Clonal Hematopoiesis, Inflammation, and Hematologic Malignancy
Annu Rev Pathol. 2023 Oct 13. doi: 10.1146/annurev-pathmechdis-051222-122724. Online ahead of print.ABSTRACTSomatic or acquired mutations are postzygotic genetic variations that can occur within any tissue. These mutations accumulate during aging and have classically been linked to malignant processes. Tremendous advancements over the past years have led to a deeper understanding of the role of somatic mutations in benign and malignant age-related diseases. Here, we review the somatic mutations that accumulate in the blood and their connection to disease states, with a particular focus on inflammatory diseases and myelodys...
Source: Annual Review of Pathology - October 13, 2023 Category: Pathology Authors: Rashmi Kanagal-Shamanna David B Beck Katherine R Calvo Source Type: research
Clonal Hematopoiesis, Inflammation, and Hematologic Malignancy
Annu Rev Pathol. 2023 Oct 13. doi: 10.1146/annurev-pathmechdis-051222-122724. Online ahead of print.ABSTRACTSomatic or acquired mutations are postzygotic genetic variations that can occur within any tissue. These mutations accumulate during aging and have classically been linked to malignant processes. Tremendous advancements over the past years have led to a deeper understanding of the role of somatic mutations in benign and malignant age-related diseases. Here, we review the somatic mutations that accumulate in the blood and their connection to disease states, with a particular focus on inflammatory diseases and myelodys...
Source: Annual Review of Pathology - October 13, 2023 Category: Pathology Authors: Rashmi Kanagal-Shamanna David B Beck Katherine R Calvo Source Type: research
Clonal Hematopoiesis, Inflammation, and Hematologic Malignancy
Annu Rev Pathol. 2023 Oct 13. doi: 10.1146/annurev-pathmechdis-051222-122724. Online ahead of print.ABSTRACTSomatic or acquired mutations are postzygotic genetic variations that can occur within any tissue. These mutations accumulate during aging and have classically been linked to malignant processes. Tremendous advancements over the past years have led to a deeper understanding of the role of somatic mutations in benign and malignant age-related diseases. Here, we review the somatic mutations that accumulate in the blood and their connection to disease states, with a particular focus on inflammatory diseases and myelodys...
Source: Annual Review of Pathology - October 13, 2023 Category: Pathology Authors: Rashmi Kanagal-Shamanna David B Beck Katherine R Calvo Source Type: research
Alternative treatment modality for severe aplastic anemia in a resource-limited setting: a single-institution prospective cohort study from Upper Egypt
In conclusion, E-PAG+ CsA was found to be a safe and effective alternative treatment for children with SAA particularly in countries with limited resources. (Source: Annals of Hematology)
Source: Annals of Hematology - October 11, 2023 Category: Hematology Source Type: research
Impaired immunosuppressive effect of bone marrow mesenchymal stem cell-derived exosomes on T cells in aplastic anemia
CONCLUSION: In summary, AA-Exos had impaired immunosuppressive effect on T cells, less ability to rescue AA mice and differently expressed miRNA profile, which might partly account for the pathogenesis of AA as well as provide a new target of AA treatment.PMID:37794484 | DOI:10.1186/s13287-023-03496-0 (Source: Cell Research)
Source: Cell Research - October 4, 2023 Category: Cytology Authors: Shichong Wang Jiali Huo Yilin Liu Lingyun Chen Xiang Ren Xingxin Li Min Wang Peng Jin Jinbo Huang Neng Nie Jing Zhang Yingqi Shao Meili Ge Yizhou Zheng Source Type: research
Deciphering treatment patterns in non-severe/moderate aplastic anemia: an international observational study
Leukemia, Published online: 04 October 2023; doi:10.1038/s41375-023-02047-zDeciphering treatment patterns in non-severe/moderate aplastic anemia: an international observational study (Source: Leukemia)
Source: Leukemia - October 4, 2023 Category: Hematology Authors: Bruno Fattizzo Carmelo Gurnari Giulio Cassanello Marta Bortolotti Hussein Awada Sabrina Giammarco Dario Consonni Simona Sica Shreyans Gandhi Roochi Trikha Joanna Large Sarah Salter Jaroslaw P. Maciejewski Wilma Barcellini Austin G. Kulasekararaj Source Type: research
Opportunistic bacterial, viral and fungal infections of the lung
Respiratory opportunistic infections are a major cause of morbidity and mortality in severely immunocompromised patients, such as those treated with biological therapies, chemotherapy and solid organ or stem cell transplants, and those with haematological malignancy, aplastic anaemia or HIV infection. The type and degree of immune defect dictates the profile of potential opportunistic pathogens; T-cell-mediated defects increase the risk of viral (cytomegalovirus, respiratory viruses) and Pneumocystis jirovecii infections, whereas neutrophil defects are associated with bacterial pneumonia and invasive aspergillosis. (Source: Medicine)
Source: Medicine - October 3, 2023 Category: Internal Medicine Authors: Katharine M. Pates, Jimstan N. Periselneris, Jeremy S. Brown Tags: Pulmonary infection Source Type: research
Spontaneous regression of tumours. Possible cross reactivity of autoantibodies against carbonic anhydrase I
J Cell Mol Med. 2023 Sep 29. doi: 10.1111/jcmm.17970. Online ahead of print.ABSTRACTSpontaneous tumour regression in patients after high dose therapy and autologous stem cell transplantation or patients with standard therapy is accompanied with the presence of high titers autoantibodies against carbonic anhydrase I (CA I). The concomitant presence of aplastic anaemia-like syndrome in these patients points to parallel bone marrow suppression during this period. It seems that CA I, an 'obscure' enzyme, does not have any significant physiological role in humans. One possible explanation points to the fact that autoantibodies ...
Source: J Cell Mol Med - September 30, 2023 Category: Molecular Biology Authors: J án Lakota Source Type: research
Spontaneous regression of tumours. Possible cross reactivity of autoantibodies against carbonic anhydrase I
J Cell Mol Med. 2023 Sep 29. doi: 10.1111/jcmm.17970. Online ahead of print.ABSTRACTSpontaneous tumour regression in patients after high dose therapy and autologous stem cell transplantation or patients with standard therapy is accompanied with the presence of high titers autoantibodies against carbonic anhydrase I (CA I). The concomitant presence of aplastic anaemia-like syndrome in these patients points to parallel bone marrow suppression during this period. It seems that CA I, an 'obscure' enzyme, does not have any significant physiological role in humans. One possible explanation points to the fact that autoantibodies ...
Source: Molecular Medicine - September 30, 2023 Category: Molecular Biology Authors: J án Lakota Source Type: research
Spontaneous regression of tumours. Possible cross reactivity of autoantibodies against carbonic anhydrase I
J Cell Mol Med. 2023 Sep 29. doi: 10.1111/jcmm.17970. Online ahead of print.ABSTRACTSpontaneous tumour regression in patients after high dose therapy and autologous stem cell transplantation or patients with standard therapy is accompanied with the presence of high titers autoantibodies against carbonic anhydrase I (CA I). The concomitant presence of aplastic anaemia-like syndrome in these patients points to parallel bone marrow suppression during this period. It seems that CA I, an 'obscure' enzyme, does not have any significant physiological role in humans. One possible explanation points to the fact that autoantibodies ...
Source: J Cell Mol Med - September 30, 2023 Category: Molecular Biology Authors: J án Lakota Source Type: research
Spontaneous regression of tumours. Possible cross reactivity of autoantibodies against carbonic anhydrase I
J Cell Mol Med. 2023 Sep 29. doi: 10.1111/jcmm.17970. Online ahead of print.ABSTRACTSpontaneous tumour regression in patients after high dose therapy and autologous stem cell transplantation or patients with standard therapy is accompanied with the presence of high titers autoantibodies against carbonic anhydrase I (CA I). The concomitant presence of aplastic anaemia-like syndrome in these patients points to parallel bone marrow suppression during this period. It seems that CA I, an 'obscure' enzyme, does not have any significant physiological role in humans. One possible explanation points to the fact that autoantibodies ...
Source: Molecular Medicine - September 30, 2023 Category: Molecular Biology Authors: J án Lakota Source Type: research
Spontaneous regression of tumours. Possible cross reactivity of autoantibodies against carbonic anhydrase I
J Cell Mol Med. 2023 Sep 29. doi: 10.1111/jcmm.17970. Online ahead of print.ABSTRACTSpontaneous tumour regression in patients after high dose therapy and autologous stem cell transplantation or patients with standard therapy is accompanied with the presence of high titers autoantibodies against carbonic anhydrase I (CA I). The concomitant presence of aplastic anaemia-like syndrome in these patients points to parallel bone marrow suppression during this period. It seems that CA I, an 'obscure' enzyme, does not have any significant physiological role in humans. One possible explanation points to the fact that autoantibodies ...
Source: J Cell Mol Med - September 30, 2023 Category: Molecular Biology Authors: J án Lakota Source Type: research
New-onset aplastic anemia after SARS-CoV-2 vaccination
Int J Hematol. 2023 Sep 28. doi: 10.1007/s12185-023-03666-z. Online ahead of print.ABSTRACTAplastic anemia (AA) is a rare autoimmune disease. Drugs, viruses, and radiation are among the most common etiologic factors, and most cases have immune pathophysiology. SARS-CoV-2 vaccines have been linked with rare side effects, including cases of acquired aplastic anemia. Here we review all the reported cases of new-onset AA after SARS-CoV-2 vaccination, and discuss their clinical characteristics and management. 18 patients in these case reports had a median age of 58 years. The time from vaccination to onset of aplastic anemia ra...
Source: International Journal of Hematology - September 28, 2023 Category: Hematology Authors: Elena Chatzikalil Antonis Kattamis Panagiotis Diamantopoulos Elena E Solomou Source Type: research
New-onset aplastic anemia after SARS-CoV-2 vaccination
Int J Hematol. 2023 Sep 28. doi: 10.1007/s12185-023-03666-z. Online ahead of print.ABSTRACTAplastic anemia (AA) is a rare autoimmune disease. Drugs, viruses, and radiation are among the most common etiologic factors, and most cases have immune pathophysiology. SARS-CoV-2 vaccines have been linked with rare side effects, including cases of acquired aplastic anemia. Here we review all the reported cases of new-onset AA after SARS-CoV-2 vaccination, and discuss their clinical characteristics and management. 18 patients in these case reports had a median age of 58 years. The time from vaccination to onset of aplastic anemia ra...
Source: International Journal of Hematology - September 28, 2023 Category: Hematology Authors: Elena Chatzikalil Antonis Kattamis Panagiotis Diamantopoulos Elena E Solomou Source Type: research
New-onset aplastic anemia after SARS-CoV-2 vaccination
Int J Hematol. 2023 Sep 28. doi: 10.1007/s12185-023-03666-z. Online ahead of print.ABSTRACTAplastic anemia (AA) is a rare autoimmune disease. Drugs, viruses, and radiation are among the most common etiologic factors, and most cases have immune pathophysiology. SARS-CoV-2 vaccines have been linked with rare side effects, including cases of acquired aplastic anemia. Here we review all the reported cases of new-onset AA after SARS-CoV-2 vaccination, and discuss their clinical characteristics and management. 18 patients in these case reports had a median age of 58 years. The time from vaccination to onset of aplastic anemia ra...
Source: International Journal of Hematology - September 28, 2023 Category: Hematology Authors: Elena Chatzikalil Antonis Kattamis Panagiotis Diamantopoulos Elena E Solomou Source Type: research
