Flavonoids with Anti-Herpes Simplex Virus Properties: Deciphering Their Mechanisms in Disrupting the Viral Life Cycle
Viruses. 2023 Nov 29;15(12):2340. doi: 10.3390/v15122340.ABSTRACTThe herpes simplex virus (HSV) is a double-stranded DNA human virus that causes persistent infections with recurrent outbreaks. HSV exists in two forms: HSV-1, responsible for oral herpes, and HSV-2, primarily causing genital herpes. Both types can lead to significant complications, including neurological issues. Conventional treatment, involving acyclovir and its derivatives, faces challenges due to drug resistance. This underscores the imperative for continual research and development of new drugs, with a particular emphasis on exploring the potential of na...
Source: Herpes - December 23, 2023 Category: Infectious Diseases Authors: Miroslava Šudomová Sherif T S Hassan Source Type: research
Flavonoids with Anti-Herpes Simplex Virus Properties: Deciphering Their Mechanisms in Disrupting the Viral Life Cycle
Viruses. 2023 Nov 29;15(12):2340. doi: 10.3390/v15122340.ABSTRACTThe herpes simplex virus (HSV) is a double-stranded DNA human virus that causes persistent infections with recurrent outbreaks. HSV exists in two forms: HSV-1, responsible for oral herpes, and HSV-2, primarily causing genital herpes. Both types can lead to significant complications, including neurological issues. Conventional treatment, involving acyclovir and its derivatives, faces challenges due to drug resistance. This underscores the imperative for continual research and development of new drugs, with a particular emphasis on exploring the potential of na...
Source: Herpes - December 23, 2023 Category: Infectious Diseases Authors: Miroslava Šudomová Sherif T S Hassan Source Type: research
Clinical Review of Risk of Nephrotoxicity with Acyclovir Use for Treatment of Herpes Simplex Virus Infections in Neonates and Children
CONCLUSIONS: The risk of ACV-associated nephrotoxicity was lower among neonates compared with older children. Future studies are needed to identify the optimal dosage that minimizes toxicities and maximizes the efficacy of ACV in children with HSE.PMID:38130345 | PMC:PMC10731947 | DOI:10.5863/1551-6776-28.6.490 (Source: Herpes)
Source: Herpes - December 22, 2023 Category: Infectious Diseases Authors: Nahed O ElHassan Brendan Crawford Zain Alamarat Jacob T Painter Source Type: research
Clinical Review of Risk of Nephrotoxicity with Acyclovir Use for Treatment of Herpes Simplex Virus Infections in Neonates and Children
CONCLUSIONS: The risk of ACV-associated nephrotoxicity was lower among neonates compared with older children. Future studies are needed to identify the optimal dosage that minimizes toxicities and maximizes the efficacy of ACV in children with HSE.PMID:38130345 | PMC:PMC10731947 | DOI:10.5863/1551-6776-28.6.490 (Source: Herpes)
Source: Herpes - December 22, 2023 Category: Infectious Diseases Authors: Nahed O ElHassan Brendan Crawford Zain Alamarat Jacob T Painter Source Type: research
Multidermatomal herpes zoster triggered by psychological stress in an immunocompetent young adult: a rare case report and clinical insights
CONCLUSION: This case underscores the rare occurrence of multidermatomal HZ in an immunocompetent young adult triggered by psychological stress. The atypical presentation and potential role of stress in viral reactivation emphasize the complex interaction between the nervous and immune systems. Integrated clinical management, stress reduction strategies, and antiviral therapy were effective in resolving the condition. Further research is warranted to elucidate the mechanisms underlying stress-induced viral reactivation and its clinical implications.PMID:38098591 | PMC:PMC10718367 | DOI:10.1097/MS9.0000000000001409 (Source: Annals of Medicine)
Source: Annals of Medicine - December 15, 2023 Category: Internal Medicine Authors: Tek N Yogi Amrit Bhusal Suman Subedi Shailendra Katwal Kshitiz Acharya Source Type: research
Multidermatomal herpes zoster triggered by psychological stress in an immunocompetent young adult: a rare case report and clinical insights
CONCLUSION: This case underscores the rare occurrence of multidermatomal HZ in an immunocompetent young adult triggered by psychological stress. The atypical presentation and potential role of stress in viral reactivation emphasize the complex interaction between the nervous and immune systems. Integrated clinical management, stress reduction strategies, and antiviral therapy were effective in resolving the condition. Further research is warranted to elucidate the mechanisms underlying stress-induced viral reactivation and its clinical implications.PMID:38098591 | PMC:PMC10718367 | DOI:10.1097/MS9.0000000000001409 (Source: Herpes)
Source: Herpes - December 15, 2023 Category: Infectious Diseases Authors: Tek N Yogi Amrit Bhusal Suman Subedi Shailendra Katwal Kshitiz Acharya Source Type: research
Multidermatomal herpes zoster triggered by psychological stress in an immunocompetent young adult: a rare case report and clinical insights
CONCLUSION: This case underscores the rare occurrence of multidermatomal HZ in an immunocompetent young adult triggered by psychological stress. The atypical presentation and potential role of stress in viral reactivation emphasize the complex interaction between the nervous and immune systems. Integrated clinical management, stress reduction strategies, and antiviral therapy were effective in resolving the condition. Further research is warranted to elucidate the mechanisms underlying stress-induced viral reactivation and its clinical implications.PMID:38098591 | PMC:PMC10718367 | DOI:10.1097/MS9.0000000000001409 (Source: Annals of Medicine)
Source: Annals of Medicine - December 15, 2023 Category: Internal Medicine Authors: Tek N Yogi Amrit Bhusal Suman Subedi Shailendra Katwal Kshitiz Acharya Source Type: research
A randomized phase II study of acyclovir for the prevention of chemotherapy-induced oral mucositis in patients undergoing autologous hematopoietic stem cell transplantation
CONCLUSIONS: Prophylactic use of oral acyclovir effectively reduced the incidence of CIOM in patients with HM who were undergoing AHSCT.TRIAL REGISTRATIONS: This trial was registered at the Clinical Research Information Service in the Republic of Korea under the number KCT0003885 (registration date 03/05/2019).PMID:38102638 | DOI:10.1186/s12903-023-03623-6 (Source: Cancer Control)
Source: Cancer Control - December 15, 2023 Category: Cancer & Oncology Authors: Junshik Hong Hee-Kyung Park Sung-Ho Chang Ja Min Byun Dong-Yeop Shin Youngil Koh Sung-Soo Yoon Youngnim Choi Inho Kim Source Type: research
A randomized phase II study of acyclovir for the prevention of chemotherapy-induced oral mucositis in patients undergoing autologous hematopoietic stem cell transplantation
CONCLUSIONS: Prophylactic use of oral acyclovir effectively reduced the incidence of CIOM in patients with HM who were undergoing AHSCT.TRIAL REGISTRATIONS: This trial was registered at the Clinical Research Information Service in the Republic of Korea under the number KCT0003885 (registration date 03/05/2019).PMID:38102638 | DOI:10.1186/s12903-023-03623-6 (Source: Herpes)
Source: Herpes - December 15, 2023 Category: Infectious Diseases Authors: Junshik Hong Hee-Kyung Park Sung-Ho Chang Ja Min Byun Dong-Yeop Shin Youngil Koh Sung-Soo Yoon Youngnim Choi Inho Kim Source Type: research
Multidermatomal herpes zoster triggered by psychological stress in an immunocompetent young adult: a rare case report and clinical insights
CONCLUSION: This case underscores the rare occurrence of multidermatomal HZ in an immunocompetent young adult triggered by psychological stress. The atypical presentation and potential role of stress in viral reactivation emphasize the complex interaction between the nervous and immune systems. Integrated clinical management, stress reduction strategies, and antiviral therapy were effective in resolving the condition. Further research is warranted to elucidate the mechanisms underlying stress-induced viral reactivation and its clinical implications.PMID:38098591 | PMC:PMC10718367 | DOI:10.1097/MS9.0000000000001409 (Source: Herpes)
Source: Herpes - December 15, 2023 Category: Infectious Diseases Authors: Tek N Yogi Amrit Bhusal Suman Subedi Shailendra Katwal Kshitiz Acharya Source Type: research
Multidermatomal herpes zoster triggered by psychological stress in an immunocompetent young adult: a rare case report and clinical insights
CONCLUSION: This case underscores the rare occurrence of multidermatomal HZ in an immunocompetent young adult triggered by psychological stress. The atypical presentation and potential role of stress in viral reactivation emphasize the complex interaction between the nervous and immune systems. Integrated clinical management, stress reduction strategies, and antiviral therapy were effective in resolving the condition. Further research is warranted to elucidate the mechanisms underlying stress-induced viral reactivation and its clinical implications.PMID:38098591 | PMC:PMC10718367 | DOI:10.1097/MS9.0000000000001409 (Source: Annals of Medicine)
Source: Annals of Medicine - December 15, 2023 Category: Internal Medicine Authors: Tek N Yogi Amrit Bhusal Suman Subedi Shailendra Katwal Kshitiz Acharya Source Type: research
A randomized phase II study of acyclovir for the prevention of chemotherapy-induced oral mucositis in patients undergoing autologous hematopoietic stem cell transplantation
To prove our hypothesis that acyclovir prophylaxis in autologous hematopoietic stem cell transplantation (AHSCT) recipients with hematologic malignancies (HM) reduces the incidence of chemotherapy-induced oral... (Source: BMC Oral Health)
Source: BMC Oral Health - December 15, 2023 Category: Dentistry Authors: Junshik Hong, Hee-Kyung Park, Sung-Ho Chang, Ja Min Byun, Dong-Yeop Shin, Youngil Koh, Sung-Soo Yoon, Youngnim Choi and Inho Kim Tags: Research Source Type: research
Analysis of antiviral drug properties of thymidine kinase of herpes B virus using recombinant herpes simplex virus 1
In this study, we examined the property of BV thymidine kinase (TK) against anti-herpes drugs using a recombinant herpes simplex virus type 1 (HSV-1) carrying BV TK gene. We found that HSV-1 carrying BV TK was similarly sensitive to GCV as HSV-1 carrying varicella zoster virus TK. In addition, we demonstrated that BV TK was not mutated in the GCV- and ACV-resistant HSV-1 carrying BV TK, suggesting that ACV- or GCV-resistant BV might be rare during treatment with these antiviral drugs. These data can provide a new insight into the properties of BV TK in terms of the development of drug resistance.PMID:38095468 | DOI:10.1128...
Source: Herpes - December 14, 2023 Category: Infectious Diseases Authors: Phu Hoang Anh Nguyen Shuetsu Fukushi Souichi Yamada Shizuko Harada Tomoki Yoshikawa Hitomi Kinoshita Madoka Kawahara Takuma Ogawa Hideki Ebihara Meng Ling Moi Masayuki Saijo Source Type: research
Analysis of antiviral drug properties of thymidine kinase of herpes B virus using recombinant herpes simplex virus 1
In this study, we examined the property of BV thymidine kinase (TK) against anti-herpes drugs using a recombinant herpes simplex virus type 1 (HSV-1) carrying BV TK gene. We found that HSV-1 carrying BV TK was similarly sensitive to GCV as HSV-1 carrying varicella zoster virus TK. In addition, we demonstrated that BV TK was not mutated in the GCV- and ACV-resistant HSV-1 carrying BV TK, suggesting that ACV- or GCV-resistant BV might be rare during treatment with these antiviral drugs. These data can provide a new insight into the properties of BV TK in terms of the development of drug resistance.PMID:38095468 | DOI:10.1128...
Source: Herpes - December 14, 2023 Category: Infectious Diseases Authors: Phu Hoang Anh Nguyen Shuetsu Fukushi Souichi Yamada Shizuko Harada Tomoki Yoshikawa Hitomi Kinoshita Madoka Kawahara Takuma Ogawa Hideki Ebihara Meng Ling Moi Masayuki Saijo Source Type: research
Herpetic Whitlow Associated With an Eating Disorder: A Case Report
Cureus. 2023 Nov 11;15(11):e48654. doi: 10.7759/cureus.48654. eCollection 2023 Nov.ABSTRACTHerpetic whitlow is a localized cutaneous viral infection primarily affecting the fingers, caused by herpes simplex virus types 1 (HSV-1) or 2 (HSV-2). It can be recurrent due to behavioral factors associated with eating disorders, such as bulimia nervosa. We would like to introduce "Jehany Sign," suggesting the term for the association of bulimia nervosa with HSV infections. Here, we present the case of a 50-year-old pre-diabetic female with recurrent herpetic whitlow on her left index finger associated with self-induced vomiting an...
Source: Herpes - December 13, 2023 Category: Infectious Diseases Authors: Fawaz H Aljehani Abdullah M Alharthi Amal W AlDoboke Ammar A Bakhsh Amjad Z Alharbi Source Type: research
