Comparison of stem cell transplantation using unrelated, haploidentical, and sibling donors for patients with acquired severe aplastic anemia : A single center, retrospective, cohort study

The preferred donor (haploidentical vs. matched unrelated donor) choice in patients with acquired severe aplastic anemia (SAA) who lack a human leukocyte antigen (HLA)-matched sibling donors (MSDs) and fail upfront immunosuppressive treatment (IST) therapy is unknown. We retrospectively investigated SAA patients (n=58) who underwent allogeneic stem cell transplantation (allo-SCT) between January 2012 and October 2022. The 5-year overall survival (OS) (87.5% ± 11.7% vs. 98.0% ± 6.5% vs. 83.3% ± 7.6%, respectively, p= 0.926) and 5-year failure-free survival (FFS) (60.0% ± 18.2% vs.

Source: Biology of Blood and Marrow Transplantation - November 14, 2023 Category: Hematology Authors: Weijia Fu, Su Gao, Yanrong Luo, Li Chen, Jie Chen, Lei Gao, Libing Wang, Lili Xu, Yang Wang, Ziwei Wang, Wenqin Yue, Hui Cheng, Gusheng Tang, Jianmin Wang, Jianmin Yang, Xiong Ni Source Type: research