Oropharyngeal Stenosis Caused by Significant Scar Hyperplasia Following Tonsillectomy: A Case Report
Ear Nose Throat J. 2024 Feb 15:1455613241233750. doi: 10.1177/01455613241233750. Online ahead of print.ABSTRACTOropharyngeal stenosis (OPS) is a relatively rare long-term complication of tonsillectomy in children, resulting from the narrowing of the upper aerodigestive tract between the soft palate, pharyngeal sidewalls, and base of the tongue. This is the first reported case of OPS due to significant scar hyperplasia; however, whether it is as prone to recurrence as skin scar hypertrophy remains unknown. In this article, we present the case of a 5-year-old girl who presented to our otolaryngology clinic with sleep snoring...
Source: Ear, Nose and Throat Journal - February 15, 2024 Category: ENT & OMF Authors: Zhi-Tao Fan Xue-Xia Wang Wen-Xin Dong Tong Qiao Jing-Rui Liu Yue-Tang Wang Chao-Bing Liu Source Type: research
Expression of FOXI1 and POU2F3 varies among different salivary gland neoplasms and is higher in Warthin tumor
ConclusionThe expression patterns of the characteristic transcription factors found in ionocytes and tuft cells vary among salivary gland tumor types and are higher in WT, which might be relevant for understanding and diagnosing salivary gland neoplasms. (Source: Hormones and Cancer)
Source: Hormones and Cancer - February 15, 2024 Category: Cancer & Oncology Source Type: research
Pediatric chronic rhinosinusitis
ConclusionsPCRS is very common in children causing poor QOL for these children. Medical management remains the main stay of treatment with attention to management of co-morbidities that may contribute to the disease severity. Making the correct diagnosis will help with the choice of surgical intervention if medical management fails. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - February 9, 2024 Category: ENT & OMF Source Type: research
A case of adenoid cystic carcinoma with hepatic metastasis
Asian J Surg. 2024 Feb 7:S1015-9584(24)00138-6. doi: 10.1016/j.asjsur.2024.01.086. Online ahead of print.NO ABSTRACTPMID:38331622 | DOI:10.1016/j.asjsur.2024.01.086 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - February 8, 2024 Category: Surgery Authors: Yinuo Wang Chuzhi Yuan Ning Xu Feng Runlin Source Type: research
Pulmonary adenoid cystic carcinoma ‐ a spectrum of disease: two case reports
Although encountered infrequently in clinical practice, pulmonary adenoid cystic carcinoma is typically a slow-growing indolent condition however, a small proportion of patients present with acute, progressive symptoms and represent a diagnostic and therapeutic challenge. Novel treatments including proton beam therapy and 3D stent reconstruction have been successfully used in this cohort. AbstractAdenoid cystic carcinoma (ACC) is a rare form of adenocarcinoma that usually begins in the oral cavity, with most cases arising from the salivary glands. Owing to its low incidence, the precise clinical and pathological features, ...
Source: Respirology Case Reports - February 8, 2024 Category: Respiratory Medicine Authors: Margaret Gleeson,
Megan Finan,
Karen Redmond Tags: CASE REPORT Source Type: research
Omission of radiotherapy to lymph node level III in patients with cN0 adenoid cystic carcinoma of the major salivary gland: a single center experience
ConclusionIn patients with cN0 ACC of the major salivary gland, PNI improves regional control, and the level III nodal region sparing radiotherapy does not increase the risk of level III recurrence, while potentially reducing toxicity. (Source: La Radiologia Medica)
Source: La Radiologia Medica - February 3, 2024 Category: Radiology Source Type: research
An update on diagnosis and management of obstructive sleep apnoea in the first 2 years of life
In conclusion, management of OSAS in the first 2 years of life is unique and requires consideration of comorbidities and clinical presentation along with PSG results for treatment decisions, and a multidisciplinary approach to treatment with medical and otolaryngology teams. (Source: European Respiratory Review)
Source: European Respiratory Review - January 31, 2024 Category: Respiratory Medicine Authors: Polytarchou, A., Moudaki, A., Van de Perck, E., Boudewyns, A., Kaditis, A. G., Verhulst, S., Ersu, R. Tags: Sleep medicine Sleep and Breathing Conference Reviews Source Type: research
EN1 promotes lung metastasis of salivary adenoid cystic carcinoma by regulating the PI3K-AKT pathway and epithelial-mesenchymal transition
Engrailed homeobox 1 (EN1) is a candidate oncogene that is epigenetically modified in salivary adenoid cystic carcinoma (SACC). We investigated the expression of EN1 in SACC tissues and cells, EN1 promoter methyl... (Source: Cancer Cell International)
Source: Cancer Cell International - January 30, 2024 Category: Cancer & Oncology Authors: Yajuan Cui, Ye Zhang, Yuping Liu, Zheng Zhou, Lijing Zhu and Chuan-Xiang Zhou Tags: Research Source Type: research
A novel classification for guiding the surgical approach for cranio-orbital lesions: a single institution case series of 45 cases and a literature review
AbstractWe aim to share our experience of the removal of cranio-orbital lesions (COLs) and propose a novel classification to guide the tailored approach selection. We retrospectively reviewed 45 consecutive patients with COLs who underwent surgery performed by the same neurosurgeon between November 2010 and November 2022. The surgical approach was selected according to the anatomical region classification of the COLs. For lesions limited to space A (lateral superior orbital fissure, SOF), the pterion or extended pterion approach (PA or EPA) was used. For lesions limited to space B (extraconal compartment medial SOF, and ca...
Source: Neurosurgical Review - January 29, 2024 Category: Neurosurgery Source Type: research
Wnt/ β-catenin-C-kit axis may play a role in adenoid cystic carcinoma prognostication
Pathol Res Pract. 2024 Feb;254:155148. doi: 10.1016/j.prp.2024.155148. Epub 2024 Jan 20.ABSTRACTAdenoid cystic carcinoma (ACC) is one of the most common malignant salivary gland tumors. ACC is composed of myoepithelial and epithelial neoplastic cells which grow slowly and have a tendency for neural invasion. The long term prognosis is still relatively poor. Although several gene abnormalities, such as fusions involving MYB or MYBL1 oncogenes and the transcription factor gene NFIB, and overexpression of KIT have been reported in ACC, their precise functions in the pathogenesis of ACC remain unclear. We recently demonstrated...
Source: Pathology, Research and Practice - January 26, 2024 Category: Pathology Authors: Shinsuke Fujii Kana Hasegawa Takashi Maehara Kari J Kurppa Kristiina Heikinheimo Kristy A Warner Satoshi Maruyama Yudai Tajiri Jacques E N ör Jun-Ichi Tanuma Shintaro Kawano Tamotsu Kiyoshima Source Type: research
Effectiveness of Adenoidectomy as a Standalone Procedure in Improving the Quality of Life of Children with Obstructive Sleep Apnea
AbstractAdenoid hypertrophy (AH) and its sequel like nasal obstruction, obstructive sleep apnoea (OSA), recurrent rhinitis and middle ear disorders are common diseases of pediatric age group, forming the major bulk of pediatric outpatient visits. The recommended approach to treating OSA in children is through adenotonsillectomy. Adenoidectomy is the surgical procedure of removal of hypertrophied adenoid tissues, which is the most common surgery performed by Ear, Nose, and Throat (ENT) surgeons. Given that adenoidectomy alone might lead to reduced instances of adverse outcomes, decreased risk of complications, and lower exp...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - January 23, 2024 Category: ENT & OMF Source Type: research
Anti-NOTCH1 therapy with OMP-52 M51 inhibits salivary adenoid cystic carcinoma by depressing epithelial-mesenchymal transition (EMT) process and inducing ferroptosis
Toxicol Appl Pharmacol. 2024 Jan 20:116825. doi: 10.1016/j.taap.2024.116825. Online ahead of print.ABSTRACTSalivary adenoid cystic carcinoma (ACC) is a common type of salivary gland cancer, and the mechanisms underlying its progression still remain poorly understood without efficient therapies. NOTCH1, an evolutionally conserved cell-cell signaling pathway, is involved in the progression of ACC. In our study, we attempted to explore whether NOTCH1 suppression using the monoclonal anti-NOTCH1 antibody OMP-52 M51 could be of potential for ACC treatment. Here, we identified NOTCH1 elevation in human ACC tissues compared with ...
Source: Toxicology and Applied Pharmacology - January 22, 2024 Category: Toxicology Authors: Ran Li Zelong Hu Quanxin Qiao Die Zhou Minglei Sun Source Type: research
Carcinosarcoma of the parotid gland: a case report and review of the literature
ConclusionCarcinosarcoma is a high-grade aggressive lesion with a poor prognosis and should be treated aggressively. More studies are needed to understand the origin of these tumors. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 20, 2024 Category: General Medicine Source Type: research
Evaluation of NTRK expression and fusions in a large cohort of early-stage lung cancer
AbstractTropomyosin receptor kinases (TRK) are attractive targets for cancer therapy. As TRK-inhibitors are approved for all solid cancers with detectable fusions involving the Neurotrophic tyrosine receptor kinase (NTRK)-genes, there has been an increased interest in optimizing testing regimes. In this project, we wanted to find the prevalence ofNTRK fusions in a cohort of various histopathological types of early-stage lung cancer in Norway and to investigate the association between TRK protein expression and specific histopathological types, including their molecular and epidemiological characteristics. We used immunohis...
Source: Clinical and Experimental Medicine - January 19, 2024 Category: Research Source Type: research
Neoadjuvant Intra-arterial Cytoreductive Chemotherapy Improves Outcomes in Lacrimal Gland Adenoid Cystic Carcinoma
CONCLUSION: IACC improves disease-specific survival in comparison to a population-based cohort treated with excision. Additional patients treated with IACC at multiple institutions are required to provide further external validity.PMID:38227581 | DOI:10.1093/oncolo/oyad346 (Source: The Oncologist)
Source: The Oncologist - January 16, 2024 Category: Cancer & Oncology Authors: Philippos Apolinario Costa David T Tse Pasquale Benedetto Source Type: research
