Spatial proteomics identifies a spectrum of immune dysregulation in acquired bone marrow failure syndromes
In this study, we used spatial proteomics to compare the immunobiology of the BM microenvironment and identify common mechanisms of immune dysregulation under these conditions. Archival BM trephines from patients exhibited downregulation of the immunoregulatory protein VISTA and the M2 macrophage marker and suppressor of T-cell activation ARG1 with increased expression of the immune checkpoint B7-H3 compared to normal controls. Increased CD163 and CD14 expression suggested monocyte/macrophage skewing, which, combined with dysregulation of STING and VISTA, is indicative of an environment of reduced immunoregulation resultin...
Source: Frontiers in Immunology - September 25, 2023 Category: Allergy & Immunology Source Type: research
Eltrombopag with or without Tacrolimus for relapsed/refractory acquired aplastic anaemia: a prospective randomized trial
Blood Cancer Journal, Published online: 19 September 2023; doi:10.1038/s41408-023-00921-8Eltrombopag with or without Tacrolimus for relapsed/refractory acquired aplastic anaemia: a prospective randomized trial (Source: Blood Cancer Journal)
Source: Blood Cancer Journal - September 19, 2023 Category: Hematology Authors: Jiang Ji Ziqi Wan Jing Ruan Yuan Yang Qinglin Hu Zesong Chen Chen Yang Miao Chen Bing Han Source Type: research
Comparison of eltrombopag and avatrombopag in the treatment of refractory/relapsed aplastic anemia: a single-center retrospective study in China
CONCLUSION: With worse liver or renal function, AVA had a similar OR/CR rate but a shorter median time to response and fewer adverse events for patients with relapsed/refractory AA.PMID:37719987 | PMC:PMC10503291 | DOI:10.1177/20406207231191310 (Source: Adv Data)
Source: Adv Data - September 18, 2023 Category: Epidemiology Authors: Zhuxin Zhang Qinglin Hu Chen Yang Miao Chen Bing Han Source Type: research
Comparison of haploidentical stem cell transplantation with post-transplant cyclophosphamide versus umbilical cord blood transplantation in adult patients with aplastic anemia
Aplastic anemia is a bone marrow (BM) failure disorder that may lead to life-threatening complications, such as infection and bleeding, if hematopoiesis is not restored through treatment. Allogeneic hematopoietic stem cell transplantation (HSCT) from an alternative donor is an important treatment option for patients with immunosuppressive therapy (IST)-refractory aplastic anemia when an HLA-matched donor is not available1-3. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - September 18, 2023 Category: Hematology Authors: Yasushi Onishi, Takehiko Mori, Hirohito Yamazaki, Nobuhiro Hiramoto, Yoshitaka Zaimoku, Minoru Kanaya, Kosei Matsue, Makoto Onizuka, Nobuyuki Aotsuka, Naoyuki Uchida, Koichi Onodera, Junya Kanda, Hirohisa Nakamae, Ryusuke Yamamoto, Takuro Kuriyama, Takafu Source Type: research
Uniform conditioning regardless of donor in bone marrow transplantation for severe aplastic anemia
Haematologica. 2023 Sep 7. doi: 10.3324/haematol.2023.284022. Online ahead of print.ABSTRACTNot available.PMID:37675516 | DOI:10.3324/haematol.2023.284022 (Source: Haematologica)
Source: Haematologica - September 7, 2023 Category: Hematology Authors: Amy E DeZern Marianna Zahurak Richard J Jones Robert A Brodsky Source Type: research
Aplastic anemia after SARS-CoV-2 infection or vaccines: case series and literature review
Blood Transfus. 2023 Sep 4. doi: 10.2450/BloodTransfus.500. Online ahead of print.NO ABSTRACTPMID:37677091 | DOI:10.2450/BloodTransfus.500 (Source: Blood Transfusion)
Source: Blood Transfusion - September 7, 2023 Category: Hematology Authors: Bruno Fattizzo Raffaella Pasquale Giorgio A Croci Loredana Pettine Giulio Cassanello Wilma Barcellini Source Type: research
Uniform conditioning regardless of donor in bone marrow transplantation for severe aplastic anemia
Haematologica. 2023 Sep 7. doi: 10.3324/haematol.2023.284022. Online ahead of print.ABSTRACTNot available.PMID:37675516 | DOI:10.3324/haematol.2023.284022 (Source: Haematologica)
Source: Haematologica - September 7, 2023 Category: Hematology Authors: Amy E DeZern Marianna Zahurak Richard J Jones Robert A Brodsky Source Type: research
Aplastic anemia after SARS-CoV-2 infection or vaccines: case series and literature review
Blood Transfus. 2023 Sep 4. doi: 10.2450/BloodTransfus.500. Online ahead of print.NO ABSTRACTPMID:37677091 | DOI:10.2450/BloodTransfus.500 (Source: Blood Transfusion)
Source: Blood Transfusion - September 7, 2023 Category: Hematology Authors: Bruno Fattizzo Raffaella Pasquale Giorgio A Croci Loredana Pettine Giulio Cassanello Wilma Barcellini Source Type: research
Uniform conditioning regardless of donor in bone marrow transplantation for severe aplastic anemia
Haematologica. 2023 Sep 7. doi: 10.3324/haematol.2023.284022. Online ahead of print.ABSTRACTNot available.PMID:37675516 | DOI:10.3324/haematol.2023.284022 (Source: Haematologica)
Source: Haematologica - September 7, 2023 Category: Hematology Authors: Amy E DeZern Marianna Zahurak Richard J Jones Robert A Brodsky Source Type: research
Aplastic anemia after SARS-CoV-2 infection or vaccines: case series and literature review
Blood Transfus. 2023 Sep 4. doi: 10.2450/BloodTransfus.500. Online ahead of print.NO ABSTRACTPMID:37677091 | DOI:10.2450/BloodTransfus.500 (Source: Blood Transfusion)
Source: Blood Transfusion - September 7, 2023 Category: Hematology Authors: Bruno Fattizzo Raffaella Pasquale Giorgio A Croci Loredana Pettine Giulio Cassanello Wilma Barcellini Source Type: research
Uniform conditioning regardless of donor in bone marrow transplantation for severe aplastic anemia
Haematologica. 2023 Sep 7. doi: 10.3324/haematol.2023.284022. Online ahead of print.ABSTRACTNot available.PMID:37675516 | DOI:10.3324/haematol.2023.284022 (Source: Haematologica)
Source: Haematologica - September 7, 2023 Category: Hematology Authors: Amy E DeZern Marianna Zahurak Richard J Jones Robert A Brodsky Source Type: research
Aplastic anemia after SARS-CoV-2 infection or vaccines: case series and literature review
Blood Transfus. 2023 Sep 4. doi: 10.2450/BloodTransfus.500. Online ahead of print.NO ABSTRACTPMID:37677091 | DOI:10.2450/BloodTransfus.500 (Source: Blood Transfusion)
Source: Blood Transfusion - September 7, 2023 Category: Hematology Authors: Bruno Fattizzo Raffaella Pasquale Giorgio A Croci Loredana Pettine Giulio Cassanello Wilma Barcellini Source Type: research
Uniform conditioning regardless of donor in bone marrow transplantation for severe aplastic anemia
Haematologica. 2023 Sep 7. doi: 10.3324/haematol.2023.284022. Online ahead of print.ABSTRACTNot available.PMID:37675516 | DOI:10.3324/haematol.2023.284022 (Source: Haematologica)
Source: Haematologica - September 7, 2023 Category: Hematology Authors: Amy E DeZern Marianna Zahurak Richard J Jones Robert A Brodsky Source Type: research
Aplastic anemia after SARS-CoV-2 infection or vaccines: case series and literature review
Blood Transfus. 2023 Sep 4. doi: 10.2450/BloodTransfus.500. Online ahead of print.NO ABSTRACTPMID:37677091 | DOI:10.2450/BloodTransfus.500 (Source: Blood Transfusion)
Source: Blood Transfusion - September 7, 2023 Category: Hematology Authors: Bruno Fattizzo Raffaella Pasquale Giorgio A Croci Loredana Pettine Giulio Cassanello Wilma Barcellini Source Type: research
Uniform conditioning regardless of donor in bone marrow transplantation for severe aplastic anemia
Haematologica. 2023 Sep 7. doi: 10.3324/haematol.2023.284022. Online ahead of print.ABSTRACTNot available.PMID:37675516 | DOI:10.3324/haematol.2023.284022 (Source: Haematologica)
Source: Haematologica - September 7, 2023 Category: Hematology Authors: Amy E DeZern Marianna Zahurak Richard J Jones Robert A Brodsky Source Type: research
