Fight Aging! Newsletter, March 4th 2024
In conclusion, HSV (but not CMV) infection may be indicative of doubled dementia risk.
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Increased Dietary Leucine Activates mTOR Signaling in Macrophages, Accelerating Atherosclerosis
https://www.fightaging.org/archives/2024/02/increased-dietary-leucine-activates-mtor-signaling-in-macrophages-accelerating-atherosclerosis/
Leucine is an essential amino acid, only obtained from the diet rather than synthesized by our cells. Leucine supplementation has been proposed as a way to slow the loss of muscle mass with age, as leucine processing becomes dysregulated with aging in a way...
Source: Fight Aging! - March 3, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Telomere Length as a Target for Therapy
Average telomere length in a tissue is some reflection of (a) stem cell activity and (b) pace of cell division. Telomeres, repeated DNA sequences at the ends of chromosomes, lose some of their length with each cell division, and cells self-destruct or become senescent when telomeres become too short. This limits the ability of somatic cells to replicate, reducing the odds that a given cell will mutate to become cancerous by imposing a limit on cell activity and cell life span, enforcing turnover of cells in tissues. Stem cells, in comparison, are a small, well protected, privileged set of cell populations that use telomera...
Source: Fight Aging! - February 26, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The miracle cure: the world ’ s first successful bone marrow transplant for aplastic anemia
An excerpt from Living Medicine: Don Thomas, Marrow Transplantation, and the Cell Therapy Revolution. Late in the summer of 1960, Dr. Clem Finch invited Dr. Don Thomas to Seattle to give a talk about his early experience with transplantation. Clem, who had been Thomas’s hematology fellowship instructor at the Brigham in Boston, had since moved
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The miracle cure: the world’s first successful bone marrow transplant for aplastic anemia originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 6, 2023 Category: General Medicine Authors: Fred Appelbaum, MD Tags: Conditions Oncology/Hematology Source Type: blogs
Adverse effects of hydroxychloroquine
In case you were ever stupid enough to follow Trump’s lead you would have already injected ultraviolets in your eyeballs by now to save you from Covid and maybe bathed in Domestos or sulfuric acid or both! Anyway, his latest bullshine claim is that he’s been taking the antimalarial drug hydroxychloroquine to keep Covid at bay.
Well, for starters there is no evidence that this drug acts as a prophylactic against infection with SARS CoV-2 or indeed any pathogen other than the causative agent of otherwise drug-resistant malaria. It’s primary use is in treating lupus. There was some testing done weeks ago to...
Source: David Bradley Sciencebase - Songs, Snaps, Science - May 19, 2020 Category: Science Authors: David Bradley Tags: Health and Medicine Source Type: blogs
Fight Aging! Newsletter, June 10th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - June 9, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Telomerase Gene Therapy Treats Neurodegeneration in Mice
Researchers have been testing telomerase gene therapies in mice for more than a decade now, demonstrating extension of life, improved stem cell and tissue function, reduced cancer incidence, and so forth. The research results here, treating neurodegeneration in mice, are a representative example of the sort of work that has emerged in recent years. Telomerase primarily acts to lengthen telomeres, the repeated DNA sequences at the ends of chromosomes. Telomeres shorten with each cell division, a part of the mechanism determining the Hayflick limit to cell replication. Thus the general upregulation of telomerase should resul...
Source: Fight Aging! - June 3, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Death of Cancer: Book Review and Reflections
By CHADI NABHAN MD, MBA, FACP
Some books draw you in based on a catchy title, a provocative book jacket, or familiarity with the author. For me, recollections of medical school primers written by the renowned lymphoma pioneer Vincent DeVita Jr. and my own path as an oncologist immediately attracted me to “The Death of Cancer.” I felt a connection to this book before even reading it and prepped myself for an optimistic message about how the cancer field is moving forward. Did I get what I bargained for?
Co-authored with his daughter, Elizabeth DeVita-Raeburn, DeVita brings us back decades ago to when he had just st...
Source: The Health Care Blog - January 1, 2019 Category: Consumer Health News Authors: matthew holt Tags: Health Care Books Physicians Book Review Chadi Nabhan Chemotherapy Oncology randomized controlled trials The Death of Cancer Vincent DeVita Source Type: blogs
Fight Aging! Newsletter, August 27th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - August 26, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Additional Evidence to Demonstrate that Telomerase Gene Therapy Does Not Increase Cancer Risk in Mice
In recent years, researchers working on forms of telomerase gene therapy have produced evidence to show that increased levels and activity of telomerase does not raise cancer risk in mice. The open access paper and publicity materials noted below report the latest example. Extra telomerase increases the sort of activities that are beneficial in the context of improved regenerative capacity, but might be thought to raise the risk of cancer when they take place in the damaged environment of old tissue. This means more stem cell activity, more cellular replication, and so forth.
Somatic cells are limited in the degree ...
Source: Fight Aging! - August 21, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Purging Healthcare of Unnatural Acts
BY UWE REINHARDT
In tribute to Uwe we are re-running this instant classic from THCB’s archives. Originally published on Jan 31, 2017.
Everyone knows (or should know) that forcing a commercial health insurer to write for an individual a health insurance policy at a premium that falls short of the insurer’s best ex ante estimate of the cost of health care that individual will require is to force that insurer into what economists might call an unnatural act.
Remarkably, countries that rely on competing private health insurers to operate their universal, national health insurance systems all do just that. They allow...
Source: The Health Care Blog - November 21, 2017 Category: Consumer Health News Authors: John Irvine Tags: Repeal Replace Trending Uwe Reinhardt Source Type: blogs
New Successful Treatment of Severe Aplastic Anemia with Cord Blood
Aplastic anemia, a rare form of anemia, comes from a loss of red blood cells in bone marrow. It stops production of blood cells and causes fatigue, and can lead to infections and excessive bleeding. This condition can happen at any age, and often occurs suddenly. Cord blood, which holds the most adaptable stem cells available, is becoming the preferred therapy for this blood condition.
Recently the stem cells from cord blood have been used for the treatment of severe aplastic anemia following acute liver failure and living related liver transplantation.
Severe aplastic anemia, a life-threatening hematologic emergency requi...
Source: Cord Blood News - May 8, 2017 Category: Perinatology & Neonatology Authors: Maze Cord Blood Tags: Cord Blood medical research cord blood research Source Type: blogs
Purging Healthcare of Unnatural Acts
BY UWE REINHARDT
Everyone knows (or should know) that forcing a commercial health insurer to write for an individual a health insurance policy at a premium that falls short of the insurer’s best ex ante estimate of the cost of health care that individual will require is to force that insurer into what economists might call an unnatural act.
Remarkably, countries that rely on competing private health insurers to operate their universal, national health insurance systems all do just that. They allow each insurer to set the premium for a government-mandated , comprehensive benefit package, but require that each insurer “...
Source: The Health Care Blog - January 31, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Uwe Reinhardt Source Type: blogs
Arguing for Telomerase Therapies to Treat Aging
At the high level, the arguments for deploying telomerase-based therapies to lengthen average telomere length in various tissues and cell populations as a treatment for aging have not changed much over the past decade. The data and details have evolved with progress in investigative research, but the digest of the views held by the faction who think this way remains this: that average telomere length is enough of a cause of issues in aging, as opposed to being a reflection of other processes with few secondary effects of its own, to merit addressing. My view of the state of research is still that average telomere length lo...
Source: Fight Aging! - April 21, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Test your medicine knowledge: 48-year-old woman with fatigue
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 48-year-old woman is evaluated for fatigue and intermittent abdominal discomfort of 2 months’ duration and occasional dark urine. Medical and family histories are unremarkable. Her only medication is an oral contraceptive pill.
On physical examination, temperature is 37.2 °C (99.0 °F), blood pressure is 125/74 mm Hg, pulse rate is 68/min, and respiration rate is 13/min. Pallor is observed, and abdominal tenderness is present on palpation. No icterus, bruising, or splenomegaly is noted.
Laboratory studi...
Source: Kevin, M.D. - Medical Weblog - October 17, 2015 Category: Journals (General) Authors: mksap Tags: Conditions Hematology Source Type: blogs
A history of SSRIs
This is a re-post from something I wrote in March 2007 – on reflection, perhaps it should be more accurately entitled A History of SSRIs and the Damage they do to Patients.
I think there may well be a lot of discussion in the coming months about Seroxat dependency and the terrible withdrawal symptoms that many people have to endure as they try to stop taking Seroxat and so I think that the download – A History of SSRIs is more relevant today than ever.
Looking at my original post, I was remiss as I didn’t credit the author of the download – so belated apologies to Prof David Healy (I th...
Source: seroxat secrets... - October 2, 2015 Category: Addiction Authors: admin Tags: Big Pharma Depression Drug Marketing Glaxo Paxil Seroxat Source Type: blogs
