All Roads Lead to Interferon- γ: From Known to Untraveled Pathways in Acquired Aplastic Anemia
Medicina (Kaunas). 2023 Dec 14;59(12):2170. doi: 10.3390/medicina59122170.ABSTRACTBone marrow failure (BMF) syndromes are a heterogeneous group of benign hematological conditions with common clinical features including reduced bone marrow cellularity and peripheral blood cytopenias. Acquired aplastic anemia (AA) is caused by T helper(Th)1-mediated immune responses and cytotoxic CD8+ T cell-mediated autologous immune attacks against hematopoietic stem and progenitor cells (HSPCs). Interferon-γ (IFNγ), tumor necrosis factor-α, and Fas-ligand are historically linked to AA pathogenesis because they drive Th1 and cytotoxic T...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Bianca Serio Valentina Giudice Carmine Selleri Source Type: research
All Roads Lead to Interferon- γ: From Known to Untraveled Pathways in Acquired Aplastic Anemia
Medicina (Kaunas). 2023 Dec 14;59(12):2170. doi: 10.3390/medicina59122170.ABSTRACTBone marrow failure (BMF) syndromes are a heterogeneous group of benign hematological conditions with common clinical features including reduced bone marrow cellularity and peripheral blood cytopenias. Acquired aplastic anemia (AA) is caused by T helper(Th)1-mediated immune responses and cytotoxic CD8+ T cell-mediated autologous immune attacks against hematopoietic stem and progenitor cells (HSPCs). Interferon-γ (IFNγ), tumor necrosis factor-α, and Fas-ligand are historically linked to AA pathogenesis because they drive Th1 and cytotoxic T...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Bianca Serio Valentina Giudice Carmine Selleri Source Type: research
All Roads Lead to Interferon- γ: From Known to Untraveled Pathways in Acquired Aplastic Anemia
Medicina (Kaunas). 2023 Dec 14;59(12):2170. doi: 10.3390/medicina59122170.ABSTRACTBone marrow failure (BMF) syndromes are a heterogeneous group of benign hematological conditions with common clinical features including reduced bone marrow cellularity and peripheral blood cytopenias. Acquired aplastic anemia (AA) is caused by T helper(Th)1-mediated immune responses and cytotoxic CD8+ T cell-mediated autologous immune attacks against hematopoietic stem and progenitor cells (HSPCs). Interferon-γ (IFNγ), tumor necrosis factor-α, and Fas-ligand are historically linked to AA pathogenesis because they drive Th1 and cytotoxic T...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Bianca Serio Valentina Giudice Carmine Selleri Source Type: research
All Roads Lead to Interferon- γ: From Known to Untraveled Pathways in Acquired Aplastic Anemia
Medicina (Kaunas). 2023 Dec 14;59(12):2170. doi: 10.3390/medicina59122170.ABSTRACTBone marrow failure (BMF) syndromes are a heterogeneous group of benign hematological conditions with common clinical features including reduced bone marrow cellularity and peripheral blood cytopenias. Acquired aplastic anemia (AA) is caused by T helper(Th)1-mediated immune responses and cytotoxic CD8+ T cell-mediated autologous immune attacks against hematopoietic stem and progenitor cells (HSPCs). Interferon-γ (IFNγ), tumor necrosis factor-α, and Fas-ligand are historically linked to AA pathogenesis because they drive Th1 and cytotoxic T...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Bianca Serio Valentina Giudice Carmine Selleri Source Type: research
All Roads Lead to Interferon- γ: From Known to Untraveled Pathways in Acquired Aplastic Anemia
Medicina (Kaunas). 2023 Dec 14;59(12):2170. doi: 10.3390/medicina59122170.ABSTRACTBone marrow failure (BMF) syndromes are a heterogeneous group of benign hematological conditions with common clinical features including reduced bone marrow cellularity and peripheral blood cytopenias. Acquired aplastic anemia (AA) is caused by T helper(Th)1-mediated immune responses and cytotoxic CD8+ T cell-mediated autologous immune attacks against hematopoietic stem and progenitor cells (HSPCs). Interferon-γ (IFNγ), tumor necrosis factor-α, and Fas-ligand are historically linked to AA pathogenesis because they drive Th1 and cytotoxic T...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Bianca Serio Valentina Giudice Carmine Selleri Source Type: research
All Roads Lead to Interferon- γ: From Known to Untraveled Pathways in Acquired Aplastic Anemia
Medicina (Kaunas). 2023 Dec 14;59(12):2170. doi: 10.3390/medicina59122170.ABSTRACTBone marrow failure (BMF) syndromes are a heterogeneous group of benign hematological conditions with common clinical features including reduced bone marrow cellularity and peripheral blood cytopenias. Acquired aplastic anemia (AA) is caused by T helper(Th)1-mediated immune responses and cytotoxic CD8+ T cell-mediated autologous immune attacks against hematopoietic stem and progenitor cells (HSPCs). Interferon-γ (IFNγ), tumor necrosis factor-α, and Fas-ligand are historically linked to AA pathogenesis because they drive Th1 and cytotoxic T...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Bianca Serio Valentina Giudice Carmine Selleri Source Type: research
All Roads Lead to Interferon- γ: From Known to Untraveled Pathways in Acquired Aplastic Anemia
Medicina (Kaunas). 2023 Dec 14;59(12):2170. doi: 10.3390/medicina59122170.ABSTRACTBone marrow failure (BMF) syndromes are a heterogeneous group of benign hematological conditions with common clinical features including reduced bone marrow cellularity and peripheral blood cytopenias. Acquired aplastic anemia (AA) is caused by T helper(Th)1-mediated immune responses and cytotoxic CD8+ T cell-mediated autologous immune attacks against hematopoietic stem and progenitor cells (HSPCs). Interferon-γ (IFNγ), tumor necrosis factor-α, and Fas-ligand are historically linked to AA pathogenesis because they drive Th1 and cytotoxic T...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Bianca Serio Valentina Giudice Carmine Selleri Source Type: research
All Roads Lead to Interferon- γ: From Known to Untraveled Pathways in Acquired Aplastic Anemia
Medicina (Kaunas). 2023 Dec 14;59(12):2170. doi: 10.3390/medicina59122170.ABSTRACTBone marrow failure (BMF) syndromes are a heterogeneous group of benign hematological conditions with common clinical features including reduced bone marrow cellularity and peripheral blood cytopenias. Acquired aplastic anemia (AA) is caused by T helper(Th)1-mediated immune responses and cytotoxic CD8+ T cell-mediated autologous immune attacks against hematopoietic stem and progenitor cells (HSPCs). Interferon-γ (IFNγ), tumor necrosis factor-α, and Fas-ligand are historically linked to AA pathogenesis because they drive Th1 and cytotoxic T...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Bianca Serio Valentina Giudice Carmine Selleri Source Type: research
Experience of life quality from patients with aplastic anemia: a descriptive qualitative study
Despite the increasing incidence of aplastic anemia in China, few studies have explored its effect on the patients ’ quality of life from the perspective of these patients. In fact, patients with aplastic disor... (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - December 21, 2023 Category: Internal Medicine Authors: Ting Liu, Yue Pan, Menghua Ye, Qiuhua Sun, Xinghong Ding and Min Xu Tags: Research Source Type: research
Plain language summary of RACE study results: addition of eltrombopag to standard treatment of severe aplastic anemia
Immunotherapy, Ahead of Print. (Source: Immunotherapy)
Source: Immunotherapy - December 13, 2023 Category: Allergy & Immunology Authors: R égis Peffault de Latour Austin Kulasekararaj Simona Iacobelli Morag Griffin Constantijn JM Halkes Carlo Dufour Antonio M Risitano Source Type: research
Emodin suppresses adipogenesis of bone marrow derived mesenchymal stem cells from aplastic anemia via increasing TRIB3 expression
CONCLUSION: Our findings propose that emodin mediated TRIB3 up-regulation alleviates the adipogenic capacity of AA BM-MSCs, and emodin could serve as a potential therapeutic regimen for AA therapy.PMID:38086146 | DOI:10.1016/j.tice.2023.102287 (Source: Tissue and Cell)
Source: Tissue and Cell - December 12, 2023 Category: Cytology Authors: Xianning Zhang Lulu Liu Jian Wang Mingkang Yao Lei Liu Haihui Liu Saisai Ren Peng Wei Panpan Cheng Xiyu Li Hao Zhang Mingtai Chen Source Type: research
Emodin suppresses adipogenesis of bone marrow derived mesenchymal stem cells from aplastic anemia via increasing TRIB3 expression
CONCLUSION: Our findings propose that emodin mediated TRIB3 up-regulation alleviates the adipogenic capacity of AA BM-MSCs, and emodin could serve as a potential therapeutic regimen for AA therapy.PMID:38086146 | DOI:10.1016/j.tice.2023.102287 (Source: Tissue and Cell)
Source: Tissue and Cell - December 12, 2023 Category: Cytology Authors: Xianning Zhang Lulu Liu Jian Wang Mingkang Yao Lei Liu Haihui Liu Saisai Ren Peng Wei Panpan Cheng Xiyu Li Hao Zhang Mingtai Chen Source Type: research
Clinical characteristics of hepatitis-associated aplastic anemia in children
AbstractTo understand the current situation of hepatitis-related aplastic anemia (HAAA) in children, we analyzed the patients with HAAA admitted to our hospital in the past 5 years to understand the disease characteristics and prognosis. The clinical data of patients with HAAA admitted to our hospital from February 2017 to May 2022 were retrospectively analyzed. A total of 81 patients with HAAA, 56 males and 25 females. The median onset age was 5.9 years. The median time from hepatitis to occurrence of hemocytopenia was 30 days, and the median follow-up time was 2.77 years. There were 23 cases (28.5%) of severe aplastic...
Source: Annals of Hematology - December 12, 2023 Category: Hematology Source Type: research
Effect of Stanozolol combined with Cyclosporine A on aplastic anemia
CONCLUSION: Stanozolol combined with Cyclosporine A is more effective than Stanozolol alone in treatment of aplastic anemia.PMID:38074827 | PMC:PMC10703648 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - December 11, 2023 Category: Research Authors: Weiwei Zhu Yue Ma Xin Li Tianjie Han Lijun Li Zhirui Zhao Zhe Yu Source Type: research
