification of Potential Epitopes in Protein Therapeutics.
o KFM Abstract BACKGROUND: The identification of fragment sequences, or motifs, within a therapeutic protein that may elicit an immune response when processed by T-cells can be provided by computer-aided approaches. Immunogenicity is a significant problem associated with protein therapeutics and should be investigated in the early stage of protein-based drug development to avoid treatment resistance and potentially life-threatening immune responses. PURPOSE: To provide a combined computer-aided protocol for investigating the immunogenic profile of a recombinant Kunitz-type inhibitor, which has been reported a...
Source: J Pharm Pharm Sci - July 17, 2018 Category: Drugs & Pharmacology Authors: Galvão da Silva BAV, Chudzinski-Tavassi AM, Pasqualoto KFM Tags: J Pharm Pharm Sci Source Type: research

Factors Affecting Opioid Treatment in Cancer Patients.
Abstract PURPOSE: Pain is prevalent in cancer patients, appearing to be moderate to severe in more than one third of them. Despite the fact that fentanyl is widely used with effective analgesic results, some patients do not correspond to treatment, resulting in opioid change. METHODS: This is a cohort study, performed in Greek patients with cancer. Its scope was to identify potential reasons responsible for opioid change, due to transdermal-fentanyl intolerance, resulting from inadequate analgesia (pain relief
Source: J Pharm Pharm Sci - July 17, 2018 Category: Drugs & Pharmacology Authors: Symeonidi M, Panagiotou I, Tsilika E, Roumeliotou A, Galanos A, Mystakidou K Tags: J Pharm Pharm Sci Source Type: research