Hypoxia induced cell dormancy of salivary adenoid cystic carcinoma through miR-922/DEC2 axis
CONCLUSIONS: miR-922/DEC2 axis was necessary to hypoxia-induced cell dormancy and played an important role in the lipid metabolism reprogramming of SACC.PMID:38141378 | PMC:PMC10751830 | DOI:10.1016/j.tranon.2023.101868 (Source: Translational Oncology)
Source: Translational Oncology - December 23, 2023 Category: Cancer & Oncology Authors: Li Dai Hongchun Xian Haofan Wang Mao Li Mei Zhang Xin-Hua Liang Ya-Ling Tang Source Type: research
Hypoxia induced cell dormancy of salivary adenoid cystic carcinoma through miR-922/DEC2 axis
CONCLUSIONS: miR-922/DEC2 axis was necessary to hypoxia-induced cell dormancy and played an important role in the lipid metabolism reprogramming of SACC.PMID:38141378 | PMC:PMC10751830 | DOI:10.1016/j.tranon.2023.101868 (Source: Translational Oncology)
Source: Translational Oncology - December 23, 2023 Category: Cancer & Oncology Authors: Li Dai Hongchun Xian Haofan Wang Mao Li Mei Zhang Xin-Hua Liang Ya-Ling Tang Source Type: research
Adenoid Cystic Cancer of the Lacrimal Gland: Management Aspects and Treatment Outcomes
AbstractAdenoid cystic carcinoma (ACC) of the lacrimal gland is the most common malignant epithelial tumor of the lacrimal gland. The biological behavior of these tumors is characterized by a slow growth with frequent nerve invasion but rare invasion of the neck nodes. Local extension intracranially with bone erosions is seen in locally advanced tumors. Distant metastasis to lungs bone and liver are commonly reported. Treatments using surgery and radiotherapy are generally preferred for adequate tumor control. However there is still no consensus on the best treatment approach. (Source: Indian Journal of Otolaryngology and ...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - December 21, 2023 Category: ENT & OMF Source Type: research
PRT543, a protein arginine methyltransferase 5 inhibitor, in patients with advanced adenoid cystic carcinoma: An open-label, phase I dose-expansion study
CONCLUSION: In this analysis, PRT543 was tolerable, and the observed efficacy was limited in patients with R/M ACC.PMID:38118249 | DOI:10.1016/j.oraloncology.2023.106634 (Source: Ann Oncol)
Source: Ann Oncol - December 20, 2023 Category: Cancer & Oncology Authors: Renata Ferrarotto Paul L Swiecicki Dan P Zandberg Robert A Baiocchi Robert Wesolowski Cristina P Rodriguez Meredith McKean Hyunseok Kang Varun Monga Rajneesh Nath Neil Palmisiano Naveen Babbar William Sun Glenn J Hanna Source Type: research
The mitotic checkpoint kinase BUB1 is a direct and actionable target of MYB in adenoid cystic carcinoma
In this study, we used immortalised breast epithelial cells and an inducibleMYB transgene as a model of ACC. Molecular profiling confirmed that MYB-driven gene expression causes a transition into an ACC-like state. Using this new cell model, we identified BUB1 as a targetable kinase directly controlled by MYB, whose pharmacological inhibition caused MYB-dependent synthetic lethality, growth arrest and apoptosis of patient-derived cells and organoids. (Source: FEBS Letters)
Source: FEBS Letters - December 20, 2023 Category: Biochemistry Authors: Ylenia Cicir ò,
Denise Ragusa,
Paloma Tejera Nevado,
Rossano Lattanzio,
Gianluca Sala,
Tessa DesRochers,
Melissa Millard,
Mattias K. Andersson,
Göran Stenman,
Arturo Sala Tags: Research Article Source Type: research
Primary adenoid cystic carcinoma of the trachea invading thyroid gland: A case report
Asian J Surg. 2023 Dec 15:S1015-9584(23)01986-3. doi: 10.1016/j.asjsur.2023.12.022. Online ahead of print.NO ABSTRACTPMID:38104011 | DOI:10.1016/j.asjsur.2023.12.022 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - December 16, 2023 Category: Surgery Authors: Yi Wang Yue Wang Ning Zhang Xiaofeng Tian Source Type: research
Primary adenoid cystic carcinoma of the trachea invading thyroid gland: A case report
Asian J Surg. 2023 Dec 15:S1015-9584(23)01986-3. doi: 10.1016/j.asjsur.2023.12.022. Online ahead of print.NO ABSTRACTPMID:38104011 | DOI:10.1016/j.asjsur.2023.12.022 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - December 16, 2023 Category: Surgery Authors: Yi Wang Yue Wang Ning Zhang Xiaofeng Tian Source Type: research
Retracted: Influences of Airway Obstruction Caused by Adenoid Hypertrophy on Growth and Development of Craniomaxillofacial Structure and Respiratory Function in Children
Comput Math Methods Med. 2023 Dec 6;2023:9804692. doi: 10.1155/2023/9804692. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2022/5096406.].PMID:38094459 | PMC:PMC10718979 | DOI:10.1155/2023/9804692 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - December 14, 2023 Category: Statistics Authors: Computational And Mathematical Methods In Medicine Source Type: research
High-grade transformation of head and neck adenoid cystic carcinoma demonstrates distinctive clinicopathological features and an unfavorable prognosis: a matched case-control study of the largest series in China
CONCLUSION: This study represents the largest single-center cohort of HGT cases to our knowledge, highlighting its frequent occurrence in the sinonasal and lacrimal glands and association with poorer outcomes. The findings support classifying HGT in ACC as Grade 4, reflecting its severity.PMID:38097822 | DOI:10.1007/s12094-023-03357-5 (Source: Cancer Control)
Source: Cancer Control - December 14, 2023 Category: Cancer & Oncology Authors: Ting-Yao Ma Jun Wu Shi-Zhi He Xue-Lian Wang Guo-Liang Yang Shu-Jing Zhang Jin Zhou Yi-Ming Ding Li-Feng Li Hong-Fei Liu Lan-Lan Xuan Xiao-Hong Chen Source Type: research
Retracted: Influences of Airway Obstruction Caused by Adenoid Hypertrophy on Growth and Development of Craniomaxillofacial Structure and Respiratory Function in Children
Comput Math Methods Med. 2023 Dec 6;2023:9804692. doi: 10.1155/2023/9804692. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2022/5096406.].PMID:38094459 | PMC:PMC10718979 | DOI:10.1155/2023/9804692 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - December 14, 2023 Category: Statistics Authors: Computational And Mathematical Methods In Medicine Source Type: research
High-grade transformation of head and neck adenoid cystic carcinoma demonstrates distinctive clinicopathological features and an unfavorable prognosis: a matched case-control study of the largest series in China
ConclusionThis study represents the largest single-center cohort of HGT cases to our knowledge, highlighting its frequent occurrence in the sinonasal and lacrimal glands and association with poorer outcomes. The findings support classifying HGT in ACC as Grade 4, reflecting its severity. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - December 14, 2023 Category: Cancer & Oncology Source Type: research
