Secondary Pure Red Cell Aplasia During Daratumumab/ Hyaluronidase Therapy for Multiple Myeloma
Oncology (Williston Park). 2023 Oct 10;37(10):419-424. doi: 10.46883/2023.25921006.ABSTRACTPredominantly autoimmune in origin, severe normochromic, normocytic anemia with reticulocytopenia in the setting of the normal production of leukocytes and megakaryocytic lineages is known as pure red cell aplasia (PRCA), which is unlike aplastic anemia in which all lineages are affected due to a stem cell defect. PRCA can be primary (such as autoimmune) or acquired, which can be an acute self-limited illness or a chronic disease that may be induced by medications, including immunotherapy such as monoclonal antibodies (mAbs). Daratum...
Source: Oncology (Williston Park, N.Y.) - October 25, 2023 Category: Cancer & Oncology Authors: Ludovic Saba Kevin S Landau Silvia Bunting Chakra P Chaulagain Source Type: research
Secondary Pure Red Cell Aplasia During Daratumumab/ Hyaluronidase Therapy for Multiple Myeloma
Oncology (Williston Park). 2023 Oct 10;37(10):419-424. doi: 10.46883/2023.25921006.ABSTRACTPredominantly autoimmune in origin, severe normochromic, normocytic anemia with reticulocytopenia in the setting of the normal production of leukocytes and megakaryocytic lineages is known as pure red cell aplasia (PRCA), which is unlike aplastic anemia in which all lineages are affected due to a stem cell defect. PRCA can be primary (such as autoimmune) or acquired, which can be an acute self-limited illness or a chronic disease that may be induced by medications, including immunotherapy such as monoclonal antibodies (mAbs). Daratum...
Source: Oncology (Williston Park, N.Y.) - October 25, 2023 Category: Cancer & Oncology Authors: Ludovic Saba Kevin S Landau Silvia Bunting Chakra P Chaulagain Source Type: research
Secondary Pure Red Cell Aplasia During Daratumumab/ Hyaluronidase Therapy for Multiple Myeloma
Oncology (Williston Park). 2023 Oct 10;37(10):419-424. doi: 10.46883/2023.25921006.ABSTRACTPredominantly autoimmune in origin, severe normochromic, normocytic anemia with reticulocytopenia in the setting of the normal production of leukocytes and megakaryocytic lineages is known as pure red cell aplasia (PRCA), which is unlike aplastic anemia in which all lineages are affected due to a stem cell defect. PRCA can be primary (such as autoimmune) or acquired, which can be an acute self-limited illness or a chronic disease that may be induced by medications, including immunotherapy such as monoclonal antibodies (mAbs). Daratum...
Source: Oncology (Williston Park, N.Y.) - October 25, 2023 Category: Cancer & Oncology Authors: Ludovic Saba Kevin S Landau Silvia Bunting Chakra P Chaulagain Source Type: research
Secondary Pure Red Cell Aplasia During Daratumumab/ Hyaluronidase Therapy for Multiple Myeloma
Oncology (Williston Park). 2023 Oct 10;37(10):419-424. doi: 10.46883/2023.25921006.ABSTRACTPredominantly autoimmune in origin, severe normochromic, normocytic anemia with reticulocytopenia in the setting of the normal production of leukocytes and megakaryocytic lineages is known as pure red cell aplasia (PRCA), which is unlike aplastic anemia in which all lineages are affected due to a stem cell defect. PRCA can be primary (such as autoimmune) or acquired, which can be an acute self-limited illness or a chronic disease that may be induced by medications, including immunotherapy such as monoclonal antibodies (mAbs). Daratum...
Source: Oncology (Williston Park, N.Y.) - October 25, 2023 Category: Cancer & Oncology Authors: Ludovic Saba Kevin S Landau Silvia Bunting Chakra P Chaulagain Source Type: research
Comparison of anti-thymocyte globulin-based immunosuppressive therapy and allogeneic hematopoietic stem cell transplantation in patients with transfusion-dependent non-severe aplastic anaemia: a retrospective study from a single centre
CONCLUSIONS: Prior treatment history, disease duration, and serum ferritin levels should be carefully weighed when making the choice between ATG-based IST and allo-HSCT for TD-NSAA.PMID:37871262 | DOI:10.1080/07853890.2023.2271475 (Source: Annals of Medicine)
Source: Annals of Medicine - October 23, 2023 Category: Internal Medicine Authors: Yingying Shen Yuzhu Li Qi Liu Wenbin Liu Qinghong Yu Huijin Hu Shan Liu Jingjie Dong Min Xu Yaonan Hong Ying Chen Shu Deng Haifeng Zhuang Zhiping Hu Shenyun Lin Yiping Shen Jianping Shen Yuhong Zhou Baodong Ye Dijiong Wu Source Type: research
Comparison of anti-thymocyte globulin-based immunosuppressive therapy and allogeneic hematopoietic stem cell transplantation in patients with transfusion-dependent non-severe aplastic anaemia: a retrospective study from a single centre
CONCLUSIONS: Prior treatment history, disease duration, and serum ferritin levels should be carefully weighed when making the choice between ATG-based IST and allo-HSCT for TD-NSAA.PMID:37871262 | PMC:PMC10595398 | DOI:10.1080/07853890.2023.2271475 (Source: Annals of Medicine)
Source: Annals of Medicine - October 23, 2023 Category: Internal Medicine Authors: Yingying Shen Yuzhu Li Qi Liu Wenbin Liu Qinghong Yu Huijin Hu Shan Liu Jingjie Dong Min Xu Yaonan Hong Ying Chen Shu Deng Haifeng Zhuang Zhiping Hu Shenyun Lin Yiping Shen Jianping Shen Yuhong Zhou Baodong Ye Dijiong Wu Source Type: research
Why Pharmacovigilance of Non-steroidal Anti-inflammatory Drugs is Important in India?
CONCLUSION: In order to rationally prescribe NSAIDs, it is essential to be aware of probable ADR's and establish prescription guidelines. Prescribers' behaviour can be changed toward excellent prescribing practices by conducting routine prescription assessments dealing with NSAIDs and providing feedback. In the near future, it will be critical to strengthen ADR data management and expand the reach of pharmacovigilance programs, ADR monitoring centers, and healthcare professionals' especially pharmacists' training in rural locations.PMID:37855282 | DOI:10.2174/0118715303247469230926092404 (Source: Endocrine, Metabolic and I...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 19, 2023 Category: Drugs & Pharmacology Authors: Subhransu Dash Preet Amol Singh Neha Bajwa Abinash Choudhury Preeti Bisht Rajiv Sharma Source Type: research
Why Pharmacovigilance of Non-steroidal Anti-inflammatory Drugs is Important in India?
CONCLUSION: In order to rationally prescribe NSAIDs, it is essential to be aware of probable ADR's and establish prescription guidelines. Prescribers' behaviour can be changed toward excellent prescribing practices by conducting routine prescription assessments dealing with NSAIDs and providing feedback. In the near future, it will be critical to strengthen ADR data management and expand the reach of pharmacovigilance programs, ADR monitoring centers, and healthcare professionals' especially pharmacists' training in rural locations.PMID:37855282 | DOI:10.2174/0118715303247469230926092404 (Source: Endocrine, Metabolic and I...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 19, 2023 Category: Endocrinology Authors: Subhransu Dash Preet Amol Singh Neha Bajwa Abinash Choudhury Preeti Bisht Rajiv Sharma Source Type: research
Why Pharmacovigilance of Non-steroidal Anti-inflammatory Drugs is Important in India?
CONCLUSION: In order to rationally prescribe NSAIDs, it is essential to be aware of probable ADR's and establish prescription guidelines. Prescribers' behaviour can be changed toward excellent prescribing practices by conducting routine prescription assessments dealing with NSAIDs and providing feedback. In the near future, it will be critical to strengthen ADR data management and expand the reach of pharmacovigilance programs, ADR monitoring centers, and healthcare professionals' especially pharmacists' training in rural locations.PMID:37855282 | DOI:10.2174/0118715303247469230926092404 (Source: Endocrine, Metabolic and I...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 19, 2023 Category: Drugs & Pharmacology Authors: Subhransu Dash Preet Amol Singh Neha Bajwa Abinash Choudhury Preeti Bisht Rajiv Sharma Source Type: research
Why Pharmacovigilance of Non-steroidal Anti-inflammatory Drugs is Important in India?
CONCLUSION: In order to rationally prescribe NSAIDs, it is essential to be aware of probable ADR's and establish prescription guidelines. Prescribers' behaviour can be changed toward excellent prescribing practices by conducting routine prescription assessments dealing with NSAIDs and providing feedback. In the near future, it will be critical to strengthen ADR data management and expand the reach of pharmacovigilance programs, ADR monitoring centers, and healthcare professionals' especially pharmacists' training in rural locations.PMID:37855282 | DOI:10.2174/0118715303247469230926092404 (Source: Endocrine, Metabolic and I...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 19, 2023 Category: Endocrinology Authors: Subhransu Dash Preet Amol Singh Neha Bajwa Abinash Choudhury Preeti Bisht Rajiv Sharma Source Type: research
Clonal Hematopoiesis, Inflammation, and Hematologic Malignancy
Annu Rev Pathol. 2023 Oct 13. doi: 10.1146/annurev-pathmechdis-051222-122724. Online ahead of print.ABSTRACTSomatic or acquired mutations are postzygotic genetic variations that can occur within any tissue. These mutations accumulate during aging and have classically been linked to malignant processes. Tremendous advancements over the past years have led to a deeper understanding of the role of somatic mutations in benign and malignant age-related diseases. Here, we review the somatic mutations that accumulate in the blood and their connection to disease states, with a particular focus on inflammatory diseases and myelodys...
Source: Annual Review of Pathology - October 13, 2023 Category: Pathology Authors: Rashmi Kanagal-Shamanna David B Beck Katherine R Calvo Source Type: research
Clonal Hematopoiesis, Inflammation, and Hematologic Malignancy
Annu Rev Pathol. 2023 Oct 13. doi: 10.1146/annurev-pathmechdis-051222-122724. Online ahead of print.ABSTRACTSomatic or acquired mutations are postzygotic genetic variations that can occur within any tissue. These mutations accumulate during aging and have classically been linked to malignant processes. Tremendous advancements over the past years have led to a deeper understanding of the role of somatic mutations in benign and malignant age-related diseases. Here, we review the somatic mutations that accumulate in the blood and their connection to disease states, with a particular focus on inflammatory diseases and myelodys...
Source: Annual Review of Pathology - October 13, 2023 Category: Pathology Authors: Rashmi Kanagal-Shamanna David B Beck Katherine R Calvo Source Type: research
Clonal Hematopoiesis, Inflammation, and Hematologic Malignancy
Annu Rev Pathol. 2023 Oct 13. doi: 10.1146/annurev-pathmechdis-051222-122724. Online ahead of print.ABSTRACTSomatic or acquired mutations are postzygotic genetic variations that can occur within any tissue. These mutations accumulate during aging and have classically been linked to malignant processes. Tremendous advancements over the past years have led to a deeper understanding of the role of somatic mutations in benign and malignant age-related diseases. Here, we review the somatic mutations that accumulate in the blood and their connection to disease states, with a particular focus on inflammatory diseases and myelodys...
Source: Annual Review of Pathology - October 13, 2023 Category: Pathology Authors: Rashmi Kanagal-Shamanna David B Beck Katherine R Calvo Source Type: research
Clonal Hematopoiesis, Inflammation, and Hematologic Malignancy
Annu Rev Pathol. 2023 Oct 13. doi: 10.1146/annurev-pathmechdis-051222-122724. Online ahead of print.ABSTRACTSomatic or acquired mutations are postzygotic genetic variations that can occur within any tissue. These mutations accumulate during aging and have classically been linked to malignant processes. Tremendous advancements over the past years have led to a deeper understanding of the role of somatic mutations in benign and malignant age-related diseases. Here, we review the somatic mutations that accumulate in the blood and their connection to disease states, with a particular focus on inflammatory diseases and myelodys...
Source: Annual Review of Pathology - October 13, 2023 Category: Pathology Authors: Rashmi Kanagal-Shamanna David B Beck Katherine R Calvo Source Type: research
Clonal Hematopoiesis, Inflammation, and Hematologic Malignancy
Annu Rev Pathol. 2023 Oct 13. doi: 10.1146/annurev-pathmechdis-051222-122724. Online ahead of print.ABSTRACTSomatic or acquired mutations are postzygotic genetic variations that can occur within any tissue. These mutations accumulate during aging and have classically been linked to malignant processes. Tremendous advancements over the past years have led to a deeper understanding of the role of somatic mutations in benign and malignant age-related diseases. Here, we review the somatic mutations that accumulate in the blood and their connection to disease states, with a particular focus on inflammatory diseases and myelodys...
Source: Annual Review of Pathology - October 13, 2023 Category: Pathology Authors: Rashmi Kanagal-Shamanna David B Beck Katherine R Calvo Source Type: research
