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New-onset aplastic anemia after SARS-CoV-2 vaccination
Int J Hematol. 2023 Sep 28. doi: 10.1007/s12185-023-03666-z. Online ahead of print.ABSTRACTAplastic anemia (AA) is a rare autoimmune disease. Drugs, viruses, and radiation are among the most common etiologic factors, and most cases have immune pathophysiology. SARS-CoV-2 vaccines have been linked with rare side effects, including cases of acquired aplastic anemia. Here we review all the reported cases of new-onset AA after SARS-CoV-2 vaccination, and discuss their clinical characteristics and management. 18 patients in these case reports had a median age of 58 years. The time from vaccination to onset of aplastic anemia ra...
Source: International Journal of Hematology - September 28, 2023 Category: Hematology Authors: Elena Chatzikalil Antonis Kattamis Panagiotis Diamantopoulos Elena E Solomou Source Type: research

GSE235652 The methylome of buccal epithelial cells is influenced by age, sex, and physiological properties
In this study, we aimed to identify how the methylome of buccal epithelial cells, a non-invasive and easily accessible tissue, is associated with demographic and health-related variables commonly used in clinical settings, such as age, sex, blood immune composition, hemoglobin levels, and others. We developed a model to assess the association of multiple factors with the human methylome and identify the genomic loci significantly impacted by each trait. We demonstrated that DNA methylation variation is accurately modeled by several factors. We confirmed the well-known impact of age and sex and unveiled novel clinical facto...
Source: GEO: Gene Expression Omnibus - September 28, 2023 Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Homo sapiens Source Type: research

Cancers, Vol. 15, Pages 4758: Trends in Outcome of Hematopoietic Stem Cell Transplantation: 5000 Transplantations and 30 Years of Single-Center Experience
azantsev Olga Alexandrovna Slesarchuk Anna Gennadyevna Smirnova Anna Alekseevna Osipova Liliya Vladimirovna Stelmakh Alexey Yurievich Polushin Oleg Valerievich Goloshchapov Maxim Pavlovich Bogomolny Maria Arkadievna Estrina Marina Olegovna Popova Maxim Anatolievich Kucher Alisa Georgievna Volkova Alexander Leonidovich Alyansky Dmitrii Eduardovich Pevtcov Natalia Evgenievna Ivanova Elena Vitalievna Babenko Nikolai Nikolaevich Mamaev Tatiana Leonidovna Gindina Alina Alexandrovna Vitrishchak Alexei Borisovich Chukhlovin Elena Vladimirovna Semenova Sergei Nicolaevich Bondarenko Alexa...
Source: Cancers - September 28, 2023 Category: Cancer & Oncology Authors: Ludmila Stepanovna Zubarovskaya Ivan Sergeevich Moiseev Maria Dmidrievna Vladovskaya Natalia Borisovna Mikhailova Elena Vladislavovna Morozova Tatyana Alexandrovna Bykova Yulia Yurievna Vlasova Olesya Vladimirovna Paina Ilya Viktorovich Kazantsev Olga Ale Tags: Article Source Type: research

Spatial proteomics identifies a spectrum of immune dysregulation in acquired bone marrow failure syndromes
In this study, we used spatial proteomics to compare the immunobiology of the BM microenvironment and identify common mechanisms of immune dysregulation under these conditions. Archival BM trephines from patients exhibited downregulation of the immunoregulatory protein VISTA and the M2 macrophage marker and suppressor of T-cell activation ARG1 with increased expression of the immune checkpoint B7-H3 compared to normal controls. Increased CD163 and CD14 expression suggested monocyte/macrophage skewing, which, combined with dysregulation of STING and VISTA, is indicative of an environment of reduced immunoregulation resultin...
Source: Frontiers in Immunology - September 25, 2023 Category: Allergy & Immunology Source Type: research

Eltrombopag with or without Tacrolimus for relapsed/refractory acquired aplastic anaemia: a prospective randomized trial
Blood Cancer Journal, Published online: 19 September 2023; doi:10.1038/s41408-023-00921-8Eltrombopag with or without Tacrolimus for relapsed/refractory acquired aplastic anaemia: a prospective randomized trial (Source: Blood Cancer Journal)
Source: Blood Cancer Journal - September 19, 2023 Category: Hematology Authors: Jiang Ji Ziqi Wan Jing Ruan Yuan Yang Qinglin Hu Zesong Chen Chen Yang Miao Chen Bing Han Source Type: research

Comparison of eltrombopag and avatrombopag in the treatment of refractory/relapsed aplastic anemia: a single-center retrospective study in China
CONCLUSION: With worse liver or renal function, AVA had a similar OR/CR rate but a shorter median time to response and fewer adverse events for patients with relapsed/refractory AA.PMID:37719987 | PMC:PMC10503291 | DOI:10.1177/20406207231191310 (Source: Adv Data)
Source: Adv Data - September 18, 2023 Category: Epidemiology Authors: Zhuxin Zhang Qinglin Hu Chen Yang Miao Chen Bing Han Source Type: research

Comparison of haploidentical stem cell transplantation with post-transplant cyclophosphamide versus umbilical cord blood transplantation in adult patients with aplastic anemia
Aplastic anemia is a bone marrow (BM) failure disorder that may lead to life-threatening complications, such as infection and bleeding, if hematopoiesis is not restored through treatment. Allogeneic hematopoietic stem cell transplantation (HSCT) from an alternative donor is an important treatment option for patients with immunosuppressive therapy (IST)-refractory aplastic anemia when an HLA-matched donor is not available1-3. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - September 18, 2023 Category: Hematology Authors: Yasushi Onishi, Takehiko Mori, Hirohito Yamazaki, Nobuhiro Hiramoto, Yoshitaka Zaimoku, Minoru Kanaya, Kosei Matsue, Makoto Onizuka, Nobuyuki Aotsuka, Naoyuki Uchida, Koichi Onodera, Junya Kanda, Hirohisa Nakamae, Ryusuke Yamamoto, Takuro Kuriyama, Takafu Source Type: research

Comparison of Haploidentical Stem Cell Transplantation with Post-Transplantation Cyclophosphamide versus Umbilical Cord Blood Transplantation in Adult Patients with Aplastic Anemia
Aplastic anemia is a bone marrow (BM) failure disorder that may lead to life-threatening complications, such as infection and bleeding, if hematopoiesis is not restored through treatment. Allogeneic hematopoietic stem cell transplantation (HSCT) from an alternative donor is an important treatment option for patients with immunosuppressive therapy (IST)-refractory aplastic anemia when an HLA-matched donor is not available [1 –3]. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - September 18, 2023 Category: Hematology Authors: Yasushi Onishi, Takehiko Mori, Hirohito Yamazaki, Nobuhiro Hiramoto, Yoshitaka Zaimoku, Minoru Kanaya, Kosei Matsue, Makoto Onizuka, Nobuyuki Aotsuka, Naoyuki Uchida, Koichi Onodera, Junya Kanda, Hirohisa Nakamae, Ryusuke Yamamoto, Takuro Kuriyama, Takafu Tags: Allogeneic - Adult Source Type: research

Uniform conditioning regardless of donor in bone marrow transplantation for severe aplastic anemia
Haematologica. 2023 Sep 7. doi: 10.3324/haematol.2023.284022. Online ahead of print.ABSTRACTNot available.PMID:37675516 | DOI:10.3324/haematol.2023.284022 (Source: Haematologica)
Source: Haematologica - September 7, 2023 Category: Hematology Authors: Amy E DeZern Marianna Zahurak Richard J Jones Robert A Brodsky Source Type: research

Aplastic anemia after SARS-CoV-2 infection or vaccines: case series and literature review
Blood Transfus. 2023 Sep 4. doi: 10.2450/BloodTransfus.500. Online ahead of print.NO ABSTRACTPMID:37677091 | DOI:10.2450/BloodTransfus.500 (Source: Blood Transfusion)
Source: Blood Transfusion - September 7, 2023 Category: Hematology Authors: Bruno Fattizzo Raffaella Pasquale Giorgio A Croci Loredana Pettine Giulio Cassanello Wilma Barcellini Source Type: research