Role of differential proteomics in studying pharmacological mechanisms of traditional Chinese medicines.
Authors: Wang Y, Javed I, Zhang X, Liu D, Zhang C Abstract Traditional Chinese Medicines (TCMs) have been used for more than 3,000 years. However, most TCMs are used based on previous experience, and their exact mechanisms are still unclear. Proteomics, as a major component of systems biology, is an appropriate tool that could bring breakthroughs in the study of pharmacological mechanisms of TCMs. Researchers made substantial progress by using the proteomics approach to investigate the mechanism of TCMs. In this review, we summarize the current applications of proteomics in the mechanistic study of TCMs. Proteomics...
Source: Journal of Pharmacy and Pharmaceutical Sciences - September 12, 2019 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

PPAR γ agonist, pioglitazone, suppresses melanoma cancer in mice by inhibiting TLR4 signaling.
CONCLUSIONS: The results indicate that pioglitazone, a PPARγ agonist, has a beneficial protective effect against melanoma via interfering with the TLR4-dependent signaling pathways. PMID: 31509504 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - September 12, 2019 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Overview and Future Potential of Fast Dissolving Buccal Films as Drug Delivery System for Vaccines.
Authors: Uddin MN, Allon A, Roni MA, Kouzi S Abstract Vaccination is considered one of the most successful public health interventions of the modern era. Vaccines are categorized based on the antigen used, delivery system and the route of administration. Traditional vaccines are produced from the dead, attenuated or inactivated pathogens that cause disease. However, newly developed vaccines are DNA based, liposome based, and virus like particle (VLP) based which are more effective and specific to some malignant diseases. The delivery system of vaccines has been advanced along with time as well. New delivery systems...
Source: Journal of Pharmacy and Pharmaceutical Sciences - August 8, 2019 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Effects of Three Anti-Seizure Drugs on Cholinergic and Metabolic Activity in Experimental Status Epilepticus.
CONCLUSIONS: Hippocampal ACh release closely follows seizure activity in SE and is attenuated when SE subsides. Pregabalin, valproic acid and levetiracetam all terminate seizures in the rat SE model and attenuate cholinergic and metabolic changes within two hours. PMID: 31356760 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - July 30, 2019 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

In vivo PET Imaging of [11C]CIMBI-5, a 5-HT2AR Agonist Radiotracer in Nonhuman Primates.
CONCLUSION: The lower binding potential of [11C]CIMBI-5 in comparison to [11C]MDL100907 is likely due to the preferential binding of the former to the high affinity site in vivo in contrast to the antagonist,  [11C]MDL100907, which binds to both high and low affinity sites. PMID: 31356761 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - July 30, 2019 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Analysis of the Association Between Polymorphisms within PAI-1 and ACE genes and Ischemic Stroke Outcome After rt-PA Therapy.
CONCLUSION: Results of our study suggest that stroke patients with ACE II genotype, treated with rt-PA, may be at risk of HT. PMID: 31013014 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - April 24, 2019 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Methodological Characteristics of Clinical Trials: Impact of Mandatory Trial Registration.
Authors: Kakkar AK, Padhy BM, Sarangi SC, Gupta YK Abstract PURPOSE: Numerous studies across multiple specialties have evaluated the impact of trial registration on quality of study reports and found significant improvements over several domains. However, the impact of mandatory trial registration on the quality of clinical trial protocols remains hitherto unexplored. METHODS: We carried out a retrospective cohort study of clinical trial applications submitted to drug regulatory authority of India for initial review with the objective of comparing methodological characteristics of their protocols. Since trial r...
Source: Journal of Pharmacy and Pharmaceutical Sciences - April 24, 2019 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Norfloxacin, a Fluoroquinolone Antibiotic, Inhibits Langerhans Cell-Mediated Th1 and Th2 Cell Development.
CONCLUSIONS: The present results show that topical application of norfloxacin inhibits the development of AD-like skin lesions in NC/Nga mice. This suggests that topical application of norfloxacin to AD lesions colonized with S. aureus would act on both superficial S. aureus and epidermal LCs, thus possibly inhibiting the development of Th1 and Th2 cells in vivo, and controlling the severity of AD. PMID: 30974054 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - April 13, 2019 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Effect of the Fexofenadine on the expression of HRH-1 and HRH-4 receptor in Peripheral Blood Mononuclear Cell isolated from children with diagnosed allergy - in vitro study Short communication.
CONCLUSIONS: Results clearly overturned our hypothesis about the possibility of using FXF to block over-expression HRH-4 and open new way of treatment in allergy diseases. PMID: 30742585 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - February 12, 2019 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Prediction of Hepatic Clearance of Stereoselective Metabolism of Carvedilol in Liver Microsomes and Hepatocytes of Sprague-Dawley and Cytochrome P450 2D-Deficient Dark Agouti Rats.
Authors: Iwaki M, Niwa T, Tanaka H, Kawase A, Komura H Abstract Hepatic clearance (CLh) of carvedilol (CAR), which is eliminated via stereoselective metabolism by the CYP2D subfamily of cytochromes P450 (CYPs), was predicted using liver microsomes and hepatocytes from Sprague-Dawley (SD) rats and CYP2D-deficient Dark Agouti (DA) rats to determine the usefulness of prediction method. Plasma concentrations of CAR following intravenous injection to DA rats were higher than those in SD rats. The volume of distribution at steady state and total clearance (CLtot) of S-CAR were approximately two times greater than those o...
Source: Journal of Pharmacy and Pharmaceutical Sciences - January 27, 2019 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

A Survey of the Regulatory Requirements for the Acceptance of Foreign Comparator Products by Participating Regulators and Organizations of the International Generic Drug Regulators Programme.
In conclusion, there is currently no consensus amongst regulators on the acceptability of foreign comparator products. PMID: 30599818 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - January 3, 2019 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

A Review of Beneficial Low-Intensity Exercises in Diabetic Peripheral Neuropathy Patients.
Authors: Johnson CE, Takemoto JK Abstract The American Diabetic Association standards of medical care for diabetic patients recommends moderate intensity exercise to help manage diabetes; however, this recommendation may be unmanageable for patients who have become inactive or unable to reach this intensity. The purpose of this review is to determine if low-intensity exercises demonstrate improvement in diabetic peripheral neuropathy symptoms in order to utilize these exercises as a starting point for inactive patients. Studies in low-intensity exercises from 2013 to May 2018 were systematically searched in PubMed,...
Source: Journal of Pharmacy and Pharmaceutical Sciences - January 3, 2019 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

PAMAM-dendrimer Enhanced Antibacterial Effect of Vancomycin Hydrochloride Against Gram-Negative Bacteria.
CONCLUSIONS: The present study revealed that both G3 and G5 cationic PAMAM dendrimers are able to make Gram-negative bacteria sensitive to vancomycin, resulting in decline of MIC values up to 64 times, possibly by increasing its permeation through bacterial membrane. These results look promising for broadening the antibacterial spectrum of vancomycin and such a strategy might be used for increasing the overall life of antibiotics. PMID: 30589641 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - December 28, 2018 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Non-alcoholic Steatohepatitis (NASH) Drug Discovery - Building a Consensus on ADME Screening Tools and Clinical Pharmacology Strategies to Aid Candidate Development.
Authors: Dash RP, Babu RJ, Srinivas NR Abstract Number of drugs with different mechanisms of actions is undergoing clinical trials for non-alcoholic steatohepatitis (NASH). Given the complexity of the disease with respect to pathophysiology in the liver and associated changes in the renal function, it becomes apparent that a clear ADME (absorption, distribution, metabolism and excretion) strategy needs to be put in place for a successful nomination of a drug candidate for NASH. This review discusses using in vitro and in vivo ADME screens to understand the properties of drugs and to establish whether or not the cho...
Source: Journal of Pharmacy and Pharmaceutical Sciences - November 27, 2018 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Development, Characterization, and Pharmacokinetic Evaluation of a CRV431 Loaded Self-Microemulsifying Drug Delivery System.
CONCLUSIONS: The developed SMEDDS formulation should allow for effective clinical development of CRV431, targeted to the treatment of liver diseases including hepatitis B (HBV), fibrosis, and hepatocellular carcinoma. PMID: 30472978 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - November 27, 2018 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Polymorphisms of Catechol-O-Methyl Transferase (COMT) Gene in Vulnerability to Levodopa-Induced Dyskinesia.
CONCLUSIONS: The results failed to clearly support a contribution of the studied polymorphisms; this may be related to a dominant relationship with the disease duration confounding the effect on the prevalence of LID. PMID: 30075828 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - August 5, 2018 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Calcium Signal Pathway is Involved in Prostaglandin E2 Induced Cardiac Fibrosis in Cardiac Fibroblasts.
CONCLUSIONS: PGE2 may promote cardiac fibrosis via EP1 receptor and calcium signal pathway. PMID: 30075829 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - August 5, 2018 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Icariside II Attenuates Chronic Hydrocephalus in an Experimental Subarachnoid Hemorrhage Rat Model.
Conclusion ICA II might suppress fibrosis via inhibition of TGF-β1/Smad/CTGF pathway, prevent the development of SAH related chronic hydrocephalus, and improve long term neurocognitive defects following SAH. PMID: 30070971 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - August 4, 2018 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

in vitro- and in vivo Evaluation of Methotrexate-Loaded Hydrogel Nanoparticles Intended to Treat Primary CNS Lymphoma via Intranasal Administration.
Conclusion: According to in vivo studies, nanogel produced significantly higher concentration of MTX in the brain but not in the plasma when compared to the free drug solution. Besides, in comparison to intravenous administration of the same nanogel it was indicated that intranasal administration significantly increases the brain concentration of MTX. PMID: 30053381 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - July 29, 2018 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Clearance Concepts: Fundamentals and Application to Pharmacokinetic Behavior of Drugs.
This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 30041730 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - July 26, 2018 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Transport of AOPP-Albumin into Human Alveolar Epithelial A549 Cell.
CONCLUSION: AOPP-albumin is transported into alveolar epithelial cells through clathrin-mediated endocytosis, which may be important to prevent further ROS generation. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 29975628 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - July 6, 2018 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Inhibitory Effects of Baicalein Derived from Japanese Traditional Herbal Medicine on SN-38 Glucuronidation.
CONCLUSIONS: These findings strongly suggested that SN-38 glucuronidation is inhibited by BA. BA could act as a pharmacokinetic regulating factor associated with SN-38 glucuronidation. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 29891024 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - June 13, 2018 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Clinical Outcomes of Aspirin Interaction with Other Non-Steroidal Anti-Inflammatory Drugs: A Systematic Review.
CONCLUSION: Aspirin appears to maintain its cardioprotective effect in the presence of naproxen, ibuprofen, meloxicam and rofecoxib. The limited available data suggest that the effect of interaction at the platelet aggregation level may dissipate shortly, or the reduced platelet aggregation yielded by the interaction may be sufficient for cardioprotection; i.e., no need for near complete aggregation. In addition, cardioprotective effect of Aspirin, despite reduced platelet aggregation caused by NANSAIDs, may be through its involvement in other mechanisms such as the renin-angiotensin system and/or metabolism of arachidonic...
Source: Journal of Pharmacy and Pharmaceutical Sciences - June 13, 2018 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Comparison of Ticagrelor with Clopidogrel in Reducing Interleukin-17 and Myeloperoxidase Expression in Thrombus and Improving Postprocedural Coronary Flow in ST-segment Elevation Myocardial Infarction Patients.
This study aimed to explore the effects of ticagrelor (a P2Y12 receptor inhibitor) on interleukin (IL)-17 and myeloperoxidase (MPO) expression in coronary thrombus as well as on the coronary blood flow in ST-segment elevation myocardial infarction (STEMI) patients following percutaneous coronary intervention (PCI). METHODS: Forty STEMI patients who were admitted to the First Affiliated Hospital of Harbin Medical University between August 1, 2014 and December 30, 2014 were enrolled in this study according to a set inclusion criteria. They were randomized to ticagrelor and clopidogrel groups and treated with 180 mg ticag...
Source: Journal of Pharmacy and Pharmaceutical Sciences - June 13, 2018 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Licofelone Attenuates LPS-induced Depressive-like Behavior in Mice: A Possible Role for Nitric Oxide.
CONCLUSIONS: NO down-regulation possibly through iNOS and nNOS inhibition may involve in the antidepressant property of licofelone. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 29789101 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - May 24, 2018 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

An Update on Drug-induced Oral Reactions.
This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 29789102 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - May 24, 2018 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Evaluation of Ion-pair Formation of Adefovir to Improve Permeation across Artificial and Biological Membranes.
CONCLUSION: These results suggest that the adefovir-CPC ion-paired system has potential for improving the permeation of adefovir across the intestinal membrane. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 29789103 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - May 24, 2018 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Functionalized Caprolactone-Polyethylene Glycol Based Thermo-Responsive Hydrogels of Silibinin for the Treatment of Malignant Melanoma.
CONCLUSION: Our results imply a great potential for PolyGel TM formulations of silibinin for local treatment of malignant melanoma. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's content page. PMID: 29789104 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - May 24, 2018 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Targeted Delivery of Amantadine-loaded Methacrylate Nanosphere-ligands for the Potential Treatment of Amyotrophic Lateral Sclerosis.
CONCLUSIONS: Biocompatible amantadine-loaded nanospheres were successfully designed, characterized and optimized employing the randomized Box-Behnken statistical design. Delivery of amantadine over 72 hrs was achieved, with the nanospheres being of a size capable of internalization by the NSC- 34 cells. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 29510799 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - March 8, 2018 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Microneedles as Enhancer of Drug Absorption Through the Skin and Applications in Medicine and Cosmetology.
This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 29510800 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - March 8, 2018 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

The Remarkable Cationic Peptides: A Boon to Pharmaceutical Sciences?
This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 29510801 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - March 8, 2018 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Association Between HLA genotypes and Oxcarbazepine-induced Cutaneous Adverse Drug Reactions: A Systematic Review and Meta-Analysis.
CONCLUSIONS: Strong associations between the HLA-B*1502 and OXC-cADRs (SJS and maculopapular rash) were found in both controls from general population and OXC-tolerant groups. There was also an association between HLA-B*3101 and OXC-induced maculopapular rash. For patient safety, genetic screening especially for HLA-B*1502 prior to OXC therapy at least in these closely related ethnicities is warranted. Further studies need to better define other ethnicities at risk and a wider range of MHC gene subtypes. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by cl...
Source: Journal of Pharmacy and Pharmaceutical Sciences - January 27, 2018 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Ciprofloxacin does not Prolong the QTc Interval: A Clinical Study in ICU Patients and Review of the Literature.
Conclusion. Based on our results and the results of previous studies, it is unlikely that ciprofloxacin has a clinically relevant QT prolonging effect or an increased risk of TdP. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 29145929 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - November 18, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Assessment of Predicted Rate and Associated Factors of Dabigatran-induced Bleeding Events in Malaysian Patients with Non-Valvular Atrial Fibrillation.
CONCLUSIONS: The predicted rate for dabigatran-induced major bleeding episodes is low but these adverse events carry a high fatality risk. Preventive measures should target older patients who have prior bleeding or congestive heart failure. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 29145930 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - November 18, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

In vitro and in silico Approaches to Study Cytochrome P450-Mediated Interactions.
This article gives a review of some of the current in vitro and in silico methods used to characterize cytochrome P450(CYP)-mediated drug metabolism for estimating pharmacokinetic variability and the magnitude of drug-drug interactions. Examples demonstrating the predictive applicability of specific in vitro and in silico approaches are described. Commonly encountered confounding factors and sources of bias and error in these approaches are presented. With the advent of technological advancement in high throughput screening and computer power, the in vitro and in silico methods are becoming more efficient and reliable and ...
Source: Journal of Pharmacy and Pharmaceutical Sciences - November 18, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Lipid Emulsion, More Than Reversing Bupivacaine Cardiotoxicity: Potential Organ Protection.
This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 29145932 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - November 18, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Quantitative Structure - Pharmacokinetics Relationships for Plasma Protein Binding of Basic Drugs.
CONCLUSIONS: PPB of basic drugs is favored by the lipophilicity, the presence of aromatic C-atoms (either non-substituted, or involved in bridged aromatic systems) and molecular volume.  The fraction ionized as a base fB and the presence of quaternary C-atoms contribute negatively to PPB. A short checklist of criteria for high PPB is defined, and an empirical rule for distinguishing between low, high and very high plasma protein binders is proposed based. This rule allows correct classification of 69% of the very high binders, 71% of the high binders and 91% of the low binders in plasma. This article is open to P...
Source: Journal of Pharmacy and Pharmaceutical Sciences - November 18, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Economic Evaluations on Antimicrobial Stewardship Programme: A Systematic Review.
CONCLUSIONS: All studies were generally well-conducted with relatively good quality of reporting. Implementing ASP in the hospital setting may be cost-effective. However, comprehensive cost-effectiveness data for ASP remain relatively scant, underlining the need for more prospective clinical and epidemiological studies to incorporate robust economic analyses into clinical decisions. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 29145934 [PubMed - in process] (Source: Journal of Pharmacy and P...
Source: Journal of Pharmacy and Pharmaceutical Sciences - November 18, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Effectiveness of Pharmacist-led Anticoagulation Management on Clinical Outcomes: A Systematic Review and Meta-Analysis.
CONCLUSIONS: According to the grading of evidence, we concluded that the risk of total haemorrhage events, minor haemorrhage events and thrombosis events significantly decreased in pharmacist-led anticoagulation management group compared with other management models and no significant difference in TTR, TER, major haemorrhage events and mortality between two groups. Longer follow-up period RCT studies with large sample size should be done in the future to confirm effectiveness of pharmacist-led anticoagulation management model. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers&...
Source: Journal of Pharmacy and Pharmaceutical Sciences - November 18, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Biosimilars: State of Clinical and Regulatory Science.
Authors: Klein AV, Wang J, Feagan BG, Omoto M Abstract On May 12, 2017, various issues and challenges associated with biologics were discussed during a session of the annual joint conference of Canadian Society for Pharmaceutical Sciences and Canadian Chapter of Controlled Release Society at Hyatt Regency Hotel, Montréal, QC, Canada.  An update on the Canadian regulatory guidelines for biosimilars was given, followed by viewpoints expressed by regulatory, academic and industry scientists.  Topics of discussion included: reference biologic drug, clinical considerations, immunogenicity, extrapolation...
Source: Journal of Pharmacy and Pharmaceutical Sciences - November 18, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Safety and Efficacy of Rotigotine for Treating Parkinson's Disease: A Meta-Analysis of Randomised Controlled Trials.
Authors: Chen F, Jin L, Nie Z Abstract We aimed to comprehensively analyse the safety and efficiency of rotigotine for treating Parkinson's disease (PD). We conducted systematic literature searches of Cochrane library, PubMed and Embase databases up to April 2016, with 'Rotigotine', 'Parkinson Disease'and 'Parkinson's disease' as key searching terms. Outcomes, including Unified Parkinson's Disease Rating Scale (UPDRS) Part III and Part II scores, 'off' time, adverse events (AEs), serious AEs and discontinuation because of AEs, were compared between rotigotine and placebo groups under a fixed or random effect model....
Source: Journal of Pharmacy and Pharmaceutical Sciences - August 18, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Intravaginal Delivery Approaches for Contraception: An Overview with Emphasis on Gels.
This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 28810947 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - August 18, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Development and Validation of a Robust and Efficient HPLC Method for the Simultaneous Quantification of Levodopa, Carbidopa, Benserazide and Entacapone in Complex Matrices.
CONCLUSION: The new method allows for robust and fast separation of levodopa, carbidopa, benserazide and entacapone without any interference caused by excipients or ingredients of compendial and biorelevant dissolution media and thus presents a valuable tool in both formulation development and in vitro drug release screening of numerous fixed-dose combinations of antiparkinson drugs. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 28810948 [PubMed - in process] (Source: Journal of Pharmacy and ...
Source: Journal of Pharmacy and Pharmaceutical Sciences - August 18, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Analysis of Non-Pivotal Bioequivalence Studies Submitted in Abbreviated New Drug Submissions for Delayed-Release Drug Products.
This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 28810949 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - August 18, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Clofibrate Attenuates ROS Production by Lipid Overload in Cultured Rat Hepatoma Cells.
Authors: Chen Y, Li W, Wang G, Burczynski FJ Abstract PURPOSE: To investigate the effect of clofibrate on inducing liver fatty acid binding protein (FABP1) following a high-fat load in a hepatocyte cell culture model. METHODS: Rat hepatoma cells (CRL-1548) were treated with a fatty acid (FA) mixture consisting of oleate:palmitate (2:1) in the presence of 3% albumin. Cells were treated with 0, 0.5, 1, 2, or 3 mM FA for 24 and 48 hr, or further treated with 500 µM clofibrate (CLO) to induce FABP1 levels. Cytotoxicity was determined using the WST-1 assay. Intracellular lipid droplets were quantitated followi...
Source: Journal of Pharmacy and Pharmaceutical Sciences - August 18, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Overview of Nanoparticle Coating of Dental Implants for Enhanced Osseointegration and Antimicrobial Purposes.
CONCLUSIONS: Considering the reported success, more clinically and in vivo information on the nanoparticle-based implant coatings will add to the successful application of the device in the clinic. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 28554344 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - May 31, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Quantitative Structure - Pharmacokinetic Relationships for Plasma Clearance of Basic Drugs with Consideration of the Major Elimination Pathway.
CONCLUSIONS: Plasma protein binding was the major restrictive factor for the CL of drugs, primarily cleared by metabolism.  The clearance was favored by lipophilicity and several structural features like OH-groups, aromatic rings, large hydrophobic centers, aliphatic groups, connected with electro-negative atoms, and non-substituted aromatic C-atoms. The presence of Cl-atoms and abundance of 6-member aromatic rings or fused rings had negative effect.  The presence of ether O-atoms contributed negatively to the CL of both metabolism and renally excreted drugs, and urine excretion was favored by the presence of 3-v...
Source: Journal of Pharmacy and Pharmaceutical Sciences - May 31, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Clay and Polymer-Based Composites Applied to Drug Release: A Scientific and Technological Prospection.
This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 28554346 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - May 31, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

A Short Guide to Electrophysiology and Ion Channels.
This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 28459656 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - May 2, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Investigation of a Potential Pharmacokinetic Interaction Between Nebivolol and Fluvoxamine in Healthy Volunteers.
CONCLUSIONS: Due to enzymatic inhibition, fluvoxamine increases the exposure to nebivolol and its active hydroxylated metabolite in healthy volunteers. This did not influence the blood pressure and heart-rate lowering effects of the beta-blocker administered as single-dose. However, more detail studies involving actual patients are required to further investigate the clinical relevance of this drug interaction. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 28459657 [PubMed - in process] (Sour...
Source: Journal of Pharmacy and Pharmaceutical Sciences - May 2, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research