Safety of romiplostim administered immediately after cord-blood transplantation: a phase 1 trial
AbstractGraft failure and delayed hematopoietic recovery are the major limitations of cord-blood transplantation (CBT). Romiplostim, a thrombopoietin-receptor agonist, promotes megakaryopoiesis and multilineage hematopoiesis in aplastic anemia. The decreased number of hematopoietic stem cells in the early phase after CBT and aplastic anemia share certain characteristics. Therefore, we hypothesized that romiplostim administration immediately after CBT may promote multilineage hematopoietic recovery. We investigated the safety and preliminary efficacy of administering romiplostim a day after CBT. This phase 1 dose-escalation...
Source: Annals of Hematology - August 17, 2023 Category: Hematology Source Type: research
Correlation between human leukocyte antigen ligands and killer cell immunoglobulin-like receptors in aplastic anemia patients from Shaanxi Han
This study revealed the contribution of KIR genes in the etiology of AA cases. (Source: Immunogenetics)
Source: Immunogenetics - August 17, 2023 Category: Genetics & Stem Cells Source Type: research
SARS-CoV-2 vaccination in 361 non-transplanted patients with aplastic anemia and/or paroxysmal nocturnal hemoglobinuria
Haematologica. 2023 Aug 16. doi: 10.3324/haematol.2023.283863. Online ahead of print.NO ABSTRACTPMID:37584297 | DOI:10.3324/haematol.2023.283863 (Source: Haematologica)
Source: Haematologica - August 16, 2023 Category: Hematology Authors: Morag Griffin Dirk-Jan Eikema Inge Verheggen Alexander Kulagin Jennifer M-L Tjon Bruno Fattizzo Wendy Ingram Uzma Zaidi Lana Desnica Sabrina Giammarco Joanna Drozd-Sokolowska Blanca Xicoy Andrea Patriarca Michael Loschi Anna Szmigielska-Kaplon Fabian Beie Source Type: research
SARS-CoV-2 vaccination in 361 non-transplanted patients with aplastic anemia and/or paroxysmal nocturnal hemoglobinuria
Haematologica. 2023 Aug 16. doi: 10.3324/haematol.2023.283863. Online ahead of print.NO ABSTRACTPMID:37584297 | DOI:10.3324/haematol.2023.283863 (Source: Haematologica)
Source: Haematologica - August 16, 2023 Category: Hematology Authors: Morag Griffin Dirk-Jan Eikema Inge Verheggen Alexander Kulagin Jennifer M-L Tjon Bruno Fattizzo Wendy Ingram Uzma Zaidi Lana Desnica Sabrina Giammarco Joanna Drozd-Sokolowska Blanca Xicoy Andrea Patriarca Michael Loschi Anna Szmigielska-Kaplon Fabian Beie Source Type: research
SARS-CoV-2 vaccination in 361 non-transplanted patients with aplastic anemia and/or paroxysmal nocturnal hemoglobinuria
Haematologica. 2023 Aug 16. doi: 10.3324/haematol.2023.283863. Online ahead of print.NO ABSTRACTPMID:37584297 | DOI:10.3324/haematol.2023.283863 (Source: Haematologica)
Source: Haematologica - August 16, 2023 Category: Hematology Authors: Morag Griffin Dirk-Jan Eikema Inge Verheggen Alexander Kulagin Jennifer M-L Tjon Bruno Fattizzo Wendy Ingram Uzma Zaidi Lana Desnica Sabrina Giammarco Joanna Drozd-Sokolowska Blanca Xicoy Andrea Patriarca Michael Loschi Anna Szmigielska-Kaplon Fabian Beie Source Type: research
SARS-CoV-2 vaccination in 361 non-transplanted patients with aplastic anemia and/or paroxysmal nocturnal hemoglobinuria
Haematologica. 2023 Aug 17. doi: 10.3324/haematol.2023.283863. Online ahead of print.NO ABSTRACTPMID:37584297 | DOI:10.3324/haematol.2023.283863 (Source: Haematologica)
Source: Haematologica - August 16, 2023 Category: Hematology Authors: Morag Griffin Dirk-Jan Eikema Inge Verheggen Alexander Kulagin Jennifer M-L Tjon Bruno Fattizzo Wendy Ingram Uzma Zaidi Lana Desnica Sabrina Giammarco Joanna Drozd-Sokolowska Blanca Xicoy Andrea Patriarca Michael Loschi Anna Szmigielska-Kaplon Fabian Beie Source Type: research
SARS-CoV-2 vaccination in 361 non-transplanted patients with aplastic anemia and/or paroxysmal nocturnal hemoglobinuria
Haematologica. 2023 Aug 17. doi: 10.3324/haematol.2023.283863. Online ahead of print.NO ABSTRACTPMID:37584297 | DOI:10.3324/haematol.2023.283863 (Source: Haematologica)
Source: Haematologica - August 16, 2023 Category: Hematology Authors: Morag Griffin Dirk-Jan Eikema Inge Verheggen Alexander Kulagin Jennifer M-L Tjon Bruno Fattizzo Wendy Ingram Uzma Zaidi Lana Desnica Sabrina Giammarco Joanna Drozd-Sokolowska Blanca Xicoy Andrea Patriarca Michael Loschi Anna Szmigielska-Kaplon Fabian Beie Source Type: research
SARS-CoV-2 vaccination in 361 non-transplanted patients with aplastic anemia and/or paroxysmal nocturnal hemoglobinuria
Haematologica. 2023 Aug 17. doi: 10.3324/haematol.2023.283863. Online ahead of print.NO ABSTRACTPMID:37584297 | DOI:10.3324/haematol.2023.283863 (Source: Haematologica)
Source: Haematologica - August 16, 2023 Category: Hematology Authors: Morag Griffin Dirk-Jan Eikema Inge Verheggen Alexander Kulagin Jennifer M-L Tjon Bruno Fattizzo Wendy Ingram Uzma Zaidi Lana Desnica Sabrina Giammarco Joanna Drozd-Sokolowska Blanca Xicoy Andrea Patriarca Michael Loschi Anna Szmigielska-Kaplon Fabian Beie Source Type: research
Rehmannia Glutinosa Polysaccharide Regulates Bone Marrow Microenvironment via HIF-1 α/NF-κB Signaling Pathway in Aplastic Anemia Mice
This study aimed to explore the mechanism of action of Rehmannia glutinosa polysaccharide (RGP) in AA. Busulfan was used to induce AA in BALB/c mice; blood cell count and Ray's Giemsa staining were used to assess the severity of hematopoietic failure; HE was performed to assess the pathological state of the marrow cavity; ELISA was performed to assess IL-4, IL-10, IL-6, IL-12, IL-1β, TNF-α, MCP-1, VEGF, and EPO; and WB was performed to evaluate the effects of RGP on the HIF-1α/NF-κB signaling. Significant downregulation of hemocyte levels in the blood and nucleated cells in the bone marrow was reversed by RGP and Cyclo...
Source: An Acad Bras Cienc - August 9, 2023 Category: Science Authors: N A Liu Jun-Qiu Liu Yong Liu Qing Zhu Dandan Zheng Feng Li Ling-Zhan Meng Min Qiu Source Type: research
Rehmannia Glutinosa Polysaccharide Regulates Bone Marrow Microenvironment via HIF-1 α/NF-κB Signaling Pathway in Aplastic Anemia Mice
This study aimed to explore the mechanism of action of Rehmannia glutinosa polysaccharide (RGP) in AA. Busulfan was used to induce AA in BALB/c mice; blood cell count and Ray's Giemsa staining were used to assess the severity of hematopoietic failure; HE was performed to assess the pathological state of the marrow cavity; ELISA was performed to assess IL-4, IL-10, IL-6, IL-12, IL-1β, TNF-α, MCP-1, VEGF, and EPO; and WB was performed to evaluate the effects of RGP on the HIF-1α/NF-κB signaling. Significant downregulation of hemocyte levels in the blood and nucleated cells in the bone marrow was reversed by RGP and Cyclo...
Source: An Acad Bras Cienc - August 9, 2023 Category: Science Authors: N A Liu Jun-Qiu Liu Yong Liu Qing Zhu Dandan Zheng Feng Li Ling-Zhan Meng Min Qiu Source Type: research
Rehmannia Glutinosa Polysaccharide Regulates Bone Marrow Microenvironment via HIF-1 α/NF-κB Signaling Pathway in Aplastic Anemia Mice
This study aimed to explore the mechanism of action of Rehmannia glutinosa polysaccharide (RGP) in AA. Busulfan was used to induce AA in BALB/c mice; blood cell count and Ray's Giemsa staining were used to assess the severity of hematopoietic failure; HE was performed to assess the pathological state of the marrow cavity; ELISA was performed to assess IL-4, IL-10, IL-6, IL-12, IL-1β, TNF-α, MCP-1, VEGF, and EPO; and WB was performed to evaluate the effects of RGP on the HIF-1α/NF-κB signaling. Significant downregulation of hemocyte levels in the blood and nucleated cells in the bone marrow was reversed by RGP and Cyclo...
Source: An Acad Bras Cienc - August 9, 2023 Category: Science Authors: N A Liu Jun-Qiu Liu Yong Liu Qing Zhu Dandan Zheng Feng Li Ling-Zhan Meng Min Qiu Source Type: research
Rehmannia Glutinosa Polysaccharide Regulates Bone Marrow Microenvironment via HIF-1 α/NF-κB Signaling Pathway in Aplastic Anemia Mice
This study aimed to explore the mechanism of action of Rehmannia glutinosa polysaccharide (RGP) in AA. Busulfan was used to induce AA in BALB/c mice; blood cell count and Ray's Giemsa staining were used to assess the severity of hematopoietic failure; HE was performed to assess the pathological state of the marrow cavity; ELISA was performed to assess IL-4, IL-10, IL-6, IL-12, IL-1β, TNF-α, MCP-1, VEGF, and EPO; and WB was performed to evaluate the effects of RGP on the HIF-1α/NF-κB signaling. Significant downregulation of hemocyte levels in the blood and nucleated cells in the bone marrow was reversed by RGP and Cyclo...
Source: An Acad Bras Cienc - August 9, 2023 Category: Science Authors: N A Liu Jun-Qiu Liu Yong Liu Qing Zhu Dandan Zheng Feng Li Ling-Zhan Meng Min Qiu Source Type: research
Rehmannia Glutinosa Polysaccharide Regulates Bone Marrow Microenvironment via HIF-1 α/NF-κB Signaling Pathway in Aplastic Anemia Mice
This study aimed to explore the mechanism of action of Rehmannia glutinosa polysaccharide (RGP) in AA. Busulfan was used to induce AA in BALB/c mice; blood cell count and Ray's Giemsa staining were used to assess the severity of hematopoietic failure; HE was performed to assess the pathological state of the marrow cavity; ELISA was performed to assess IL-4, IL-10, IL-6, IL-12, IL-1β, TNF-α, MCP-1, VEGF, and EPO; and WB was performed to evaluate the effects of RGP on the HIF-1α/NF-κB signaling. Significant downregulation of hemocyte levels in the blood and nucleated cells in the bone marrow was reversed by RGP and Cyclo...
Source: An Acad Bras Cienc - August 9, 2023 Category: Science Authors: N A Liu Jun-Qiu Liu Yong Liu Qing Zhu Dandan Zheng Feng Li Ling-Zhan Meng Min Qiu Source Type: research
Rehmannia Glutinosa Polysaccharide Regulates Bone Marrow Microenvironment via HIF-1 α/NF-κB Signaling Pathway in Aplastic Anemia Mice
This study aimed to explore the mechanism of action of Rehmannia glutinosa polysaccharide (RGP) in AA. Busulfan was used to induce AA in BALB/c mice; blood cell count and Ray's Giemsa staining were used to assess the severity of hematopoietic failure; HE was performed to assess the pathological state of the marrow cavity; ELISA was performed to assess IL-4, IL-10, IL-6, IL-12, IL-1β, TNF-α, MCP-1, VEGF, and EPO; and WB was performed to evaluate the effects of RGP on the HIF-1α/NF-κB signaling. Significant downregulation of hemocyte levels in the blood and nucleated cells in the bone marrow was reversed by RGP and Cyclo...
Source: An Acad Bras Cienc - August 9, 2023 Category: Science Authors: N A Liu Jun-Qiu Liu Yong Liu Qing Zhu Dandan Zheng Feng Li Ling-Zhan Meng Min Qiu Source Type: research
The reconstitution of T-cells after Allogeneic Hematopoietic Stem Cell Transplant in a Pediatric Patient with Congenital Amegakaryocytic Thrombocytopenia (CAMT)
CONCLUSION: Successful treatment of acute GvHD prevented advancing the condition to chronic GvHD, and this was accompanied by delayed T-cell reconstitution through an increase in Treg:Tcons ratio.PMID:37526450 | DOI:10.2174/1871530323666230801100113 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 1, 2023 Category: Drugs & Pharmacology Authors: Shideh Namazi Bayegi Amir Ali Hamidieh Maryam Behfar Amene Saghazadeh Mahmood Bozorgmehr Nader Tajik Ali Akbar Delbandi Samaneh Delavari Mehdi Shekarabi Nima Rezaei Source Type: research
