Analysis of antiviral drug properties of thymidine kinase of herpes B virus using recombinant herpes simplex virus 1
In this study, we examined the property of BV thymidine kinase (TK) against anti-herpes drugs using a recombinant herpes simplex virus type 1 (HSV-1) carrying BV TK gene. We found that HSV-1 carrying BV TK was similarly sensitive to GCV as HSV-1 carrying varicella zoster virus TK. In addition, we demonstrated that BV TK was not mutated in the GCV- and ACV-resistant HSV-1 carrying BV TK, suggesting that ACV- or GCV-resistant BV might be rare during treatment with these antiviral drugs. These data can provide a new insight into the properties of BV TK in terms of the development of drug resistance.PMID:38095468 | DOI:10.1128...
Source: Herpes - December 14, 2023 Category: Infectious Diseases Authors: Phu Hoang Anh Nguyen Shuetsu Fukushi Souichi Yamada Shizuko Harada Tomoki Yoshikawa Hitomi Kinoshita Madoka Kawahara Takuma Ogawa Hideki Ebihara Meng Ling Moi Masayuki Saijo Source Type: research
Analysis of antiviral drug properties of thymidine kinase of herpes B virus using recombinant herpes simplex virus 1
In this study, we examined the property of BV thymidine kinase (TK) against anti-herpes drugs using a recombinant herpes simplex virus type 1 (HSV-1) carrying BV TK gene. We found that HSV-1 carrying BV TK was similarly sensitive to GCV as HSV-1 carrying varicella zoster virus TK. In addition, we demonstrated that BV TK was not mutated in the GCV- and ACV-resistant HSV-1 carrying BV TK, suggesting that ACV- or GCV-resistant BV might be rare during treatment with these antiviral drugs. These data can provide a new insight into the properties of BV TK in terms of the development of drug resistance.PMID:38095468 | DOI:10.1128...
Source: Herpes - December 14, 2023 Category: Infectious Diseases Authors: Phu Hoang Anh Nguyen Shuetsu Fukushi Souichi Yamada Shizuko Harada Tomoki Yoshikawa Hitomi Kinoshita Madoka Kawahara Takuma Ogawa Hideki Ebihara Meng Ling Moi Masayuki Saijo Source Type: research
Herpetic Whitlow Associated With an Eating Disorder: A Case Report
Cureus. 2023 Nov 11;15(11):e48654. doi: 10.7759/cureus.48654. eCollection 2023 Nov.ABSTRACTHerpetic whitlow is a localized cutaneous viral infection primarily affecting the fingers, caused by herpes simplex virus types 1 (HSV-1) or 2 (HSV-2). It can be recurrent due to behavioral factors associated with eating disorders, such as bulimia nervosa. We would like to introduce "Jehany Sign," suggesting the term for the association of bulimia nervosa with HSV infections. Here, we present the case of a 50-year-old pre-diabetic female with recurrent herpetic whitlow on her left index finger associated with self-induced vomiting an...
Source: Herpes - December 13, 2023 Category: Infectious Diseases Authors: Fawaz H Aljehani Abdullah M Alharthi Amal W AlDoboke Ammar A Bakhsh Amjad Z Alharbi Source Type: research
Varicella-zoster virus vasculopathy in a patient with multiple sclerosis receiving natalizumab
We present a case of a woman in her 30s with relapsing-remitting multiple sclerosis, treated with natalizumab, who developed ophthalmic varicella zoster virus (VZV) infection, with subsequent vasculopathy causing cerebral ischaemic lesions. She was treated with acyclovir, prednisolone and acetylsalicylic acid and fully recovered. VZV vasculopathy is associated with stroke and immunomodulating treatments may increase the risks of these adverse events. To date, nine VZV-related vasculopathy cases in patients treated with natalizumab have been reported in English literature and are summarised in this paper. Although rare, VZV...
Source: Herpes - December 11, 2023 Category: Infectious Diseases Authors: Anna Elmst åhl Fredrik Buchwald Andreea Ilinca Source Type: research
Varicella-zoster virus vasculopathy in a patient with multiple sclerosis receiving natalizumab
We present a case of a woman in her 30s with relapsing-remitting multiple sclerosis, treated with natalizumab, who developed ophthalmic varicella zoster virus (VZV) infection, with subsequent vasculopathy causing cerebral ischaemic lesions. She was treated with acyclovir, prednisolone and acetylsalicylic acid and fully recovered. VZV vasculopathy is associated with stroke and immunomodulating treatments may increase the risks of these adverse events. To date, nine VZV-related vasculopathy cases in patients treated with natalizumab have been reported in English literature and are summarised in this paper. Although rare, VZV...
Source: Herpes - December 11, 2023 Category: Infectious Diseases Authors: Anna Elmst åhl Fredrik Buchwald Andreea Ilinca Source Type: research
Signal mining study of severe cutaneous adverse events of valaciclovir or acyclovir based on FAERS database
CONCLUSION: By analyzing the FAERS database, the risk trends of SCARs caused by valaciclovir or acyclovir have been identified, providing valuable insights to recognize various types of SCARs in clinics.PMID:38069611 | DOI:10.1080/17512433.2023.2294002 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - December 9, 2023 Category: Drugs & Pharmacology Authors: KaiLi Mao Jiang Li XinLiang Zhu HuaYu Sun SongYang Zhong WeiLi Mao Source Type: research
Signal mining study of severe cutaneous adverse events of valaciclovir or acyclovir based on FAERS database
CONCLUSION: By analyzing the FAERS database, the risk trends of SCARs caused by valaciclovir or acyclovir have been identified, providing valuable insights to recognize various types of SCARs in clinics.PMID:38069611 | DOI:10.1080/17512433.2023.2294002 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - December 9, 2023 Category: Drugs & Pharmacology Authors: KaiLi Mao Jiang Li XinLiang Zhu HuaYu Sun SongYang Zhong WeiLi Mao Source Type: research
Signal mining study of severe cutaneous adverse events of valaciclovir or acyclovir based on FAERS database
CONCLUSION: By analyzing the FAERS database, the risk trends of SCARs caused by valaciclovir or acyclovir have been identified, providing valuable insights to recognize various types of SCARs in clinics.PMID:38069611 | DOI:10.1080/17512433.2023.2294002 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - December 9, 2023 Category: Drugs & Pharmacology Authors: KaiLi Mao Jiang Li XinLiang Zhu HuaYu Sun SongYang Zhong WeiLi Mao Source Type: research
Signal mining study of severe cutaneous adverse events of valaciclovir or acyclovir based on FAERS database
CONCLUSION: By analyzing the FAERS database, the risk trends of SCARs caused by valaciclovir or acyclovir have been identified, providing valuable insights to recognize various types of SCARs in clinics.PMID:38069611 | DOI:10.1080/17512433.2023.2294002 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - December 9, 2023 Category: Drugs & Pharmacology Authors: KaiLi Mao Jiang Li XinLiang Zhu HuaYu Sun SongYang Zhong WeiLi Mao Source Type: research
Signal mining study of severe cutaneous adverse events of valaciclovir or acyclovir based on FAERS database
CONCLUSION: By analyzing the FAERS database, the risk trends of SCARs caused by valaciclovir or acyclovir have been identified, providing valuable insights to recognize various types of SCARs in clinics.PMID:38069611 | DOI:10.1080/17512433.2023.2294002 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - December 9, 2023 Category: Drugs & Pharmacology Authors: KaiLi Mao Jiang Li XinLiang Zhu HuaYu Sun SongYang Zhong WeiLi Mao Source Type: research
Antiviral activity of terpenes isolated from marine brown seaweeds against herpes simplex virus type 2
Nat Prod Res. 2023 Dec 6:1-6. doi: 10.1080/14786419.2023.2288234. Online ahead of print.ABSTRACTHerpes simplex virus type 2 (HSV-2) is the most common agent of sexually transmitted infections around the world. Currently, no vaccine is available, and acyclovir is the reference compound in treatment HSV-2 infections. However, the emergence of resistant strains has reduced the efficacy in treatment. Several studies have shown marine seaweed biological activities, but there are no studies yet about the activity anti-HSV-2 of two its secundary metabolites, atomaric acid (1) and marine dolastane (2), isolated from Stypopodium zo...
Source: Natural Product Research - December 6, 2023 Category: Biochemistry Authors: Lorena da Gra ça Pedrosa de Macena Leonardo Dos Santos Corr êa Amorim Kau ê Francisco Corrêa de Souza E Souza Lu íza Dantas Pereira Claudio Cesar Cirne Dos Santos Caroline de Souza Barros Carlos Jos é Brito Ramos Marcos Vinicius Santana Helena Carla Source Type: research
Antiviral activity of terpenes isolated from marine brown seaweeds against herpes simplex virus type 2
Nat Prod Res. 2023 Dec 6:1-6. doi: 10.1080/14786419.2023.2288234. Online ahead of print.ABSTRACTHerpes simplex virus type 2 (HSV-2) is the most common agent of sexually transmitted infections around the world. Currently, no vaccine is available, and acyclovir is the reference compound in treatment HSV-2 infections. However, the emergence of resistant strains has reduced the efficacy in treatment. Several studies have shown marine seaweed biological activities, but there are no studies yet about the activity anti-HSV-2 of two its secundary metabolites, atomaric acid (1) and marine dolastane (2), isolated from Stypopodium zo...
Source: Herpes - December 6, 2023 Category: Infectious Diseases Authors: Lorena da Gra ça Pedrosa de Macena Leonardo Dos Santos Corr êa Amorim Kau ê Francisco Corrêa de Souza E Souza Lu íza Dantas Pereira Claudio Cesar Cirne Dos Santos Caroline de Souza Barros Carlos Jos é Brito Ramos Marcos Vinicius Santana Helena Carla Source Type: research
Antiviral activity of terpenes isolated from marine brown seaweeds against herpes simplex virus type 2
Nat Prod Res. 2023 Dec 6:1-6. doi: 10.1080/14786419.2023.2288234. Online ahead of print.ABSTRACTHerpes simplex virus type 2 (HSV-2) is the most common agent of sexually transmitted infections around the world. Currently, no vaccine is available, and acyclovir is the reference compound in treatment HSV-2 infections. However, the emergence of resistant strains has reduced the efficacy in treatment. Several studies have shown marine seaweed biological activities, but there are no studies yet about the activity anti-HSV-2 of two its secundary metabolites, atomaric acid (1) and marine dolastane (2), isolated from Stypopodium zo...
Source: Natural Product Research - December 6, 2023 Category: Biochemistry Authors: Lorena da Gra ça Pedrosa de Macena Leonardo Dos Santos Corr êa Amorim Kau ê Francisco Corrêa de Souza E Souza Lu íza Dantas Pereira Claudio Cesar Cirne Dos Santos Caroline de Souza Barros Carlos Jos é Brito Ramos Marcos Vinicius Santana Helena Carla Source Type: research
Congenital herpes simplex with ophthalmic and multisystem features: a case report
CONCLUSIONS: In the management of neonatal HSV, early diagnosis is essential for the timely initiation of antiviral therapy. Our report highlights that ocular assessment can be crucial in the correct diagnostic investigation of this condition.PMID:38044450 | DOI:10.1186/s12887-023-04423-1 (Source: Herpes)
Source: Herpes - December 3, 2023 Category: Infectious Diseases Authors: Samuel Montenegro Pereira Rian Vilar Lima Maria Carolina Rocha Muniz Marcus Breno Farias Ara újo Luiz de Moraes Ferreira J únior Juliana Tiburtino de Queiroz Sales Martins Cl áudia Faustino Coelho Luz David Ant ônio Camelo Cid Daniel da Rocha Lucena Source Type: research
HSD121 Study of Effective Treatment of Genital Herpes in Women in Ukraine
Genital herpes is a common sexually transmitted disease caused by the herpes simplex virus (HSV), characterized by lifelong infection,periodic reactivation. Worldwide, more than 400 million people have genital herpes caused by HSV-2. For patients with genital HSV-1 infection or those with asymptomatic HSV-2 infection, suppressive therapy may be considered for those with significant psychosocial distress due to genital herpes and suspected sexual partner infection.There are several strategies for the use of antiherpetic drugs (acyclovir, famciclovir, valacyclovir), which have been studied and tested in cases of first infect...
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: O. Zaliska, O. Matvienko, Y. Matvienko, N. Maksymovych, M. Malachynska, L. Minko Source Type: research
