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High rates of intestinal colonization with carbapenemase producing Enterobacteriaceae in hematopoietic stem cell transplant recipients
Acta Microbiol Immunol Hung. 2024 Feb 21. doi: 10.1556/030.2024.02210. Online ahead of print.ABSTRACTCarbapenem resistant Enterobacteriaceae (CRE) are major human pathogens because, these cause high number of difficult-to-treat infections. Allogeneic hematopoietic stem cell transplant (AHSCT) recipients are highly exposed to these type of bacteria. The aim of our study was to investigate prevalence of CRE colonization in AHSCT patients and to determine genes encoding carbapenem resistance. A retrospective study conducted between January 2015 and December 2019, involved 55 patients colonized with CRE strains. We determined ...
Source: Acta Microbiologica et Immunologica Hungarica - February 21, 2024 Category: Microbiology Authors: Ikram Ayari Yosra Chebbi Anis Raddaoui Dorra Belloumi Siwar Frigui Rim Werhni Tarek Ben Othmen Nour Abedejlil Wafa Achour Source Type: research

Role of miRNAs in T-cell activation and Th17/Treg-cell imbalance in acquired aplastic anemia
CONCLUSION: The study for the first time highlights the plausible role of different miRNAs in deregulating the Th17/Treg-cell imbalance in aAA, and comprehensively suggest the role of altered NF-kB and mTOR pathways in aAA. The axis may be actively explored for development of newer therapeutic targets in aAA.PMID:38357712 | DOI:10.1111/ijlh.14243 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - February 15, 2024 Category: Hematology Authors: G Sabreen Khaliqur Rahman Ruchi Gupta Chandra P Chaturvedi Jyotika Srivastava Dinesh Chandra Manish K Singh S Yadav Akhilesh Sharma Manoj Sarkar Rajesh Kashyap Source Type: research

When inflammatory stressors dramatically change, disease phenotypes may transform between autoimmune hematopoietic failure and myeloid neoplasms
Aplastic anemia (AA) and hypoplastic myelodysplastic syndrome are paradigms of autoimmune hematopoietic failure (AHF). Myelodysplastic syndrome and acute myeloid leukemia are unequivocal myeloid neoplasms (MNs). Currently, AA is also known to be a clonal hematological disease. Genetic aberrations typically observed in MNs are detected in approximately one-third of AA patients. In AA patients harboring MN-related genetic aberrations, a poor response to immunosuppressive therapy (IST) and an increased risk of transformation to MNs occurring either naturally or after IST are predicted. Approximately 10%–15% of patients with...
Source: Frontiers in Immunology - February 15, 2024 Category: Allergy & Immunology Source Type: research