Herpes simplex virus reactivation among hematopoietic stem cell transplant recipients: re-evaluating acyclovir dosage
Bone Marrow Transplantation, Published online: 16 April 2024; doi:10.1038/s41409-024-02273-8Herpes simplex virus reactivation among hematopoietic stem cell transplant recipients: re-evaluating acyclovir dosage (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 16, 2024 Category: Hematology Authors: Nada Alsuhebany Bashayer Alshehri Atheer Aldairem Muneerah M. Aleissa Hajar AlQahtani Khalid Albarqi Basil Almotairi Mohammed AlAmri Walid Alanazi Saeed Alay Bader Alahmari Mohsen Alzahrani Source Type: research
Combination of ganciclovir and trifluridine prevents drug-resistance emergence in HSV-1
Antimicrob Agents Chemother. 2024 Apr 15:e0011024. doi: 10.1128/aac.00110-24. Online ahead of print.ABSTRACTOcular herpes simplex virus 1 (HSV-1) infections can lead to visual impairment. Long-term acyclovir (ACV) prophylaxis reduces the frequency of recurrences but is associated with drug resistance. Novel therapies are needed to treat drug-resistant HSV-1 infections. Here, we describe the effects of trifluridine (TFT) in combination with ACV or ganciclovir (GCV) on HSV-1 replication and drug-resistance emergence. Wild-type HSV-1 was grown under increasing doses of one antiviral (ACV, GCV, or TFT) or combinations thereof ...
Source: Antimicrobial Agents and Chemotherapy - April 15, 2024 Category: Microbiology Authors: Hanna Helena Schalkwijk Neesha Rajesh Shewakramani Kalyan Das Graciela Andrei Robert Snoeck Source Type: research
Management of Oral Manifestations of Herpes Simplex Virus, Varicella Zoster Virus, and Human Papillomavirus
Compend Contin Educ Dent. 2024 Apr;45(4):192-197; quiz 198.ABSTRACTHuman herpes virus is a family of DNA viruses that includes herpes simplex virus (HSV) and varicella zoster virus (VZV). HSV-1 and HSV-2 are fairly common and result in oral and genital lesions. Recurrent infections of herpes include lesions on the lips resulting in pain and possibly societal stigma, making adequate treatment of these conditions crucial. VZV is the cause of chicken pox and shingles. Acyclovir and other nucleoside analogues have been the gold standard of treatment for HSV and VZV, but newer, more effective treatments are being developed, whi...
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Lauren Elkada Aviv Ouanounou Source Type: research
Combination of ganciclovir and trifluridine prevents drug-resistance emergence in HSV-1
Antimicrob Agents Chemother. 2024 Apr 15:e0011024. doi: 10.1128/aac.00110-24. Online ahead of print.ABSTRACTOcular herpes simplex virus 1 (HSV-1) infections can lead to visual impairment. Long-term acyclovir (ACV) prophylaxis reduces the frequency of recurrences but is associated with drug resistance. Novel therapies are needed to treat drug-resistant HSV-1 infections. Here, we describe the effects of trifluridine (TFT) in combination with ACV or ganciclovir (GCV) on HSV-1 replication and drug-resistance emergence. Wild-type HSV-1 was grown under increasing doses of one antiviral (ACV, GCV, or TFT) or combinations thereof ...
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Hanna Helena Schalkwijk Neesha Rajesh Shewakramani Kalyan Das Graciela Andrei Robert Snoeck Source Type: research
Multiple ocular manifestations in a patient diagnosed with herpes zoster ophthalmicus: case report
Conclusions: Final visual acuity for the left eye remained 1 despite numerous manifestations of the disease. Abbreviations: VZV = Varicella-zoster virus, BCVA = best-corrected visual acuity, OU = both eyes, OD = right eye, OS = left eye, IOP = intraocular pressure, NCT = non-contact tonometer, ZVX = Zostavax vaccine.PMID:38617727 | PMC:PMC11007559 | DOI:10.22336/rjo.2024.16 (Source: Herpes)
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: David-Ionu ț Beuran Mioara-Laura Macovei Ioana Ruxandra Boca Source Type: research
Herpes simplex keratitis: A brief clinical overview
World J Virol. 2024 Mar 25;13(1):89934. doi: 10.5501/wjv.v13.i1.89934.ABSTRACTThe aim of our minireview is to provide a brief overview of the diagnosis, clinical aspects, treatment options, management, and current literature available regarding herpes simplex keratitis (HSK). This type of corneal viral infection is caused by the herpes simplex virus (HSV), which can affect several tissues, including the cornea. One significant aspect of HSK is its potential to cause recurrent episodes of inflammation and damage to the cornea. After the initial infection, the HSV can establish a latent infection in the trigeminal ganglion, ...
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Mutali Musa Ehimare Enaholo Gladness Aluyi-Osa George Nnamdi Atuanya Leopoldo Spadea Carlo Salati Marco Zeppieri Source Type: research
Combination of ganciclovir and trifluridine prevents drug-resistance emergence in HSV-1
Antimicrob Agents Chemother. 2024 Apr 15:e0011024. doi: 10.1128/aac.00110-24. Online ahead of print.ABSTRACTOcular herpes simplex virus 1 (HSV-1) infections can lead to visual impairment. Long-term acyclovir (ACV) prophylaxis reduces the frequency of recurrences but is associated with drug resistance. Novel therapies are needed to treat drug-resistant HSV-1 infections. Here, we describe the effects of trifluridine (TFT) in combination with ACV or ganciclovir (GCV) on HSV-1 replication and drug-resistance emergence. Wild-type HSV-1 was grown under increasing doses of one antiviral (ACV, GCV, or TFT) or combinations thereof ...
Source: Antimicrobial Agents and Chemotherapy - April 15, 2024 Category: Microbiology Authors: Hanna Helena Schalkwijk Neesha Rajesh Shewakramani Kalyan Das Graciela Andrei Robert Snoeck Source Type: research
Amenamevir for Treating Acyclovir-Resistant or Refractory Herpes Simplex Virus Infection in Allogeneic Hematopoietic Stem Cell Transplantation Recipients. Two Case Reports
Int J Antimicrob Agents. 2024 Apr 10:107169. doi: 10.1016/j.ijantimicag.2024.107169. Online ahead of print.NO ABSTRACTPMID:38608846 | DOI:10.1016/j.ijantimicag.2024.107169 (Source: Herpes)
Source: Herpes - April 12, 2024 Category: Infectious Diseases Authors: L éo Sallée Laetitia Souchet David Boutolleau St éphanie Nguyen Source Type: research
Viruses, Vol. 16, Pages 593: Antiviral Chemotherapy in Avian Medicine & mdash;A Review
Viruses, Vol. 16, Pages 593: Antiviral Chemotherapy in Avian Medicine—A Review
Viruses doi: 10.3390/v16040593
Authors:
Ines Szotowska
Aleksandra Ledwoń
This review article describes the current knowledge about the use of antiviral chemotherapeutics in avian species, such as farm poultry and companion birds. Specific therapeutics are described in alphabetical order including classic antiviral drugs, such as acyclovir, abacavir, adefovir, amantadine, didanosine, entecavir, ganciclovir, interferon, lamivudine, penciclovir, famciclovir, oseltamivir, ribavirin, and zidovudine, repurposed drugs, such as iver...
Source: Viruses - April 12, 2024 Category: Virology Authors: Ines Szotowska Aleksandra Ledwo ń Tags: Review Source Type: research
Machine Learning Exploration of the Relationship Between Drugs and the Blood –Brain Barrier: Guiding Molecular Modification
ConclusionsThe machine learning models developed can accurately predict BBB permeability, and many drug molecules are likely to have increased BBB penetration if the number of Hydrogen Bond Donors and Acceptors are reduced. These findings suggest that molecular modifications can enhance the efficacy of CNS drugs and provide practical strategies for drug design and development. This is particularly relevant for improving drug penetration of the BBB.Graphical Abstract (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 11, 2024 Category: Drugs & Pharmacology Source Type: research
Acute Encephalitis Syndrome in Children and Adolescents: A Five-Year Descriptive Study From South India
CONCLUSIONS: A definitive diagnosis was obtained in about half of the children with AES. Viral (30.4%) and rickettsial infections (22%) were the common etiologies identified. Poor outcome was observed in 32 % of patients.PMID:38584403 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 8, 2024 Category: Pediatrics Authors: Betsy Rebecca Maya Thomas Asha Mary Abraham Sangeetha Yoganathan Ebor Jacob Sathish Kumar Anna Simon Anitha Jasper Winsley Rose Source Type: research
Acute Encephalitis Syndrome in Children and Adolescents: A Five-Year Descriptive Study From South India
CONCLUSIONS: A definitive diagnosis was obtained in about half of the children with AES. Viral (30.4%) and rickettsial infections (22%) were the common etiologies identified. Poor outcome was observed in 32 % of patients.PMID:38584403 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 8, 2024 Category: Pediatrics Authors: Betsy Rebecca Maya Thomas Asha Mary Abraham Sangeetha Yoganathan Ebor Jacob Sathish Kumar Anna Simon Anitha Jasper Winsley Rose Source Type: research
Acute Encephalitis Syndrome in Children and Adolescents: A Five-Year Descriptive Study From South India
CONCLUSIONS: A definitive diagnosis was obtained in about half of the children with AES. Viral (30.4%) and rickettsial infections (22%) were the common etiologies identified. Poor outcome was observed in 32 % of patients.PMID:38584403 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 8, 2024 Category: Pediatrics Authors: Betsy Rebecca Maya Thomas Asha Mary Abraham Sangeetha Yoganathan Ebor Jacob Sathish Kumar Anna Simon Anitha Jasper Winsley Rose Source Type: research
CNS Viral Infections —What to Consider for Improving Drug Treatment: A Plea for Using Mathematical Modeling Approaches
AbstractNeurotropic viruses may cause meningitis, myelitis, encephalitis, or meningoencephalitis. These inflammatory conditions of the central nervous system (CNS) may have serious and devastating consequences if not treated adequately. In this review, we first summarize how neurotropic viruses can enter the CNS by (1) crossing the blood-brain barrier or blood-cerebrospinal fluid barrier; (2) invading the nose via the olfactory route; or (3) invading the peripheral nervous system. Neurotropic viruses may then enter the intracellular space of brain cells via endocytosis and/or membrane fusion. Antiviral drugs are currently ...
Source: CNS Drugs - April 5, 2024 Category: Neurology Source Type: research
